Visualitza Articles (Departament de Medicina i Ciències de la Vida) per autoria "Sadiq, S. Kashif"

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The HIV-1 nucleocapsid regulates its own condensation by phase-separated activity-enhancing sequestration of the viral protease during maturation

Lyonnais, Sébastien; Sadiq, S. Kashif; Lorca Oró, Cristina; Dufau, Laure; Nieto-Marquez, Sara; Escribà, Tuixent; Gabrielli, Natalia, 1978-; Tan, Xiao; Ouizougun-Oubari, Mohamed; Okoronkwo, Josephine; Reboud-Ravaux, Michèle; Gatell, Josep M.; Marquet, Roland; Paillart, Jean-Christophe; Meyerhans, Andreas; Tisné, Carine; Gorelick, Robert J.; Mirambeau, Gilles (MDPI, 2021)

A growing number of studies indicate that mRNAs and long ncRNAs can affect protein populations by assembling dynamic ribonucleoprotein (RNP) granules. These phase-separated molecular 'sponges', stabilized by quinary ...
The myxobacterial metabolite soraphen A inhibits HIV-1 by reducing virus production and altering virion composition

Fleta Soriano, Eric, 1983-; Smutná, Katarína, 1991-; Martinez, Javier P.; Lorca Oró, Cristina; Sadiq, S. Kashif; Mirambeau, Gilles; Lopez-Iglesias, Carmen; Bosch, Marta; Pol, Albert; Brönstrup, Mark; Díez Antón, Juana, 1962-; Meyerhans, Andreas (American Society for Microbiology, 2017)

Soraphen A is a myxobacterial metabolite that blocks the acetyl-coenzyme A carboxylase of the host and was previously identified as a novel HIV inhibitor. Here, we report that soraphen A acts by reducing virus production ...