• A dynamic in vitro model of Down syndrome neurogenesis with trisomy 21 gene dosage correction

  Bansal, Prakhar; Banda, Erin C.; Glatt-Deeley, Heather R.; Stoddard, Christopher E.; Linsley, Jeremy W.; Arora, Neha; Deleschaux, Cécile; Ahern, Darcy T.; Kondaveeti, Yuvabharath; Massey, Rachael E.; Nicouleau, Michael; Wang, Shijie; Sabariego Navarro, Miguel; Dierssen, Mara; Finkbeiner, Steven; Pinter, Stefan F. (American Association for the Advancement of Science (AAAS), 2024)

  Excess gene dosage from chromosome 21 (chr21) causes Down syndrome (DS), spanning developmental and acute phenotypes in terminal cell types. Which phenotypes remain amenable to intervention after development is unknown. ...
• An extension of the Walsh-Hadamard transform to calculate and model epistasis in genetic landscapes of arbitrary shape and complexity

  Faure, Andre J.; Lehner, Ben, 1978-; Miró Pina, Verónica; Serrano Colomé, Clàudia; Weghorn, Donate (Public Library of Science (PLoS), 2024)

  Accurate models describing the relationship between genotype and phenotype are necessary in order to understand and predict how mutations to biological sequences affect the fitness and evolution of living organisms. The ...
• Deconwolf enables high-performance deconvolution of widefield fluorescence microscopy images

  Wernersson, Erik; Gelali, Eleni; Girelli, Gabriele; Wang, Su; Castillo, David; Mattsson Langseth, Christoffer; Verron, Quentin; Nguyen, Huy Q.; Chattoraj, Shyamtanu; Martinez Casals, Anna; Blom, Hans; Lundberg, Emma; Nilsson, Mats; Martí Renom, Marc A.; Wu, Chao-Ting; Crosetto, Nicola; Bienko, Magda (Nature Research, 2024)

  Microscopy-based spatially resolved omic methods are transforming the life sciences. However, these methods rely on high numerical aperture objectives and cannot resolve crowded molecular targets, limiting the amount of ...
• The hepatocyte epidermal growth factor receptor (EGFR) pathway regulates the cellular interactome within the liver fibrotic niche

  Gonzalez-Sanchez, Ester; Vaquero, Javier; Caballero Díaz, Daniel; Grzelak, Jan; Fusté, Noel P.; Bertran, Esther; Amengual, Josep; García Sáez, Juan; Martín-Mur, Beatriz; Gut, Marta; Esteve-Codina, Anna; Alay, Ania; Coulouarn, Cedric; Calero Pérez, Silvia; Valdecantos, Pilar; Valverde, Angela M.; Sánchez, Aránzazu; Herrera, Blanca; Fabregat, Isabel (Wiley, 2024)

  Liver fibrosis is the consequence of chronic liver injury in the presence of an inflammatory component. Although the main executors of this activation are known, the mechanisms that lead to the inflammatory process that ...
• PHF2-mediated H3K9me balance orchestrates heterochromatin stability and neural progenitor proliferation

  Aguirre, Samuel; Pappa, Stella; Serna Pujol, Núria; Padilla, Natàlia; Iacobucci, Simona; Nacht, A. Silvina; Vicent, Guillermo Pablo; Jordan Vallès, Albert; Cruz, Xavier de la; Martínez Balbás, Marian A. (EMBO Press, 2024)

  Heterochromatin stability is crucial for progenitor proliferation during early neurogenesis. It relays on the maintenance of local hubs of H3K9me. However, understanding the formation of efficient localized levels of H3K9me ...
• The Wnt-dependent master regulator NKX1-2 controls mouse pre-implantation development

  Nakagawa, Shoma; Carnevali, Davide; Tan, Xiangtian; Alvarez, Mariano J.; Parfitt, David-Emlyn; Di Vicino, Umberto; Arumugam, Karthik; Shin, William; Aranda, Sergi; Normanno, Davide; Sebastián Pérez, Rubén; Cannatá, Chiara; Cortes, Paola; Neguembor, Maria Victoria; Shen, Michael M.; Califano, Andrea; Cosma, Maria Pia (Elsevier, 2024)

  Embryo size, specification, and homeostasis are regulated by a complex gene regulatory and signaling network. Here we used gene expression signatures of Wnt-activated mouse embryonic stem cell (mESC) clones to reverse ...
• TANGO1 inhibitors reduce collagen secretion and limit tissue scarring

  Raote, Ishier; Häkkinen, Hanna-Maria; Vibe, Carine; Broadbent, Katrina; Carolis, Carlo; Ruprecht, Verena; Malhotra, Vivek (Nature Research, 2024)

  Uncontrolled secretion of ECM proteins, such as collagen, can lead to excessive scarring and fibrosis and compromise tissue function. Despite the widespread occurrence of fibrotic diseases and scarring, effective therapies ...
• Active transcription and epigenetic reactions synergistically regulate meso-scale genomic organization

  Kant, Aayush; Guo, Zixian; Vinayak, Vinayak; Neguembor, Maria Victoria; Li, Wing Shun; Agrawal, Vasundhara; Pujadas, Emily; Almassalha, Luay; Backman, Vadim; Lakadamyali, Melike; Cosma, Maria Pia; Shenoy, Vivek B. (Nature Research, 2024)

  In interphase nuclei, chromatin forms dense domains of characteristic sizes, but the influence of transcription and histone modifications on domain size is not understood. We present a theoretical model exploring this ...
• Developing a platform for secretion of biomolecules in Mycoplasma feriruminatoris

  Gonzalez de Miguel, Javier; Montero-Blay, Ariadna, 1994-; Ciampi, Ludovica; Rodriguez-Arce, Irene; Serrano Pubull, Luis, 1982- (BioMed Central, 2024)

  Background: Having a simple and fast dividing organism capable of producing and exposing at its surface or secreting functional complex biomolecules with disulphide bridges is of great interest. The mycoplasma bacterial ...
• Non-canonical role for the BAF complex subunit DPF3 in mitosis and ciliogenesis

  Verrillo, Giulia; Obeid, Anna Maria; Genco, Alexia; Scrofani, Jacopo, 1984-; Orange, François; Hanache, Sarah; Mignon, Julien; Leyder, Tanguy; Michaux, Catherine; Kempeneers, Céline; Bricmont, Noëmie; Herkenne, Stephanie; Vernos, Isabelle, 1959-; Martin, Maud; Mottet, Denis (Company of Biologists, 2024)

  DPF3, along with other subunits, is a well-known component of the BAF chromatin remodeling complex, which plays a key role in regulating chromatin remodeling activity and gene expression. Here, we elucidated a non-canonical ...
• Characterization of the common genetic variation in the spanish population of Navarre

  Maillo, Alberto; Beltran, Sergi; Gómez Cabrero, David (MDPI, 2024)

  Large-scale genomic studies have significantly increased our knowledge of genetic variability across populations. Regional genetic profiling is essential for distinguishing common benign variants from disease-causing ones. ...
• Association between radiation dose, thyroid hormone, and IQ levels in children exposed to radiation in utero after the Chernobyl accident

  Liutsko, Liudmila; Igumnov, Sergey; Drozdovitch, Vladimir; Cardis, Elisabeth (Taylor & Francis, 2024)

  Few studies have explored the effects of n utero radiation exposure on human health and cognition and none have taken into account thyroid hormone levels (T3), which have shown to affect cognitive performance. We investigated ...
• Cohort Profile: Barcelona Life Study Cohort (BiSC)

  Dadvand, Payam; Gascon Merlos, Mireia, 1984-; Bustamante Pineda, Mariona; Rivas, Ioar; Foraster Pulido, Maria, 1984-; Basagaña Flores, Xavier; Cosín Tomàs, Marta; Ferrer Vergés, Muriel; Gómez Herrera, Laura C.; Jiménez Arenas, Pol; Júlvez Calvo, Jordi; Morillas, Àlex; Nieuwenhuijsen, Mark J.; Persavento, Cecilia; Pujol, Jesús; Vrijheid, Martine; Sunyer Deu, Jordi; BiSC Group (Oxford University Press, 2024)
• Short-term exposure to air pollution and hospital admission after COVID-19 in Catalonia: the COVAIR-CAT study

  Alari, Anna; Ranzani, Otavio; Olmos, Sergio; Milà, Carles; Rico, Alex; Ballester, Joan; Basagaña Flores, Xavier; Dadvand, Payam; Duarte Salles, Talita, 1985-; Nieuwenhuijsen, Mark J.; Vivanco Hidalgo, Rosa María; Tonne, Cathryn (Oxford University Press, 2024)

  Background: A growing body of evidence has reported positive associations between long-term exposure to air pollution and poor COVID-19 outcomes. Inconsistent findings have been reported for short-term air pollution, mostly ...
• Physical activity and body mass related to catch-up lung function growth in childhood: a population-based accelerated cohort study

  Koch, Sarah; Prado Peralta, María Gabriela; Carsin, Anne-Elie; Abellan, Alicia; Roda, Célina; Torrent, Maties; Iñiguez, Carmen; Ballester Díez, Ferran; Ferrero, Amparo; Zabaleta, Carlos; Lertxundi, Aitana; Guxens Junyent, Mònica; Vrijheid, Martine; Sunyer Deu, Jordi; Casas Sanahuja, Maribel; García Aymerich, Judith (BMJ Publishing Group, 2024)

  Objective: The existence of catch-up lung function growth and its predictors is uncertain. We aimed to identify lung function trajectories and their predictors in a population-based birth cohort. Methods: We applied ...
• Metabolomic signatures of exposure to nitrate and trihalomethanes in drinking water and colorectal cancer risk in a Spanish Multicentric Study (MCC-Spain)

  Alcolea, Jose A.; Donat-Vargas, Carolina; Chatziioannou, Anastasia Chrysovalantou; Keski-Rahkonen, Pekka; Robinot, Nivonirina; Molina, Antonio J.; Amiano, Pilar; Gómez-Acebo, Inés; Castaño Vinyals, Gemma; Maitre, Léa; Chadeau-Hyam, Marc; Dagnino, Sonia; Cheng, Sibo Lucas; Scalbert, Augustin; Vineis, Paolo; Kogevinas, Manolis; Villanueva Belmonte, Cristina (American Chemical Society (ACS), 2023)

  We investigated the metabolomic profile associated with exposure to trihalomethanes (THMs) and nitrate in drinking water and with colorectal cancer risk in 296 cases and 295 controls from the Multi Case-Control Spain ...
• Comprehensive map of ribosomal 2'-O-methylation and C/D box snoRNAs in Drosophila melanogaster

  Sklias, Athena; Cruciani, Sonia; Marchand, Virginie; Spagnuolo, Mariangela; Lavergne, Guillaume; Bourguignon, Valérie; Brambilla, Alessandro; Dreos, René; Marygold, Steven J.; Novoa Pardo, Ana María; Motorin, Yuri; Roignant, Jean-Yves (Oxford University Press, 2024)

  During their maturation, ribosomal RNAs (rRNAs) are decorated by hundreds of chemical modifications that participate in proper folding of rRNA secondary structures and therefore in ribosomal function. Along with pseudouridine, ...
• Membrane to cortex attachment determines different mechanical phenotypes in LGR5+ and LGR5- colorectal cancer cells

  Conti, Sefora; Venturini, Valeria; Cañellas Socias, Adrià; Cortina Duran, Carme; Abenza, Juan F.; Stephan-Otto Attolini, Camille; Middendorp Guerra, Emily; Xu, Catherine K.; Li, Jia Hui; Rossetti, Leone; Stassi, Giorgio; Roca-Cusachs, Pere; Diz-Muñoz, Alba; Ruprecht, Verena; Guck, Jochen; Batlle Gómez, Eduard; Labernadie, Anna; Trepat, Xavier (Nature Research, 2024)

  Colorectal cancer (CRC) tumors are composed of heterogeneous and plastic cell populations, including a pool of cancer stem cells that express LGR5. Whether these distinct cell populations display different mechanical ...
• Intron detention tightly regulates the stemness/differentiation switch in the adult neurogenic niche

  González Iglesias, Ainara; Arcas Mantas, Aida; Domingo Muelas, Ana; Mancini, Estefanía; Galcerán, Joan; Valcárcel, J. (Juan); Fariñas, Isabel; Nieto, M. Ángela (Nature Research, 2024)

  The adult mammalian brain retains some capacity to replenish neurons and glia, holding promise for brain regeneration. Thus, understanding the mechanisms controlling adult neural stem cell (NSC) differentiation is crucial. ...
• CSDE1: a versatile regulator of gene expression in cancer

  Ciocia, Annagiulia; Mestre Farràs, Neus; Vicent Nacht, Ignacio; Guitart, Tanit; Gebauer, Fátima (Oxford University Press, 2024)

  RNA-binding proteins (RBPs) have garnered significant attention in the field of cancer due to their ability to modulate diverse tumor traits. Once considered untargetable, RBPs have sparked renewed interest in drug ...

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