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Visualitza Articles (Departament de Medicina i Ciències de la Vida) per matèria "Addiction"

Ara mostrant els elements 1-11 de 11

A gender perspective of addictive disorders

Fonseca Casals, Francina, 1972-; Robles-Martínez, María; Tirado Muñoz, Judit; Alías i Ferri, María; Mestre-Pintó, Juan Ignacio; Coratu, Ana Maria; Torrens, Marta (Springer, 2021)

Purpose of review: Substance use disorders (SUD) affect differentially women and men. Although the prevalence has been reported higher in men, those women with addictive disorders present a more vulnerable profile and are ...
A specific prelimbic-nucleus accumbens pathway controls resilience versus vulnerability to food addiction

Domingo Rodriguez, Laura, 1992-; Ruiz de Azua, Iñigo; Domínguez, Eduardo; Senabre, Eric; Serra, Irene; Kummer, Sami, 1985-; Navandar, Mohit; Baddenhausen, Sarah; Hofmann, Clementine; Andero, Raül; Gerber, Susanne; Navarrete, Marta; Dierssen, Mara; Lutz, Beat; Martín García, Elena, 1975-; Maldonado, Rafael, 1961- (Nature Research, 2020)

Food addiction is linked to obesity and eating disorders and is characterized by a loss of behavioral control and compulsive food intake. Here, using a food addiction mouse model, we report that the lack of cannabinoid ...
Absence of delta-9-tetrahydrocannabinol dysphoric effects in dynorphin-deficient mice

Zimmer, Andreas; Valjent, Emmanuel; König, Monika; Zimmer, Anne M.; Robledo, Patricia, 1958-; Hahn, Heidi; Valverde Granados, Olga; Maldonado, Rafael, 1961- (Society for Neuroscience, 2001)

The involvement of dynorphin on Delta-9-tetrahydrocannabinol (THC) and morphine responses has been investigated by using mice with a targeted inactivation of the prodynorphin (Pdyn) gene. Dynorphin-deficient mice show ...
Cannabinoid withdrawal syndrome is reduced in pre-proenkephalin knock-out mice

Valverde Granados, Olga; Maldonado, Rafael, 1961-; Valjent, Emmanuel; Zimmer, Anne M.; Zimmer, Andreas (Society for Neuroscience, 2000)

The functional interactions between the endogenous cannabinoid and opioid systems were evaluated in pre-proenkephalin-deficient mice. Antinociception induced in the tail-immersion test by acute Delta9-tetrahydrocannabinol ...
Effects of mixing energy drinks with alcohol on driving-related skills

Pérez Mañá, Clara; Mateus Rodriguez, Julian Andrés; Díaz-Pellicer, Patricia; Díaz-Baggerman, Ariadna; Pérez, Marta; Pujadas Bastardes, Mitona; Fonseca Casals, Francina, 1972-; Papaseit Fontanet, Esther; Pujol, Jesús; Langohr, Klaus; Torre Fornell, Rafael de la (Oxford University Press, 2022)

Background: Energy drinks (EDs) reduce sleepiness and fatigue and improve driving performance whereas alcohol does just the opposite. Although it is a trendy combination among young people, the effects of alcohol mixed ...
Neurobiological mechanisms involved in nicotine dependence and reward: participation of the endogenous opioid system

Berrendero Díaz, Fernando, 1971-; Robledo, Patricia, 1958-; Trigo i Rodríguez, Josep M.; Martín García, Elena, 1975-; Maldonado, Rafael, 1961- (Elsevier, 2010)

Nicotine is the primary component of tobacco that maintains the smoking habit and develops addiction. The adaptive changes of nicotinic acetylcholine receptors produced by repeated exposure to nicotine play a crucial role ...
Sex-specific effects of synbiotic exposure in mice on addictive-like behavioral alterations induced by chronic alcohol intake are associated with changes in specific gut bacterial taxa and brain tryptophan metabolism

Pizarro Lozano, Mª Nieves; Kossatz de Mello, Elk, 1977-; González, Pedro; Gamero, Alba; Veza, Emma; Fernández, Cristina; Gabaldón Estevan, Juan Antonio, 1973-; Torre Fornell, Rafael de la; Robledo, Patricia, 1958- (Frontiers, 2021)

Chronic alcohol intake has been shown to disrupt gut microbiota homeostasis, but whether microbiota modulation could prevent behavioral alterations associated with chronic alcohol intake remains unknown. We investigated ...
The absence of VGLUT3 predisposes to cocaine abuse by increasing dopamine and glutamate signaling in the nucleus accumbens

Sakae, Diana Yae; Martín García, Elena, 1975-; Gutiérrez Cuesta, Javier; Maldonado, Rafael, 1961-; El Mestikawy, Salah (Nature Publishing Group, 2015)

Tonically active cholinergic interneurons (TANs) from the nucleus accumbens (NAc) are centrally involved in reward behavior. TANs express a vesicular glutamate transporter referred to as VGLUT3 and thus use both acetylcholine ...
Transcriptional signatures in prefrontal cortex confer vulnerability versus resilience to food and cocaine addiction-like behavior

Navandar, Mohit; Martín García, Elena, 1975-; Maldonado, Rafael, 1961-; Lutz, Beat; Gerber, Susanne; Ruiz de Azua, Iñigo (Nature Research, 2021)

Addiction is a chronic relapsing brain disease characterized by compulsive reward-seeking despite harmful consequences. The mechanisms underlying addiction are orchestrated by transcriptional reprogramming in the reward ...
USP7/Maged1-mediated H2A monoubiquitination in the paraventricular thalamus: an epigenetic mechanism involved in cocaine use disorder

Cheron, Julian; Beccari, Leonardo; Hagué, Perrine; Icick, Romain; Despontin, Chloé; Carusone, Teresa; Defrance, Matthieu; Bhogaraju, Sagar; Martín García, Elena, 1975-; Capellan, Roberto; Maldonado, Rafael, 1961-; Vorspan, Florence; Bonnefont, Jérôme; d'Exaerde, Alban de Kerchove (Nature Research, 2023)

The risk of developing drug addiction is strongly influenced by the epigenetic landscape and chromatin remodeling. While histone modifications such as methylation and acetylation have been studied in the ventral tegmental ...
Vulnerability to addiction

Maldonado, Rafael, 1961-; Calvé Pérez, Pablo, 1993-; García Blanco, Alejandra; Domingo Rodriguez, Laura, 1992-; Senabre, Eric; Martín García, Elena, 1975- (Elsevier, 2021)

Addiction is a chronic brain disease that has dramatic health and socioeconomic consequences worldwide. Multiple approaches have been used for decades to clarify the neurobiological basis of this disease and to identify ...