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Browsing Articles (Departament de Ciències Experimentals i de la Salut) by Title

Browsing Articles (Departament de Ciències Experimentals i de la Salut) by Title

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  • Francisco-Velilla, Rosario; Fernández-Chamorro, Javier; Dotu, Ivan; Martinez Salas, Encarnación (Oxford University Press, 2018)
    Gemin5 is a predominantly cytoplasmic protein that downregulates translation, beyond controlling snRNPs assembly. The C-terminal region harbors a non-canonical RNA-binding site consisting of two domains, RBS1 and RBS2, ...
  • Valdivia, Hugo O.; Scholte, Larissa; Oliveira, Guilherme; Gabaldón Estevan, Juan Antonio, 1973-; Bartholomeu, Daniella C. (BioMed Central, 2015)
    Background. Leishmaniasis is a neglected parasitic disease with diverse clinical manifestations and a complex epidemiology. It has been shown that its parasite-related traits vary between species and that they modulate ...
  • Dudel, Christian; López Gómez, María Andreé, 1985-; Benavides, Fernando G. (Fernando García); Myrskylä, Mikko (SpringerOpen, 2018)
    While there has been considerable debate about extending the length of working life, relatively little is known about this issue. We use data from the Spanish Continuous Working Life Sample for 2004–2013 to calculate period ...
  • Derrien, Thomas; Guigó Serra, Roderic; Johnson, Rory (Frontiers, 2012)
    The transcriptome of a cell is represented by a myriad of different RNA molecules with and without protein-coding capacities. In recent years, advances in sequencing technologies have allowed researchers to more fully ...
  • Zijlema, Wilma; Stasinska, Ania; Blake, David; Dirgawati, Mila; Flicker, Leon; Yeap, Bu B.; Golledge, Jonathan; Hankey, Graeme J.; Nieuwenhuijsen, Mark J.; Heyworth, Jane (Elsevier, 2019)
    Background/Aim: Natural outdoor environments may mitigate harmful environmental factors associated with city living. We studied the longitudinal relationship between natural (‘green and blue’) outdoor environments and ...
  • Jungfleisch, Jennifer, 1986-; Chowdhury, Ashis; Alves-Rodrigues, Isabel; Tharun, Sundaresan; Díez Antón, Juana, 1962- (Cold Spring Harbor Laboratory Press, 2015)
    The Lsm1-7-Pat1 complex binds to the 3' end of cellular mRNAs and promotes 3' end protection and 5'-3' decay. Interestingly, this complex also specifically binds to cis-acting regulatory sequences of viral positive-strand ...
  • Pinto, Sandra N.; Dias, Susana A.; Cruz, Ana F.; Mil-Homens, Dalila; Fernandes, Fabio; Valle, Javier; Andreu Martínez, David; Prieto, Manuel; Castanho, Miguel A.R.B.; Coutinho, Ana; Salomé Veiga, Ana (Oxford University Press, 2019)
    Objectives: To investigate the mechanism of action at the molecular level of pepR, a multifunctional peptide derived from the Dengue virus capsid protein, against Staphylococcus aureus biofilms. Methods: Biofilm mass, ...
  • Vilagut Saiz, Gemma, 1975-; Forero, Carlos G.; Pinto Meza, Alejandra; Haro Abad, Josep Maria; de Graaf, Ron; Bruffaerts, Ronny; Kovess, Viviane; De Girolamo, Giovanni; Matschinger, Herbert; Ferrer Forés, Maria Montserrat; Alonso Caballero, Jordi; ESEMeD Investigators (Elsevier, 2013)
    OBJECTIVES: To evaluate the performance of the Mental Component of the Short-Form 12 Health Survey, Version 1(SF-12v1), as a screening measure of depressive disorders. METHODS: Data come from the European Study of the ...
  • Heras, Sara R.; Macias, Sara; Plass Pórtulas, Mireya, 1982-; Fernandez, Noemí; Cano Ferrer, David; Eyras Jiménez, Eduardo; Garcia Perez, José L.; Cáceres, Javier F. (Nature Research, 2013)
    More than half of the human genome is made of transposable elements whose ongoing mobilization is a driving force in genetic diversity; however, little is known about how the host regulates their activity. Here, we show ...
  • Ylla Bou, Guillem, 1990-; Fromm, Bastian; Piulachs i Bagà, M. Dolors; Bellés, Xavier, 1952- (Taylor & Francis (Routledge), 2016)
    Is there a correlation between miRNA diversity and levels of organismic complexity? Exhibiting extraordinary levels of morphological and developmental complexity, insects are the most diverse animal class on earth. Their ...
  • Guiducci, Giulia; Paone, Alessio; Tramonti, Angela; Giardina, Giorgio; Rinaldo, Serena; Bouzidi, Amani; Magnifico, Maria C.; Marani, Marina; Menendez, Javier A.; Fatica, Alessandro; Macone, Alberto; Armaos, Alexandros; Tartaglia, Gian Gaetano; Contestabile, Roberto; Paiardini, Alessandro; Cutruzzolà, Francesca (Oxford University Press, 2019)
    Enzymes of intermediary metabolism are often reported to have moonlighting functions as RNA-binding proteins and have regulatory roles beyond their primary activities. Human serine hydroxymethyltransferase (SHMT) is essential ...
  • Seoane, Luís F., 1985-; Solé Vicente, Ricard, 1962- (Nature Publishing Group, 2018)
    What is the nature of language? How has it evolved in different species? Are there qualitative, well-defined classes of languages? Most studies of language evolution deal in a way or another with such theoretical contraption ...
  • Fleta Soriano, Eric, 1983-; Smutna, Katarína; Martinez, Javier P.; Lorca Oró, Cristina; Sadiq, S. Kashif; Mirambeau, Gilles; Lopez-Iglesias, Carmen; Bosch, Marta; Pol, Albert; Brönstrup, Mark; Díez Antón, Juana, 1962-; Meyerhans, Andreas (American Society for Microbiology, 2017)
    Soraphen A is a myxobacterial metabolite that blocks the acetyl-coenzyme A carboxylase of the host and was previously identified as a novel HIV inhibitor. Here, we report that soraphen A acts by reducing virus production ...
  • Evans, Jonathan P.; Smith, Alexander; Gibbons, Chris; Alonso Caballero, Jordi; Valderas Martínez, José María (Dove medical press, 2018)
    The interest in patient-reported outcome measures (PROMs) continues to increase as recognition of their potential utility rises in an effort to make health systems more patient-centered. The US National Institutes of Health ...
  • Roverato, Alberto; Castelo Valdueza, Robert (Wiley, 2017)
    Genetic interactions confer robustness on cells in response to genetic perturbations. This often occurs through molecular buffering mechanisms that can be predicted by using, among other features, the degree of coexpression ...
  • Irles, Paula; Elshaer, Nashwa Ahmed Ali Mohammed, 1986-; Piulachs i Bagà, M. Dolors (Royal Society, 2016)
    The Notch pathway is an essential regulator of cell proliferation and differentiation during development. Its involvement in insect oogenesis has been examined in insect species with meroistic ovaries, and it is known to ...
  • Warren, Wesley C.; Kuderna, Lukas F.K.; Alexander, Alana; Catchen, Julian; Pérez Silva, José G.; López Otín, Carlos; Quesada, Víctor; Minx, Patrick; Tomlinson, Chad; Montague, Michael J.; Farias, Fabiana; Walter, Ronald B.; Marquès i Bonet, Tomàs, 1975-; Glenn, Travis; Kieran, Troy John; Wise, Sandra S.; Wise, John Pierce; Waterhouse, Robert M. (Oxford University Press, 2017)
    The sperm whale, made famous by Moby Dick, is one of the most fascinating of all ocean-dwelling species given their unique life history, novel physiological adaptations to hunting squid at extreme ocean depths, and their ...
  • Matalonga, Jonathan; Kiefer, Kerstin, 1986-; Vicente García, Rubén, 1978-; Valledor, Annabel F. (Elsevier, 2017)
    Macrophages exert potent effector functions against invading microorganisms but constitute, paradoxically, a preferential niche for many bacterial strains to replicate. Using a model of infection by Salmonella Typhimurium, ...
  • Antipov, Sergey S.; Tutukina, Maria; Preobrazhenskaya, Elena V.; Kondrashov, Fyodor A., 1979-; Patrushev, Maksim Vladimirovich; Toshchakov, Stepan; Dominova, Irina N.; Shvyreva, Uliana S.; Vrublevskaya, Veronika V.; Morenkov, Oleg S.; Sukharicheva, Natalya A.; Panyukov, Valeriy V.; Ozoline, Olga N. (Public Library of Science (PLoS), 2017)
    Dps is a multifunctional homododecameric protein that oxidizes Fe2+ ions accumulating them in the form of Fe2O3 within its protein cavity, interacts with DNA tightly condensing bacterial nucleoid upon starvation and performs ...
  • Biel, Sara; Mesa, Maria-Dolores; Torre Fornell, Rafael de la; Espejo, Juan-Antonio; Fernández-Navarro, Jose-Ramón; Fitó Colomer, Montserrat; Sánchez-Rodriguez, Estefanía; Rosa, Carmen; Marchal, Rosa; de Dios Alche, Juan; Expósito, Manuela; Brenes, Manuel; Gandul, Beatriz; Calleja, Miguel Angel; Covas Planells, Maria Isabel (BioMed Central, 2016)
    Background: Virgin olive oil, a recognized healthy food, cannot be consumed in great quantities. We aim to assess in humans whether an optimized virgin olive oil with high phenolic content (OVOO, 429 mg/Kg) and a functional ...

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