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Articles (Departament de Ciències Experimentals i de la Salut)

Articles (Departament de Ciències Experimentals i de la Salut)

 

Articles de recerca, en accés obert, del Departament de Ciències Experimentals i de la Salut de la UPF.

Recent Submissions

  • Milà Alomà, Marta; Brinkmalm, Ann; Ashton, Nicholas J.; Kvartsberg, Hlin; Shekari, Mahnaz; Operto, Grégory; Salvadó, Gemma; Falcon, Carles; Domingo Gispert, Juan; Vilor Tejedor, Natàlia, 1988-; Arenaza Urquijo, Eider M.; Grau-Rivera, Oriol; Sala Vila, Aleix; Sanchez-Benavides, Gonzalo; González de Echávarri, José Maria; Minguillón, Carolina; Fauria, Karine; Niñerola-Baizán, Aida; Perissinotti, Andrés; Kollmorgen, Gwendlyn; Suridjan, Ivonne; Zetterberg, Henrik; Molinuevo, José Luis; Blennow, Kaj; Suárez-Calvet, Marc; ALFA Study (Lippincott Williams & Wilkins, 2021)
    Background and objectives: To determine whether CSF synaptic biomarkers are altered in the early preclinical stage of the Alzheimer continuum and associated with Alzheimer disease (AD) risk factors, primary pathology, and ...
  • Garrido, Victoria; Piñero-Lambea, Carlos; Rodriguez-Arce, Irene; Paetzold, Bernhard, 1981-; Ferrar, Tony; Weber, Marc; Garcia Ramallo, Eva; Gallo López, Carolina, 1984-; Collantes, María; Peñuelas, Iván; Serrano Pubull, Luis, 1982-; Grilló, María-Jesús; Lluch-Senar, Maria 1982- (Wiley Open Access, 2021)
    Bacteria present a promising delivery system for treating human diseases. Here, we engineered the genome-reduced human lung pathogen Mycoplasma pneumoniae as a live biotherapeutic to treat biofilm-associated bacterial ...
  • Fábrega, María José; Knödlseder, Nastassia; Nevot, Guillermo; Sanvicente, Marta; Toloza, Lorena; Santos-Moreno, Javier; Güell Cargol, Marc (American Chemical Society (ACS), 2021)
    In the past few years, new bacterial-cell-free transcription-translation systems have emerged as potent and quick platforms for protein production as well as for prototyping of DNA regulatory elements, genetic circuits, ...
  • Varela-Rial, Alejandro; Maryanow, Iain; Majewski, Maciej; Doerr, Stefan, 1987-; Schapin, Nikolai; Jiménez Luna, José, 1993-; De Fabritiis, Gianni (American Chemical Society (ACS), 2022)
    Deep learning has been successfully applied to structure-based protein-ligand affinity prediction, yet the black box nature of these models raises some questions. In a previous study, we presented KDEEP, a convolutional ...
  • Sandín, Daniel; Valle, Javier; Chaves-Arquero, Belén; Prats-Ejarque, Guillem; Larrosa, María Nieves; González-López, Juan José; Jiménez, María Ángeles; Boix, Ester; Andreu Martínez, David; Torrent Burgas, Marc (American Chemical Society (ACS), 2021)
    Multidrug resistance against conventional antibiotics poses an important threat to human health. In this context, antimicrobial peptides (AMPs) have been extensively studied for their antibacterial activity and promising ...
  • Mendonça, Diogo A.; Bakker, Mariët; Cruz-Oliveira, Christine; Neves, Vera; Jiménez, Maria Angeles; Defaus, Sira; Cavaco, Marco; Salomé Veiga, Ana; Cadima-Couto, Iris; Castanho, Miguel A.R.B.; Andreu Martínez, David; Todorovski, Toni (American Chemical Society (ACS), 2021)
    Passing through the blood-brain barrier (BBB) to treat neurological conditions is one of the main hurdles in modern medicine. Many drugs with promising in vitro profiles become ineffective in vivo due to BBB restrictive ...
  • Gallo, Maria; Moreno, Estefanía; Defaus, Sira; Ortega Alvaro, Antonio; Gonzalez, Angel; Robledo, Patricia, 1958-; Cavaco, Marco; Neves, Vera; Castanho, Miguel A.R.B.; Casadó, Vicent; Pardo Carrasco, Leonardo; Maldonado, Rafael, 1961-; Andreu Martínez, David (American Chemical Society (ACS), 2021)
    The activation of cannabinoid CB1 receptors (CB1R) by Δ9-tetrahydrocannabinol (THC), the main component of Cannabis sativa, induces analgesia. CB1R activation, however, also causes cognitive impairment via the serotonin ...
  • Doerr, Stefan, 1987-; Majewski, Maciej; Pérez, Adrià; Krämer, Andreas; Clementi, Cecilia; Noé, Frank; Giorgino, Toni; De Fabritiis, Gianni (American Chemical Society (ACS), 2021)
    Molecular dynamics simulations provide a mechanistic description of molecules by relying on empirical potentials. The quality and transferability of such potentials can be improved leveraging data-driven models derived ...
  • Duran Nebreda, Salvador, 1987-; Pla, Jordi; Vidiella Rocamora, Blai; Piñero, Jordi; Conde Pueyo, Núria, 1983-; Solé Vicente, Ricard, 1962- (American Chemical Society (ACS), 2021)
    Multicellular entities are characterized by intricate spatial patterns, intimately related to the functions they perform. These patterns are often created from isotropic embryonic structures, without external information ...
  • García-Díaz, Nuria; Casar, Berta; Alonso Alonso, Ruth; Quevedo, Laura; Rodríguez, Marta; Ruso-Julve, Fulgencio; Esteve-Codina, Anna; Gut, Marta; Gru, Alejandro A.; González Vela, María del Carmen; Gut, Ivo Glynne; Rodriguez-Peralto, José Luis; Varela, Ignacio; Ortiz-Romero, Pablo L.; Piris, Miguel A.; Vaqué, José Pedro (Elsevier, 2021)
    Developing mechanistic rationales can improve the clinical management of cutaneous T-cell lymphomas. There is considerable genetic and biological evidence of a malignant network of signaling mechanisms, highly influenced ...
  • Burgos, Raul; Weber, Marc; Gallo López, Carolina, 1984-; Lluch-Senar, Maria 1982-; Serrano Pubull, Luis, 1982- (Elsevier, 2021)
    Trans-translation is a ubiquitous bacterial mechanism of ribosome rescue mediated by a transfer-messenger RNA (tmRNA) that adds a degradation tag to the truncated nascent polypeptide. Here, we characterize this quality ...
  • Nieto, Paula; Elosua-Bayés, Marc; Trincado Alonso, Juan Luis, 1987-; Marchese, Domenica, 1986-; Massoni-Badosa, Ramon; Nieto, Juan C.; Aguilar-Fernández, Sergio; Mereu, Elisabetta; Moutinho, Catia; Ruiz, Sara; Lorden, Patricia; Gut, Ivo Glynne; Heyn, Holger (Cold Spring Harbor Laboratory Press (CSHL Press), 2021)
    The tumor immune microenvironment is a main contributor to cancer progression and a promising therapeutic target for oncology. However, immune microenvironments vary profoundly between patients, and biomarkers for prognosis ...
  • Bianco, Erica; Laval, Guillaume; Font-Porterias, Neus; García-Fernández, Carla; Dobón Berenguer, Begoña, 1987-; Sabido-Vera, Rubén; Sukarova-Stefanovska, Emilija; Kučinskas, Vaidutis; Makukh, Halyna; Pamjav, Horolma; Quintana Murci, Lluis; Netea, Mihai G; Bertranpetit, Jaume, 1952-; Calafell i Majó, Francesc; Comas, David, 1969- (Oxford University Press, 2020)
    The Roma Diaspora-traditionally known as Gypsies-remains among the least explored population migratory events in historical times. It involved the migration of Roma ancestors out-of-India through the plateaus of Western ...
  • Ballestín, Raúl; Alegre Zurano, Laia; Ferrer-Pérez, Carmen; Cantacorps, Lídia; Miñarro, José; Valverde Granados, Olga; Rodríguez-Arias, Marta (Elsevier, 2021)
    Using the social defeat (SD) model, numerous studies have shown that stressed mice display an enhanced response to the motivational effects of cocaine in the self-administration (SA) and conditioned-place preference (CPP) ...
  • García, Angelina; Nores, Rodrigo; Motti, Josefina M. B.; Pauro, Maia; Luisi, Pierre, 1985-; Bravi, Claudio M.; Fabra, Mariana; Gosling, Anna; Kardailsky, Olga; Boocock, James; Solé Morata, Neus, 1988-; Matisoo Smith, Elizabeth; Comas, David, 1969-; Demarchi, Darío A. (Oxford University Press, 2021)
    The inverted triangle shape of South America places Argentina territory as a geographical crossroads between the two principal peopling streams that followed either the Pacific or the Atlantic coasts, which could have then ...
  • Flores Bello, André, 1992-; Bauduer, Frédéric; Salaberria, Jasone; Oyharçabal, Bernard; Calafell i Majó, Francesc; Bertranpetit, Jaume, 1952-; Quintana Murci, Lluis; Comas, David, 1969- (Elsevier, 2021)
    Basques have historically lived along the Western Pyrenees, in the Franco-Cantabrian region, straddling the current Spanish and French territories. Over the last decades, they have been the focus of intense research due ...
  • Velázquez, Ana Magdalena; Roglans, Núria; Bentanachs, Roger; Gené, Maria; Sala Vila, Aleix; Lázaro, Iolanda; Rodríguez-Morató, Jose, 1987-; Sánchez, Rosa María; Laguna, Juan Carlos; Alegret, Marta (MDPI, 2020)
    Non-alcoholic fatty liver disease is a highly prevalent condition without specific pharmacological treatment, characterized in the initial stages by hepatic steatosis. It was suggested that lipid infiltration in the liver ...
  • Bouzas, Cristina; Schröder, Helmut, 1958-; Castañer, Olga; Zomeño Fajardo, Maria Dolores; Goday Arno, Alberto; Tur, J. Antoni (MDPI, 2020)
    One-year dietary quality change according to the preceding maximum weight in a lifestyle intervention program (PREDIMED-Plus trial, 55-75-year-old overweight or obese adults; n = 5695) was assessed. A validated food frequency ...
  • Ramírez López, Angela; Pastor, Antonio; Torre Fornell, Rafael de la; La Porta, Carmen, 1985-; Ozaita Mintegui, Andrés, 1969-; Cabañero Ferri, David; Maldonado, Rafael, 1961- (Wiley, 2021)
    Background: Neuropathic pain is a complex condition characterized by sensory, cognitive and affective symptoms that magnify the perception of pain. The underlying pathogenic mechanisms are largely unknown and there is an ...
  • Rubín-García, María; Vitelli Storelli, Facundo; Molina, Antonio J.; Zamora-Ros, Raúl; Aragonés, Núria; Ardanaz Aicua, Eva; Castaño Vinyals, Gemma; Obón-Santacana Mireia; Gómez-Acebo, Inés; Molina-Barceló, Ana; Fernández-Tardón, Guillermo; Jiménez-Moleón, José Juan; Alguacil Ojeda, Juan; Chirlaque, María Dolores; Toledo, Estefania; Pérez-Gómez, Beatriz; Pollan, Marina; Kogevinas, Manolis; Martín, Vicente (MDPI, 2020)
    Several anticancer properties have been largely attributed to phenolics in in vivo and in vitro studies, but epidemiologic evidence is still scarce. Furthermore, some classes have not been studied in relation to gastric ...

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