Browsing Articles (Departament de Medicina i Ciències de la Vida) by Subject "Ubiqüitina"

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A novel melanocortin-4 receptor mutation MC4R-P272L associated with severe obesity has increased propensity to be ubiquitinated in the ER in the face of correct folding

Pérez Jurado, Luis Alberto; Granell, Susana; Serra Juhé, Clara, 1984-; Martos Moreno, Gabriel A.; Díaz, Francisca; Baldini, Giulia; Argente, Jesús (Public Library of Science (PLoS), 2012)

Heterozygous mutations in the melanocortin-4 receptor (MC4R) gene represent the most frequent cause of monogenic obesity in humans. MC4R mutation analysis in a cohort of 77 children with morbid obesity identified previously ...
Sterol homeostasis requires regulated degradation of squalene monooxygenase by the ubiquitin ligase Doa10/Teb4

Foresti, Ombretta; Ruggiano, Annamaria, 1985-; Hannibal-Bach, Hans K.; Ejsing, Christer S.; Carvalho, Pedro C. (eLife, 2013)

Sterol homeostasis is essential for the function of cellular membranes and requires feedback inhibition of HMGR, a rate-limiting enzyme of the mevalonate pathway. As HMGR acts at the beginning of the pathway, its regulation ...

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