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Browsing Articles (Departament de Ciències Experimentals i de la Salut) by Title

Browsing Articles (Departament de Ciències Experimentals i de la Salut) by Title

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  • Parra Farré, Genís; Reymond, Alexandre; Dabbouseh, Noura; Dermitzakis, Emmanuouil T.; Thomson, Timothy M.; Antonarakis, Stylianos E.; Guigó Serra, Roderic (Cold Spring Harbor Laboratory Press-CSHL Press, 2006)
    The “one-gene, one-protein” rule, coined by Beadle and Tatum, has been fundamental to molecular biology. The rule implies that the genetic complexity of an organism depends essentially on its gene number. The discovery, ...
  • Sonay, Tugce Bilgin; Carvalho, Tiago Loureiro de, 1987-; Robinson, Mark D.; Greminger, Maja P.; Krützen, Michael; Comas, David, 1969-; Highnam, Gareth; Mittelman, David; Sharp, Andrew J.; Marquès i Bonet, Tomàs, 1975-; Wagner, Andreas (Cold Spring Harbor Laboratory Press (CSHL Press), 2015)
    Tandem repeats (TRs) are stretches of DNA that are highly variable in length and mutate rapidly. They are thus an important source of genetic variation. This variation is highly informative for population and conservation ...
  • Santos, António J. M.; Nogueira, Cristina; Ortega Bellido, María; Malhotra, Vivek (Rockefeller University Press, 2016)
    Procollagens, pre-chylomicrons, and pre–very low-density lipoproteins (pre-VLDLs) are too big to fit into conventional COPII-coated vesicles, so how are these bulky cargoes exported from the endoplasmic reticulum (ER)? We ...
  • Page, Brent D.G.; Wright, Roni H.G.; Font Mateu, Jofre, 1977-; Beato, Miguel; Helleday, Thomas (Nature Research, 2018)
    With a diverse network of substrates, NUDIX hydrolases have emerged as a key family of nucleotide-metabolizing enzymes. NUDT5 (also called NUDIX5) has been implicated in ADP-ribose and 8-oxo-guanine metabolism and was ...
  • Kamdem Toukam, Donatien; Tenbusch, Matthias; Stang, Alexander; Temchura, Vladimir; Storcksdieck Genannt Bonsmann, Michael; Grewe, Bastian; Koch, Stefanie; Meyerhans, Andreas; Nichinda, Godwin; Kaptue, Lazare; Überla, Klaus (Public Library of Science (PLoS), 2012)
    Although human immunodeficiency type 1 (HIV-1) infection induces strong antibody responses to the viral envelope glycoprotein (Env) only a few of these antibodies possess the capacity to neutralize a broad range of strains. ...
  • Rué, Laura; Bañez Coronel, Mónica; Creus-Muncunill, Jordi; Giralt, Albert; Alcalá-Vida, Rafael; Mentxaka, Gartze; Kagerbauer, Birgit; Zomeño-Abellán, M. Teresa; Aranda, Zeus; Venturi, Veronica; Pérez-Navarro, Esther; Estivill, Xavier, 1955-; Martí, Eulàlia (American Society for Clinical Investigation, 2016)
    Huntington's disease (HD) is a polyglutamine disorder caused by a CAG expansion in the Huntingtin (HTT) gene exon 1. This expansion encodes a mutant protein whose abnormal function is traditionally associated with HD ...
  • Busquets Garcia, Arnau, 1985-; Gomis González, Maria; Guegan, Thomas, 1983-; Agustín Pavón, Carmen; Pastor, Antonio; Mato, Susana; Pérez Samartín, A.; Matute, Carlos; Torre Fornell, Rafael de la; Dierssen, Mara; Maldonado, Rafael, 1961-; Ozaita Mintegui, Andrés, 1969- (Nature Publishing Group, 2013)
    Fragile X syndrome (FXS), the most common monogenic cause of inherited intellectual disability and autism, is caused by the silencing of the FMR1 gene, leading to the loss of fragile X mental retardation protein (FMRP), a ...
  • Jiménez Guri, Eva; Wotton, Karl R.; Jaeger, Johannes, 1973- (Royal Society, 2018)
    Gap genes are involved in segment determination during early development of the vinegar fly Drosophila melanogaster and other dipteran insects (flies, midges and mosquitoes). They are expressed in overlapping domains along ...
  • Engelken, Johannes; Brinkmann, Henner; Adamska, Iwona (BioMed Central, 2010)
    Background: The extended light-harvesting complex (LHC) protein superfamily is a centerpiece of eukaryotic photosynthesis, comprising the LHC family and several families involved in photoprotection, like the LHC-like and ...
  • Chang, Jia-Ming, 1978-; Di Tommaso, Paolo; Lefort, Vincent; Gascuel, Olivier; Notredame, Cedric (Oxford University Press, 2015)
    This article introduces the Transitive Consistency Score (TCS) web server; a service making it possible to estimate the local reliability of protein multiple sequence alignments (MSAs) using the TCS index. The evaluation ...
  • Giráldez, Fernando (Frontiers, 2020)
    This article describes a two-decade experience in teaching “Neurosciences for the Humanities: art, philosophy and the brain. “The course is a discussion about sensory physiology, knowledge, and the arts. The physiology of ...
  • O'Connor, Giselle; Piñero Casas, Maria; Basagaña Flores, Xavier; López Vicente, Mònica, 1988-; Davand, Payam; Torrent Quetglas, Maties; Martínez-Murciano, David; García Esteban, Raquel; Marinelli, Marcella; Sunyer Deu, Jordi; Júlvez Calvo, Jordi (Elsevier, 2016)
    This study is aiming to evaluate the association between television viewing during childhood and long-term adolescent neuropsychological outcomes and the potential explanatory pathways. This is a longitudinal study based ...
  • Pérez Crespo, Laura; Prats Uribe, Albert; Tobias, Aurelio; Duran-Tauleria Enric; Coronado, Ricard; Hervás, Amaia; Guxens Junyent, Mònica (Wiley, 2019)
    This study aims to estimate the prevalence of autism spectrum disorders (ASD) in 2017 and the ASD diagnosis incidence between 2009 and 2017 in children living in Catalonia region in Spain, and their temporal and geographical ...
  • Fernando, Carol A.; Conrad, Patricia A.; Bartels, Cynthia F.; Marquès i Bonet, Tomàs, 1975-; To, Michael; Balow, Stephanie A.; Nakamura, Yukio; Warman, Matthew L. (Wiley, 2010)
    The six mammalian CCN genes (Cyr61, CTGF, Nov, WISP1, WISP2, WISP3) encode a family of secreted, cysteine-rich, multimodular proteins having roles in cell proliferation, adhesion, migration, and differentiation during ...
  • Martínez Solanas, Èrica, 1982-; Basagaña Flores, Xavier (Elsevier, 2019)
    Exposure to extreme ambient temperatures has been widely described to increase mortality. Exploring changes in susceptibility to temperatures over time can provide useful information for policy planning and can provide ...
  • Martínez Solanas, Èrica, 1982-; Basagaña Flores, Xavier (Public Library of Science (PLoS), 2019)
    Background: The exposure to extreme ambient temperatures has been reported to increase mortality, although less is known about its impact on morbidity. The analysis of temporal changes in temperature-health associations ...
  • Kuchina, Anna; Espinar, Lorena; Cagatay, Tolga; Balbin, Alejandro O.; Zhang, Fang; Alvarado, Alma; García Ojalvo, Jordi; Süel, Gürol M. (Nature Publishing Group, 2011)
    Multipotent differentiation, where cells adopt one of several possible fates, occurs in diverse systems ranging from bacteria to mammals. This decision-making process is driven by multiple differentiation programs that ...
  • Jedynak, Maciej; Pons, Antonio J.; García Ojalvo, Jordi; Goodfellow, Marc (Elsevier, 2017)
    Macroscopic models of brain networks typically incorporate assumptions regarding the characteristics of afferent noise, which is used to represent input from distal brain regions or ongoing fluctuations in non-modelled ...
  • López-Campos, José Luis; Rodríguez Chiaradia, Diego Agustín; Quintana-Gallego, Esther; Martínez-Llorens, Juana Mª; Carrasco Hernández, Laura; Barreiro Portela, Esther (Taylor & Francis, 2019)
    With the 60th anniversary of the CIBA symposium, it is worth evaluating research questions that should be prioritized in the future. Coming research initiatives can be summarized in 10 main areas. (1) From epidemiology the ...
  • Garrido, Romina; Trowbridge, Casandra A.; Tamura, Nana (Public Library of Science (PLoS), 2019)

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