Tesis doctorals llegides a la UPF en format digital en accés obert introduïdes a la plataforma TDX (Tesis Doctorals en Xarxa), on també es poden consultar tesis d'altres centres.
G protein-coupled receptors (GPCRs) are central to cellular signaling and pivotal in drug development. This thesis investigates allosteric communication in GPCRs, crucial for their effective modulation in pharmacotherapy. ...
Esta tesis tiene como objetivos evaluar el entorno alimentario alrededor de las escuelas de Barcelona en términos de proximidad y disponibilidad de establecimientos alimentarios y su relación con el nivel socioeconómico ...
RNA modifications, collectively known as the ‘epitranscriptome’, play a major role in multiple
biological processes, including splicing regulation, gene expression regulation and antibiotic
resistance. Unfortunately, ...
Esta tesis aborda la malnutrición y la sarcopenia en pacientes con enfermedades crónicas, centrándose en la enfermedad pulmonar obstructiva crónica (EPOC) y la enfermedad renal crónica. Utilizando los criterios de la Global ...
This thesis explores technical factors influencing brain PET quantification, developing brain PET harmonization framework, assessing Centiloid robustness as a clinical biomarker, and evaluating the associations between ...
The origin of animals has puzzled scientists for centuries. The transition from a unicellular eukaryote to animals is undoubtedly one of the biggest evolutionary transitions in Earth’s history. To unravel the evolutionary ...
Polycomb repressive complexes (PRC1/2) are key chromatin regulators in development. Their deregulation is implicated in various cancers including leukaemia. Meanwhile, MLL-rearrangements by chromosomal translocations and ...
Esta Tesis Doctoral presenta la edición y el estudio global de seis certificados de peregrinación a los lugares santos de La Meca y Medina, datados entre los ss. XV y XVI. La particularidad de esta tipología documental ...
García de Castro García, Gonzalo(Universitat Pompeu Fabra, 2024-04-12)
Bilingual infants acquire words at a similar rate as monolingual ones, despite navigating a more
intricate linguistic environment. The mechanisms behind this phenomenon remain elusive. Our
project addressed the potential ...
Alternative splicing is a post-transcriptional process that allows the generation of
multiple transcript and protein isoforms from a single gene by differential processing
of exons and introns. This Thesis focuses on ...
RNA is a molecule that is released by the different tissues into the
circulation. When it is found in the circulation it is called cell-free
RNA (cfRNA). This type of molecule has great potential as a
noninvasive biomarker ...
Microtubules form diverse arrays according to the cell type or the cell cycle stage to facilitate the context-specific functions of the cytoskeleton. One way by which cells achieve this is by restricting the formation of ...
Methods for genome engineering have enabled construction of synthetic genomes,
therapeutically reprogrammed cells, synthetic organs, and modification of human genomes.
Design and discovery of genome editors has enabled ...
Özer, Ege Ekin(Universitat Pompeu Fabra, 2024-04-12)
In this thesis, we explored neural entrainment as a potential mechanism to underline the
behavioral evidence that certain phonological properties of listeners’ native language affects
speech segmentation. In two experimental ...
Las neoplasias mieloproliferativas Philadelphia-negativas son enfermedades clonales que se
originan en las células madre hematopoyéticas, ocasionadas por la adquisición de mutaciones
driver que afectan a la vía JAK/STAT. ...
This dissertation sheds light on the impact of emotions on consumer behavior within
culinary contexts. Comprising three chapters, the research presents a holistic
exploration through lab experiments and field studies. ...
La metàstasis és responsable del 90% de les morts per càncer, demostrant l’existent manca de coneixement en relació als seus mecanismes moleculars.
Investigacions anteriors del nostre laboratori han demostrat la importància ...
This PhD thesis explores the potential embedded in living organisms, understood as highly complex machines which can sense, compute, and react to changes in their surroundings. From this general idea, we have made use of ...
The complete blood count (CBC) is one of the most commonly performed test due to its clinical utility, versatility and safety. Thus, there are well established consensus rules to review a CBC through the peripheral blood ...
Metastasis is the major cause of death from Breast Cancer (BCa). During its progression,
divergent opinions have arisen regarding the hormonal status of the BCa subtypes.
The mammary gland is composed of different cell ...