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Visualitzant Articles (Departament de Medicina i Ciències de la Vida) per títol

Visualitzant Articles (Departament de Medicina i Ciències de la Vida) per títol

Ara mostrant els elements 1530-1549 de 5361

DYRK1A-mediated phosphorylation of GluN2A at Ser1048 regulates the surface expression and channel activity of GluN1/GluN2A receptors

Grau, Cristina; Arató, Krisztina, 1981-; Fernández-Fernández, José Manuel, 1967-; Valderrama, Aitana; Sindreu, Carlos; Fillat i Fonts, Cristina; Ferrer, Isidre; Luna, Susana de la; Altafaj, Xavier (Frontiers, 2014)

N-methyl-D-aspartate glutamate receptors (NMDARs) play a pivotal role in neural development and synaptic plasticity, as well as in neurological disease. Since NMDARs exert their function at the cell surface, their density ...
Dysfunctional brain reward system in child obesity

Pujol Martí, Jesús, 1981-; Blanco Hinojo, Laura, 1981-; Martínez-Vilavella, Gerard; Deus, Joan; Pérez Solá, Victor; Sunyer Deu, Jordi (Oxford University Press, 2021)

Eating habits leading to obesity may reflect nonhomeostatic behavior based on excessive immediate-reward seeking. However, it is currently unknown to what extent excess weight is associated with functional alterations in ...
E-cadherin downregulation sensitizes PTEN-mutant tumors to PI3Kβ silencing

Millán-Uclés, África; Zuluaga, Susana; Marqués, Marta; Vallejo-Díaz, Jesus; Sanz, Lorena; Cariaga-Martínez, Ariel E.; Real, Francisco X.; Carrera, Ana C. (Impact Journals, 2016)

Alterations in phosphatidylinositol 3-kinase (PI3K) and in PTEN (phosphatase and tensin homolog), the negative regulator of the PI3K pathway, are found in nearly half of human tumors. As PI3Kβ, the main isoform activated ...
Earliest amyloid and tau deposition modulate the influence of limbic networks during closed-loop hippocampal downregulation

Skouras, Stavros; Torner, Jordi; Andersson, Patrik; Koush, Yury; Falcón, Carles; Minguillón, Carolina; Fauria, Karine; Alpiste, Francesc; Blenow, Kaj; Zetterberg, Henrik; Gispert López, Juan Domingo; Molinuevo, José Luis; ALFA Study (Oxford University Press, 2020)

Research into hippocampal self-regulation abilities may help determine the clinical significance of hippocampal hyperactivity throughout the pathophysiological continuum of Alzheimer's disease. In this study, we aimed to ...
Early 5-HT6 receptor blockade prevents symptom onset in a model of adolescent cannabis abuse

Berthoux, Coralie; Hamieh, Al Mahdy; Rogliardo, Angelina; Doucet, Emilie L.; Coudert, Camille; Ango, Fabrice; Grychowska, Katarzyna; Chaumont-Dubel, Séverine; Zajdel, Pawel; Maldonado, Rafael, 1961-; Bockaert, Joël; Marin, Philippe; Bécamel, Carine (EMBO Press, 2020)

Cannabis abuse during adolescence confers an increased risk for developing later in life cognitive deficits reminiscent of those observed in schizophrenia, suggesting common pathological mechanisms that remain poorly ...
Early brain connectivity alterations and cognitive impairment in a rat model of Alzheimer’s disease

Muñoz-Moreno, Emma; Tudela, Raúl; López-Gil, Xavier; Soria Rodríguez, Guadalupe (BioMed Central, 2018)

Animal models of Alzheimer’s disease (AD) are essential to understanding the disease progression and to development of early biomarkers. Because AD has been described as a disconnection syndrome, magnetic resonance imaging ...
Early childhood growth is associated with lung function at 7 years: a prospective population-based study

Peralta, Gabriela P.; Abellan, Alicia; Montazeri, Parisa, 1988-; Basterrechea, Mikel; Esplugues, Ana; González-Palacios, Sandra; Roda, Célina; Santa Marina, Loreto; Sunyer Deu, Jordi; Vrijheid, Martine; Casas Sanahuja, Maribel; García Aymerich, Judith (European Respiratory Society, 2020)

Previous studies have related early postnatal growth with later lung function but their interpretation is limited by the methods used to assess a child's growth. We aimed to assess the association of early childhood growth, ...
Early life exposure to air pollution, green spaces and built environment, and body mass index growth trajectories during the first 5 years of life: A large longitudinal study

Bont, Jeroen de; Hughes, Rachael; Tilling, Kate; Díaz, Yesika; de Castro, Montserrat; Cirach, Marta; Fossati, Serena; Nieuwenhuijsen, Mark J.; Duarte Salles, Talita, 1985-; Vrijheid, Martine (Elsevier, 2020)

Urban environments are characterized by multiple exposures that may influence body mass index (BMI) growth in early life. Previous studies are few, with inconsistent results and no evaluation of simultaneous exposures. ...
Early life exposure to perfluoroalkyl substances (PFAS) and ADHD: a meta-nalysis of nine european population-based studies

Forns i Guzman, Joan, 1981-; Verner, Marc-Andre; Iszatt, Nina; Nowack, Nikola; Bach, Cathrine Carlsen; Vrijheid, Martine; Costa, Olga; Andiarena, Ainara; Sovcikova, Eva; Høyer, Birgit Bjerre; Wittsiepe, Jürgen; López Espinosa, Maria José; Ibarluzea, Jesús; Hertz-Picciotto, Irva; Toft, Gunnar; Stigum, Hein; Guxens Junyent, Mònica; Liew, Zeyan; Eggesbø, Merete (National Institute of Environmental Health Sciences, 2020)

Introduction: To date, the evidence for an association between perfluoroalkyl substances (PFAS) exposure and attention deficit and hyperactivity disorder (ADHD) is inconclusive. Objective: We investigated the association ...
Early life exposures contributing to accelerated lung function decline in adulthood - a follow-up study of 11,000 adults from the general population

Kirkeleit, Jorunn; Carsin, Anne-Elie; García Aymerich, Judith; Svanes, Cecilie (Elsevier, 2023)

Background: We aimed to assess whether exposure to risk factors in early life from conception to puberty continue to contribute to lung function decline later in life by using a pooled cohort comprising approx. 11,000 ...
Early life microbial exposure and fractional exhaled nitric oxide in school-age children: a prospective birth cohort study

Casas, Lidia; Tischer, Christina; Wouters, Inge M.; Torrent Quetglas, Maties; Gehring, Ulrike; García Esteban, Raquel; Thiering, Elisabeth; Postma, Dirkje S.; de Jongste, Johan; Smit, Henriëtte A.; Borrás Santos, Alícia, 1974-; Zock, Jan-Paul; Hyvärinen, Anne; Heinrich, Joachim; Sunyer Deu, Jordi (BioMed Central, 2013)

BACKGROUND: Inflammation is a key factor in the pathogenesis of respiratory diseases. Early life exposure to microbial agents may have an effect on the development of the immune system and on respiratory health later in ...
Early life tobacco exposure and children's telomere length: The HELIX project

Osorio Yáñez, Citlalli; Clemente Batalha Pardal, Diana, 1990-; Maitre, Léa; Vives Usano, Marta, 1990-; Bustamante Pineda, Mariona; Martínez, David; Casas Sanahuja, Maribel; Urquiza, José M.; Tamayo-Uria, Ibon; Sunyer Deu, Jordi; Vrijheid, Martine (Elsevier, 2020)

Telomere length and mitochondrial DNA content are considered biomarkers of cellular aging, oxidative stress, and inflammation, but there is almost no information on their association with tobacco smoke exposure in fetal ...
Early neurological deterioration, easy methods to detect it.

Cuadrado-Godia, Elisa (Medknow Publications, 2015)
Early outcomes of component separation techniques: an analysis of the Spanish registry of incisional Hernia (EVEREG)

Pereira Rodríguez, José Antonio; Bravo-Salva, Alejandro; Montcusí Ventura, Blanca; Hernández-Granados, Pilar; Rodrigues Gonçalves, Victor; López-Cano, Manuel; EVEREG Registry Members (SpringerOpen, 2021)

Aim: To analyze the outcomes of component separation techniques (CST) to treat incisional hernias (IH) in a large multicenter cohort of patients. Methods: All IH repair using CST, registered in EVEREG from July 2012 to ...
Early outcomes of kidney transplantation from elderly donors after circulatory death (GEODAS study).

Pérez-Saez, María José; Pascual Santos, Julio; Portolés, José; GEODAS Group (BioMed Central, 2019)

BACKGROUND: Spain has dramatically increased the number of controlled circulatory death donors (cDCD). The initial selection criteria for considering cDCD for kidney transplantation (KT) have been expanded progressively, ...
Early smoking-onset age and risk of cardiovascular disease and mortality

Fa-Binefa, Manel; Clará Velasco, Alberto; Pérez-Fernández, Silvia; Grau Magaña, Maria; Dégano, Irene R.; Martí-Lluch, Ruth; Ramos, Rafel; Marrugat de la Iglesia, Jaume; Elosua Llanos, Roberto (Elsevier, 2019)

Early smoking onset age (SOA) is a public health concern with scant empirical evidence of its role in health outcomes. The study had two aims: i) to assess whether an early SOA was associated with the risk of fatal and ...
Early tracheostomy for managing ICU capacity during the COVID-19 outbreak: A propensity-matched cohort study

Hernández, Gonzalo; Masclans Enviz, Joan Ramon; Castellvi, Andrea; Marin Corral, Judith; Roca, Oriol (Elsevier, 2022)

Background: During the first wave of the COVID-19 pandemic, shortages of ventilators and ICU beds overwhelmed health care systems. Whether early tracheostomy reduces the duration of mechanical ventilation and ICU stay is ...
Early-life and health behaviour influences on lung function in early adulthood

Mahmoud, Osama; Granell, Raquel; Peralta, Gabriela P.; García Aymerich, Judith; Jarvis, Deborah; Henderson, John; Sterne, Jonathan (European Respiratory Society, 2023)

Early-life exposures may influence lung function at different stages of the life course. However, the relative importance of characteristics at different stages of infancy and childhood are unclear. To examine the associations ...
Early-life environmental exposure determinants of child behavior in Europe: A longitudinal, population-based study

Maitre, Léa; Júlvez Calvo, Jordi; López Vicente, Mònica, 1988-; Warembourg, Charline; Tamayo-Uria, Ibon; Guxens Junyent, Mònica; Basagaña Flores, Xavier; Casas Sanahuja, Maribel; de Castro, Montserrat; González, Juan Ramón; Hernandez-Ferrer, Carles, 1987-; Márquez, Sandra; Nieuwenhuijsen, Mark J.; Urquiza, José M.; Vrijheid, Martine (Elsevier, 2021)

Background: Environmental exposures in early life influence the development of behavioral outcomes in children, but research has not considered multiple exposures. We therefore aimed to investigate the impact of a broad ...
Early-life environmental exposures and childhood obesity: an exposome-wide approach

Vrijheid, Martine; Fossati, Serena; Maitre, Léa; Márquez, Sandra; Casas Sanahuja, Maribel; de Castro, Montserrat; Donaire González, David; Robinson, Oliver; Sunyer Deu, Jordi; Tamayo-Uria, Ibon; Urquiza, José M.; Valentín, Antònia; Warembourg, Charline; Nieuwenhuijsen, Mark J.; Basagaña Flores, Xavier; Chatzi, Leda (National Institute of Environmental Health Sciences, 2020)

Background: Chemical and nonchemical environmental exposures are increasingly suspected to influence the development of obesity, especially during early life, but studies mostly consider single exposure groups. Objectives: ...