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Browsing Articles (Departament de Ciències Experimentals i de la Salut) by Title

Browsing Articles (Departament de Ciències Experimentals i de la Salut) by Title

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  • Sigl, Verena; Vidal Ocabo, Enrique; Penninger, Josef M. (Nature Publishing Group, 2016)
    Breast cancer is the most common female cancer, affecting approximately one in eight women during their life-time. Besides environmental triggers and hormones, inherited mutations in the breast cancer 1 (BRCA1) or BRCA2 ...
  • Amat, Ramon; Böttcher, René; Le Dily, François; Vidal Ocabo, Enrique; Quilez Oliete, Javier; Cuartero, Yasmina; Beato, Miguel; Nadal Clanchet, Eulàlia de; Posas Garriga, Francesc (Cold Spring Harbor Laboratory Press (CSHL Press), 2019)
    Nuclear architecture is decisive for the assembly of transcriptional responses. However, how chromosome organization is dynamically modulated to permit rapid and transient transcriptional changes in response to environmental ...
  • Mathers, Thomas C.; Gabaldón Estevan, Juan Antonio, 1973-; Julca, Irene; Loska, Damian; Hogenhout, Saskia A. (BioMed Central, 2017)
    BACKGROUND: The prevailing paradigm of host-parasite evolution is that arms races lead to increasing specialisation via genetic adaptation. Insect herbivores are no exception and the majority have evolved to colonise a ...
  • Rubio Moscardó, Fanny; Bosch Morató, Mònica, 1986-; Plata, Cristina; Gené, Gemma; Muñoz López, Francisco José, 1964-; Valverde, M. A. (Miguel Ángel), 1963-; Clarimón Echevarría, Jordi (Public Library of Science (PLoS), 2013)
    Calcium signaling in the brain is fundamental to the learning and memory process and there is evidence to suggest that its dysfunction is involved in the pathological pathways underlying Alzheimer’s disease (AD). Recently, ...
  • Fasano, Stefania; D'Antoni, Angela; Orban, Paul C.; Valjent, Emmanuel; Putignano, Elena; Vara, Hugo; Pizzorusso, Tommaso; Giustetto, Maurizio; Yoon, Bongjune; Soloway, Paul; Maldonado, Rafael, 1961-; Caboche, Jocelyne; Brambilla, Riccardo (Elsevier, 2009)
    Background: Ras-extracellular signal-regulated kinase (Ras-ERK) signaling is central to the molecular machinery underlying cognitive functions. In the striatum, ERK1/2 kinases are co-activated by glutamate and dopamine ...
  • Rubio Pérez, Carlota, 1990-; Déu Pons, Jordi; Tamborero Noguera, David; López Bigas, Núria; González-Pérez, Abel (BioMed Central, 2016)
    BACKGROUND: Profiling the somatic mutations of genes which may inform about tumor evolution, prognostics and treatment is becoming a standard tool in clinical oncology. Commercially available cancer gene panels rely on ...
  • Martínez-Jiménez, Francisco, 1988-; Overington, John P.; Al-Lazikani, Bissan; Martí Renom, Marc A. (Nature Publishing Group, 2017)
    Drug resistance is one of the major problems in targeted cancer therapy. A major cause of resistance is changes in the amino acids that form the drug-target binding site. Despite of the numerous efforts made to individually ...
  • González Quiroz, Marvin; Nitsch, Dorothea; Hamilton, Sophie; O'Callaghan Gordo, Cristina; Saran, Rajiv; Glaser, Jason; Correa Rotter, Ricardo; Jakobsson, Kristina; Singh, Ajay; Gunawardena, Nalika; Levin, Adeera; Remuzzi, Giuseppe; Caplin, Ben; Pearce, Neil E.; DEGREE Study Steering Committee (BMJ Publishing Group, 2019)
    Introduction: A recently recognised form of chronic kidney disease (CKD) of unknown origin (CKDu) is afflicting communities, mostly in rural areas in several regions of the world. Prevalence studies are being conducted in ...
  • Bechara, Elias; Sebestyén, Endre; Bernardis, Isabella; Eyras Jiménez, Eduardo; Valcárcel, J. (Juan) (Elsevier, 2013)
    RBM5, a regulator of alternative splicing of apoptotic genes, and its highly homologous RBM6 and RBM10 are RNA-binding proteins frequently deleted or mutated in lung cancer. We report that RBM5/6 and RBM10 antagonistically ...
  • Gutiérrez Sacristán, Alba; Guedj, Romain; Korodi, Gabor; Stedman, Jason; Furlong, Laura I., 1971-; Patel, Chirag J.; Kohane, Isaac S.; Avillach, Paul (Oxford University Press, 2018)
    MOTIVATION: In the era of big data and precision medicine, the number of databases containing clinical, environmental, self-reported and biochemical variables is increasing exponentially. Enabling the experts to focus on ...
  • Steward, Charles A.; Uszczynska-Ratajczak, Barbara; Guigó Serra, Roderic; Frankish, Adam (Nature Research, 2019)
    The developmental and epileptic encephalopathies (DEE) are a group of rare, severe neurodevelopmental disorders, where even the most thorough sequencing studies leave 60-65% of patients without a molecular diagnosis. Here, ...
  • Knapp, Michael; Lalueza Fox, Carles, 1965-; Hofreiter, Michael (BioMed Central, 2015)
    For a long time, the analysis of ancient human DNA represented one of the most controversial disciplines in an already controversial field of research. Scepticism in this field was only matched by the long-lasting controversy ...
  • Cruz Garcia, David; Brouwers, Nathalie; Malhotra, Vivek; Curwin, Amy (Rockefeller University Press, 2020)
    Nutrient deprivation triggers the release of signal-sequence-lacking Acb1 and the antioxidant superoxide dismutase 1 (SOD1). We now report that secreted SOD1 is functionally active and accompanied by export of other ...
  • Alcaine Colet, Anna; Wotton, Karl R.; Jiménez Guri, Eva (PeerJ Inc., 2015)
    Megaselia scalaris (Loew, 1866) (Diptera, phoridae) is a cosmopolitan fly species used in forensic science, and has been developed as a laboratory model species. They feed on decaying corpses as well as a wide variety of ...
  • Alves, Joao M.; Lima, Ana C.; Pais, Isa A.; Amir, Nadir; Celestino, Ricardo; Piras, Giovanna; Monne, Maria; Comas, David, 1969-; Heutink, Peter; Chikhi, Lounès; Amorim, António; Lopes, Alexandra M. (Oxford University Press, 2015)
    A polymorphic inversion that lies on chromosome 17q21 comprises two major haplotype families (H1 and H2) that not only differ in orientation but also in copy-number. Although the processes driving the spread of the ...
  • Álvarez Iglesias, Vanesa; Mosquera Miguel, Ana; Cuscó Martí, Ivon, 1973-; Carracedo, Ángel; Pérez Jurado, Luis Alberto; Salas, Antonio (BioMed Central, 2011)
    Background: There is increasing evidence that impairment of mitochondrial energy metabolism plays an important role in the pathophysiology of autism spectrum disorders (ASD; OMIM number: 209850). A significant proportion ...
  • Yang, Jae-Seong; Garriga-Canut, Mireia; Link, Nele; Carolis, Carlo; Broadbent, Katrina; Beltran-Sastre, Violeta; Serrano Pubull, Luis, 1982-; Maurer, Sebastian (Nature Research, 2018)
    Knowing which proteins and RNAs directly interact is essential for understanding cellular mechanisms. Unfortunately, discovering such interactions is costly and often unreliable. To overcome these limitations, we developed ...
  • Arauna, Lara R; Mendoza Revilla, Javier; Mas Sandoval, Àlex, 1989-; Izaabel, Hassan; Bekada, Asmahan; Benhamamouch, Soraya; Fadhlaoui-Zid, Karima; Zalloua, Pierre A.; Hellenthal, Garrett; Comas, David, 1969- (Oxford University Press, 2017)
    North Africa is characterized by its diverse cultural and linguistic groups and its genetic heterogeneity. Genomic data has shown an amalgam of components mixed since pre-Holocean times. Though no differences have been ...
  • Marigorta, Urko M.; Lao Grueso, Oscar, 1976-; Casals López, Ferran; Calafell i Majó, Francesc; Morcillo Suárez, Carlos, 1969-; Faria, Rui; Bosch Fusté, Elena; Serra, François; Bertranpetit, Jaume, 1952-; Dopazo, Hernán; Navarro i Cuartiellas, Arcadi, 1969- (BioMed Central, 2011)
    Background: Searching for associations between genetic variants and complex diseases has been a very active area of research for over two decades. More than 51,000 potential associations have been studied and published, a ...
  • Arkhipova, Oksana V.; Meer, Margarita V., 1986-; Mikoulinskaia, Galina V.; Zakharova, Marina V.; Galushko, Alexander S.; Akimenko, Vasilii K.; Kondrashov, Fyodor A., 1979- (Public Library of Science (PLoS), 2015)
    The origin and evolution of novel biochemical functions remains one of the key questions in molecular evolution. We study recently emerged methacrylate reductase function that is thought to have emerged in the last century ...

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