• Subclinical congestion assessed by lung ultrasound in ST segment elevation myocardial infarction

  Carreras-Mora, José; Simón-Ramón, Clara; Vidal Burdeus, María; Rodríguez Sotelo, Laura; Sionis, Alessandro; Giralt Borrell, Teresa; Izquierdo-Marquisá, Andrea; Rodríguez González, Clara; Farré López, Núria; Cainzos-Achirica, Miguel; Tizón-Marcos, Helena; Garcia-Picart, Joan; Milà Pascual, Laia; Vaquerizo Montilla, Beatriz; Rivas-Lasarte, Mercedes; Ribas Barquet, Núria (BMJ Publishing Group, 2023)

  Objective: We evaluated the prognostic value of subclinical congestion assessed by lung ultrasound (LUS) in patients admitted for ST segment elevation myocardial infarction (STEMI). Methods: This was a multicentre study ...
• The impact of recent demography on functional genetic variation in north african human groups

  Lucas-Sánchez, Marcel; Abdeli, Amine; Bekada, Asmahan; Calafell i Majó, Francesc; Benhassine, Traki; Comas, David, 1969- (Oxford University Press, 2024)

  The strategic location of North Africa has made the region the core of a wide range of human demographic events, including migrations, bottlenecks, and admixture processes. This has led to a complex and heterogeneous genetic ...
• Pan-pox-specific T-cell responses in HIV-1-infected individuals after JYNNEOS vaccination

  Sisteré-Oró, Marta; Du, Juan; Wortmann, Diana D. J.; Filippi, Marina D.; Cañas-Ruano, Esperanza; Arrieta Aldea, Itziar; Marcos-Blanco, Agustín; Castells, Xavier; Grau Cerrato, Santiago; García-Giralt, Natalia; Perez-Zsolt, Daniel; Boreika, Rytis; Izquierdo-Useros, Nuria; Güerri Fernández, Roberto; Meyerhans, Andreas (Wiley, 2024)

  People living with human immunodeficiency virus (HIV) are the individuals most affected by the current Monkeypox virus outbreak that was first announced in May 2022. Here we report Pan-pox-specific T-cell responses in a ...
• NK cell-triggered CCL5/IFNγ-CXCL9/10 axis underlies the clinical efficacy of neoadjuvant anti-HER2 antibodies in breast cancer

  Santana-Hernández, Sara; Suárez Olmos, Jesús; Servitja Tormo, Sonia; Berenguer-Molins, Pau; Costa García, Marcel, 1989-; Comerma Blesa, Laura, 1983-; Rea, Anna; Perera Bel, Júlia; Menendez Romero, Silvia; Arpí Llucià, Oriol; Bermejo, Begoña; Martínez, María Teresa; Cejalvo, Juan Miguel; Comino-Méndez, Iñaki; Pascual, Javier; Alba, Emilio; López-Botet, M. (Miguel); Rojo, Federico; Rovira, Ana; Albanell Mestres, Joan; Muntasell i Castellví, Aura, 1972- (BioMed Central, 2024)

  Background: The variability in responses to neoadjuvant treatment with anti-HER2 antibodies prompts to personalized clinical management and the development of innovative treatment strategies. Tumor-infiltrating Natural ...
• Round-robin testing for LMO2 and MYC as immunohistochemical markers to screen MYC rearrangements in aggressive large B-cell lymphoma

  Papaleo, Natalia; Climent, Fina; Tapia, Gustavo; Luizaga Velasco, Luis; Azcarate, Juan; Bosch-Schips, Jan; Muñoz-Mármol, Ana M.; Salido Galeote, Marta; Lome-Maldonado, Carmen; Vázquez, Ivonne; Colomo Saperas, Luis Alberto (Springer, 2023)

  Aggressive large B-cell lymphomas (aLBCL) include a heterogeneous group of lymphomas with diverse biological features. One of the approaches to the diagnosis of aLBCL is based on the identification of MYC rearrangements ...
• Enhancing protein-ligand binding affinity predictions using neural network potentials

  Sabanés Zariquiey, Francesc; Galvelis, Raimondas; Gallicchio, Emilio; Chodera, John D.; Markland, Thomas E.; De Fabritiis, Gianni (American Chemical Society (ACS), 2024)

  This letter gives results on improving protein-ligand binding affinity predictions based on molecular dynamics simulations using machine learning potentials with a hybrid neural network potential and molecular mechanics ...
• International expert consensus on diagnosis and treatment of lung cancer complicated by chronic obstructive pulmonary disease

  Zhou, Chengzhi; Barreiro Portela, Esther; Chen, Rongchang (AME Publishing, 2023)

  Background: Lung cancer combined by chronic obstructive pulmonary disease (LC-COPD) is a common comorbidity and their interaction with each other poses significant clinical challenges. However, there is a lack of ...
• NNP/MM: Accelerating molecular dynamics simulations with machine learning potentials and molecular mechanics

  Galvelis, Raimondas; Varela-Rial, Alejandro; Doerr, Stefan, 1987-; Fino, Roberto; Eastman, Peter; Markland, Thomas E.; Chodera, John D.; De Fabritiis, Gianni (American Chemical Society (ACS), 2023)

  Machine learning potentials have emerged as a means to enhance the accuracy of biomolecular simulations. However, their application is constrained by the significant computational cost arising from the vast number of ...
• Validation of the alchemical transfer method for the estimation of relative binding affinities of molecular series

  Sabanés Zariquiey, Francesc; Pérez, Adrià; Majewski, Maciej; Gallicchio, Emilio; De Fabritiis, Gianni (American Chemical Society (ACS), 2023)

  The accurate prediction of protein-ligand binding affinities is crucial for drug discovery. Alchemical free energy calculations have become a popular tool for this purpose. However, the accuracy and reliability of these ...
• Ambient temperature and seasonal variation in inpatient mortality from respiratory diseases: a retrospective observational study

  Achebak, Hicham; García Aymerich, Judith; Rey, Grégoire; Chen, Zhaoyue; Méndez Turrubiates, Raúl Fernando; Ballester, Joan (Elsevier, 2023)

  Background: The seasonal fluctuation in mortality and hospital admissions from respiratory diseases, with a winter peak and a summer trough, is widely recognized in extratropical countries. However, little is known about ...
• The impact of mutational clonality in predicting the response to immune checkpoint inhibitors in advanced urothelial cancer

  Boll, Lilian Marie; Perera Bel, Júlia; Rodriguez-Vida, Alejo; Arpí Llucià, Oriol; Rovira, Ana; Juanpere, Nuria; Vázquez Montes de Oca, Sergio; Hernández Llodrà, Silvia; Lloreta Trull, Josep, 1958-; Albà Soler, Mar; Bellmunt Molins, Joaquim, 1959- (Nature Research, 2023)

  Immune checkpoint inhibitors (ICI) have revolutionized cancer treatment and can result in complete remissions even at advanced stages of the disease. However, only a small fraction of patients respond to the treatment. To ...
• Exploring adaptive phenotypes for the human calcium-sensing receptor polymorphism R990G

  Sinigaglia, Barbara; Escudero, Jorge; Biagini, Simone Andrea, 1983-; García Calleja, Jorge; Moreno, Josep; Dobón Berenguer, Begoña, 1987-; Acosta, Sandra; Mondal, Mayukh, 1989-; Walsh Capdevila, Sandra, 1991-; Aguileta, Gabriela; Vallès, Mònica; Forrow, Stephen; Martín Caballero, Juan; Migliano, Andrea Bamberg; Bertranpetit, Jaume, 1952-; Muñoz López, Francisco José, 1964-; Bosch Fusté, Elena (Oxford University Press, 2024)

  Rainforest hunter-gatherers from Southeast Asia are characterized by specific morphological features including a particularly dark skin color (D), short stature (S), woolly hair (W), and the presence of steatopygia (S)-fat ...
• Adherence to inhaled corticosteroids in patients with asthma prior to and during the COVID-19 pandemic

  Rodríguez, Isabel; López-Caro, Juan Carlos; González-Carranza, Silvia; Cerrato, Maria Elena; Prado, Maria del Mar de; Gómez-Molleda, Francisca; Pinel, Margarita; Saiz, Maria Teresa; Fuentes, Carmen; Barreiro Portela, Esther; Santibáñez, Miguel (Nature Research, 2023)

  The electronic prescription refill rate (EPRR) of 183 consecutive patients was determined over a 19-month retrospective study period, divided into 7 months PRE (Sep-19 to Mar-20) and 12 months POST pandemic (Apr-20 to ...
• ​Comparative genomics of Balto, a famous historic dog, captures lost diversity of 1920s sled dogs

  Moon, Katherine L.; Huson, Heather J.; Morrill, Kathleen; Wang, Ming-Shan; Li, Xue; Srikanth, Krishnamoorthy; Zoonomia Consortium; Lindblad-Toh, Kerstin; Svenson, Gavin J.; Karlsson, Elinor K.; Shapiro, Beth (American Association for the Advancement of Science (AAAS), 2023)

  We reconstruct the phenotype of Balto, the heroic sled dog renowned for transporting diphtheria antitoxin to Nome, Alaska, in 1925, using evolutionary constraint estimates from the Zoonomia alignment of 240 mammals and 682 ...
• Evolutionary constraint and innovation across hundreds of placental mammals

  Christmas, Matthew J.; Valenzuela, Alejandro; Marquès i Bonet, Tomàs, 1975-; Navarro i Cuartiellas, Arcadi, 1969-; Karlsson, Elinor K. (American Association for the Advancement of Science (AAAS), 2023)

  Zoonomia is the largest comparative genomics resource for mammals produced to date. By aligning genomes for 240 species, we identify bases that, when mutated, are likely to affect fitness and alter disease risk. At least ...
• Control-independent mosaic single nucleotide variant detection with DeepMosaic

  Yang, Xiaoxu; Xu, Xin; Breuss, Martin W.; Antaki, Danny; Ball, Laurel L.; Chung, Changuk; Shen, Jiawei; Li, Chen; George, Renee D.; Wang, Yifan; Bae, Taejeong; Cheng, Yuhe; Abyzov, Alexej; Wei, Liping; Alexandrov, Ludmil B.; Sebat, Jonathan L.; NIMH Brain Somatic Mosaicism Network; Gleeson, Joseph G. (Nature Research, 2023)

  Mosaic variants (MVs) reflect mutagenic processes during embryonic development and environmental exposure, accumulate with aging and underlie diseases such as cancer and autism. The detection of noncancer MVs has been ...
• Antidepressant use in low- middle- and high-income countries: a World Mental Health Surveys report

  Kazdin, Alan E.; Alonso Caballero, Jordi; WHO World Mental Health Survey Collaborators (Cambridge University Press, 2023)

  Background: The most common treatment for major depressive disorder (MDD) is antidepressant medication (ADM). Results are reported on frequency of ADM use, reasons for use, and perceived effectiveness of use in general ...
• Sharper scissors: How TREX2 fine-tunes CRISPR-Cas9 nickases for precise editing

  Güell Cargol, Marc, 1982- (Elsevier, 2024)
• A systematic review of digital interventions for smoking cessation in patients with serious mental illness

  Martínez Agulleiro, Luis; Patil, Bhagyashree; Firth, Joseph; Sawyer, Chelsea; Amann, Benedikt Lorenz; Fonseca Casals, Francina, 1972-; Torrens, Marta; Pérez Solá, Victor; Castellanos, Francisco X.; Kane, John M.; Guinart, Dani (Cambridge University Press, 2023)

  Tobacco smoking is highly prevalent among patients with serious mental illness (SMI), with known deleterious consequences. Smoking cessation is therefore a prioritary public health challenge in SMI. In recent years, several ...
• Polyploidy as a strategy to increase taxane production in yew cell cultures: Obtaining and characterizing a Taxus baccata tetraploid cell line

  Escrich Montañana, Ainoa; Hidalgo Martínez, Diego; Bonfill Baldrich, Ma. Mercedes; Palazón Barandela, Javier; Sánchez Muñoz, Raúl, 1990-; Moyano Claramunt, Elisabet (Elsevier, 2023)

  Novel approaches to optimize the production of plant specialized metabolites are crucial to reach maximum productivity of plant biofactories. Plant polyploidization frequently enhances protein synthesis and thereby increases ...

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