• Intestinal Blastocystis is linked to healthier diets and more favorable cardiometabolic outcomes in 56,989 individuals from 32 countries

  Piperni, Elisa; Vallès Colomer, Mireia; Asnicar, Francesco (Elsevier, 2024)

  Diet impacts human health, influencing body adiposity and the risk of developing cardiometabolic diseases. The gut microbiome is a key player in the diet-health axis, but while its bacterial fraction is widely studied, the ...
• DNA methylation enables recurrent endogenization of giant viruses in an animal relative

  Sarre, Luke A.; Kim, Iana V.; Ovchinnikov, Vladimir; Olivetta, Marine; Suga, Hiroshi; Dudin, Omaya; Sebé-Pedrós, Arnau; Mendoza, Alex de (American Association for the Advancement of Science (AAAS), 2024)

  5-Methylcytosine (5mC) is a widespread silencing mechanism that controls genomic parasites. In eukaryotes, 5mC has gained complex roles in gene regulation beyond parasite control, yet 5mC has also been lost in many lineages. ...
• The structure and mechanics of the cell cortex depend on the location and adhesion state

  Flormann, Daniel; Kainka, Lucina; Montalvo, Gala; Rheinlaender, Johannes; Thalla, D.; Vesperini, Doriane; Pohland, M. O.; Kaub, K. H.; Schu, M.; Pezzano, Fabio; Ruprecht, Verena; Terriac, Emmanuel; Hawkins, Rhoda; Lautenschläger, Franziska (National Academy of Sciences, 2024)

  Cells exist in different phenotypes and can transition between them. A phenotype may be characterized by many different aspects. Here, we focus on the example of whether the cell is adhered or suspended and choose particular ...
• Biodiversity as a firewall to engineered microbiomes for restoration and conservation

  Maull, Victor; Solé Vicente, Ricard, 1962- (Royal Society, 2024)

  The possibility of abrupt transitions threatens to poise ecosystems into irreversibly degraded states. Synthetic biology has recently been proposed to prevent them from crossing tipping points. However, there is little ...
• Long non-coding RNAs involved in Drosophila development and regeneration

  Camilleri Robles, Carlos; Amador, Raziel; Tiebe, Marcel; Teleman, Aurelio A.; Serras, Florenci; Guigó Serra, Roderic; Corominas Guiu, Montserrat (Oxford University Press, 2024)

  The discovery of functional long non-coding RNAs (lncRNAs) changed their initial concept as transcriptional noise. LncRNAs have been identified as regulators of multiple biological processes, including chromatin structure, ...
• Risk factors and clinical impact of multidrug resistance in healthcare-associated bacteraemic urinary tract infections: a post-hoc analysis of a multicentre prospective cohort in Spain

  Gómez-Zorrilla, Silvia; Sendra, Elena; López Montesinos, Inmaculada; Duran Jordà, Xavier, 1974-; Horcajada Gallego, Juan Pablo; ITUBRAS-2 Group (Elsevier, 2024)

  Background: The global burden associated with antimicrobial resistance is of increasing concern. Aim: To evaluate risk factors associated with multidrug-resistant (MDR) infection and its clinical impact in a cohort of ...
• Relationship between respiratory microbiome and systemic inflammatory markers in COPD: A pilot study

  Casadevall Fusté, Carme; Quero, Sara; Millares, Laura; Faner, Rosa; Cosío, Borja G.; Peces-Barba Romero, Germán; Castro-Acosta, Ady Angélica; Montón, Concepción; Palou, Alexandre; Pascual Guàrdia, Sergi, 1979-; Agustí García-Navarro, Àlvar; Gea Guiral, Joaquim; Monsó Molas, Eduard; BIOMEPOC group (MDPI, 2024)

  The respiratory microbiome may influence the development and progression of COPD by modulating local immune and inflammatory events. We aimed to investigate whether relative changes in respiratory bacterial abundance are ...
• Modelling the demographic history of human North African genomes points to a recent soft split divergence between populations

  Serradell Noguera, Jose Miguel; Lorenzo Salazar, Jose M.; Flores, Carlos; Lao Grueso, Oscar, 1976-; Comas, David, 1969- (BioMed Central, 2024)

  Background: North African human populations present a complex demographic scenario due to the presence of an autochthonous genetic component and population substructure, plus extensive gene flow from the Middle East, Europe, ...
• Heterologous mRNA/MVA delivering trimeric-RBD as effective vaccination regimen against SARS-CoV-2: COVARNA Consortium

  Marcos Villar, Laura; Meyerhans, Andreas; Gómez, Carmen Elena (Taylor & Francis, 2024)

  Despite the high efficiency of current SARS-CoV-2 mRNA vaccines in reducing COVID-19 morbidity and mortality, waning immunity and the emergence of resistant variants underscore the need for novel vaccination strategies. ...
• Physical activity, sedentary behaviour, and childhood asthma: a European collaborative analysis

  Eijkemans, Marianne; García Aymerich, Judith; López Vicente, Mònica, 1988-; Sunyer Deu, Jordi; Thijs, Carel (BMJ Publishing Group, 2024)

  Objectives: To investigate the associations of physical activity (PA) and sedentary behaviour in early childhood with asthma and reduced lung function in later childhood within a large collaborative study. Design: Pooling ...
• Glycated hemoglobin, type 2 diabetes, and poor diabetes control are positively associated with impulsivity changes in aged individuals with overweight or obesity and metabolic syndrome

  Gómez Martínez, Carlos; Babio, Nancy; Camacho Barcia, Lucía; Júlvez Calvo, Jordi; Nishi, Stephanie; Vázquez, Zenaida; Forcano, Laura; Álvarez-Sala, Andrea; Cuenca Royo, Aida Ma, 1981-; Torre Fornell, Rafael de la; Fanlo Maresma, Marta; Tello, Susanna; Corella, Dolores; Arias Vásquez, Alejandro; Dalsgaard, Søren; Franke, Barbara; Fernández Aranda, Fernando; Salas Salvadó, Jordi (Wiley, 2024)

  Impulsivity has been proposed to have an impact on glycemic dysregulation. However, it remains uncertain whether an unfavorable glycemic status could also contribute to an increase in impulsivity levels. This study aims ...
• Elucidation of the epitranscriptomic RNA modification landscape of Chikungunya Virus

  Baquero Pérez, Belinda; Bortoletto, Enrico; Rosani, Umberto; Delgado-Tejedor, Anna; Medina, Rebeca; Novoa, Eva Maria; Venier, Paola; Díez Antón, Juana, 1962- (MDPI, 2024)

  The genomes of positive-sense (+) single-stranded RNA (ssRNA) viruses are believed to be subjected to a wide range of RNA modifications. In this study, we focused on the chikungunya virus (CHIKV) as a model (+) ssRNA virus ...
• At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods

  Mesinovic, Munib; Wong, Xin Ci; Rajahram, Giri Shan; Citarella, Barbara Wanjiru; Peariasamy, Kalaiarasu M.; van Someren Greve, Frank; Olliaro Piero L.; Merson, Laura; Clifton, Lei; Kartsonaki, Christiana; ISARIC Clinical Characterisation Group (Nature Research, 2024)

  By September 2022, more than 600 million cases of SARS-CoV-2 infection have been reported globally, resulting in over 6.5 million deaths. COVID-19 mortality risk estimators are often, however, developed with small ...
• Microproteins encoded by noncanonical ORFs are a major source of tumor-specific antigens in a liver cancer patient meta-cohort

  Camarena, Marta E.; Theunissen, Patrick; Ruiz, Marta; Ruiz Orera, Jorge, 1988-; Calvo Serra, Beatriz; Castelo Valdueza, Robert; Castro Alejos, Carla; Sarobe, Pablo; Fortes, Puri; Perera Bel, Júlia; Albà Soler, Mar (American Association for the Advancement of Science (AAAS), 2024)

  The expression of tumor-specific antigens during cancer progression can trigger an immune response against the tumor. Here, we investigate if microproteins encoded by noncanonical open reading frames (ncORFs) are a relevant ...
• Modeling the impact of neuromorphological alterations in Down syndrome on fast neural oscillations

  Clusella, Pau; Manubens-Gil, Linus, 1989-; García Ojalvo, Jordi; Dierssen, Mara (Public Library of Science (PLoS), 2024)

  Cognitive disorders, including Down syndrome (DS), present significant morphological alterations in neuron architectural complexity. However, the relationship between neuromorphological alterations and impaired brain ...
• Lack of Bmal1 leads to changes in rhythmicity and impairs motivation towards natural stimuli

  Berbegal-Sáez, Paula; Gallego-Landin, Ines; Macía, Javier; Alegre Zurano, Laia; Castro Zavala, Adriana, 1988-; Welz, Patrick-Simon; Benitah, Salvador A.; Valverde Granados, Olga (Royal Society, 2024)

  Maintaining proper circadian rhythms is essential for coordinating biological functions in mammals. This study investigates the effects of daily arrhythmicity using Bmal1-knockout (KO) mice as a model, aiming to understand ...
• Exploring the therapeutic potential of defective interfering particles in reducing the replication of SARS-CoV-2

  Locke, Macauley; Grebennikov, Dmitry; Sazonov, Igor; López García, Martín; Loguinova, Marina; Meyerhans, Andreas; Bocharov, Gennady A.; Molina-París, Carmen (MDPI, 2024)

  SARS-CoV-2 still presents a global threat to human health due to the continued emergence of new strains and waning immunity among vaccinated populations. Therefore, it is still relevant to investigate potential therapeutics, ...
• The human VGLUT3-pT8I mutation elicits uneven striatal DA signaling, food or drug maladaptive consumption in male mice

  Favier, Mathieu; Martín García, Elena, 1975-; Maldonado, Rafael, 1961-; El Mestikawy, Salah (Nature Research, 2024)

  Cholinergic striatal interneurons (ChIs) express the vesicular glutamate transporter 3 (VGLUT3) which allows them to regulate the striatal network with glutamate and acetylcholine (ACh). In addition, VGLUT3-dependent ...
• CapTrap-seq: a platform-agnostic and quantitative approach for high-fidelity full-length RNA sequencing

  Carbonell Sala, Silvia; Perteghella, Tamara; Lagarde, Julien; Nishiyori, Hiromi; Palumbo, Emilio; Arnan Ros, Carme; Takahashi, Hazuki; Carninci, Piero; Uszczynska-Ratajczak, Barbara; Guigó Serra, Roderic (Nature Research, 2024)

  Long-read RNA sequencing is essential to produce accurate and exhaustive annotation of eukaryotic genomes. Despite advancements in throughput and accuracy, achieving reliable end-to-end identification of RNA transcripts ...
• The Catalan initiative for the Earth BioGenome Project: contributing local data to global biodiversity genomics

  Corominas Guiu, Montserrat; Guigó Serra, Roderic (Oxford University Press, 2024)

  The Catalan Initiative for the Earth BioGenome Project (CBP) is an EBP-affiliated project network aimed at sequencing the genome of the >40 000 eukaryotic species estimated to live in the Catalan-speaking territories ...

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