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Articles (Departament de Ciències Experimentals i de la Salut)

Articles (Departament de Ciències Experimentals i de la Salut)

 

Articles de recerca, en accés obert, del Departament de Ciències Experimentals i de la Salut de la UPF.

Recent Submissions

  • Malinova, Antonia; Veghini, Lisa; Real, Francisco X.; Corbo, Vincenzo (Frontiers, 2021)
    Infidelity to cell fate occurs when differentiated cells lose their original identity and either revert to a more multipotent state or transdifferentiate into a different cell type, either within the same embryonic lineage ...
  • Barrios, Vicente; Chowen, Julie A.; Martín Rivada, Álvaro; Guerra-Cantera, Santiago; Pozo-Román, Jesús; Yakar, Shoshana; Rosenfeld, Ron G.; Pérez Jurado, Luis Alberto; Suárez, Juan; Argente, Jesús (MDPI, 2021)
    The growth hormone (GH)/insulin-like growth factor (IGF) axis plays fundamental roles during development, maturation, and aging. Members of this axis, composed of various ligands, receptors, and binding proteins, are ...
  • Salat Canela, Clàudia, 1989-; Carmona, Mercè; Martín-García, Rebeca; Pérez, Pilar; Ayté del Olmo, José; Hidalgo Hernando, Elena (Elsevier, 2021)
    Cdc42 GTPase rules cell polarity and growth in fission yeast. It is negatively and positively regulated by GTPase-activating proteins (GAPs) and guanine nucleotide exchange factors (GEFs), respectively. Active Cdc42-GTP ...
  • Alvarez-Perez, Beltran; Poras, Hervé; Maldonado, Rafael, 1961- (Wiley, 2021)
    Despite the increasing impact of opioid use disorders on society, there is a disturbing lack of effective medications for their clinical management. An interesting innovative strategy to treat these disorders consists in ...
  • Flores Bello, André, 1992-; Font-Porterias, Neus; Aizpurua-Iraola, Julen; Duarri-Redondo, Sara; Comas, David, 1969- (BioMed Central, 2021)
    Background: The general picture of human genetic variation has been vastly depicted in the last years, yet many populations remain broadly understudied. In this work, we analyze for the first time the Merchero population, ...
  • Conti, David V.; Kogevinas, Manolis; Haiman, Christopher A. (Nature Research, 2021)
    Prostate cancer is a highly heritable disease with large disparities in incidence rates across ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer genome-wide.
  • O'Callaghan Gordo, Cristina; Rosales, Jaime; Lizárraga, Pilar; Barclay, Frederica; Okamoto, Tami; Papoulias, Diana M.; Espinosa Díaz, Ana; Orta-Martínez, Martí; Kogevinas, Manolis; Astete, John (Elsevier, 2021)
    Background: High blood lead levels (BLLs) have been previously reported in indigenous people living in communities in the northern Peruvian Amazon. Oil extraction activities have been conducted in the area since the 1970s ...
  • White, Anna E.; Dios Martínez, Toni de, 1994-; Carrión, Pablo; Bonora, Gian Luca; Llovera, Laia; Cilli, Elisabetta; Lizano González, Esther, 1974-; Khabdulina, Maral K.; Tleugabulov, Daniyar T.; Olalde Marquínez, Íñigo, 1987-; Marquès i Bonet, Tomàs, 1975-; Balloux, François; Pettener, Davide; van Dorp, Lucy; Luiselli, Donata; Lalueza Fox, Carles, 1965- (MDPI, 2021)
    The Asian Central Steppe, consisting of current-day Kazakhstan and Russia, has acted as a highway for major migrations throughout history. Therefore, describing the genetic composition of past populations in Central Asia ...
  • Van der Stel, Wanda; Pastor Maeso, Manuel; Gómez-Tamayo, José C.; Van de Water, Bob (Spektrum Akademischer Verlag, 2021)
    Read-across approaches are considered key in moving away from in vivo animal testing towards addressing data-gaps using new approach methods (NAMs). Ample successful examples are still required to substantiate this strategy. ...
  • Dhandapani, Laasya; Salzer, Marion C.; Duran, Juan M.; Zaffagnini, Gabriele; De Guirior, Cristian; Martínez-Zamora, Maria Angeles; Böke, Elvan (Company of Biologists, 2022)
    Oocytes spend the majority of their lifetime in a primordial state. The cellular and molecular biology of primordial oocytes is largely unexplored; yet, it is necessary to study them to understand the mechanisms through ...
  • Raote, Ishier; Saxena, Sonashree; Campelo, Felix; Malhotra, Vivek (Elsevier, 2021)
    TANGO1 protein facilitates the endoplasmic reticulum (ER) export of large cargoes that cannot be accommodated in 60 nm transport vesicles. It assembles into a ring in the plane of the ER membrane to create a distinct domain. ...
  • Alemany, Silvia; Vilor Tejedor, Natàlia, 1988-; Milà Alomà, Marta; Suárez-Calvet, Marc; Salvadó, Gemma; Arenaza Urquijo, Eider M.; Sánchez Benavides, Gonzalo; Grau-Rivera, Oriol; Minguillón, Carolina; Fauria, Karine; Domingo Gispert, Juan; Gascon Merlos, Mireia, 1984-; Nieuwenhuijsen, Mark J.; Sunyer Deu, Jordi; ALFA Study (Elsevier, 2021)
    Background: Air quality contributes to incidence of Alzheimer's disease (AD) although the underlying neurobiological mechanisms are unclear. This study was aimed to examine the association between air pollution and ...
  • Garrison, Helen; Agostinho, Marta; Alvarez, Laura; Bekaert, Sofia; Bengtsson, Luiza; Broglio, Elisabetta; Couso, Digna; Araújo Gomes, Raquel; Ingram, Zoe; Martínez, Emma; Mena, Ana Lúcia; Nickel, Dörthe; Norman, Michael; Pinheiro, Inês; Solís-Mateos, Marta; Bertero, Michela G. (EMBO Press, 2021)
    Open Science calls for transparent science and involvement of various stakeholders. Here are examples of and advice for meaningful stakeholder engagement.
  • Ribera, Jordi; Portolés, Irene; Córdova-Jover, Bernat; Rodríguez-Vita, Juan; Casals, Gregori; Gónzalez-de la Presa, Bernardino; Graupera, Mariona; Solsona-Vilarrasa, Estel; Garcia-Ruiz, Carmen; Fernández-Checa, José C.; Soria, Guadalupe; Tudela, Raúl; Esteve-Codina, Anna; Espadas, Guadalupe; Sabidó Aguadé, Eduard, 1981-; Jiménez, Wladimiro; Sessa, William C.; Morales-Ruiz, Manuel (Nature Research, 2021)
    DHX15 is a downstream substrate for Akt1, which is involved in key cellular processes affecting vascular biology. Here, we explored the vascular regulatory function of DHX15. Homozygous DHX15 gene deficiency was lethal in ...
  • Campos Mata, Leire de, 1991-; Tejedor Vaquero, Sonia, 1988-; Tachó-Piñot, Roser; Piñero González, Janet, 1977-; Grasset, Emilie K.; Arrieta Aldea, Itziar; Rodrigo Melero, Natalia; Carolis, Carlo; Horcajada Gallego, Juan Pablo; Cerutti, Andrea, 1965-; Villar García, Judit; Magri, Giuliana, 1978- (Wiley Open Access, 2021)
    Objectives: SARS-CoV-2 infection induces virus-reactive memory B cells expressing unmutated antibodies, which hints at their emergence from naïve B cells. Yet, the dynamics of virus-specific naïve B cells and their impact ...
  • Hernández, Gonzalo; Masclans Enviz, Joan Ramon; Castellvi, Andrea; Marin Corral, Judith; Roca, Oriol (Elsevier, 2022)
    Background: During the first wave of the COVID-19 pandemic, shortages of ventilators and ICU beds overwhelmed health care systems. Whether early tracheostomy reduces the duration of mechanical ventilation and ICU stay is ...
  • Paz-Graniel, Indira; Schröder, Helmut, 1958-; Castañer, Olga; Salas-Salvadó, Jordi (Elsevier, 2021)
    Background & aims: The association between drinking water consumption and adiposity has been poorly explored. Therefore, we aimed to analyse the associations between the frequency of drinking water consumption and body ...
  • Grau Cerrato, Santiago; Ferrández, Olivia; Martín García, Elena, 1975-; Maldonado, Rafael, 1961- (Elsevier, 2021)
    Objectives: There is an urgent need to ameliorate the possibilities of transporting reconstituted mRNA vaccines from the centralized preparation centres to the vaccination sites to improve the efficiency of the vaccination ...
  • Sanz Álvarez, Marta; Martín-Aparicio, Ester; Luque, Melani; Zazo, Sandra; Martínez-Useros, Javier; Eroles, Pilar; Rovira, Ana; Albanell Mestres, Joan; Madoz-Gúrpide, Juan; Rojo, Federico (MDPI, 2021)
    The use of anti-HER2 therapies has significantly improved clinical outcome in patients with HER2-positive breast cancer, yet a substantial proportion of patients acquire resistance after a period of treatment. The PI3K/AKT/mTOR ...
  • Echeverría Esnal, Daniel; Sorli Redó, M. Luisa; Prim, Núria; Martín-Ontiyuelo, Clara; Horcajada Gallego, Juan Pablo; Grau Cerrato, Santiago (MDPI, 2021)
    Background: Ampicillin resistant and glycopeptide susceptible Enterococcus faecium bloodstream infection (GSEF-BSI) incidence has risen. However, the treatment of choice remains unknown. Daptomycin use for the treatment ...

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