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Browsing Articles (Departament de Ciències Experimentals i de la Salut) by Title

Browsing Articles (Departament de Ciències Experimentals i de la Salut) by Title

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  • Bosch Fusté, Elena; Laayouni, Hafid, 1968-; Morcillo Suárez, Carlos, 1969-; Casals López, Ferran; Moreno Estrada, Andrés; Ferrer Admetlla, Anna; Gardner, Michelle; Rosa, Araceli; Comas, David, 1969-; Graffelman, Jan; Calafell i Majó, Francesc; Bertranpetit, Jaume, 1952- (BioMed Central, 2009)
    Background: It is well known that the pattern of linkage disequilibrium varies between human populations, with remarkable geographical stratification. Indirect association studies routinely exploit linkage disequilibrium ...
  • Meyer, Markus; Plass Pórtulas, Mireya, 1982-; Pérez Valle, Jorge; Eyras Jiménez, Eduardo; Vilardell, Josep (Elsevier, 2011)
    Poor understanding of the spliceosomal mechanisms to select intronic 3' ends (3'ss) is a major obstacle to deciphering eukaryotic genomes. Here, we discern the rules for global 3'ss selection in yeast. We show that, in ...
  • de la Cruz Peña, María Jose; Martínez Hernández, Francisco; García Heredia, Inmaculada; Lluesma Gómez, Mónica; Fornas Carreño, Oscar; Martínez García, Manuel (MDPI, 2018)
    Single-cell genomics has unveiled the metabolic potential of dominant microbes inhabiting different environments, including the human body. The lack of genomic information for predominant microbes of the human body, such ...
  • Salat Canela, Clàudia; Paulo Mirasol, Esther, 1984-; Sánchez Mir, Laura; Carmona, Mercè; Ayté del Olmo, José; Oliva Miguel, Baldomero; Hidalgo Hernando, Elena (American Society for Biochemistry and Molecular Biology (ASBMB), 2017)
    Adaptation to stress triggers the most dramatic shift in gene expression in fission yeast (Schizosaccharomyces pombe), and this response is driven by signaling via the MAPK Sty1. Upon activation, Sty1 accumulates in the ...
  • Mallorquí-Bagué, Nuria; Fagundo, Ana B.; Jiménez Murcia, Susana; Torre Fornell, Rafael de la; Baños, Rosa M.; Botella, Cristina; Casanueva, Felipe F.; Crujeiras, Ana B.; Fernández García, José C.; Fernández Real, Jose M.; Frühbeck, Gema; Granero, Roser; Rodríguez, Amaia; Tolosa-Sola, Iris; Ortega, Francesc; Tinahones Madueño, Francisco José; Alvarez-Moya, Eva; Ochoa, Cristian; Menchón, José M.; Fernández Aranda, Fernando (Public Library of Science (PLoS) , 2016)
    INTRODUCTION: Addictions are associated with decision making impairments. The present study explores decision making in Substance use disorder (SUD), Gambling disorder (GD) and Obesity (OB) when assessed by Iowa Gambling ...
  • Aparicio i Prat, Estel, 1986-; Arnan Ros, Carme; Sala, Ilaria; Bosch Roca, Núria; Guigó Serra, Roderic; Johnson, Rory (BioMed Central, 2015)
    Background. CRISPR genome-editing technology makes it possible to quickly and cheaply delete non-protein-coding regulatory elements. We present a vector system adapted for this purpose called DECKO (Double Excision CRISPR ...
  • Tilgner, Hagen, 1980-; Knowles, David G.; Johnson, Rory; Davis, Carrie A.; Chakrabortty, Sudipto; Djebali, Sarah; Curado, Joao; Snyder, Michael; Gingeras, Thomas R.; Guigó Serra, Roderic (Cold Spring Harbor Laboratory Press (CSHL Press), 2012)
    Splicing remains an incompletely understood process. Recent findings suggest that chromatin structure participates in its regulation. Here, we analyze the RNA from subcellular fractions obtained through RNA-seq in the cell ...
  • Sabbaghi Mehrjardi, Mohammad Ali; Gil Gómez, Gabriel; Guardia Laguarta, Cristina; Servitja Tormo, Sonia; Arpí Llucià, Oriol; Menendez Romero, Silvia; Arumí, Montserrat; Serrano, Laia; Salido Galeote, Marta; Muntasell i Castellví, Aura, 1972-; Martínez-García, Maria; Tusquets Trias de Bes, Ignacio; Rovira Guerín, Ana; Albanell Mestres, Joan (American Association for Cancer Research (AACR), 2017)
    Purpose: Trastuzumab-emtansine (T-DM1) is a standard treatment in advanced HER2-positive breast cancer. However, resistance inevitably occurs. We aimed to identify mechanisms of acquired T-DM1 resistance.Experimental Design: ...
  • Argente, Jesús; Flores, Raquel; Gutiérrez Arumi, Armand, 1980-; Verma, Bhupendra; Martos Moreno, Gabriel A.; Cuscó Martí, Ivon, 1973-; Oghabian, Ali; Chowen, Julie A.; Frilander, Mikko J; Pérez Jurado, Luis Alberto (Wiley-VCH Verlag, 2014)
    The molecular basis of a significant number of cases of isolated growth hormone deficiency remains unknown. We describe three sisters affected with severe isolated growth hormone deficiency and pituitary hypoplasia caused ...
  • Dalmases Massegú, Alba, 1982-; González González, Irene; Menendez Romero, Silvia; Arpí Llucià, Oriol; Corominas Torres, Josep Maria; Servitja Tormo, Sonia; Tusquets, Ignasi; Chamizo, Cristina; Rincón, Raúl; Espinosa Blay, Lluís; Bigas Salvans, Anna; Eroles, Pilar; Furriol, Jessica; Lluch, Ana; Rovira Guerín, Ana; Albanell Mestres, Joan; Rojo, Federico (Impact Journals, 2014)
    NF-кB has been linked to doxorubicin resistance in breast cancer patients. NF-кB nuclear translocation and DNA binding in doxorubicin treated-breast cancer cells have been extensively examined; however its functional ...
  • Trussart, Marie, 1985-; Yus, Eva; Martínez, Sira; Baù, Davide; Tahara, Yuhei O.; Pengo, Thomas; Widjaja, Michael; Kretschmer, Simon; Swoger, Jim; Djordjevic, Steven P.; Turnbull, Lynne; Whitchurch, Cynthia B.; Miyata, Makoto; Martí Renom, Marc A.; Lluch-Senar, Maria 1982-; Serrano Pubull, Luis, 1982- (Nature Publishing Group, 2017)
    DNA-binding proteins are central regulators of chromosome organization; however, in genome-reduced bacteria their diversity is largely diminished. Whether the chromosomes of such bacteria adopt defined three-dimensional ...
  • Lluch-Senar, Maria 1982-; Delgado, Javier; Chen, Wei-Hua; Lloréns Rico, Verónica, 1989-; O’Reilly, Francis J.; Wodke, Judith A.H.; Unal, E. Besray; Yus, Eva; Martínez, Sira; Nichols, Robert J.; Ferrar, Tony; Vivancos Prellezo, Ana; Schmeisky, Arne; Stülke, Jörg; Noort, Vera van; Gavin, Anne-Claude; Bork, Peer; Serrano Pubull, Luis, 1982- (Wiley Blackwell, 2015)
    Identifying all essential genomic components is critical for the assembly of minimal artificial life. In the genome-reduced bacterium Mycoplasma pneumoniae, we found that small ORFs (smORFs; < 100 residues), accounting for ...
  • Garcia-Elias Heras, Anna; Alloza, Leonor; Puigdecanet Riubugent, Eulàlia; Nonell Mazelón, Lara; Tajes Orduña, Marta; Curado, Joao; Enjuanes Grau, Cristina; Díaz, Oscar; Bruguera-Cortada, Jordi; Martí-Almor, Julio; Comín Colet, Josep; Benito Villabriga, Begoña (Nature Publishing Group, 2017)
    MicroRNAs (miRNAs) have emerged as promising biomarkers of disease. Their potential use in clinical practice requires standardized protocols with very low miRNA concentrations, particularly in plasma samples. Here we tested ...
  • Hernández Acosta, Astrid; Baños i Díez, Josep Eladi; Llop, Cristina; Farré Albaladejo, Magí (Public Library of Science (PLoS), 2014)
    Aim: Lack of knowledge concerning the nature of placebo and why it is necessary may influence the participation of patients in clinical trials. The objective of the present study is to review how placebo is described in ...
  • Tauste Campo, Adrià; Principe, Alessandro; Ley Nacher, Miguel; Rocamora Zúñiga, Rodrigo Alberto; Deco, Gustavo (Public Library of Science (PLoS), 2018)
    Epileptic seizures are known to follow specific changes in brain dynamics. While some algorithms can nowadays robustly detect these changes, a clear understanding of the mechanism by which these alterations occur and ...
  • Fontanillas, Eric; E. Hood, Michael; Badouin, Hélène; Petit, Elsa; Barbe, Valérie; Gouzy, Jérôme; Vienne, Damien M. de; Aguileta, Gabriela; Poulain, Julie; Wincker, Patrick; Chen, Zehua; Toh, Su San; Cuomo, Christina A.; Perlin, Michael H.; Gladieux, Pierre; Giraud, Tatiana (Oxford University Press, 2015)
    Dimorphic mating-type chromosomes in fungi are excellent models for understanding the genomic consequences of recombination suppression. Their suppressed recombination and reduced effective population size are expected to ...
  • Agustín Pavón, Carmen; Mielcarek, Michael; Garriga-Canut, Mireia; Isalan, Mark (BioMed Central, 2016)
    BACKGROUND: Synthetic zinc finger (ZF) proteins can be targeted to desired DNA sequences and are useful tools for gene therapy. We recently developed a ZF transcription repressor (ZF-KOX1) able to bind to expanded DNA ...
  • Álvarez Lerma, Francisco; Marin Corral, Judith; Vila, Clara; Masclans Enviz, Joan Ramon; González de Molina, Francisco Javier; Martín Loeches, Ignacio; Barbadillo, Sandra; Rodríguez, Alejandro; H1N1 GETGAG/SEMICYUC Study Group (BioMed Central, 2016)
    Background: Patients infected with influenza A (H1N1)pdm09 virus requiring admission to the ICU remain an important source of mortality during the influenza season. The objective of the study was to assess the impact of a ...
  • De Backer, Jean-François; Monlezun, Stéphanie; Detraux, Bérangère; Gazan, Adeline; Vanopdenbosch, Laura; Cheron, Julian; Cannazza, Giuseppe; Valverde, Sébastien; Cantacorps, Lídia; Nassar, Mérie; Venance, Laurent; Valverde Granados, Olga; Faure, Philippe; Zoli, Michele; De Backer, Olivier; Gall, David; Schiffmann, Serge N.; de Kerchove d'Exaerde, Alban (Wiley-Blackwell, 2018)
    Melanoma antigen genes (Mage) were first described as tumour markers. However, some of Mage are also expressed in healthy cells where their functions remain poorly understood. Here, we describe an unexpected role for one ...
  • Aso Pérez, Ester; Maldonado, Rafael, 1961-; Murtra, Patricia; Balerio, Graciela N.; Berrendero Díaz, Fernando, 1971- (Wiley-Blackwell, 2004)
    The possible interactions between Delta9-tetrahydrocannabinol (THC) and nicotine remain unclear in spite of the current association of cannabis and tobacco in humans. The aim of the present study was to explore the ...

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