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Articles (Departament de Ciències Experimentals i de la Salut)

Articles (Departament de Ciències Experimentals i de la Salut)

 

Articles de recerca, en accés obert, del Departament de Ciències Experimentals i de la Salut de la UPF.

Recent Submissions

  • García Baos, Alba; Alegre Zurano, Laia; Cantacorps Centellas, Lídia, 1991-; Martín Sánchez, Ana; Valverde Granados, Olga (Elsevier, 2021)
    Alcohol is a psychoactive substance highly used worldwide, whose harmful use might cause a broad range of mental and behavioural disorders. Underlying brain impact, the neuroinflammatory response induced by alcohol is ...
  • Richart, Laia; Lapi, Eleonora; Pancaldi, Vera; Cuenca-Ardura, Mirabai; Carrillo-de-Santa Pau, Enrique; Madrid-Mencía, Miguel; Neyret-Kahn, Hélène; Radvanyi, François; Rodríguez, Juan Antonio; Cuartero, Yasmina; Serra, François; Le Dily, François; Valencia, Alfonso; Martí Renom, Marc A.; Real, Francisco X. (Oxford University Press, 2021)
    Cohesin exists in two variants containing STAG1 or STAG2. STAG2 is one of the most mutated genes in cancer and a major bladder tumor suppressor. Little is known about how its inactivation contributes to tumorigenesis. Here, ...
  • Pallarès-Masmitjà, Maria; Ivančić, Dimitrije; Mir-Pedrol, Júlia; Jaraba-Wallace, Jessica; Tagliani, Tommaso; Oliva Miguel, Baldomero; Rahmeh, Amal; Sánchez-Mejías, Avencia; Güell Cargol, Marc (Nature Research, 2021)
    While multiple technologies for small allele genome editing exist, robust technologies for targeted integration of large DNA fragments in mammalian genomes are still missing. Here we develop a gene delivery tool (FiCAT) ...
  • Peralta-Garcia, Alejandro; Torrens Fontanals, Mariona; Stepniewski, Tomasz Maciej, 1988-; Grau-Expósito, Judith; Perea, David; Ayinampudi, Vikram; Waldhoer, Maria; Zimmermann, Mirjam; Buzón, María J.; Genescà, Meritxell; Selent, Jana (MDPI, 2021)
    Since the start of the COVID-19 outbreak, pharmaceutical companies and research groups have focused on the development of vaccines and antiviral drugs against SARS-CoV-2. Here, we apply a drug repurposing strategy to ...
  • Ataya Fernández, Michelle, 1993-; Redondo Pachón, María Dolores; Llinàs-Mallol, Laura; Yélamos López, José; Alari-Pahissa, Elisenda; Pérez-Sáez, María José; Altadill, Mireia; Raïch-Regué, Dàlia; Vilches, Carlos; Pascual Santos, Julio; Crespo Barrio, Marta; López-Botet, Miguel (American Association of Immunologists - AAI, 2021)
    Human CMV infection is frequent in kidney transplant recipients (KTR). Pretransplant Ag-specific T cells and adaptive NKG2C+ NK cells associate with reduced incidence of infection in CMV+ KTR. Expansions of adaptive NKG2C+ ...
  • Lucas-Sánchez, Marcel; Serradell, Jose M.; Comas, David, 1969- (Oxford University Press, 2021)
    Compared with the rest of the African continent, North Africa has provided limited genomic data. Nonetheless, the genetic data available show a complex demographic scenario characterized by extensive admixture and drift. ...
  • Rodin, Rachel E.; Brain Somatic Mosaicism Network; Walsh, Christopher A. (Nature Research, 2021)
    We characterize the landscape of somatic mutations-mutations occurring after fertilization-in the human brain using ultra-deep (~250×) whole-genome sequencing of prefrontal cortex from 59 donors with autism spectrum disorder ...
  • Fontseré Alemany, Clàudia, 1992-; Alvarez-Estape, Marina; Kuhlwilm, Martin; Marquès i Bonet, Tomàs, 1975-; Lizano González, Esther, 1974- (Wiley, 2021)
    Noninvasive samples as a source of DNA are gaining interest in genomic studies of endangered species. However, their complex nature and low endogenous DNA content hamper the recovery of good quality data. Target capture ...
  • Welker, Frido; Chiva, Cristina; Kuhlwilm, Martin; Manuel Montero, Marc de, 1991-; Gelabert Xirinachs, Pere, 1991-; Marquès i Bonet, Tomàs, 1975-; Sabidó Aguadé, Eduard, 1981-; Lalueza Fox, Carles, 1965-; Cappellini, Enrico (Nature Research, 2020)
    The phylogenetic relationships between hominins of the Early Pleistocene epoch in Eurasia, such as Homo antecessor, and hominins that appear later in the fossil record during the Middle Pleistocene epoch, such as Homo ...
  • Amargant i Riera, Farners, 1990-; Pujol, Aïda; Ferrer-Vaquer, Anna; Durban, Mercè; Martínez, Meritxell; Vassena, Rita; Vernos, Isabelle, 1959- (Oxford University Press, 2021)
    The mechanism of conversion of the human sperm basal body to a centrosome after fertilization, and its role in supporting human early embryogenesis, has not been directly addressed so far. Using proteomics and immunofluorescence ...
  • Galera Laporta, Letícia, 1985-; Comerci, Colin J.; García Ojalvo, Jordi; Süel, Gürol M. (Elsevier, 2021)
    Metal ions are essential for life and represent the second most abundant constituent (after water) of any living cell. While the biological importance of inorganic ions has been appreciated for over a century, we are far ...
  • Matsuda, Mitsuhiro; Hayashi, Hanako; García Ojalvo, Jordi; Yoshioka-Kobayashi, Kumiko; Kageyama, Ryoichiro; Yamanaka, Yoshihiro; Ikeya, Makoto; Toguchida, Junya; Alev, Cantas; Ebisuya, Miki (American Association for the Advancement of Science (AAAS), 2020)
    Although mechanisms of embryonic development are similar between mice and humans, the time scale is generally slower in humans. To investigate these interspecies differences in development, we recapitulate murine and human ...
  • Casal, Miguel A.; Galella Toledo, Santiago; Vilarroya, Óscar; García Ojalvo, Jordi (American Institute of Physics (AIP), 2020)
    Recurrent neuronal networks are known to be endowed with fading (short-term) memory, whereas long-term memory is usually considered to be hard-wired in the network connectivity via Hebbian learning, for instance. Here, we ...
  • Yang, Chih-Yu; Bialecka-Fornal, Maja; Weatherwax, Colleen; Larkin, Joseph; Prindle, Arthur; Liu, Jintao; García Ojalvo, Jordi; Süel, Gürol M. (Elsevier, 2020)
    Cellular membrane potential plays a key role in the formation and retrieval of memories in the metazoan brain, but it remains unclear whether such memory can also be encoded in simpler organisms like bacteria. Here, we ...
  • Castro e Silva, Marcos Araújo; Nunes, Kelly; Barbosa Lemes, Renan; Mas Sandoval, Àlex, 1989-; Guerra Amorim, Carlos Eduardo; Krieger, José Eduardo; Mill, José Geraldo; Salzano, Francisco Mauro; Bortolini, Maria Cátira; Pereira, Alexandre da Costa; Comas, David, 1969-; Hünemeier, Tábita (National Academy of Sciences, 2020)
    In the 15th century, ∼900,000 Native Americans, mostly Tupí speakers, lived on the Brazilian coast. By the end of the 18th century, the coastal native populations were declared extinct. The Tupí arrived on the east coast ...
  • Fábrega, María José; Knödlseder, Nastassia; Nevot, Guillermo; Sanvicente, Marta; Toloza, Lorena; Santos-Moreno, Javier; Güell Cargol, Marc (American Chemical Society (ACS), 2021)
    In the past few years, new bacterial-cell-free transcription-translation systems have emerged as potent and quick platforms for protein production as well as for prototyping of DNA regulatory elements, genetic circuits, ...
  • Varela-Rial, Alejandro; Maryanow, Iain; Majewski, Maciej; Doerr, Stefan, 1987-; Schapin, Nikolai; Jiménez Luna, José, 1993-; De Fabritiis, Gianni (American Chemical Society (ACS), 2022)
    Deep learning has been successfully applied to structure-based protein-ligand affinity prediction, yet the black box nature of these models raises some questions. In a previous study, we presented KDEEP, a convolutional ...
  • Sandín, Daniel; Valle, Javier; Chaves-Arquero, Belén; Prats-Ejarque, Guillem; Larrosa, María Nieves; González-López, Juan José; Jiménez, María Ángeles; Boix, Ester; Andreu Martínez, David; Torrent Burgas, Marc (American Chemical Society (ACS), 2021)
    Multidrug resistance against conventional antibiotics poses an important threat to human health. In this context, antimicrobial peptides (AMPs) have been extensively studied for their antibacterial activity and promising ...
  • Mendonça, Diogo A.; Bakker, Mariët; Cruz-Oliveira, Christine; Neves, Vera; Jiménez, Maria Angeles; Defaus, Sira; Cavaco, Marco; Salomé Veiga, Ana; Cadima-Couto, Iris; Castanho, Miguel A.R.B.; Andreu Martínez, David; Todorovski, Toni (American Chemical Society (ACS), 2021)
    Passing through the blood-brain barrier (BBB) to treat neurological conditions is one of the main hurdles in modern medicine. Many drugs with promising in vitro profiles become ineffective in vivo due to BBB restrictive ...
  • Gallo, Maria; Moreno, Estefanía; Defaus, Sira; Ortega Alvaro, Antonio; Gonzalez, Angel; Robledo, Patricia, 1958-; Cavaco, Marco; Neves, Vera; Castanho, Miguel A.R.B.; Casadó, Vicent; Pardo Carrasco, Leonardo; Maldonado, Rafael, 1961-; Andreu Martínez, David (American Chemical Society (ACS), 2021)
    The activation of cannabinoid CB1 receptors (CB1R) by Δ9-tetrahydrocannabinol (THC), the main component of Cannabis sativa, induces analgesia. CB1R activation, however, also causes cognitive impairment via the serotonin ...

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