Visualitza Articles (Departament de Medicina i Ciències de la Vida) per matèria "Interleukin-1β (IL-1β)"

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GRASP55 and UPR control interleukin-1β aggregation and secretion

Chiritoiu, Marioara; Brouwers, Nathalie; Turacchio, Gabriele; Pirozzi, Marianella; Malhotra, Vivek (Elsevier, 2019)

Signal-sequence-lacking interleukin (IL)-1β, is cleaved by caspase-1 to mature mIL-1β, which is secreted, without entering the endoplasmic reticulum. We report that macrophages of GRASP55-/- mice are defective in mIL-1β ...