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Browsing Documents OpenAIRE (Open Access Infrastructure for Research in Europe) by Author "Muñoz Cánoves, Pura, 1962-"

Browsing Documents OpenAIRE (Open Access Infrastructure for Research in Europe) by Author "Muñoz Cánoves, Pura, 1962-"

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  • 3-Deazaadenosine alleviates senescence to promote cellular fitness and cell therapy efficiency in mice
    Guerrero, Ana; Innes, Andrew J.; Roux, Pierre-François; Buisman, Sonja C.; Jung, Johannes; Ortet Cortada, Laura; Moiseeva, Victoria, 1992-; Wagner, Verena; Robinson, Lucas; Ausema, Albertina; Potapova, Anna; Perdiguero, Eusebio, 1968-; Weersing, Ellen; Aarts, Marieke; Martin, Nadine; Wuestefeld, Torsten; Muñoz Cánoves, Pura, 1962-; Haan, Gerald de; Bischof, Oliver; Gil, Jesús (Nature Research, 2022)
    Cellular senescence is a stable type of cell cycle arrest triggered by different stresses. As such, senescence drives age-related diseases and curbs cellular replicative potential. Here, we show that 3-deazaadenosine (3DA), ...
  • Aberrant repair and fibrosis development in skeletal muscle
    Mann, Christopher J.; Perdiguero, Eusebio, 1968-; Kharraz, Yacine; Aguilar, Susana; Pessina, Patrizia; Serrano, Antonio L.; Muñoz Cánoves, Pura, 1962- (BioMed Central, 2011)
    The repair process of damaged tissue involves the coordinated activities of several cell types in response to local and systemic signals. Following acute tissue injury, infiltrating inflammatory cells and resident stem ...
  • Amelioration of Duchenne muscular dystrophy in mdx mice by elimination of matrix-associated fibrin-driven inflammation coupled to the αMβ2 leukocyte integrin receptor
    Vidal Iglesias, Berta; Ardite, Esther; Suelves, Mònica; Ruiz Bonilla, Vanesa, 1979-; Janué, Anna; Flick, Matthew J.; Degen, Jay L.; Serrano, Antonio L.; Muñoz Cánoves, Pura, 1962- (Oxford University Press, 2012)
    In Duchenne muscular dystrophy (DMD), a persistently altered and reorganizing extracellular matrix (ECM) within inflamed muscle promotes damage and dysfunction. However, the molecular determinants of the ECM that mediate ...
  • Assessing autophagy in muscle stem cells
    Campanario, Silvia; Ramírez Pardo, Ignacio; Hong, Xiaotong; Isern, Joan; Muñoz Cánoves, Pura, 1962- (Frontiers, 2021)
    The skeletal muscle tissue in the adult is relatively stable under normal conditions but retains a striking ability to regenerate by its resident stem cells (satellite cells). Satellite cells exist in a quiescent (G0) ...
  • Attenuated epigenetic suppression of muscle stem cell necroptosis is required for efficient regeneration of dystrophic muscles
    Sreenivasan, Krishnamoorthy; Ianni, Alessandro; Künne, Carsten; Strilic, Boris; Günther, Stefan; Perdiguero, Eusebio, 1968-; Krüger, Marcus; Spuler, Simone; Offermanns, Stefan; Gómez del Arco, Pablo; Redondo, Juan Miguel; Muñoz Cánoves, Pura, 1962-; Kim, Johnny; Braun, Thomas (Elsevier, 2020)
    Somatic stem cells expand massively during tissue regeneration, which might require control of cell fitness, allowing elimination of non-competitive, potentially harmful cells. How or if such cells are removed to restore ...
  • Brain-muscle communication prevents muscle aging by maintaining daily physiology
    Kumar, Arun; Vaca Dempere, Mireia, 1994-; Mortimer, Thomas; Deryagin, Oleg; Smith, Jacob G.; Petrus, Paul; Koronowski, Kevin B.; Greco, Carolina M.; Segalés Dalmau, Jessica; Andrés, Eva; Lukesova, Vera; Zinna, Valentina M.; Welz, Patrick-Simon; Serrano Sánchez, Antonio L.; Perdiguero, Eusebio, 1968-; Sassone-Corsi, Paolo; Aznar Benitah, Salvador; Muñoz Cánoves, Pura, 1962- (American Association for the Advancement of Science (AAAS), 2024)
    A molecular clock network is crucial for daily physiology and maintaining organismal health. We examined the interactions and importance of intratissue clock networks in muscle tissue maintenance. In arrhythmic mice showing ...
  • CHD4 ensures stem cell lineage fidelity during skeletal muscle regeneration
    Sreenivasan, Krishnamoorthy; Rodríguez de la Rosa, Alejandra; Kim, Johnny; Mesquita, Diana; Segalés Dalmau, Jessica; Gómez del Arco, Pablo; Espejo, Isabel; Ianni, Alessandro; Di Croce, Luciano; Relaix, Frederic; Redondo, Juan Miguel; Braun, Thomas; Serrano Sánchez, Antonio L.; Perdiguero, Eusebio, 1968-; Muñoz Cánoves, Pura, 1962- (Elsevier, 2021)
    Regeneration of skeletal muscle requires resident stem cells called satellite cells. Here, we report that the chromatin remodeler CHD4, a member of the nucleosome remodeling and deacetylase (NuRD) repressive complex, is ...
  • Circadian transcriptome processing and analysis: a workflow for muscle stem cells
    Sica, Valentina; Deryagin, Oleg; Smith, Jacob G.; Muñoz Cánoves, Pura, 1962- (Wiley, 2023)
    Circadian rhythms coordinate biological processes with Earth's 24-h daily light/dark cycle. In the last years, efforts in the field of chronobiology have sought to understand the ways in which the circadian clock controls ...
  • Computational modelling of stem cell-niche interactions facilitates discovery of strategies to enhance tissue regeneration and counteract ageing
    Potapov, Ilya; García Prat, Laura; Ravichandran, Srikanth; Muñoz Cánoves, Pura, 1962-; del Sol, Antonio (Wiley-Blackwell, 2022)
    The stem cell niche is a specialized microenvironment for stem cells in an adult tissue. The niche provides cues for the maintenance and regulation of stem cell activities and thus presents a target for potential rejuvenating ...
  • Cripto shapes macrophage plasticity and restricts EndMT in injured and diseased skeletal muscle
    Iavarone, Francescopaolo; Guardiola, Ombretta; Scagliola, Alessandra; Andolfi, Gennaro; Esposito, Federica; Serrano Sánchez, Antonio L.; Perdiguero, Eusebio, 1968-; Brunelli, Silvia; Muñoz Cánoves, Pura, 1962-; Minchiotti, Gabriella (EMBO Press, 2020)
    Macrophages are characterized by a high plasticity in response to changes in tissue microenvironment, which allows them to acquire different phenotypes and to exert essential functions in complex processes, such as tissue ...
  • Editorial: role of stem cells in skeletal muscle development, regeneration, repair, aging, and disease
    Muñoz Cánoves, Pura, 1962-; Carvajal, Jaime J.; López de Munain, Adolfo; Izeta, Ander (Frontiers, 2016)
  • Fibrogenic cell plasticity blunts tissue regeneration and aggravates muscular dystrophy
    Pessina, Patrizia; Kharraz, Yacine; Jardí, Mercè; Fukada, So-ichiro; Serrano, Antonio L.; Perdiguero, Eusebio, 1968-; Muñoz Cánoves, Pura, 1962- (Elsevier, 2015)
    Preservation of cell identity is necessary for homeostasis of most adult tissues. This process is challenged every time a tissue undergoes regeneration after stress or injury. In the lethal Duchenne muscular dystrophy ...
  • Glucose 6-P dehydrogenase delays the onset of frailty by protecting against muscle damage
    Arc-Chagnaud, Coralie; Salvador-Pascual, Andrea; Garcia-Dominguez, Esther; Olaso-Gonzalez, Gloria; Correas, Angela G.; Serna, Eva; Brioche, Thomas; Chopard, Angele; Fernandez-Marcos, Pablo J.; Serrano, Manuel; Serrano, Antonio L.; Muñoz Cánoves, Pura, 1962-; Sebastiá, Vicente; Viña, Jose; Gomez-Cabrera, Mari Carmen (Wiley, 2021)
    Background: Frailty is a major age-associated syndrome leading to disability. Oxidative damage plays a significant role in the promotion of frailty. The cellular antioxidant system relies on reduced nicotinamide adenine ...
  • Impact of Bmal1 rescue and time-restricted feeding on liver and muscle proteomes during the active phase in mice
    Smith, Jacob G.; Molendijk, Jeffrey; Blazev, Ronnie; Chen, Wan Hsi; Zhang, Qing; Litwin, Christopher; Zinna, Valentina M.; Welz, Patrick-Simon; Aznar Benitah, Salvador; Greco, Carolina M.; Sassone-Corsi, Paolo; Muñoz Cánoves, Pura, 1962-; Parker, Benjamin L.; Koronowski, Kevin B. (Elsevier, 2023)
    Molecular clocks and daily feeding cycles support metabolism in peripheral tissues. Although the roles of local clocks and feeding are well defined at the transcriptional level, their impact on governing protein abundance ...
  • In vivo transcriptomic profiling using cell encapsulation identifies effector pathways of systemic aging
    Mashinchian, Omid; Hong, Xiaotong; Michaud, Joris; Migliavacca, Eugenia; Lefebvre, Gregory; Boss, Christophe; De Franceschi, Filippo; Le Moal, Emmeran; Collerette-Tremblay, Jasmin; Isern, Joan; Metairon, Sylviane; Raymond, Frederic; Descombes, Patrick; Bouche, Nicolas; Muñoz Cánoves, Pura, 1962-; Feige, Jerome N.; Bentzinger, C. Florian (eLife, 2022)
    Sustained exposure to a young systemic environment rejuvenates aged organisms and promotes cellular function. However, due to the intrinsic complexity of tissues it remains challenging to pinpoint niche-independent effects ...
  • Integration of feeding behavior by the liver circadian clock reveals network dependency of metabolic rhythms
    Greco, Carolina M.; Welz, Patrick-Simon; Kumar, Arun; Vaca-Dempere, Mireia; Deryagian, Oleg; Muñoz Cánoves, Pura, 1962-; Sassone-Corsi, Paolo (American Association for the Advancement of Science (AAAS), 2021)
    The mammalian circadian clock, expressed throughout the brain and body, controls daily metabolic homeostasis. Clock function in peripheral tissues is required, but not sufficient, for this task. Because of the lack of ...
  • Interleukin-6 myokine signaling in skeletal muscle: a double-edged sword?
    Muñoz Cánoves, Pura, 1962-; Scheele, Camilla; Pedersen, Bente K.; Serrano, Antonio L. (Wiley, 2013)
    Interleukin (IL)-6 is a cytokine with pleiotropic functions in different tissues and organs. Skeletal muscle produces and releases significant levels of IL-6 after prolonged exercise and is therefore considered as a myokine. ...
  • Liver and muscle circadian clocks cooperate to support glucose tolerance in mice
    Smith, Jacob G.; Kumar, Arun; Deryagin, Oleg; Vaca Dempere, Mireia, 1994-; Sica, Valentina; Welz, Patrick-Simon; Muñoz Cánoves, Pura, 1962-; Sassone-Corsi, Paolo (Elsevier, 2023)
    Physiology is regulated by interconnected cell and tissue circadian clocks. Disruption of the rhythms generated by the concerted activity of these clocks is associated with metabolic disease. Here we tested the interactions ...
  • Mitochondrial dynamics maintain muscle stem cell regenerative competence throughout adult life by regulating metabolism and mitophagy
    Hong, Xiaotong; Isern, Joan; Campanario, Silvia; Perdiguero, Eusebio, 1968-; Ramírez Pardo, Ignacio; Segalés Dalmau, Jessica; Hernansanz-Agustín, Pablo; Curtabbi, Andrea; Deryagin, Oleg; Pollán, Angela; González-Reyes, José A.; Villalba, José M.; Sandri, Marco; Serrano Sánchez, Antonio L.; Enríquez, José Antonio; Muñoz Cánoves, Pura, 1962- (Elsevier, 2022)
    Skeletal muscle regeneration depends on the correct expansion of resident quiescent stem cells (satellite cells), a process that becomes less efficient with aging. Here, we show that mitochondrial dynamics are essential ...
  • Novel and optimized strategies for inducing fibrosis in vivo: focus on Duchenne Muscular Dystrophy
    Pessina, Patrizia; Cabrera, Daniel; Morales, María Gabriela; Riquelme, Cecilia A; Gutiérrez, Jaime; Serrano, Antonio L.; Brandan, Enrique; Muñoz Cánoves, Pura, 1962- (BioMed Central, 2014)
    Background: Fibrosis, an excessive collagen accumulation, results in scar formation, impairing function of vital organs and tissues. Fibrosis is a hallmark of muscular dystrophies, including the lethal Duchenne muscular ...

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