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Browsing Articles (Departament de Ciències Experimentals i de la Salut) by Title

Browsing Articles (Departament de Ciències Experimentals i de la Salut) by Title

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  • Ziegenhain, Christoph; Vieth, Beate I.H.; Parekh, Swati; Reinius, Björn; Guillaumet-Adkins, Amy; Smets, Martha; Leonhardt, Heinrich; Heyn, Holger; Hellmann, Ines; Enard, Wolfgang (Elsevier, 2017)
    Single-cell RNA sequencing (scRNA-seq) offers new possibilities to address biological and medical questions. However, systematic comparisons of the performance of diverse scRNA-seq protocols are lacking. We generated data ...
  • Gerstein, Mark B.; Djebali, Sarah; Lagarde, Julien; Pervouchine, Dmitri D.; Guigó Serra, Roderic; Tanzer, Andrea; Waterston, Robert (Nature Publishing Group, 2014)
    The transcriptome is the readout of the genome. Identifying common features in it across distant species can reveal fundamental principles. To this end, the ENCODE and modENCODE consortia have generated large amounts of ...
  • Castelo Valdueza, Robert; Reymond, Alexandre; Wyss, Carine; Cámara, Francisco; Parra Farré, Genís; Antonarakis, Stylianos E.; Guigó Serra, Roderic; Eyras Jiménez, Eduardo (Oxford University Press, 2005)
    The recent availability of the chicken genome sequence poses the question of whether there are human protein-coding genes conserved in chicken that are currently not included in the human gene catalog. Here, we show, using ...
  • Parra Farré, Genís; Agarwal, Pankaj; Abril Ferrando, Josep Francesc; Wiehe, Thomas; Fickett, James W.; Guigó Serra, Roderic (Cold Spring Harbor Laboratory Press-CSHL Press, 2003)
    The completion of the sequencing of the mouse genome promises to help predict human genes with greater accuracy. While current ab initio gene prediction programs are remarkably sensitive (i.e., they predict at least a ...
  • Gabaldón Estevan, Juan Antonio, 1973-; Martin, Tiphaine; Marcet Houben, Marina; Durrens, Pascal; Bolotin Fukuhara, Monique; Lespinet, Olivier; Arnaise, Sylvie; Boisnard, Stéphanie; Aguileta, Gabriela; Atanasova, Ralitsa; Bouchier, Christiane; Couloux, Arnaud; Creno, Sophie; Almeida Cruz, José; Devillers, Hugo; Enache-Angoulvant, Aadela; Guitard, Juliette; Jaouen, Laure; Ma, Laurence; Marck, Christian; Neuvéglise, Cécile; Pelletier, Eric; Pinard, Amélie; Poulain, Julie; Recoquillay, Julien; Westhof, Eric; Wincker, Patrick; Dujon, Bernard; Hennequin, Christophe; Fairhead, Cécile (BioMed Central, 2013)
    BACKGROUND: Candida glabrata follows C. albicans as the second or third most prevalent cause of candidemia worldwide. These two pathogenic yeasts are distantly related, C. glabrata being part of the Nakaseomyces, a group ...
  • Boada Centeno, Núria; Planas Iglesias, Joan, 1980-; Oliva Miguel, Baldomero (BioMed Central, 2005)
    Comparative modeling is becoming an increasingly helpful technique in microbial cell factories as the knowledge of the three-dimensional structure of a protein would be an invaluable aid to solve problems on protein ...
  • Mak, Sarah Siu Tze; Gopalakrishnan, Shyam; Carøe, Christian; Geng, Chunyu; Liu, Shanlin; Sinding, Mikkel Holger S.; Kuderna, Lukas F.K.; Zhang, Wenwei; Fu, Shujin; Vieira, Filipe Garrett; Germonpré, Mietje; Bocherens, Hervé; Fedorov, Sergey E.; Petersen, Bent; Sicheritz-Ponten, Thomas; Marquès i Bonet, Tomàs, 1975-; Zhang, Guojie; Jiang, Hui; Gilbert, M Thomas (Oxford University Press, 2017)
    Ancient DNA research has been revolutionized following development of next-generation sequencing platforms. Although a number of such platforms have been applied to ancient DNA samples, the Illumina series are the dominant ...
  • Faria, Rui; Weiss, Steven; Alexandrino, Paulo (BioMed Central, 2012)
    Background: Comparative broad-scale phylogeographic studies of aquatic organisms provide insights on biotic responses to the paleohydrological dynamics associated with climatic oscillations. These insights can be used to ...
  • Ma, Siming; Avanesov, Andrei S.; Porter, Emily; Lee, Byung Cheon; Mariotti, Marco, 1984-; Zemskaya, Nadezhda; Guigó Serra, Roderic; Moskalev, Alexey A.; Gladyshev, Vadim N. (Wiley, 2018)
    Lifespan varies dramatically among species, but the biological basis is not well understood. Previous studies in model organisms revealed the importance of nutrient sensing, mTOR, NAD/sirtuins, and insulin/IGF1 signaling ...
  • Jiménez Guri, Eva; Huerta Cepas, Jaime; Cozzuto, Luca; Wotton, Karl R.; Kang, Hui; Himmelbauer, Heinz; Roma, Guglielmo; Gabaldón Estevan, Juan Antonio, 1973-; Jaeger, Johannes, 1973- (BioMed Central, 2013)
    BACKGROUND: Modern sequencing technologies have massively increased the amount of data available for comparative genomics. Whole-transcriptome shotgun sequencing (RNA-seq) provides a powerful basis for comparative studies. ...
  • Porta-Pardo, Eduard; Kamburov, Atanas; Tamborero Noguera, David; Pons, Tirso; Grases, Daniela; Valencia, Alfonso; López Bigas, Núria; Getz, Gad; Godzik, Adam (Nature Publishing Group, 2017)
    Understanding genetic events that lead to cancer initiation and progression remains one of the biggest challenges in cancer biology. Traditionally, most algorithms for cancer-driver identification look for genes that have ...
  • Meng, Huicui; Matthan, Nirupa R.; Wu, Dayong; Li, Lijun; Rodríguez-Morató, Jose, 1987-; Cohen, Rebecca; Galluccio, Jean M.; Dolnikowski, Gregory G.; Lichtenstein, Alice H. (American Society for Nutrition, 2019)
    Background: Direct comparisons between SFAs varying in chain length, specifically palmitic acid (16:0) and stearic acid (18:0), relative to the latter's metabolic product, oleic acid (18:1), on cardiometabolic risk factors ...
  • Abril Ferrando, Josep Francesc; Castelo Valdueza, Robert; Guigó Serra, Roderic (Cold Spring Harbor Laboratory Press-CSHL Press, 2005)
    We have carried out an initial analysis of the dynamics of the recent evolution of the splice-sites sequences on a large collection of human, rodent (mouse and rat), and chicken introns. Our results indicate that the ...
  • Popota, Foteini D.,1980-; Aguiar, Pablo; Herance, J. Raúl; Pareto, Deborah; Rojas, Santiago; Ros, Domènec; Pavía Segura, Javier; Gispert López, Juan Domingo (Institute of Electrical and Electronics Engineers (IEEE), 2012)
    The purpose of this work was to evaluate the performance of the microPET R4 system for rodents according to the NU 4-2008 standards of the National Electrical Manufacturers Association (NEMA) for small-animal positron ...
  • Franco-Jarava, C.; Comas, David, 1969-; Orren, Ann; Hernández-González, M.; Colobran, R. (Wiley, 2017)
    Complement C5 deficiency (C5D) is a rare primary immunodeficiency associated with recurrent infections, particularly meningitis, by Neisseria species. To date, studies to elucidate the molecular basis of hereditary C5D ...
  • Morales, Lucia; Noel, Benjamin; Porcel, Betina; Marcet Houben, Marina; Hullo, Marie-Françoise; Sacerdot, Christine; Tekaia, Fredj; Leh-Louis, Véronique; Despons, Laurence; Khanna, Varun; Aury, Jean-Marc; Barbe, Valérie; Coloux, Arnaud; Labadie, Karine; Pelletier, Eric; Souciet, Jean-Luc; Boekhout, Teun; Gabaldón Estevan, Juan Antonio, 1973-; Wincker, Patrick; Dujon, Bernard (Oxford University Press, 2013)
    The numerous yeast genome sequences presently available provide a rich source of information for functional as well as evolutionary genomics but unequally cover the large phylogenetic diversity of extant yeasts. We present ...
  • Soriano, Miguel C.; García Ojalvo, Jordi; Mirasso, Claudio R.; Fischer, Ingo (American Physical Society, 2013)
    Complex phenomena in photonics, in particular, dynamical properties of semiconductor lasers due to delayed coupling, are reviewed. Although considered a nuisance for a long time, these phenomena now open interesting ...
  • Sailani, M. Reza; Rabionet, Kelly; Serra Juhé, Clara, 1984-; Pérez Jurado, Luis Alberto; Estivill, Xavier, 1955-; Antonarakis, Stylianos E. (Cold Spring Harbor Laboratory Press (CSHL Press), 2013)
    Congenital heart defect (CHD) occurs in 40% of Down syndrome (DS) cases. While carrying three copies of chromosome 21 increases the risk for CHD, trisomy 21 itself is not sufficient to cause CHD. Thus, additional genetic ...
  • Mariotti, Marco, 1984-; Ridge, Perry G.; Zhang, Yan; Lobanov, Alexei V.; Pringle, Thomas H.; Guigó Serra, Roderic; Hatfield, Dolph L.; Gladyshev, Vadim N. (Public Library of Science (PLoS), 2012)
    BACKGROUND: Selenium is an essential trace element in mammals due to its presence in proteins in the form of selenocysteine (Sec). Human genome codes for 25 Sec-containing protein genes, and mouse and rat genomes for 24. ...
  • Tamborero Noguera, David; González-Pérez, Abel; Pérez Llamas, Christian, 1976-; Déu Pons, Jordi; Kandoth, Cyriac; Reimand, Jüri; Lawrence, Michael S.; Getz, Gad; Bader, Gary D.; Ding, Li; López Bigas, Núria (Nature Publishing Group, 2013)
    With the ability to fully sequence tumor genomes/exomes, the quest for cancer driver genes can now be undertaken in an unbiased manner. However, obtaining a complete catalog of cancer genes is difficult due to the heterogeneous ...

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