• Exploring the genetic and genomic connection underlying neurodegeneration with brain iron accumulation and the risk for Parkinson’s disease

  Alvarez Jerez, Pilar; Alcantud, Jose Luis; Reyes-Ramírez, Lucia de los; Moore, Anni; Ruz, Clara; Vives Montero, Francisco; Rodriguez-Losada, Noela; Saini, Prabhjyot; Gan-Or, Ziv; Alvarado, Chelsea X.; Makarious, Mary B.; Billingsley, Kimberley J.; Blauwendraat, Cornelis; Noyce, Alastair J.; Singleton, Andrew B.; Duran, Raquel; Bandres-Ciga, Sara (Nature Research, 2023)

  Neurodegeneration with brain iron accumulation (NBIA) represents a group of neurodegenerative disorders characterized by abnormal iron accumulation in the brain. In Parkinson's Disease (PD), iron accumulation is a cardinal ...
• Automated optimisation of solubility and conformational stability of antibodies and proteins

  Rosace, Angelo; Bennett, Anja; Oeller, Marc; Mortensen, Mie M.; Sakhnini, Laila; Lorenzen, Nikolai; Poulsen, Christian; Sormanni, Pietro (Nature Research, 2023)

  Biologics, such as antibodies and enzymes, are crucial in research, biotechnology, diagnostics, and therapeutics. Often, biologics with suitable functionality are discovered, but their development is impeded by developability ...
• Robustness and innovation in synthetic genotype networks

  Santos-Moreno, Javier; Tasiudi, Eve; Kusumawardhani, Hadiastri; Stelling, Joerg; Schaerli, Yolanda (Nature Research, 2023)

  Genotype networks are sets of genotypes connected by small mutational changes that share the same phenotype. They facilitate evolutionary innovation by enabling the exploration of different neighborhoods in genotype space. ...
• Natural green spaces, sensitization to allergens, and the role of gut microbiota during infancy

  Buchholz, Vienna; Bridgman, Sarah L.; Nielsen, Charlene C.; Gascon Merlos, Mireia, 1984-; Tun, Hein M.; Simons, Elinor; Turvey, Stuart E.; Subbarao, Padmaja; Takaro, Tim K.; Brook, Jeffrey R.; Scott, James A.; Mandhane, Piush J.; Kozyrskyj, Anita L. (American Society for Microbiology, 2023)

  The environment plays an instrumental role in the developmental origins of health and disease. Protective features of the environment in the development of asthma and atopy have been insufficiently studied. We used data ...
• Analyzing the role of cancer-associated fibroblast activation on macrophage polarization

  Bruch Oms, Marina; Olivera-Salguero, Rubén, 1991-; Mazzolini, Rocco; Valle Pérez, Beatriz del; Mayo González, Paula; Beteta, Ángel; Peña Arranz, Raúl; García de Herreros, Antonio (Wiley, 2023)

  Snail1 is a transcriptional factor required for cancer-associated fibroblast (CAF) activation, and mainly detected in CAFs in human tumors. In the mouse mammary tumor virus-polyoma middle tumor-antigen (MMTV-PyMT) model ...
• Beauveria bassiana rewires molecular mechanisms related to growth and defense in tomato

  Proietti, Silvia; Falconieri, Gaia Salvatore; Bertini, Laura; Pascale, Alberto; Bizzarri, Elisabetta; Morales Sanfrutos, Julia; Sabidó Aguadé, Eduard, 1981-; Ruocco, Michelina; Monti, Maurilia M.; Russo, Assunta; Dziurka, Kinga; Ceci, Marcello; Loreto, Francesco; Caruso, Carla (Oxford University Press, 2023)

  Plant roots can exploit beneficial associations with soil-inhabiting microbes, promoting growth and expanding the immune capacity of the host plant. In this work, we aimed to provide new information on changes occurring ...
• Electronic Cigarette Use in 12 European countries: results from the TackSHS survey

  Gallus, Silvano; Lugo, Alessandra; Stival, Chiara; Cerrai, Sonia; Clancy, Luke; Filippidis, Filippos T.; Gorini, Giuseppe; López, Maria José; López Nicolás, Ángel; Molinaro, Sabrina; Odone, Anna; Soriano, Joan B.; Tigova, Olena; van den Brandt, Piet A.; Vardavas, Constantine; Fernández, Esteve; TackSHS Project Investigators (Japan Epidemiological Association, 2023)

  Background: Limited data on electronic cigarette prevalence, patterns, and settings of use are available from several European countries. Methods: Within the TackSHS project, a face-to-face survey was conducted in 2017-2018 ...
• A longitudinal study of free leptin index in pre-eclamptic pregnancies

  Garcés, María Fernanda; Buell-Acosta, Julieth Daniela; Rodríguez-Navarro, Haiver Antonio; Páez-Leal, María Carolina; Maldonado-Acosta, Luis Miguel; Peralta-Franco, Jhon Jairo; Burgos-Cardenas, Álvaro Javier; Ángel-Müller, Edith; Parada-Baños, Arturo José; Parra-Pineda, Mario Orlando; Eslava-Schmalbach, Javier; Escobar-Sarmiento, Camilo Andrés; Lacunza, Ezequiel; Caminos-Cepeda, Sofia Alexandra; Castaño, Justo P.; Nogueiras, Ruben; Dieguez, Carlos; Ruiz-Parra, Ariel Iván; Caminos, Jorge Eduardo (Wiley, 2023)

  The ratio between circulating levels of leptin and soluble leptin receptor (sOB-R), the free leptin index (FLI), is used as a marker of leptin resistance. Therefore, the aim of our study was to investigate the FLI in mild ...
• Why has epidemiology not (yet) succeeded in identifying the origin of the asthma epidemic?

  Antó i Boqué, Josep Maria; Pearce, Neil E.; Douwes, Jeroen; García Aymerich, Judith; Pembrey, Lucy; Richiardi, Lorenzo; Sunyer Deu, Jordi (Oxford University Press, 2023)
• Protein supplementation in a prehabilitation program in patients undergoing surgery for endometrial cancer

  Sole-Sedeno, Josep M.; Miralpeix, Ester; Muns, Maria Dolors; Rodriguez-Cosmen, Cristina; Fabregó, Berta; Kanjou, Nadwa; Medina, Francesc-Xavier; Mancebo Moreno, Gemma (MDPI, 2023)

  Enhanced recovery after surgery (ERAS) and prehabilitation programs are multidisciplinary care pathways to reduce stress response and improve perioperative outcomes, which also include nutritional interventions. The aim ...
• Association between malnutrition assessed by the global leadership initiative on malnutrition criteria and mortality in older people: a scoping review

  Sánchez-Rodríguez, María Dolores; De Meester, Dorien; Minon, Léa; Claessens, Marie; Gümüs, Neslian; Lieten, Siddhartha; Benoit, Florence; Surquin, Murielle; Marco Navarro, Ester (MDPI, 2023)

  The Global Leadership Initiative on Malnutrition (GLIM) criteria were introduced in 2018 for the diagnosis of malnutrition in adults. This review was aimed at gathering the evidence about the association between malnutrition ...
• A qualitative exploration of patient safety in a hospital setting in Spain: policy and practice recommendations on patients' and companions' participation

  Abiétar, Daniel G.; Domingo, Laia; Medina Perucha, Laura; Saavedra, Nuria; Berenguera, Anna; Lacueva-Pérez, Laia; Hurtado, Marta; Castells, Xavier; Sala, Maria (Wiley, 2023)

  Introduction: Patients' and companions' participation in healthcare could help prevent adverse events, which are a significant cause of disease and disability. Before designing interventions to increase participation, it ...
• Gender inequalities in the prevalence of low mood and related factors in schooled adolescents during the 2019–2020 school year: DESKcohort project

  Gonzalez-Casals, Helena; Vives, Jaume; Bosque Prous, Marina, 1984-; Folch Toda, Cinta; Drou-Roget, Gemma; Muntaner, Carles, 1957-; Vives Cases, Carmen; Barbaglia, María Gabriela, 1979-; Colom, Joan; Espelt Hernández, Albert, 1981- (Elsevier, 2023)

  Background: Mood disorders are the second most prevalent mental disorders in childhood and adolescence. Many undiagnosed people manifest subthreshold symptoms, like low mood, and present worse prognoses than asymptomatic ...
• A high-throughput approach to predict A-to-I effects on RNA structure indicates a change of double-stranded content in noncoding RNAs

  Delli Ponti, Riccardo, 1987-; Broglia, Laura; Vandelli, Andrea; Armaos, Alexandros, 1989-; Torrent Burgas, Marc; Sanchez de Groot, Natalia; Tartaglia, Gian Gaetano (Wiley, 2023)

  RNA molecules undergo a number of chemical modifications whose effects can alter their structure and molecular interactions. Previous studies have shown that RNA editing can impact the formation of ribonucleoprotein complexes ...
• Menstruation and social inequities in Spain: a cross-sectional online survey-based study

  Medina Perucha, Laura; López-Jiménez, Tomàs; Jacques-Aviñó, Constanza; Holst, Anna Sofie; Valls Llobet, Carme; Munrós-Feliu, Jordina; Martínez-Bueno, Cristina; Pinzón-Sanabria, Diana; Vicente-Hernández, Mª Mercedes; Berenguera, Anna (BioMed Central, 2023)

  Background: Available research suggests that menstrual inequity has an impact on (menstrual) health outcomes and emotional wellbeing. It is also a significant barrier to achieve social and gender equity and compromises ...
• Changes in bone quality after switching from a TDF to a TAF based ART: a pilot randomized study

  Soldado-Folgado, Jade; Rins-Lozano, Oriol; Arrieta Aldea, Itziar; González Mena, Alicia; Cañas-Ruano, Esperanza; Knobel Freud, Hernando; Garcia Giralt, Natàlia (Frontiers, 2023)

  Background: The impact of tenofovir disoproxil fumarate (TDF) antiretroviral (ART) regimens on bone health has been characterized mostly by bone mineral density (BMD), but recently also by bone quality (BQ). The aim of ...
• The natural history of QTc interval and its clinical impact in coronavirus disease 2019 survivors after 1 year

  Mojón Álvarez, Diana; Izquierdo, Andrea; Cubero Gallego, Héctor; Calvo-Fernández, Alicia; Marrugat de la Iglesia, Jaume; Pérez-Fernández, Silvia; Cabero, Paula; Solà-Richarte, Clàudia; Soler, Cristina; Farré López, Núria; Vaquerizo Montilla, Beatriz (Frontiers, 2023)

  Background and objective: Prolonged QTc interval on admission and a higher risk of death in SARS-CoV-2 patients have been reported. The long-term clinical impact of prolonged QTc interval is unknown. This study examined ...
• Comparison of Rotterdam and Barcelona magnetic resonance imaging risk calculators for predicting clinically significant prostate cancer

  Morote, Juan; Borque-Fernando, Ángel; Triquell, Marina; Campistol, Miriam; Servian, Pol; Abascal-Junquera, José María; Planas, Jacques; Méndez, Olga; Esteban, Luis M.; Trilla, Enrique (Elsevier, 2023)

  Background: Magnetic resonance imaging (MRI)-based risk calculators (MRI-RCs) individualise the likelihood of clinically significant prostate cancer (csPCa) and improve candidate selection for prostate biopsy beyond the ...
• Ten tips for teaching research integrity to early career students: A perspective over 20 years

  Martinez-Campos, Maruxa (Frontiers, 2022)

  Early Career Researchers (ECRs) are becoming increasingly aware of the importance of good scientific practices to ensure their work is trustworthy; but also of the effect that research culture has on those practices. Here ...
• Noncanonical Wnt signaling promotes colon tumor growth, chemoresistance and tumor fibroblast activation

  Fuertes, Guillem; Valle Pérez, Beatriz del; Pastor Ruiz, Javier; Andrades, Evelyn; Peña Arranz, Raúl; García de Herreros, Antonio; Duñach, Mireia (EMBO Press, 2023)

  Colon tumors of the mesenchymal subtype have the lowest overall survival. Snail1 is essential for the acquisition of this phenotype, characterized by increased tumor stemness and invasion, and high resistance to chemotherapy. ...

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