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Articles (Departament de Medicina i Ciències de la Vida)

Articles (Departament de Medicina i Ciències de la Vida)

 

Articles de recerca, en accés obert, del Departament de Medicina i Ciències de la Vidade la UPF.

Recent Submissions

  • Lucas-Sánchez, Marcel; Abdeli, Amine; Bekada, Asmahan; Calafell i Majó, Francesc; Benhassine, Traki; Comas, David, 1969- (Oxford University Press, 2024)
    The strategic location of North Africa has made the region the core of a wide range of human demographic events, including migrations, bottlenecks, and admixture processes. This has led to a complex and heterogeneous genetic ...
  • Sisteré-Oró, Marta; Du, Juan; Wortmann, Diana D. J.; Filippi, Marina D.; Cañas-Ruano, Esperanza; Arrieta Aldea, Itziar; Marcos-Blanco, Agustín; Castells, Xavier; Grau Cerrato, Santiago; García-Giralt, Natalia; Perez-Zsolt, Daniel; Boreika, Rytis; Izquierdo-Useros, Nuria; Güerri Fernández, Roberto; Meyerhans, Andreas (Wiley, 2024)
    People living with human immunodeficiency virus (HIV) are the individuals most affected by the current Monkeypox virus outbreak that was first announced in May 2022. Here we report Pan-pox-specific T-cell responses in a ...
  • Santana-Hernández, Sara; Suárez Olmos, Jesús; Servitja Tormo, Sonia; Berenguer-Molins, Pau; Costa García, Marcel, 1989-; Comerma Blesa, Laura, 1983-; Rea, Anna; Perera Bel, Júlia; Menendez Romero, Silvia; Arpí Llucià, Oriol; Bermejo, Begoña; Martínez, María Teresa; Cejalvo, Juan Miguel; Comino-Méndez, Iñaki; Pascual, Javier; Alba, Emilio; López-Botet, M. (Miguel); Rojo, Federico; Rovira, Ana; Albanell Mestres, Joan; Muntasell i Castellví, Aura, 1972- (BioMed Central, 2024)
    Background: The variability in responses to neoadjuvant treatment with anti-HER2 antibodies prompts to personalized clinical management and the development of innovative treatment strategies. Tumor-infiltrating Natural ...
  • Papaleo, Natalia; Climent, Fina; Tapia, Gustavo; Luizaga Velasco, Luis; Azcarate, Juan; Bosch-Schips, Jan; Muñoz-Mármol, Ana M.; Salido Galeote, Marta; Lome-Maldonado, Carmen; Vázquez, Ivonne; Colomo Saperas, Luis Alberto (Springer, 2023)
    Aggressive large B-cell lymphomas (aLBCL) include a heterogeneous group of lymphomas with diverse biological features. One of the approaches to the diagnosis of aLBCL is based on the identification of MYC rearrangements ...
  • Sabanés Zariquiey, Francesc; Galvelis, Raimondas; Gallicchio, Emilio; Chodera, John D.; Markland, Thomas E.; De Fabritiis, Gianni (American Chemical Society (ACS), 2024)
    This letter gives results on improving protein-ligand binding affinity predictions based on molecular dynamics simulations using machine learning potentials with a hybrid neural network potential and molecular mechanics ...
  • Zhou, Chengzhi; Barreiro Portela, Esther; Chen, Rongchang (AME Publishing, 2023)
    Background: Lung cancer combined by chronic obstructive pulmonary disease (LC-COPD) is a common comorbidity and their interaction with each other poses significant clinical challenges. However, there is a lack of ...
  • Galvelis, Raimondas; Varela-Rial, Alejandro; Doerr, Stefan, 1987-; Fino, Roberto; Eastman, Peter; Markland, Thomas E.; Chodera, John D.; De Fabritiis, Gianni (American Chemical Society (ACS), 2023)
    Machine learning potentials have emerged as a means to enhance the accuracy of biomolecular simulations. However, their application is constrained by the significant computational cost arising from the vast number of ...
  • Sabanés Zariquiey, Francesc; Pérez, Adrià; Majewski, Maciej; Gallicchio, Emilio; De Fabritiis, Gianni (American Chemical Society (ACS), 2023)
    The accurate prediction of protein-ligand binding affinities is crucial for drug discovery. Alchemical free energy calculations have become a popular tool for this purpose. However, the accuracy and reliability of these ...
  • Achebak, Hicham; García Aymerich, Judith; Rey, Grégoire; Chen, Zhaoyue; Méndez Turrubiates, Raúl Fernando; Ballester, Joan (Elsevier, 2023)
    Background: The seasonal fluctuation in mortality and hospital admissions from respiratory diseases, with a winter peak and a summer trough, is widely recognized in extratropical countries. However, little is known about ...
  • Boll, Lilian Marie; Perera Bel, Júlia; Rodriguez-Vida, Alejo; Arpí Llucià, Oriol; Rovira, Ana; Juanpere, Nuria; Vázquez Montes de Oca, Sergio; Hernández Llodrà, Silvia; Lloreta Trull, Josep, 1958-; Albà Soler, Mar; Bellmunt Molins, Joaquim, 1959- (Nature Research, 2023)
    Immune checkpoint inhibitors (ICI) have revolutionized cancer treatment and can result in complete remissions even at advanced stages of the disease. However, only a small fraction of patients respond to the treatment. To ...
  • Sinigaglia, Barbara; Escudero, Jorge; Biagini, Simone Andrea, 1983-; García Calleja, Jorge; Moreno, Josep; Dobón Berenguer, Begoña, 1987-; Acosta, Sandra; Mondal, Mayukh, 1989-; Walsh Capdevila, Sandra, 1991-; Aguileta, Gabriela; Vallès, Mònica; Forrow, Stephen; Martín Caballero, Juan; Migliano, Andrea Bamberg; Bertranpetit, Jaume, 1952-; Muñoz López, Francisco José, 1964-; Bosch Fusté, Elena (Oxford University Press, 2024)
    Rainforest hunter-gatherers from Southeast Asia are characterized by specific morphological features including a particularly dark skin color (D), short stature (S), woolly hair (W), and the presence of steatopygia (S)-fat ...
  • Rodríguez, Isabel; López-Caro, Juan Carlos; González-Carranza, Silvia; Cerrato, Maria Elena; Prado, Maria del Mar de; Gómez-Molleda, Francisca; Pinel, Margarita; Saiz, Maria Teresa; Fuentes, Carmen; Barreiro Portela, Esther; Santibáñez, Miguel (Nature Research, 2023)
    The electronic prescription refill rate (EPRR) of 183 consecutive patients was determined over a 19-month retrospective study period, divided into 7 months PRE (Sep-19 to Mar-20) and 12 months POST pandemic (Apr-20 to ...
  • Moon, Katherine L.; Huson, Heather J.; Morrill, Kathleen; Wang, Ming-Shan; Li, Xue; Srikanth, Krishnamoorthy; Zoonomia Consortium; Lindblad-Toh, Kerstin; Svenson, Gavin J.; Karlsson, Elinor K.; Shapiro, Beth (American Association for the Advancement of Science (AAAS), 2023)
    We reconstruct the phenotype of Balto, the heroic sled dog renowned for transporting diphtheria antitoxin to Nome, Alaska, in 1925, using evolutionary constraint estimates from the Zoonomia alignment of 240 mammals and 682 ...
  • Christmas, Matthew J.; Valenzuela, Alejandro; Marquès i Bonet, Tomàs, 1975-; Navarro i Cuartiellas, Arcadi, 1969-; Karlsson, Elinor K. (American Association for the Advancement of Science (AAAS), 2023)
    Zoonomia is the largest comparative genomics resource for mammals produced to date. By aligning genomes for 240 species, we identify bases that, when mutated, are likely to affect fitness and alter disease risk. At least ...
  • Yang, Xiaoxu; Xu, Xin; Breuss, Martin W.; Antaki, Danny; Ball, Laurel L.; Chung, Changuk; Shen, Jiawei; Li, Chen; George, Renee D.; Wang, Yifan; Bae, Taejeong; Cheng, Yuhe; Abyzov, Alexej; Wei, Liping; Alexandrov, Ludmil B.; Sebat, Jonathan L.; NIMH Brain Somatic Mosaicism Network; Gleeson, Joseph G. (Nature Research, 2023)
    Mosaic variants (MVs) reflect mutagenic processes during embryonic development and environmental exposure, accumulate with aging and underlie diseases such as cancer and autism. The detection of noncancer MVs has been ...
  • Kazdin, Alan E.; Alonso Caballero, Jordi; WHO World Mental Health Survey Collaborators (Cambridge University Press, 2023)
    Background: The most common treatment for major depressive disorder (MDD) is antidepressant medication (ADM). Results are reported on frequency of ADM use, reasons for use, and perceived effectiveness of use in general ...
  • Martínez Agulleiro, Luis; Patil, Bhagyashree; Firth, Joseph; Sawyer, Chelsea; Amann, Benedikt Lorenz; Fonseca Casals, Francina, 1972-; Torrens, Marta; Pérez Solá, Victor; Castellanos, Francisco X.; Kane, John M.; Guinart, Dani (Cambridge University Press, 2023)
    Tobacco smoking is highly prevalent among patients with serious mental illness (SMI), with known deleterious consequences. Smoking cessation is therefore a prioritary public health challenge in SMI. In recent years, several ...
  • Escrich Montañana, Ainoa; Hidalgo Martínez, Diego; Bonfill Baldrich, Ma. Mercedes; Palazón Barandela, Javier; Sánchez Muñoz, Raúl, 1990-; Moyano Claramunt, Elisabet (Elsevier, 2023)
    Novel approaches to optimize the production of plant specialized metabolites are crucial to reach maximum productivity of plant biofactories. Plant polyploidization frequently enhances protein synthesis and thereby increases ...
  • Morrison Esteve, Joana, 1977-; Pons-Vigués, Mariona; Bécares, Laia; Burström, Bo; Gandarillas, Ana; Domínguez-Berjón, María Felicitas; Díez, Elia; Costa, Giuseppe; Ruiz, Milagros; Pikhart, Hynek; Marinacci, Chiara; Hoffman, Rasmus; Santana, Paula; Borrell i Thió, Carme (BMJ Publishing Group, 2014)
    Objective. To describe the knowledge and beliefs of public policymakers on social inequalities in health and policies to reduce them in cities from different parts of Europe during 2010 and 2011. Design. Phenomenological ...

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