Visualitza Articles (Departament de Medicina i Ciències de la Vida) per matèria "Transformació cel·lular"

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Comprehensive identification of mutational cancer driver genes across 12 tumor types

Tamborero Noguera, David; González-Pérez, Abel; Pérez Llamas, Christian, 1976-; Déu Pons, Jordi; Kandoth, Cyriac; Reimand, Jüri; Lawrence, Michael S.; Getz, Gad; Bader, Gary D.; Ding, Li; López Bigas, Núria (Nature Publishing Group, 2013)

With the ability to fully sequence tumor genomes/exomes, the quest for cancer driver genes can now be undertaken in an unbiased manner. However, obtaining a complete catalog of cancer genes is difficult due to the heterogeneous ...
The mutational landscape of chromatin regulatory factors across 4,623 tumor samples

González-Pérez, Abel; Jené i Sanz, Alba, 1984-; López Bigas, Núria (BioMed Central, 2013)

Background: Chromatin regulatory factors are emerging as important genes in cancer development and are regarded as interesting candidates for novel targets for cancer treatment. However, we lack a comprehensive understanding ...