• Emergencia climática y empleo, un reto que no podemos ignorar en salud laboral

  Benavides, Fernando G. (Fernando García) (Associació Catalana de Salut Laboral, 2024)
• Assessment of human SARS CoV-2-Specific T-Cell responses elicited In Vitro by new computationally designed mRNA immunogens (COVARNA)

  Esteban, Ignasi; Pastor-Quiñones, Carmen; Usero, Lorena; Aurrecoechea, Elena; Franceschini, Lorenzo; Esprit, Arthur; Gelpí, Josep Lluís; Martínez-Jiménez, Francisco; López Bigas, Núria; Breckpot, Karine; Thielemans, Kris; Leal, Lorna; Gómez, Carmen Elena; Sisteré-Oró, Marta; Meyerhans, Andreas; Esteban, Mariano; Alonso Fernández, María José; García, Felipe; Plana, Montserrat; COVARNA Consortium (MDPI, 2023)

  The COVID-19 pandemic has brought significant changes and advances in the field of vaccination, including the implementation and widespread use of encapsidated mRNA vaccines in general healthcare practice. Here, we present ...
• Multiscale networks in multiple sclerosis

  Kennedy, Keith Endres; García Ojalvo, Jordi; Villoslada, Pablo (Public Library of Science (PLoS), 2024)

  Complex diseases such as Multiple Sclerosis (MS) cover a wide range of biological scales, from genes and proteins to cells and tissues, up to the full organism. In fact, any phenotype for an organism is dictated by the ...
• Asthma and rhinitis control in adolescents and young adults: A real-world MASK-air study

  Sousa Pinto, Bernardo; Antó i Boqué, Josep Maria; MASK-air think tank (Wiley, 2024)

  Background: In allergic rhinitis and asthma, adolescents and young adult patients are likely to differ from older patients. We compared adolescents, young adults and adults on symptoms, control levels, and medication ...
• A new blood DNA methylation signature for Koolen-de Vries syndrome: Classification of missense KANSL1 variants and comparison to fibroblast cells

  Awamleh, Zain; Choufani, Sanaa; Wu, Wendy; Rots, Dmitrijs; Dingemans, Alexander J. M.; Nadif Kasri, Nael; Boronat i Llop, Susanna, 1965-; Ibáñez-Micó, Salvador; Cuesta Herraiz, Laura; Ferrer, Irene; Martínez Carrascal, Antonio; Pérez Jurado, Luis Alberto; Aznar Laín, Gemma; Ortigoza Escobar, Juan Darío; de Vries, Bert B. A.; Koolen, David A.; Weksberg, Rosanna (Nature Research, 2024)

  Pathogenic variants in KANSL1 and 17q21.31 microdeletions are causative of Koolen-de Vries syndrome (KdVS), a neurodevelopmental syndrome with characteristic facial dysmorphia. Our previous work has shown that syndromic ...
• Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

  Pérez Jurado, Luis Alberto; Cáceres, Alejandro; Balagué-Dobón, Laura; Esko, Tõnu; López de Heredia, Miguel de; Quintela Garcia, Ines; Cruz, Raquel; Lapunzina, Pablo Daniel; Carracedo, Ángel; SCOURGE Cohort Group; González, Juan Ramón (Nature Research, 2024)

  The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially ...
• Regulation of β-cell death by ADP-ribosylhydrolase ARH3 via lipid signaling in insulitis

  Sarkar, Soumyadeep; Ramos-Rodríguez, Mireia; Juan-Mateu, Jonàs; Pasquali, Lorenzo; Nakayasu, Ernesto S. (BioMed Central, 2024)

  Background: Lipids are regulators of insulitis and β-cell death in type 1 diabetes development, but the underlying mechanisms are poorly understood. Here, we investigated how the islet lipid composition and downstream ...
• Subclinical congestion assessed by lung ultrasound in ST segment elevation myocardial infarction

  Carreras-Mora, José; Simón-Ramón, Clara; Vidal Burdeus, María; Rodríguez Sotelo, Laura; Sionis, Alessandro; Giralt Borrell, Teresa; Izquierdo-Marquisá, Andrea; Rodríguez González, Clara; Farré López, Núria; Cainzos-Achirica, Miguel; Tizón-Marcos, Helena; Garcia-Picart, Joan; Milà Pascual, Laia; Vaquerizo Montilla, Beatriz; Rivas-Lasarte, Mercedes; Ribas Barquet, Núria (BMJ Publishing Group, 2023)

  Objective: We evaluated the prognostic value of subclinical congestion assessed by lung ultrasound (LUS) in patients admitted for ST segment elevation myocardial infarction (STEMI). Methods: This was a multicentre study ...
• The impact of recent demography on functional genetic variation in north african human groups

  Lucas-Sánchez, Marcel; Abdeli, Amine; Bekada, Asmahan; Calafell i Majó, Francesc; Benhassine, Traki; Comas, David, 1969- (Oxford University Press, 2024)

  The strategic location of North Africa has made the region the core of a wide range of human demographic events, including migrations, bottlenecks, and admixture processes. This has led to a complex and heterogeneous genetic ...
• Pan-pox-specific T-cell responses in HIV-1-infected individuals after JYNNEOS vaccination

  Sisteré-Oró, Marta; Du, Juan; Wortmann, Diana D. J.; Filippi, Marina D.; Cañas-Ruano, Esperanza; Arrieta Aldea, Itziar; Marcos-Blanco, Agustín; Castells, Xavier; Grau Cerrato, Santiago; García-Giralt, Natalia; Perez-Zsolt, Daniel; Boreika, Rytis; Izquierdo-Useros, Nuria; Güerri Fernández, Roberto; Meyerhans, Andreas (Wiley, 2024)

  People living with human immunodeficiency virus (HIV) are the individuals most affected by the current Monkeypox virus outbreak that was first announced in May 2022. Here we report Pan-pox-specific T-cell responses in a ...
• NK cell-triggered CCL5/IFNγ-CXCL9/10 axis underlies the clinical efficacy of neoadjuvant anti-HER2 antibodies in breast cancer

  Santana-Hernández, Sara; Suárez Olmos, Jesús; Servitja Tormo, Sonia; Berenguer-Molins, Pau; Costa García, Marcel, 1989-; Comerma Blesa, Laura, 1983-; Rea, Anna; Perera Bel, Júlia; Menendez Romero, Silvia; Arpí Llucià, Oriol; Bermejo, Begoña; Martínez, María Teresa; Cejalvo, Juan Miguel; Comino-Méndez, Iñaki; Pascual, Javier; Alba, Emilio; López-Botet, M. (Miguel); Rojo, Federico; Rovira, Ana; Albanell Mestres, Joan; Muntasell i Castellví, Aura, 1972- (BioMed Central, 2024)

  Background: The variability in responses to neoadjuvant treatment with anti-HER2 antibodies prompts to personalized clinical management and the development of innovative treatment strategies. Tumor-infiltrating Natural ...
• Round-robin testing for LMO2 and MYC as immunohistochemical markers to screen MYC rearrangements in aggressive large B-cell lymphoma

  Papaleo, Natalia; Climent, Fina; Tapia, Gustavo; Luizaga Velasco, Luis; Azcarate, Juan; Bosch-Schips, Jan; Muñoz-Mármol, Ana M.; Salido Galeote, Marta; Lome-Maldonado, Carmen; Vázquez, Ivonne; Colomo Saperas, Luis Alberto (Springer, 2023)

  Aggressive large B-cell lymphomas (aLBCL) include a heterogeneous group of lymphomas with diverse biological features. One of the approaches to the diagnosis of aLBCL is based on the identification of MYC rearrangements ...
• Enhancing protein-ligand binding affinity predictions using neural network potentials

  Sabanés Zariquiey, Francesc; Galvelis, Raimondas; Gallicchio, Emilio; Chodera, John D.; Markland, Thomas E.; De Fabritiis, Gianni (American Chemical Society (ACS), 2024)

  This letter gives results on improving protein-ligand binding affinity predictions based on molecular dynamics simulations using machine learning potentials with a hybrid neural network potential and molecular mechanics ...
• International expert consensus on diagnosis and treatment of lung cancer complicated by chronic obstructive pulmonary disease

  Zhou, Chengzhi; Barreiro Portela, Esther; Chen, Rongchang (AME Publishing, 2023)

  Background: Lung cancer combined by chronic obstructive pulmonary disease (LC-COPD) is a common comorbidity and their interaction with each other poses significant clinical challenges. However, there is a lack of ...
• NNP/MM: Accelerating molecular dynamics simulations with machine learning potentials and molecular mechanics

  Galvelis, Raimondas; Varela-Rial, Alejandro; Doerr, Stefan, 1987-; Fino, Roberto; Eastman, Peter; Markland, Thomas E.; Chodera, John D.; De Fabritiis, Gianni (American Chemical Society (ACS), 2023)

  Machine learning potentials have emerged as a means to enhance the accuracy of biomolecular simulations. However, their application is constrained by the significant computational cost arising from the vast number of ...
• Validation of the alchemical transfer method for the estimation of relative binding affinities of molecular series

  Sabanés Zariquiey, Francesc; Pérez, Adrià; Majewski, Maciej; Gallicchio, Emilio; De Fabritiis, Gianni (American Chemical Society (ACS), 2023)

  The accurate prediction of protein-ligand binding affinities is crucial for drug discovery. Alchemical free energy calculations have become a popular tool for this purpose. However, the accuracy and reliability of these ...
• Ambient temperature and seasonal variation in inpatient mortality from respiratory diseases: a retrospective observational study

  Achebak, Hicham; García Aymerich, Judith; Rey, Grégoire; Chen, Zhaoyue; Méndez Turrubiates, Raúl Fernando; Ballester, Joan (Elsevier, 2023)

  Background: The seasonal fluctuation in mortality and hospital admissions from respiratory diseases, with a winter peak and a summer trough, is widely recognized in extratropical countries. However, little is known about ...
• The impact of mutational clonality in predicting the response to immune checkpoint inhibitors in advanced urothelial cancer

  Boll, Lilian Marie; Perera Bel, Júlia; Rodriguez-Vida, Alejo; Arpí Llucià, Oriol; Rovira, Ana; Juanpere, Nuria; Vázquez Montes de Oca, Sergio; Hernández Llodrà, Silvia; Lloreta Trull, Josep, 1958-; Albà Soler, Mar; Bellmunt Molins, Joaquim, 1959- (Nature Research, 2023)

  Immune checkpoint inhibitors (ICI) have revolutionized cancer treatment and can result in complete remissions even at advanced stages of the disease. However, only a small fraction of patients respond to the treatment. To ...
• Exploring adaptive phenotypes for the human calcium-sensing receptor polymorphism R990G

  Sinigaglia, Barbara; Escudero, Jorge; Biagini, Simone Andrea, 1983-; García Calleja, Jorge; Moreno, Josep; Dobón Berenguer, Begoña, 1987-; Acosta, Sandra; Mondal, Mayukh, 1989-; Walsh Capdevila, Sandra, 1991-; Aguileta, Gabriela; Vallès, Mònica; Forrow, Stephen; Martín Caballero, Juan; Migliano, Andrea Bamberg; Bertranpetit, Jaume, 1952-; Muñoz López, Francisco José, 1964-; Bosch Fusté, Elena (Oxford University Press, 2024)

  Rainforest hunter-gatherers from Southeast Asia are characterized by specific morphological features including a particularly dark skin color (D), short stature (S), woolly hair (W), and the presence of steatopygia (S)-fat ...
• Adherence to inhaled corticosteroids in patients with asthma prior to and during the COVID-19 pandemic

  Rodríguez, Isabel; López-Caro, Juan Carlos; González-Carranza, Silvia; Cerrato, Maria Elena; Prado, Maria del Mar de; Gómez-Molleda, Francisca; Pinel, Margarita; Saiz, Maria Teresa; Fuentes, Carmen; Barreiro Portela, Esther; Santibáñez, Miguel (Nature Research, 2023)

  The electronic prescription refill rate (EPRR) of 183 consecutive patients was determined over a 19-month retrospective study period, divided into 7 months PRE (Sep-19 to Mar-20) and 12 months POST pandemic (Apr-20 to ...

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