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Browsing Articles (Departament de Medicina i Ciències de la Vida) by Author "Guney, Emre"

Browsing Articles (Departament de Medicina i Ciències de la Vida) by Author "Guney, Emre"

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  • Aguirre Plans, Joaquim, 1993-; Piñero González, Janet, 1977-; Souza, Terezinha; Callegaro, Giulia; Kunnen, Steven J.; Sanz, Ferran; Fernández Fuentes, Narcís; Furlong, Laura I., 1971-; Guney, Emre; Oliva Miguel, Baldomero (BioMed Central, 2021)
    Background: Drug-induced liver injury (DILI) is an adverse reaction caused by the intake of drugs of common use that produces liver damage. The impact of DILI is estimated to affect around 20 in 100,000 inhabitants worldwide ...
  • Salgado Mendialdúa, Victòria; Aguirre Plans, Joaquim, 1993-; Guney, Emre; Reig-Viader, Rita; Maldonado, Rafael, 1961-; Bayés, Angels; Oliva Miguel, Baldomero; Ozaita Mintegui, Andrés, 1969- (Elsevier, 2018)
    Cannabis is the most consumed illicit drug worldwide. Its principal psychoactive component, Δ9-tetrahydrocannabinol (THC), affects multiple brain functions, including cognitive performance, by modulating cannabinoid type-1 ...
  • Casas, Ana I.; Hassan, Ahmed; Larsen, Simon J.; Gomez-Rangel, Vanessa; Elbatreek, Mahmoud; Kleikers, Pamela W. M.; Guney, Emre; Egea, Javier; López, Manuela G.; Baumbach, Jan; Schmidt, Harald H.H.W. (National Academy of Sciences, 2019)
    Drug discovery faces an efficacy crisis to which ineffective mainly single-target and symptom-based rather than mechanistic approaches have contributed. We here explore a mechanism-based disease definition for network ...
  • Aguirre Plans, Joaquim, 1993-; Piñero González, Janet, 1977-; Sanz, Ferran; Furlong, Laura I., 1971-; Fernández Fuentes, Narcís; Oliva Miguel, Baldomero; Guney, Emre (Elsevier, 2019)
    The genetic basis of complex diseases involves alterations on multiple genes. Unraveling the interplay between these genetic factors is key to the discovery of new biomarkers and treatments. In 2014, we introduced GUILDify, ...
  • Verdura, Edgard; Pérez-Cano, Laura; Sabido-Vera, Rubén; Guney, Emre; Hyvelin, Jean-Marc; Durham, Lynn; Gómez-Mancilla, Baltazar (Frontiers, 2021)
    Fragile X syndrome (FXS) is the most frequent monogenic cause of autism or intellectual disability, and research on its pathogenetic mechanisms has provided important insights on this neurodevelopmental condition. Nevertheless, ...
  • Piñero González, Janet, 1977-; Gonzalez-Perez, Abel; Guney, Emre; Aguirre Plans, Joaquim, 1993-; Sanz, Ferran; Oliva Miguel, Baldomero; Furlong, Laura I., 1971- (Frontiers, 2018)
    Understanding the mechanisms underlying drug therapeutic action and toxicity is crucial for the prevention and management of drug adverse reactions, and paves the way for a more efficient and rational drug design. The ...
  • Aguirre Plans, Joaquim, 1993-; Piñero González, Janet, 1977-; Menche, Jörg; Sanz, Ferran; Furlong, Laura I., 1971-; Schmidt, Harald H.H.W.; Oliva Miguel, Baldomero; Guney, Emre (MDPI, 2018)
    The past decades have witnessed a paradigm shift from the traditional drug discovery shaped around the idea of “one target, one disease” to polypharmacology (multiple targets, one disease). Given the lack of ...
  • Pognan, François; Centeno, Emilio; Furlong, Laura I., 1971-; Guney, Emre; Mayer, Miguel Ángel, 1960-; Pastor Maeso, Manuel; Piñero González, Janet, 1977-; Ramírez Anguita, Juan Manuel; Ronzano, Francesco; Saüch Pitarch, Josep; Sanz, Ferran (MDPI, 2021)
    eTRANSAFE is a research project funded within the Innovative Medicines Initiative (IMI), which aims at developing integrated databases and computational tools (the eTRANSAFE ToxHub) that support the translational safety ...
  • Callegaro, Giulia; Kunnen, Steven J.; Trairatphisan, Panuwat; Grosdidier, Solène; Niemeijer, Marije; den Hollander, Wouter; Guney, Emre; Piñero González, Janet, 1977-; Furlong, Laura I., 1971-; Webster, Yue W.; Saez-Rodriguez, Julio; Sutherland, Jeffrey J.; Mollon, Jennifer; Stevens, James L.; van de Water, Bob (SpringerOpen, 2021)
    Mechanism-based risk assessment is urged to advance and fully permeate into current safety assessment practices, possibly at early phases of drug safety testing. Toxicogenomics is a promising source of mechanisms-revealing ...
  • Anupama, Jigisha; Francescatto, Margherita; Rahman, Farzana; Fatima, Nazeefa; DeBlasio, Dan; Shanmugam, Avinash Kumar; Satagopam, Venkata; Santos, Alberto; Kolekar, Pandurang; Michaut, Magali; Guney, Emre (Public Library of Science (PLoS), 2018)
    Education and training are two essential ingredients for a successful career. On one hand, universities provide students a curriculum for specializing in one's field of study, and on the other, internships complement ...
  • Cuadrado, Antonio; Manda, Gina; Hassan, Ahmed; Alcaraz, María José; Barbas, Coral; Daiber, Andreas; Ghezzi, Pietro; León, Rafael; López, Manuela G.; Oliva Miguel, Baldomero; Pajares, Marta; Rojo, Ana I.; Robledinos Antón, Natalia; Valverde, Ángela María; Guney, Emre; Schmidt, Harald H.H.W. (American Society for Pharmacology and Experimental Therapeutics (ASPET), 2018)
    Systems medicine has a mechanism-based rather than a symptom- or organ-based approach to disease and identifies therapeutic targets in a nonhypothesis-driven manner. In this work, we apply this to transcription factor ...

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