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Browsing Articles (Departament de Medicina i Ciències de la Vida) by Author "Aguilar, Daniel"

Browsing Articles (Departament de Medicina i Ciències de la Vida) by Author "Aguilar, Daniel"

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  • Computational analysis of multimorbidity between asthma, eczema and rhinitis
    Aguilar, Daniel; Pinart, Mariona; Benet, Marta; García Aymerich, Judith; González Ruiz, Juan Ramón; Guerra, Stefano; Kogevinas, Manolis; Sunyer Deu, Jordi; Valverde, Sergi; Oliva Miguel, Baldomero; Antó i Boqué, Josep Maria (Public Library of Science (PLoS), 2017)
    Background: The mechanisms explaining the co-existence of asthma, eczema and rhinitis (allergic multimorbidity) are largely unknown. We investigated the mechanisms underlying multimorbidity between three main allergic ...
  • Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis.
    Sieberts, Solveig K.; García-García, Javier, 1982-; Aguilar, Daniel; Anton, Bernat; Bonet Martínez, Jaume, 1982-; Fornés Crespo, Oriol, 1983-; Marín López, Manuel Alejandro, 1987-; Planas Iglesias, Joan, 1980-; Poglayen, Daniel, 1984-; Oliva Miguel, Baldomero; Mangravite, Lara M. (Nature Publishing Group, 2016)
    Rheumatoid arthritis (RA) affects millions world-wide. While anti-TNF treatment is widelyused to reduce disease progression, treatment fails inBone-third of patients. No biomarkercurrently exists that identifies non-responders ...
  • Distinction between rhinitis alone and rhinitis with asthma using interactomics
    Aguilar, Daniel; Lemonnier, Nathanael; Melén, Erik; Bustamante Pineda, Mariona; Gruzieva, Olena; Guerra, Stefano; Keil, Thomas; Koppelman, Gerard H.; Celedón, Juan C.; Antó i Boqué, Josep Maria; Bousquet, Jean (Nature Research, 2023)
    The concept of "one-airway-one-disease", coined over 20 years ago, may be an over-simplification of the links between allergic diseases. Genomic studies suggest that rhinitis alone and rhinitis with asthma are operated by ...
  • Functional and topological characterization of transcriptional cooperativity in yeast
    Aguilar, Daniel; Oliva Miguel, Baldomero (BioMed Central, 2012)
  • Genetic and functional characterization of disease associations explains comorbidity
    Rubio Pérez, Carlota, 1990-; Güney, Emre, 1983-; Aguilar, Daniel; Piñero González, Janet, 1977-; García-García, Javier, 1982-; Iadarola, Barbara; Sanz, Ferran; Fernández Fuentes, Narcís; Furlong, Laura I., 1971-; Oliva Miguel, Baldomero (Nature Publishing Group, 2017)
    Understanding relationships between diseases, such as comorbidities, has important socio-economic implications, ranging from clinical study design to health care planning. Most studies characterize disease comorbidity using ...
  • Integration of gene expression and DNA methylation identifies epigenetically controlled modules related to PM2.5 exposure
    Merid, Simon Kebede; Bustamante Pineda, Mariona; Standl, Marie; Sunyer Deu, Jordi; Heinrich, Joachim; Lemonnier, Nathanael; Aguilar, Daniel; Antó i Boqué, Josep Maria; Bousquet, Jean; Santa Marina, Loreto; Lertxundi, Aitana; Bergström, Anna; Kull, Inger; Wheelock, Åsa M.; Koppelman, Gerard H.; Melén, Erik; Gruzieva, Olena (Elsevier, 2020)
    Air pollution has been associated with adverse health effects across the life-course. Although underlying mechanisms are unclear, several studies suggested pollutant-induced changes in transcriptomic profiles. In this ...
  • Mapping the mutual information network of enzymatic families in the protein structure to unveil functional features
    Aguilar, Daniel; Oliva Miguel, Baldomero; Marino Buslje, Cristina (Public Library of Science (PLoS), 2012)
    Amino acids committed to a particular function correlate tightly along evolution and tend to form clusters in the 3D structure of the protein. Consequently, a protein can be seen as a network of co-evolving clusters of ...
  • Topological comparison of methods for predicting transcriptional cooperativity in yeast
    Aguilar, Daniel; Oliva Miguel, Baldomero (BioMed Central, 2008)
    Background: The cooperative interaction between transcription factors has a decisive role in the control of the fate of the eukaryotic cell. Computational approaches for characterizing cooperative transcription factors in ...
  • Understanding allergic multimorbidity within the non-eosinophilic interactome
    Aguilar, Daniel; Lemonnier, Nathanael; Koppelman, Gerard H.; Melén, Erik; Oliva Miguel, Baldomero; Pinart, Mariona; Guerra, Stefano; Bousquet, Jean; Antó i Boqué, Josep Maria (Public Library of Science (PLoS), 2019)
    Background: The mechanisms explaining multimorbidity between asthma, dermatitis and rhinitis (allergic multimorbidity) are not well known. We investigated these mechanisms and their specificity in distinct cell types by ...

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