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Articles (Departament de Ciències Experimentals i de la Salut)

Articles (Departament de Ciències Experimentals i de la Salut)

 

Articles de recerca, en accés obert, del Departament de Ciències Experimentals i de la Salut de la UPF.

Recent Submissions

  • Amargant i Riera, Farners, 1990-; Pujol, Aïda; Ferrer-Vaquer, Anna; Durban, Mercè; Martínez, Meritxell; Vassena, Rita; Vernos, Isabelle, 1959- (Oxford University Press, 2021)
    The mechanism of conversion of the human sperm basal body to a centrosome after fertilization, and its role in supporting human early embryogenesis, has not been directly addressed so far. Using proteomics and immunofluorescence ...
  • Galera Laporta, Letícia, 1985-; Comerci, Colin J.; García Ojalvo, Jordi; Süel, Gürol M. (Elsevier, 2021)
    Metal ions are essential for life and represent the second most abundant constituent (after water) of any living cell. While the biological importance of inorganic ions has been appreciated for over a century, we are far ...
  • Matsuda, Mitsuhiro; Hayashi, Hanako; García Ojalvo, Jordi; Yoshioka-Kobayashi, Kumiko; Kageyama, Ryoichiro; Yamanaka, Yoshihiro; Ikeya, Makoto; Toguchida, Junya; Alev, Cantas; Ebisuya, Miki (American Association for the Advancement of Science (AAAS), 2020)
    Although mechanisms of embryonic development are similar between mice and humans, the time scale is generally slower in humans. To investigate these interspecies differences in development, we recapitulate murine and human ...
  • Casal, Miguel A.; Galella Toledo, Santiago; Vilarroya, Óscar; García Ojalvo, Jordi (American Institute of Physics (AIP), 2020)
    Recurrent neuronal networks are known to be endowed with fading (short-term) memory, whereas long-term memory is usually considered to be hard-wired in the network connectivity via Hebbian learning, for instance. Here, we ...
  • Yang, Chih-Yu; Bialecka-Fornal, Maja; Weatherwax, Colleen; Larkin, Joseph; Prindle, Arthur; Liu, Jintao; García Ojalvo, Jordi; Süel, Gürol M. (Elsevier, 2020)
    Cellular membrane potential plays a key role in the formation and retrieval of memories in the metazoan brain, but it remains unclear whether such memory can also be encoded in simpler organisms like bacteria. Here, we ...
  • Castro e Silva, Marcos Araújo; Nunes, Kelly; Barbosa Lemes, Renan; Mas Sandoval, Àlex, 1989-; Guerra Amorim, Carlos Eduardo; Krieger, José Eduardo; Mill, José Geraldo; Salzano, Francisco Mauro; Bortolini, Maria Cátira; Pereira, Alexandre da Costa; Comas, David, 1969-; Hünemeier, Tábita (National Academy of Sciences, 2020)
    In the 15th century, ∼900,000 Native Americans, mostly Tupí speakers, lived on the Brazilian coast. By the end of the 18th century, the coastal native populations were declared extinct. The Tupí arrived on the east coast ...
  • Fábrega, María José; Knödlseder, Nastassia; Nevot, Guillermo; Sanvicente, Marta; Toloza, Lorena; Santos-Moreno, Javier; Güell Cargol, Marc (American Chemical Society (ACS), 2021)
    In the past few years, new bacterial-cell-free transcription-translation systems have emerged as potent and quick platforms for protein production as well as for prototyping of DNA regulatory elements, genetic circuits, ...
  • Varela-Rial, Alejandro; Maryanow, Iain; Majewski, Maciej; Doerr, Stefan, 1987-; Schapin, Nikolai; Jiménez Luna, José, 1993-; De Fabritiis, Gianni (American Chemical Society (ACS), 2022)
    Deep learning has been successfully applied to structure-based protein-ligand affinity prediction, yet the black box nature of these models raises some questions. In a previous study, we presented KDEEP, a convolutional ...
  • Sandín, Daniel; Valle, Javier; Chaves-Arquero, Belén; Prats-Ejarque, Guillem; Larrosa, María Nieves; González-López, Juan José; Jiménez, María Ángeles; Boix, Ester; Andreu Martínez, David; Torrent Burgas, Marc (American Chemical Society (ACS), 2021)
    Multidrug resistance against conventional antibiotics poses an important threat to human health. In this context, antimicrobial peptides (AMPs) have been extensively studied for their antibacterial activity and promising ...
  • Mendonça, Diogo A.; Bakker, Mariët; Cruz-Oliveira, Christine; Neves, Vera; Jiménez, Maria Angeles; Defaus, Sira; Cavaco, Marco; Salomé Veiga, Ana; Cadima-Couto, Iris; Castanho, Miguel A.R.B.; Andreu Martínez, David; Todorovski, Toni (American Chemical Society (ACS), 2021)
    Passing through the blood-brain barrier (BBB) to treat neurological conditions is one of the main hurdles in modern medicine. Many drugs with promising in vitro profiles become ineffective in vivo due to BBB restrictive ...
  • Gallo, Maria; Moreno, Estefanía; Defaus, Sira; Ortega Alvaro, Antonio; Gonzalez, Angel; Robledo, Patricia, 1958-; Cavaco, Marco; Neves, Vera; Castanho, Miguel A.R.B.; Casadó, Vicent; Pardo Carrasco, Leonardo; Maldonado, Rafael, 1961-; Andreu Martínez, David (American Chemical Society (ACS), 2021)
    The activation of cannabinoid CB1 receptors (CB1R) by Δ9-tetrahydrocannabinol (THC), the main component of Cannabis sativa, induces analgesia. CB1R activation, however, also causes cognitive impairment via the serotonin ...
  • Doerr, Stefan, 1987-; Majewski, Maciej; Pérez, Adrià; Krämer, Andreas; Clementi, Cecilia; Noé, Frank; Giorgino, Toni; De Fabritiis, Gianni (American Chemical Society (ACS), 2021)
    Molecular dynamics simulations provide a mechanistic description of molecules by relying on empirical potentials. The quality and transferability of such potentials can be improved leveraging data-driven models derived ...
  • Duran Nebreda, Salvador, 1987-; Pla, Jordi; Vidiella Rocamora, Blai; Piñero, Jordi; Conde Pueyo, Núria, 1983-; Solé Vicente, Ricard, 1962- (American Chemical Society (ACS), 2021)
    Multicellular entities are characterized by intricate spatial patterns, intimately related to the functions they perform. These patterns are often created from isotropic embryonic structures, without external information ...
  • Milà Alomà, Marta; Brinkmalm, Ann; Ashton, Nicholas J.; Kvartsberg, Hlin; Shekari, Mahnaz; Operto, Grégory; Salvadó, Gemma; Falcon, Carles; Domingo Gispert, Juan; Vilor Tejedor, Natàlia, 1988-; Arenaza Urquijo, Eider M.; Grau-Rivera, Oriol; Sala Vila, Aleix; Sanchez-Benavides, Gonzalo; González de Echávarri, José Maria; Minguillón, Carolina; Fauria, Karine; Niñerola-Baizán, Aida; Perissinotti, Andrés; Kollmorgen, Gwendlyn; Suridjan, Ivonne; Zetterberg, Henrik; Molinuevo, José Luis; Blennow, Kaj; Suárez-Calvet, Marc; ALFA Study (Lippincott Williams & Wilkins, 2021)
    Background and objectives: To determine whether CSF synaptic biomarkers are altered in the early preclinical stage of the Alzheimer continuum and associated with Alzheimer disease (AD) risk factors, primary pathology, and ...
  • Garrido, Victoria; Piñero-Lambea, Carlos; Rodriguez-Arce, Irene; Paetzold, Bernhard, 1981-; Ferrar, Tony; Weber, Marc; Garcia Ramallo, Eva; Gallo López, Carolina, 1984-; Collantes, María; Peñuelas, Iván; Serrano Pubull, Luis, 1982-; Grilló, María-Jesús; Lluch-Senar, Maria 1982- (Wiley Open Access, 2021)
    Bacteria present a promising delivery system for treating human diseases. Here, we engineered the genome-reduced human lung pathogen Mycoplasma pneumoniae as a live biotherapeutic to treat biofilm-associated bacterial ...
  • García-Díaz, Nuria; Casar, Berta; Alonso Alonso, Ruth; Quevedo, Laura; Rodríguez, Marta; Ruso-Julve, Fulgencio; Esteve-Codina, Anna; Gut, Marta; Gru, Alejandro A.; González Vela, María del Carmen; Gut, Ivo Glynne; Rodriguez-Peralto, José Luis; Varela, Ignacio; Ortiz-Romero, Pablo L.; Piris, Miguel A.; Vaqué, José Pedro (Elsevier, 2021)
    Developing mechanistic rationales can improve the clinical management of cutaneous T-cell lymphomas. There is considerable genetic and biological evidence of a malignant network of signaling mechanisms, highly influenced ...
  • Burgos, Raul; Weber, Marc; Gallo López, Carolina, 1984-; Lluch-Senar, Maria 1982-; Serrano Pubull, Luis, 1982- (Elsevier, 2021)
    Trans-translation is a ubiquitous bacterial mechanism of ribosome rescue mediated by a transfer-messenger RNA (tmRNA) that adds a degradation tag to the truncated nascent polypeptide. Here, we characterize this quality ...
  • Nieto, Paula; Elosua-Bayés, Marc; Trincado Alonso, Juan Luis, 1987-; Marchese, Domenica, 1986-; Massoni-Badosa, Ramon; Nieto, Juan C.; Aguilar-Fernández, Sergio; Mereu, Elisabetta; Moutinho, Catia; Ruiz, Sara; Lorden, Patricia; Gut, Ivo Glynne; Heyn, Holger (Cold Spring Harbor Laboratory Press (CSHL Press), 2021)
    The tumor immune microenvironment is a main contributor to cancer progression and a promising therapeutic target for oncology. However, immune microenvironments vary profoundly between patients, and biomarkers for prognosis ...
  • Bianco, Erica; Laval, Guillaume; Font-Porterias, Neus; García-Fernández, Carla; Dobón Berenguer, Begoña, 1987-; Sabido-Vera, Rubén; Sukarova-Stefanovska, Emilija; Kučinskas, Vaidutis; Makukh, Halyna; Pamjav, Horolma; Quintana Murci, Lluis; Netea, Mihai G; Bertranpetit, Jaume, 1952-; Calafell i Majó, Francesc; Comas, David, 1969- (Oxford University Press, 2020)
    The Roma Diaspora-traditionally known as Gypsies-remains among the least explored population migratory events in historical times. It involved the migration of Roma ancestors out-of-India through the plateaus of Western ...
  • Ballestín, Raúl; Alegre Zurano, Laia; Ferrer-Pérez, Carmen; Cantacorps, Lídia; Miñarro, José; Valverde Granados, Olga; Rodríguez-Arias, Marta (Elsevier, 2021)
    Using the social defeat (SD) model, numerous studies have shown that stressed mice display an enhanced response to the motivational effects of cocaine in the self-administration (SA) and conditioned-place preference (CPP) ...

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