Browsing Documents OpenAIRE (Open Access Infrastructure for Research in Europe) by Author "Muñoz, Inés G."

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Kinetics in signal transduction pathways involving promiscuous oligomerizing receptors can be determined by receptor specificity: apoptosis induction by TRAIL

Szegezdi, Eva; van der Sloot, Almer M.; Mahalingam, Devalingam; O'Leary, Lynda; Cool, Robbert H.; Muñoz, Inés G.; Montoya, Guillermo; Quax, Wim J.; Jong, Steven M. de, 1962-; Samali, Afshin; Serrano Pubull, Luis, 1982- (American Society for Biochemistry and Molecular Biology (ASBMB), 2012)

Here we show by computer modeling that kinetics and outcome of signal transduction in case of hetero-oligomerizing receptors of a promiscuous ligand largely depend on the relative amounts of its receptors. Promiscuous ...

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