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Browsing Articles (Departament de Ciències Experimentals i de la Salut) by Title

Browsing Articles (Departament de Ciències Experimentals i de la Salut) by Title

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  • Perdiguero, Eusebio, 1968-; Sousa-Victor, Pedro; Ruiz Bonilla, Vanesa, 1979-; Jardí, Mercè; Caelles Franch, Carme; Serrano, Antonio L.; Muñoz Cánoves, Pura, 1962- (Rockefeller University Press, 2011)
    Repair of damaged tissue requires the coordinated action of inflammatory and tissue-specific cells to restore homeostasis, but the underlying regulatory mechanisms are poorly understood. In this paper, we report new roles ...
  • Laezza, Chiara; D'Alessandro, Alba; Di Croce, Luciano; Picardi, Paola; Ciaglia, Elena; Pisanti, Simona; Malfitano, Anna Maria; Comegna, Marika; Faraonio, Raffaella; Gazzerro, Patrizia; Bifulco, Maurizio (Nature Publishing Group, 2015)
    The mevalonate (MVA) pathway is an important metabolic pathway implicated in multiple aspects of tumorigenesis. In this study, we provided evidence that p53 induces the expression of a group of enzymes of the MVA pathway ...
  • Ardite, Esther; Perdiguero, Eusebio, 1968-; Vidal Iglesias, Berta; Gutarra, Susana; Serrano, Antonio L.; Muñoz Cánoves, Pura, 1962- (Rockefeller University Press, 2012)
    There is a widespread awareness that the wealth of preclinical toxicity data that the pharmaceutical industry has generated in recent decades is not exploited as efficiently as it could be. Enhanced data availability for ...
  • ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium; Deminov, German M.; Drechsel, Oliver; Ossowski, Stephan; Estivill, Xavier, 1955-; Escaramís, Geòrgia; Bosio, Mattia; Holik, Aliaksei Z.; Susak, Hana; Rabionet, Raquel; Stobbe, Miranda D.; Marquès i Bonet, Tomàs, 1975-; Navarro i Cuartiellas, Arcadi, 1969-; Gut, Ivo Glynne; Beltran, Sergi; Gut, Marta; Trotta, Jean-Remi; Whalley, Justin P.; Heath, Simon; Prasad, Aparna; Heredia Genestar, José María, 1985-; Sabarinathan, Radhakrishnan; Pich, Oriol; Gonzalez-Perez, Abel; Rubio Pérez, Carlota, 1990-; Tamborero Noguera, David; Mularoni, Loris; Deu-Pons, Jordi; Muiños, Ferran; Muyas Remolar, Francesc, 1992- (Nature Research, 2020)
    Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale . Here we report the integrative analysis of 2,658 ...
  • Rodríguez Martín, Bernardo; PCAWG Structural Variation Working Group; PCAWG Consortium; Ossowski, Stephan (Nature Research, 2020)
    About half of all cancers have somatic integrations of retrotransposons. Here, to characterize their role in oncogenesis, we analyzed the patterns and mechanisms of somatic retrotransposition in 2,954 cancer genomes from ...
  • Leiserson, Mark D.M.; Vandin, Fabio; Wu, Hsin-Ta; Dobson, Jason R.; Eldridge, Jonathan V.; Thomas, Jacob L.; Papoutsaki, Alexandra; Kim, Younhun; Niu, Beifang; McLellan, Michael; Lawrence, Michael S.; Gonzalez-Perez, Abel; Tamborero Noguera, David; Cheng, Yuwei; Ryslik, Gregory A.; López Bigas, Núria; Getz, Gad; Ding, Li; Raphael, Benjamin J. (Nature Research, 2015)
    Cancers exhibit extensive mutational heterogeneity, and the resulting long-tail phenomenon complicates the discovery of genes and pathways that are significantly mutated in cancer. We perform a pan-cancer analysis of mutated ...
  • Elsebai, Mahmoud Fahmi; Koutsoudakis, George; Saludes, Verónica; Pérez Vilaró, Gemma, 1985-; Turpeinen, Ari; Mattila, Sampo; Pirttilä, Anna Maria; Fontaine, Fabien; Mehiri, Mohamed; Meyerhans, Andreas; Díez Antón, Juana, 1962- (American Society for Microbiology, 2016)
    Hepatitis C virus (HCV) infection is the leading cause of chronic liver diseases. Water extracts of the leaves of the wild Egyptian artichoke (WEA) [Cynara cardunculus L. var. sylvestris (Lam.) Fiori] have been used for ...
  • Amaral, André F.S.; Porta Serra, Miquel; Silverman, Debra T.; Milne, Roger L.; Kogevinas, Manolis; Rothman, Nathaniel; Cantor, Kenneth P; Jackson, Brian P.; Pumarega Rodríguez, José Antonio; López, Tomàs; Carrato, Alfredo; Guarner, Luisa; Real, Francisco X.; Malats i Riera, Núria (BMJ Publishing Group, 2012)
    Background and Aims: Knowledge on the aetiology of exocrine pancreatic cancer (EPC) is scant. The best established risk factor for EPC is tobacco smoking. Among other carcinogens, tobacco contains cadmium, a metal previously ...
  • Aragón Manresa, Ferran; Karaca, M.; Novials, M.; Maldonado, Rafael, 1961-; Maechler, P.; Rubí, Blanca (Elsevier, 2015)
    BACKGROUND: Plasma levels of pancreatic polypeptide (PP) rise upon food intake. Although other pancreatic islet hormones, such as insulin and glucagon, have been extensively investigated, PP secretion and actions are still ...
  • Walker, Jerilyn A.; Jordan, Vallmer E.; Steely, Cody J.; Beckstrom, Thomas O.; McDaniel, Cullen L.; St Romain, Corey P.; Bennett, Emily C.; Robichaux, Arianna; Clement, Brooke N.; Konkel, Miriam K.; Baboon Genome Analysis Consortium; Marquès i Bonet, Tomàs, 1975-; Batzer, Mark A. (Oxford University Press, 2017)
    The genus of Papio (baboon) has six recognized species separated into Northern and Southern clades, each comprised of three species distributed across the African continent. Geographic origin and phenotypic variants such ...
  • Ng, Sam; Collisson, Eric A.; Sokolov, Artem; Goldstein, Theodore; González-Pérez, Abel; López Bigas, Núria; Benz, Christopher; Haussler, David; Stuart, Joshua M. (Oxford University Press, 2012)
    MOTIVATION: A current challenge in understanding cancer processes is to pinpoint which mutations influence the onset and progression of disease. Toward this goal, we describe a method called PARADIGM-SHIFT that can predict ...
  • Sharifian, Hoda; Lampert, Fabienne; Stojanovski, Klement; Regot Rodríguez de Mier, Sergi; Vaga, Stefania; Buser, Raymond; Lee, Sung Sik; Koeppl, Heinz; Posas Garriga, Francesc; Pelet, Serge; Peter, Matthias (Royal Society of Chemistry, 2015)
    Tight regulation of the MAP kinase Hog1 is crucial for survival under changing osmotic conditions. Interestingly, we found that Hog1 phosphorylates multiple upstream components, implying feedback regulation within the ...
  • Gureje, Oye; Alonso Caballero, Jordi; Nock, Matthew K. (Nature Research, 2011)
    Previous research suggests that parental psychopathology predicts suicidal behavior among offspring; however, the more fine-grained associations between specific parental disorders and distinct stages of the pathway to ...
  • Rajmil Rajmil, Luis Alberto; Rodríguez López, Amanda; López Aguilà, Sílvia; Alonso Caballero, Jordi (BioMed Central, 2013)
    Background: Few studies have evaluated changes on parent–child agreement in HRQOL over time. The objectives of the study were to assess parent–child agreement on child’s HRQOL in a 3-year longitudinal study, and to identify ...
  • Barreiro Portela, Esther; Gea Guiral, Joaquim (De Gruyter, 2018)
    Skeletal muscle dysfunction and mass loss is a characteristic feature in patients with chronic diseases including cancer and acute conditions such as critical illness. Maintenance of an adequate muscle mass is crucial for ...
  • Rodríguez, María Isabel; Peralta-Leal, Andreína; O'Valle, Francisco; Rodríguez-Vargas, José Manuel; González-Flores, Ariannys; Majuelos-Melguizo, Jara; López Muñoz, Laura; Serrano, Santiago; García de Herreros, Antonio; Rodríguez-Manzaneque, Juan Carlos; Fernández Montes, Rubén D.; del Moral, Raimundo G.; de Almodovar, José Mariano; Oliver, F. Javier (Public Library of Science (PLoS), 2013)
    PARP inhibition can induce anti-neoplastic effects when used as monotherapy or in combination with chemo- or radiotherapy in various tumor settings; however, the basis for the anti-metastasic activities resulting from PARP ...
  • Johnson, Brett V.; Pérez Jurado, Luis Alberto; Jolly, Lachlan A. (Elsevier, 2020)
    Background: The X-chromosome gene USP9X encodes a deubiquitylating enzyme that has been associated with neurodevelopmental disorders primarily in female subjects. USP9X escapes X inactivation, and in female subjects de ...
  • García, Ana María; Boix, Pere; Benavides, Fernando G. (Fernando García); Gadea, Rafael; Fernando, Rodrigo; Serra, Consol (Elsevier, 2016)
    Participation of stakeholders is a key requirement for the success of public health programmes. Working and employment conditions are major determinants for people's health and wellbeing, and workplaces are ideal environments ...
  • Nieuwenhuijsen, Mark J.; Khreis, Haneen; Verlinghieri, Ersilia; Mueller, Natalie, 1988-; Rojas Rueda, David, 1979- (Elsevier, 2017)
    INTRODUCTION: Urban and transport planning have large impacts on public health, but these are generally not explicitly considered and/or quantified, partly because there are no comprehensive models, methods and tools readily ...

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