• TFIIIC as a potential epigenetic modulator of histone acetylation in human stem cells

  Vezzoli, Marco; De Llobet, Lara Isabel; Di Vona, Chiara, 1981-; Morselli, Marco; Montanini, Barbara; Luna Gargantilla, Susana de la; Teichmann, Martin; Dieci, Giorgio; Ferrari, Roberto (MDPI, 2023)

  Regulation of histone acetylation dictates patterns of gene expression and hence cell identity. Due to their clinical relevance in cancer biology, understanding how human embryonic stem cells (hESCs) regulate their genomic ...
• Polygenic risk scores enhance prediction of body mass index increase in individuals with a first episode of psychosis

  Muntané, Gerard; Vázquez-Bourgon, Javier; Sada, Ester; Martorell, Lourdes; Papiol, Sergi; Bosch Fusté, Elena; Navarro i Cuartiellas, Arcadi, 1969-; Crespo-Facorro, Benedicto; Vilella, Elisabet (Cambridge University Press, 2023)

  Background: Individuals with a first episode of psychosis (FEP) show rapid weight gain during the first months of treatment, which is associated with a reduction in general physical health. Although genetics is assumed to ...
• Using protein-per-mRNA differences among human tissues in codon optimization

  Hernandez-Alias, Xavier; Benisty, Hannah, 1986-; Radusky, Leandro; Serrano Pubull, Luis, 1982-; Schaefer, Martin H. (BioMed Central, 2023)

  Background: Codon usage and nucleotide composition of coding sequences have profound effects on protein expression. However, while it is recognized that different tissues have distinct tRNA profiles and codon usages in ...
• Disruption of stem cell niche-confined R-spondin 3 expression leads to impaired hematopoiesis

  Kurtova, Antonina V.; Velten, Lars; Sauvage, Frederic J. de (American Society of Hematology, 2023)

  Self-renewal and differentiation of stem and progenitor cells are tightly regulated to ensure tissue homeostasis. This regulation is enabled both remotely by systemic circulating cues, such as cytokines and hormones, and ...
• APOE-ε4 modulates the association between regional amyloid deposition and cognitive performance in cognitively unimpaired middle-aged individuals

  Brugulat Serrat, Anna, 1986-; Sánchez Benavides, Gonzalo; Cacciaglia, Raffaele; Shekari, Mahnaz; Milà Alomà, Marta; Vilor Tejedor, Natàlia, 1988-; Operto, Grégory; Falcón, Carles; Grau-Rivera, Oriol; Arenaza Urquijo, Eider M.; Minguillón, Carolina; Fauria, Karine; Suárez-Calvet, Marc; Gispert López, Juan Domingo; ALFA Study (Springer, 2023)

  Purpose: To determine whether the APOE-ε4 allele modulates the relationship between regional β-amyloid (Aβ) accumulation and cognitive change in middle-aged cognitively unimpaired (CU) participants. Methods: The 352 CU ...
• An ethics training specific for European public health

  Camps, Victoria; Hernández-Aguado, Ildefonso; Puyol, Angel; Segura, Andreu (Frontiers, 2015)

  Training in public health ethics is not at the core of public health programmes in Europe. The fruitful progress of the United States could stimulate the European schools of public health and other academic institutions ...
• El proyecto Ineq-Cities de investigación en desigualdades urbanas en salud: diseminación y transferencia de conocimiento en España

  Camprubí, Lluís; Díez, Èlia; Morrison, Joana; Borrell i Thió, Carme (Elsevier, 2014)

  El proyecto Ineq-Cities analizó en 16 ciudades europeas las desigualdades en mortalidad en áreas pequeñas y describió intervenciones para reducir las desigualdades en salud. Esta nota de campo describe la diseminación del ...
• Evolución de las inequidades en mortalidad por causas externas entre los municipios de Antioquia (Colombia)

  Caicedo-Velásquez, Beatriz; Álvarez-Castaño, Luz Stella; Marí-Dell’Olmo, Marc; Borrell i Thió, Carme (Elsevier, 2016)

  Analizar la evolución de las inequidades en la mortalidad por causas externas en los municipios de Antioquia, departamento de Colombia, entre los años 2000 y 2010, y la asociación con sus condiciones socioeconómicas. Las ...
• Disfunción muscular respiratoria en pacientes llevados a cirugía cardiovascular

  Cáceres, Diana; Meneses, Karenth; Meneses, Karenth; Ramírez-Sarmiento, Alba; Domínguez, Clara; Bermon, Anderson; Figueredo, Antonio; Duarte, Rubén; Orozco-Levi, Mauricio (Elsevier, 2016)

  Evaluar la presencia de las alteraciones en la fuerza muscular respiratoria en pacientes programados para la cirugía cardiovascular, el impacto de la cirugía sobre la función muscular respiratoria y su relación con las ...
• A simple microfluidic platform to study age-dependent protein abundance and localization changes in Saccharomyces cerevisiae

  Cabrera, Margarita; Novarina, Daniele; Rempel, Irina L.; Veenhoff, Liesbeth M.; Chang, Michael (Shared Science Publishers, 2017)

  The budding yeast Saccharomyces cerevisiae divides asymmetrically, with a smaller daughter cell emerging from its larger mother cell. While the daughter lineage is immortal, mother cells age with each cell division and ...
• Cell survival during complete nutrient deprivation depends on lipid droplet-fueled β-Oxidation of fatty acids

  Cabodevilla, Ainara G.; Sánchez-Caballero, Laura; Nintou, Eleni; Boiadjieva, Violeta G.; Picatoste, Fernando; Gubern, Albert; Claro, Enrique (Elsevier, 2013)

  Cells exposed to stress of different origins synthesize triacylglycerols and generate lipid droplets (LD), but the physiological relevance of this response is uncertain. Using complete nutrient deprivation of cells in ...
• A systematic review on the development of asthma and allergic diseases in relation to international immigration: the leading role of the environment confirmed

  Cabieses, Báltica; Uphoff, Eleonora P.; Pinart, Mariona; Antó i Boqué, Josep Maria; Wright, John (Public Library of Science (PLoS), 2014)

  The prevalence of asthma and allergic diseases is rising worldwide. Evidence on potential causal pathways of asthma and allergies is growing, but findings have been contradictory, particularly on the interplay between ...
• Putting hornets on the genomic map

  Favreau, Emeline; Cini, Alessandro; Taylor, Daisy; Câmara Ferreira, Francisco; Bentley, Michael A.; Cappa, Federico; Cervo, Rita; Privman, Eyal; Schneider, Jadesada; Thiéry, Denis; Mashoodh, Rahia; Wyatt, Christopher Douglas Robert, 1988-; Brown, Robert L.; Bodrug-Schepers, Alexandrina; Stralis-Pavese, Nancy; Dohm, Juliane C.; Mead, Daniel; Himmelbauer, Heinz; Guigó Serra, Roderic; Sumner, Seirian (Nature Research, 2023)

  Hornets are the largest of the social wasps, and are important regulators of insect populations in their native ranges. Hornets are also very successful as invasive species, with often devastating economic, ecological and ...
• Making in silico predictive models for toxicology FAIR

  Cronin, Mark T. D.; Belfield, Samuel J.; Briggs, Katharine; Enoch, Steven J.; Firman, James W.; Frericks, Markus; Garrard, Clare; Maccallum, Peter H.; Madden, Judith C.; Pastor Maeso, Manuel; Sanz, Ferran; Soininen, Inari; Sousoni, Despoina (Elsevier, 2023)

  In silico predictive models for toxicology include quantitative structure-activity relationship (QSAR) and physiologically based kinetic (PBK) approaches to predict physico-chemical and ADME properties, toxicological effects ...
• Past connectivity but recent inbreeding in cross river gorillas determined using whole genomes from single hairs

  Alvarez-Estape, Marina; Pawar, Harvinder; Fontseré Alemany, Clàudia, 1992-; Trujillo, Amber E.; Gunson, Jessica L.; Bergl, Richard A.; Bermejo, Magdalena; Linder, Joshua M.; McFarland, Kelley; Oates, John F.; Sunderland-Groves, Jacqueline L.; Orkin, Joseph D.; Higham, James P.; Viaud-Martinez, Karine A.; Lizano González, Esther, 1974-; Marquès i Bonet, Tomàs, 1975- (MDPI, 2023)

  The critically endangered western gorillas (Gorilla gorilla) are divided into two subspecies: the western lowland (G. g. gorilla) and the Cross River (G. g. diehli) gorilla. Given the difficulty in sampling wild great ape ...
• Workplace aggression against healthcare workers in a Spanish healthcare institution between 2019 and 2021: The impact of the COVID-19 pandemic

  Díaz, Aitor; Utzet Sadurní, Mireia; Mirabent, Joan; Díaz, Pilar; Ramada Rodilla, José María, 1961-; Serra, Consol; Benavides, Fernando G. (Fernando García) (Frontiers, 2023)

  Objectives: Describe the incidence of first aggressions among healthcare workers (HCWs) before and during the COVID-19 pandemic in a Spanish healthcare institution, according to workers' socio-occupational characteristics ...
• Evolutionary algorithm for the optimization of meal intake and insulin administration in patients with type 2 diabetes

  González Flo, Eva, 1993-; Kheirabadi, Elaheh; Rodríguez Caso, Carlos; Macía, Javier (Frontiers, 2023)

  The optimal management of type 2 diabetes (T2DM) is complex and involves an appropriate combination of diet, exercise, and different pharmacological treatments. Artificial intelligence-based tools have been shown to be ...
• A male mouse model of WIN 55,212-2 self-administration to study cannabinoid addiction

  Cajiao-Manrique, María Del Mar; Maldonado, Rafael, 1961-; Martín García, Elena, 1975- (Frontiers, 2023)

  We have established for the first time a mouse model of cannabinoid addiction using WIN 55,212-2 intravenous self-administration (0.0125 mg/kg/infusion) in C57Bl/6J mice. This model allows to evaluate the addiction criteria ...
• A decision support system based on artificial intelligence and systems biology for the simulation of pancreatic cancer patient status

  Junet, Valentin; Matos Filipe, Pedro; García-Illarramendi, Juan Manuel; Ramírez, Esther; Oliva Miguel, Baldomero; Farrés, Judith; Daura, Xavier; Mas, José Manuel; Morales, Rafael (Wiley, 2023)

  Oncology treatments require continuous individual adjustment based on the measurement of multiple clinical parameters. Prediction tools exploiting the patterns present in the clinical data could be used to assist decision ...
• Direct reprogramming of human fibroblasts into insulin-producing cells using transcription factors

  Fontcuberta-PiSunyer, Marta; García-Alamán, Ainhoa; Prades, Èlia; Téllez, Noèlia; Alves-Figueiredo, Hugo; Ramos-Rodríguez, Mireia; Enrich, Carlos; Fernandez-Ruiz, Rebeca; Cervantes, Sara; Clua, Laura; Ramón-Azcón, Javier; Broca, Christophe; Wojtusciszyn, Anne; Montserrat Pulido, Núria; Pasquali, Lorenzo; Novials, Anna; Servitja, Joan-Marc; Vidal Alaball, Josep; Gomis, Ramon; Gasa, Rosa (Nature Research, 2023)

  Direct lineage reprogramming of one somatic cell into another without transitioning through a progenitor stage has emerged as a strategy to generate clinically relevant cell types. One cell type of interest is the pancreatic ...

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