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Browsing Articles (Departament de Ciències Experimentals i de la Salut) by Title

Browsing Articles (Departament de Ciències Experimentals i de la Salut) by Title

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  • Schmidt, Joshua M.; de Manuel, Marc; Marquès i Bonet, Tomàs, 1975-; Castellano Hereza, Sergi; Andrés Morán, Aida, 1976- (Public Library of Science (PLoS), 2019)
    Chimpanzees, humans' closest relatives, are in danger of extinction. Aside from direct human impacts such as hunting and habitat destruction, a key threat is transmissible disease. As humans continue to encroach upon their ...
  • Schleyer, Michael; Reid, Samuel F.; Pamir, Evren; Saumweber, Timo; Paisios, Emmanouil; Davies, Alexander; Gerber, Bertram; Louis, Matthieu (Cold Spring Harbor Laboratory Press, 2015)
    How do animals adaptively integrate innate with learned behavioral tendencies? We tackle this question using chemotaxis as a paradigm. Chemotaxis in the Drosophila larva largely results from a sequence of runs and oriented ...
  • Li, Xin; Guigó Serra, Roderic; Montgomery, Stephen B.; Genotype-Tissue Expression (GTEx) Consortium (Nature Publishing Group, 2017)
    Rare genetic variants are abundant in humans and are expected to contribute to individual disease risk. While genetic association studies have successfully identified common genetic variants associated with susceptibility, ...
  • Montano, Valeria; Marcari, Veronica; Pavanello, Mariano; Anyaele, Okorie; Comas, David, 1969-; Destro Bisol, Giovanni; Batini, Chiara (BioMed Central, 2013)
    Background: When studying the genetic structure of human populations, the role of cultural factors may be difficult to ascertain due to a lack of formal models. Linguistic diversity is a typical example of such a situation. ...
  • Canova, Cristina; Antó i Boqué, Josep Maria; Zock, Jan-Paul; Jarvis, Deborah (European Respiratory Society, 2013)
    No large study has described the seasonal variation in asthma attacks in population-based asthmatics in whom sensitisation to allergen has been measured. 2,637 young adults with asthma living in 15 countries reported the ...
  • Gascon Merlos, Mireia, 1984-; Guxens Junyent, Mònica; Vrijheid, Martine; Torrent Quetglas, Maties; Ibarluzea, Jesús; Fano, Eduardo; Llop, Sabrina; Ballester Díez, Ferran; Fernandez, Mariana F.; Tardón, Adonina; Fernández-Somoano, Ana; Sunyer Deu, Jordi (Elsevier, 2017)
    BACKGROUND: In 2003 the INMA-INfancia y Medio Ambiente (Environment and Childhood) project, a Spanish national network of birth cohorts including more than 3500 participants, was set up with the aim to assess the health ...
  • Knezevic, Iva, 1984-; González Medina, Alberto; Gaspa, Laura; Hidalgo Hernando, Elena; Ayté del Olmo, José (Wiley, 2018)
    Chromatin structure is an essential factor in the proper regulation of DNA repair, DNA replication and transcription. The INO80 complex and the SWR complex have been shown to play a fundamental role in transcription ...
  • Brack, Andrew S.; Muñoz Cánoves, Pura, 1962- (BioMed Central, 2016)
    Skeletal muscle has a remarkable capacity to regenerate by virtue of its resident stem cells (satellite cells). This capacity declines with aging, although whether this is due to extrinsic changes in the environment and/or ...
  • Schmidt, David; Reuter, Hanna; Hüttner, Katja; Ruhe, Larissa; Rabert, Franziska; Seebeck, Florian; Irimia, Manuel; Solana, Jordi; Bartscherer, Kerstin (Public Library of Science (PLoS), 2018)
    In multicellular organisms, cell type diversity and fate depend on specific sets of transcript isoforms generated by post-transcriptional RNA processing. Here, we used Schmidtea mediterranea, a flatworm with extraordinary ...
  • Scortichini, Matteo; de'Donato, Francesca; de Sario, Manuela; Leone, Michela; Åström, Christofer; Ballester, Ferran; Basagaña Flores, Xavier; Bobvos, Janos; Gasparrini, Antoni; Katsouyanni, Klea; Lanki, Timo; Menne, Bettina; Pascal, Mathilde; Michelozzi, Paola (BioMed Central, 2018)
    Background: The association between heat and daily mortality and its temporal variation are well known. However, few studies have analyzed the inter-annual variations in both the risk estimates and impacts of heat. The aim ...
  • Hernando Herráez, Irene, 1985-; Heyn, Holger; Fernández Callejo, Marcos; Vidal, Enrique; Fernández Bellon, Hugo; Prado Martínez, Javier, 1987-; Sharp, Andrew J.; Esteller, Manel; Marquès i Bonet, Tomàs, 1975- (Oxford University Press, 2015)
    Despite the increasing knowledge about DNA methylation, the understanding of human epigenome evolution is in its infancy. Using whole genome bisulfite sequencing we identified hundreds of differentially methylated regions ...
  • Merlos-Suárez, Anna; Barriga de Vicente, Francisco Martín, 1983-; Jung, Peter; Iglesias Coma, Mar; Céspedes, María Virtudes; Rossell, David; Sevillano, Marta; Hernando-Momblona, Xavier; Silva-Diz, Victoria da; Muñoz, Purificación; Clevers, Hans; Sancho, Elena; Mangues, Ramon; Batlle Gómez, Eduard (Elsevier, 2011)
    A frequent complication in colorectal cancer (CRC) is regeneration of the tumor after therapy. Here, we report that a gene signature specific for adult intestinal stem cells (ISCs) predicts disease relapse in CRC patients. ...
  • Brbić, Maria; Piškorec, Martija; Vidulin, Vedrana; Krisko, Anita; Šmuc, Tomislav; Supek, Fran (Oxford University Press, 2016)
    Bacteria and Archaea display a variety of phenotypic traits and can adapt to diverse ecological niches. However, systematic annotation of prokaryotic phenotypes is lacking. We have therefore developed ProTraits, a resource ...
  • Francisco-Velilla, Rosario; Fernández-Chamorro, Javier; Dotu, Ivan; Martinez Salas, Encarnación (Oxford University Press, 2018)
    Gemin5 is a predominantly cytoplasmic protein that downregulates translation, beyond controlling snRNPs assembly. The C-terminal region harbors a non-canonical RNA-binding site consisting of two domains, RBS1 and RBS2, ...
  • Valdivia, Hugo O.; Scholte, Larissa; Oliveira, Guilherme; Gabaldón Estevan, Juan Antonio, 1973-; Bartholomeu, Daniella C. (BioMed Central, 2015)
    Background. Leishmaniasis is a neglected parasitic disease with diverse clinical manifestations and a complex epidemiology. It has been shown that its parasite-related traits vary between species and that they modulate ...
  • Dudel, Christian; López Gómez, María Andreé, 1985-; Benavides, Fernando G. (Fernando García); Myrskylä, Mikko (SpringerOpen, 2018)
    While there has been considerable debate about extending the length of working life, relatively little is known about this issue. We use data from the Spanish Continuous Working Life Sample for 2004–2013 to calculate period ...
  • Derrien, Thomas; Guigó Serra, Roderic; Johnson, Rory (Frontiers, 2012)
    The transcriptome of a cell is represented by a myriad of different RNA molecules with and without protein-coding capacities. In recent years, advances in sequencing technologies have allowed researchers to more fully ...
  • Zijlema, Wilma; Stasinska, Ania; Blake, David; Dirgawati, Mila; Flicker, Leon; Yeap, Bu B.; Golledge, Jonathan; Hankey, Graeme J.; Nieuwenhuijsen, Mark J.; Heyworth, Jane (Elsevier, 2019)
    Background/Aim: Natural outdoor environments may mitigate harmful environmental factors associated with city living. We studied the longitudinal relationship between natural (‘green and blue’) outdoor environments and ...
  • Jungfleisch, Jennifer, 1986-; Chowdhury, Ashis; Alves-Rodrigues, Isabel; Tharun, Sundaresan; Díez Antón, Juana, 1962- (Cold Spring Harbor Laboratory Press, 2015)
    The Lsm1-7-Pat1 complex binds to the 3' end of cellular mRNAs and promotes 3' end protection and 5'-3' decay. Interestingly, this complex also specifically binds to cis-acting regulatory sequences of viral positive-strand ...
  • Pinto, Sandra N.; Dias, Susana A.; Cruz, Ana F.; Mil-Homens, Dalila; Fernandes, Fabio; Valle, Javier; Andreu Martínez, David; Prieto, Manuel; Castanho, Miguel A.R.B.; Coutinho, Ana; Salomé Veiga, Ana (Oxford University Press, 2019)
    Objectives: To investigate the mechanism of action at the molecular level of pepR, a multifunctional peptide derived from the Dengue virus capsid protein, against Staphylococcus aureus biofilms. Methods: Biofilm mass, ...

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