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Visualitza Articles (Departament de Ciències Experimentals i de la Salut) per matèria "Cannabinoides -- Receptors"

Visualitza Articles (Departament de Ciències Experimentals i de la Salut) per matèria "Cannabinoides -- Receptors"

Ordena per: Ordre: Resultats:

  • Zimmer, Andreas; Valjent, Emmanuel; König, Monika; Zimmer, Anne M.; Robledo, Patrícia, 1958-; Hahn, Heidi; Valverde Granados, Olga; Maldonado, Rafael, 1961- (Society for Neuroscience, 2001)
    The involvement of dynorphin on Delta-9-tetrahydrocannabinol (THC) and morphine responses has been investigated by using mice with a targeted inactivation of the prodynorphin (Pdyn) gene. Dynorphin-deficient mice show ...
  • Aso Pérez, Ester; Valverde Granados, Olga; Ozaita Mintegui, Andrés, 1969-; Maldonado, Rafael, 1961-; Pazos, Ángel; Ledent, Catherine; Valdizán, Elsa M. (Wiley-Blackwell, 2008)
    Stress can cause damage and atrophy of neurons in the hippocampus by deregulating the expression of neurotrophic factors that promote neuronal plasticity. The endocannabinoid system represents a physiological substrate ...
  • Maldonado, Rafael, 1961-; Rodríguez de Fonseca, Fernando (Society for Neuroscience, 2002)
    The use of cannabis sativa preparations as recreational drugs can be traced back to the earliest civilizations. However, animal models of cannabinoid addiction allowing the exploration of neural correlates of cannabinoid ...
  • Aso Pérez, Ester; Andrés Benito, Pol; Carmona, Margarita; Maldonado, Rafael, 1961-; Ferrer, Isidre (IOS Press, 2016)
    The endogenous cannabinoid system represents a promising therapeutic target to modify neurodegenerative pathways linked to Alzheimer's disease (AD). The aim of the present study was to evaluate the specific contribution ...
  • Valverde Granados, Olga; Maldonado, Rafael, 1961-; Valjent, Emmanuel; Zimmer, Anne M.; Zimmer, Andreas (Society for Neuroscience, 2000)
    The functional interactions between the endogenous cannabinoid and opioid systems were evaluated in pre-proenkephalin-deficient mice. Antinociception induced in the tail-immersion test by acute Delta9-tetrahydrocannabinol ...
  • Saravia, Rocío; Flores de los Heros, África, 1985-; Plaza-Zabala, Ainhoa, 1982-; Busquets Garcia, Arnau, 1985-; Pastor, Antonio; Torre Fornell, Rafael de la; Di Marzo, Vicenzo; Marsicano, Giovanni; Ozaita Mintegui, Andrés, 1969-; Maldonado, Rafael, 1961-; Berrendero Díaz, Fernando, 1971- (Elsevier, 2017)
    BACKGROUND: Tobacco withdrawal is associated with deficits in cognitive function, including attention, working memory, and episodic memory. Understanding the neurobiological mechanisms involved in these effects is crucial ...
  • Aso Pérez, Ester; Pazos, Ángel; Mato, Susana; Maldonado, Rafael, 1961-; Valverde Granados, Olga; Martín, Miguel; Castro, Elena (Wiley-Blackwell, 2007)
    Interaction between brain endocannabinoid (EC) and serotonin (5-HT) systems was investigated by examining 5-HT-dependent behavioural and biochemical responses in CB1 receptor knockout mice. CB1 knockout animals exhibited ...
  • Kossatz, Elk; Maldonado, Rafael, 1961-; Robledo, Patricia, 1958- (Elsevier, 2016)
    The role of CB2 cannabinoid receptors (CB2R) in global brain lesions induced by hypoxia-ischemia (HI) insult is still unresolved. The aim of this study was to evaluate the involvement of CB2R in the behavioural and biochemical ...
  • Viñals, Xavier; Moreno, Estefanía; Lanfumey, Laurence; Cordomí, Arnau; Pastor, Antonio; Torre Fornell, Rafael de la; Gasperini, Paola; Navarro, Gemma; Howell, Lesley A.; Pardo, Leonardo; Lluís, Carmen; Canela, Enric I.; McCormick, Peter J.; Maldonado, Rafael, 1961-; Robledo, Patrícia, 1958- (Public Library of Science, 2015)
    Activation of cannabinoid CB1 receptors (CB1R) by delta9-tetrahydrocannabinol (THC) produces a variety of negative effects with major consequences in cannabis users that constitute important drawbacks for the use of ...
  • Racz, Ildiko; Nadal i Roura, Xavier, 1980-; Alferink, Judith; Baños i Díez, Josep Eladi; Rehnelt, Jennifer; Martín Sánchez, Miquel, 1971-; Pintado, Belén; Gutierrez-Adan, Alfonso; Sanguino, Elena; Manzanares, Jorge; Zimmer, Andreas; Maldonado, Rafael, 1961- (Society for Neuroscience, 2008)
    Neuropathic pain is a clinical manifestation of nerve injury difficult to treat even with potent analgesic compounds. Here, we used different lines of genetically modified mice to clarify the role played by CB2 cannabinoid ...
  • Aso Pérez, Ester; Maldonado, Rafael, 1961-; Murtra, Patricia; Balerio, Graciela N.; Berrendero Díaz, Fernando, 1971- (Wiley-Blackwell, 2004)
    The possible interactions between Delta9-tetrahydrocannabinol (THC) and nicotine remain unclear in spite of the current association of cannabis and tobacco in humans. The aim of the present study was to explore the ...
  • Racz, Ildiko; Nadal i Roura, Xavier, 1980-; Alferink, Judith; Baños i Díez, Josep Eladi; Rehnelt, Jennifer; Martín, Miguel; Pintado, Belén; Gutierrez-Adan, Alfonso; Sanguino, Elena; Bellora Pereyra, Nicolás; Manzanares, Jorge; Zimmer, Andreas; Maldonado, Rafael, 1961- (Society for Neuroscience, 2008)
    Nerve injuries often lead to neuropathic pain syndrome. The mechanisms contributing to this syndrome involve local inflammatory responses, activation of glia cells, and changes in the plasticity of neuronal nociceptive ...
  • Aso Pérez, Ester; Renoir, Thibault; Valverde Granados, Olga; Lanfumey, Laurence; Maldonado, Rafael, 1961-; Hamon, Michel; Ledent, Catherine; Mengod, Guadalupe (Wiley-Blackwell, 2009)
    Serotonergic and endocannabinoid systems are important substrates for the control of emotional behavior and growing evidence show an involvement in the pathophysiology of mood disorders. In the present study, the absence ...
  • Cutando Ruiz, Laura, 1985-; Busquets Garcia, Arnau, 1985-; Puighermanal Puigvert, Emma, 1983-; Gomis González, Maria; Delgado García, José María; Gruart, Agnès; Maldonado, Rafael, 1961-; Ozaita Mintegui, Andrés, 1969- (American Society for Clinical Investigation, 2013)
    Chronic cannabis exposure can lead to cerebellar dysfunction in humans, but the neurobiological mechanisms involved remain incompletely understood. Here, we found that in mice, subchronic administration of the psychoactive ...
  • Fagundo, Ana B.; Torre Fornell, Rafael de la; Jiménez Murcia, Susana; Agüera, Zaida; Pastor, Antonio; Casanueva, Felipe F.; Granero, Roser; Baños, Rosa; Botella, Cristina; de Pino Gutiárrez, Amparo; Fernández Real, Jose M.; Fernández García, José C.; Frühbeck, Gema; Gómez Ambrosi, Javier; Menchón, José M.; Moragrega, Inés; Rodríguez, Roser; Tárrega, Salomé; Tinahones, Francisco J.; Fernández Aranda, Fernando (Public Library of Science (PLoS), 2013)
    Animal studies point to an implication of the endocannabinoid system on executive functions. In humans, several studies have suggested an association between acute or chronic use of exogenous cannabinoids (Δ9-tetrahydrocannabinol) ...
  • Ghozland, Sandy; Matthes, Hans W. D.; Simonin, Frederic; Filliol, Dominique; Kieffer, Brigitte L.; Maldonado, Rafael, 1961- (Society for Neuroscience, 2002)
    Repeated THC administration produces motivational and somatic/nadaptive changes leading to dependence in rodents. To/ninvestigate the molecular basis for cannabinoid dependence/nand its possible relationship with the ...
  • Busquets Garcia, Arnau, 1985-; Gomis González, Maria; Srivastava, Raj Kamal; Cutando Ruiz, Laura, 1985-; Ortega Alvaro, Antonio; Ruehle, Sabine; Remmers, Floortje; Bindila, Laura; Bellochio, Luigi; Marsicano, Giovanni; Lutz, Beat; Maldonado, Rafael, 1961-; Ozaita Mintegui, Andrés, 1969-; (National Academy of Sciences, 2016)
    Stressful events can generate emotional memories linked to the traumatic incident, but they also can impair the formation of nonemotional memories. Although the impact of stress on emotional memories is well studied, much ...
  • Gomis González, Maria; Busquets Garcia, Arnau, 1985-; Matute, Carlos; Maldonado, Rafael, 1961-; Mato, Susana; Ozaita Mintegui, Andrés, 1969- (MDPI, 2016)
    Fragile X syndrome (FXS) is the most common monogenetic cause of intellectual disability. The cognitive deficits in the mouse model for this disorder, the Fragile X Mental Retardation 1 (Fmr1) knockout (KO) mouse, have ...
  • Navarrete, Francisco; Rodríguez Arias, Marta; Martín García, Elena, 1975-; Navarro, Daniela; García Gutiérrez, Susana; Aguilar, Maria A.; Aracil Fernández, Auxiliadora; Berbel, Pere; Miñarro, José; Maldonado, Rafael, 1961-; Manzanares, Jorge (Nature Publishing Group, 2013)
    This study was aimed to evaluate the involvement of CB2 cannabinoid receptors (CB2r) in the rewarding, reinforcing and motivational effects of nicotine. Conditioned place preference (CPP) and intravenous self-administration ...
  • Aso Pérez, Ester; Balerio, Graciela N.; Maldonado, Rafael, 1961- (Springer, 2006)
    Rationale: Acute behavioural effects and motivational responses induced by nicotine can be modulated by the endocannabinoid system supporting the existence of a physiological interaction between these two systems. Objectives: ...