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Browsing Articles (Departament de Ciències Experimentals i de la Salut) by Title

Browsing Articles (Departament de Ciències Experimentals i de la Salut) by Title

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  • Figueras Maz, Mònica; Gómez Puertas, Lorena, 1978-; Revuelta, Gema (Universidad Nacional de Educación a Distancia (UNED), 2019)
    La investigación responsable incluye, más allá de la ética en el contenido y el proceso, la implicación de múltiples actores y público, un acceso más fácil a los resultados científicos, la perspectiva de género, y la ...
  • Horvath, Attila; Daniel, Bence; Szeles, Lajos; Cuaranta-Monroy, Ixchelt; Czimmerer, Zsolt; Ozgyin, Lilla; Steiner, Laszlo; Kiss, Mate; Simandi, Zoltan; Poliska, Szilard; Giannakis, Nikolas; Raineri, Emanuele; Gut, Ivo Glynne; Nagy, Benedek; Nagy, Laszlo (Oxford University Press, 2019)
    The concept of tissue-specific gene expression posits that lineage-determining transcription factors (LDTFs) determine the open chromatin profile of a cell via collaborative binding, providing molecular beacons to ...
  • Lear-Claveras, Ana; Ubalde López, Mònica, 1972-; Serra Saurina, Laura (BioMed Central, 2019)
    BACKGROUND: Due to the progress in screening and cancer treatments, survivor's prognosis has improved enabling a more likely return to work. However, return to work after a cancer diagnosis may be complex because of an ...
  • Prochnow, Hans; Prado Martínez, Javier, 1987-; Meyerhans, Andreas; Brönstrup, Mark (American Society for Microbiology, 2020)
    To counteract the serious health threat posed by known and novel viral pathogens, drugs that target a variety of viruses through a common mechanism have attracted recent attention due to their potential in treating ...
  • Boronat i Llop, Susanna, 1965-; Domènech, Alba; Carmona, Mercè; García Santamarina, Sarela, 1978-; Bañó, M. Carmen; Ayté del Olmo, José; Hidalgo Hernando, Elena (Public Library of Science (PLoS), 2017)
    The thioredoxin and glutaredoxin pathways are responsible of recycling several enzymes which undergo intramolecular disulfide bond formation as part of their catalytic cycles such as the peroxide scavengers peroxiredoxins ...
  • Curto Tirado, Ariadna, 1987-; Ranzani, Otavio; Milà, Carles; Sanchez, Margaux; Marshall, Julian D.; Kulkarni, Bharati; Bhogadi, Santhi; Kinra, Sanjay; Wellenius, Gregory A.; Tonne, Cathryn (Elsevier, 2019)
    Background: Limited evidence exists on the effect of particulate air pollution on blood glucose levels. We evaluated the associations of residential and personal levels of fine particulate matter (PM2.5) and black carbon ...
  • Aso Pérez, Ester; Renoir, Thibault; Valverde Granados, Olga; Lanfumey, Laurence; Maldonado, Rafael, 1961-; Hamon, Michel; Ledent, Catherine; Mengod, Guadalupe (Wiley-Blackwell, 2009)
    Serotonergic and endocannabinoid systems are important substrates for the control of emotional behavior and growing evidence show an involvement in the pathophysiology of mood disorders. In the present study, the absence ...
  • Schultheiss, Kira P.; Suga, Hiroshi; Ruiz Trillo, Iñaki; Miller, W. Todd (American Chemical Society (ACS), 2012)
    Phosphotyrosine-based signaling plays a vital role in cellular communication in multicellular organisms. Unexpectedly, unicellular choanoflagellates (the closest phylogenetic group to metazoans) possess numbers of tyrosine ...
  • Rizzo, Valeria; Sánchez Fernández, David; Fresneda, Javier; Cieslak, Alexandra; Ribera, Ignacio (BioMed Central, 2015)
    Background: A key question in evolutionary biology is the relationship between species traits and their habitats. Caves offer an ideal model to test the adjustment of species to their surrounding temperature, as they provide ...
  • Testoni, Giorgia; Duran, Jordi; García-Rocha, Mar; Vilaplana, Francisco; Serrano, Antonio L.; Sebastián, David; López Soldado, Iliana; Sullivan, Mitchell A.; Slebe Concha, Juan Felipe, 1981-; Vilaseca, Marta; Muñoz Cánoves, Pura, 1962-; Guinovart, Joan J. (Joan Josep), 1947- (Elsevier, 2017)
    Glycogenin is considered essential for glycogen synthesis, as it acts as a primer for the initiation of the polysaccharide chain. Against expectations, glycogenin-deficient mice (Gyg KO) accumulate high amounts of glycogen ...
  • González, Josefa; Martínez, José; Makalowski, Wojciech (BioMed Central, 2015)
    Background. Transposable elements (TEs) play an important role in genome function and evolution. It has been shown that TEs are a considerable source of adaptive changes in the genome of Drosophila melanogaster. Specifically, ...
  • Pascual-Reguant, Laura; Blanco, Enrique; Galan, Silvia; Le Dily, François; Cuartero, Yasmina; Serra-Bardenys, Gemma; Di Carlio, Valerio; Iturbide Martínez de Albéniz, Ane, 1989-; Cebrià i Costa, Joan Pau, 1989-; Nonell Mazelón, Lara; García de Herreros, Antonio; Di Croce, Luciano; Marti-Renom, Marc A.; Peiró Sales, Sandra (Nature Publishing Group, 2018)
    Lamins (A/C and B) are major constituents of the nuclear lamina (NL). Structurally conserved lamina-associated domains (LADs) are formed by genomic regions that contact the NL. Lamins are also found in the nucleoplasm, ...
  • Djebali, Sarah; Merkel, Angelika; Tanzer, Andrea; Lagarde, Julien; Röder, Maik; Curado, Joao; Derrien, Thomas; Ferreira, Pedro G.; González, David; Johnson, Rory; Kingswood, Colin; Ribeca, Paolo; Sammeth, Michael; Skancke, Jorgen; Tilgner, Hagen, 1980-; Guigó Serra, Roderic; Gingeras, Thomas R. (Nature Publishing Group, 2012)
    Eukaryotic cells make many types of primary and processed RNAs that are found either in specific subcellular compartments or throughout the cells. A complete catalogue of these RNAs is not yet available and their characteristic ...
  • Tukiainen, Taru; Guigó Serra, Roderic; MacArthur, Daniel G.; Genotype-Tissue Expression (GTEx) Consortium (Nature Publishing Group, 2017)
    X chromosome inactivation (XCI) silences transcription from one of the two X chromosomes in female mammalian cells to balance expression dosage between XX females and XY males. XCI is, however, incomplete in humans: up to ...
  • Quesada Diez, Rita; Poves Prim, José Ignacio; Iglesias Coma, Mar; Berjano, Enrique J.; Grande Posa, Luís; Burdío Pinilla, Fernando (SpringerOpen, 2016)
    Background: Although radiofrequency-assisted devices have sometimes been used in partial splenectomy, this is not a common technique. This report describes the first case of laparoscopic partial splenectomy using an ...
  • Sebestyén, Endre; Singh, Babita, 1986-; Miñana Gómez, Belén; Pagès Pinós, Amadís; Mateo, Francesc; Pujana, Miguel Angel; Valcárcel, J. (Juan); Eyras Jiménez, Eduardo (Cold Spring Harbor Laboratory Press (CSHL Press), 2016)
    Alternative splicing is regulated by multiple RNA-binding proteins and influences the expression of most eukaryotic genes. However, the role of this process in human disease, and particularly in cancer, is only starting ...
  • Guerra, Beniamino; García Aymerich, Judith; Antó i Boqué, Josep Maria; Puhan, Milo A.; Crystal structure of cold-aminopeptidase from Colwellia psychrerythraea (3CIA) collaborators (BioMed Central, 2018)
    BACKGROUND: External validations and comparisons of prognostic models or scores are a prerequisite for their use in routine clinical care but are lacking in most medical fields including chronic obstructive pulmonary disease ...
  • Puhan, Milo A.; Hansel, Nadia N; Sobradillo, Patricia; Enright, Paul; Lange, Peter; Hickson, DeMarc; Menezes, Ana M; Riet, Gerben ter; Held, Ulrike; Domingo i Salvany, Antònia; Mosenifar, Zab; Antó i Boqué, Josep Maria; Moons, Karel G M; Kessels, Alphons; García Aymerich, Judith; International COPD Cohorts Collaboration Working Group (BMJ Publishing Group, 2012)
    Background: Little evidence on the validity of simple and widely applicable tools to predict mortality in patients with chronic obstructive pulmonary disease (COPD) exists. Objective: To conduct a large international study ...
  • van Dijk, David; Sharon, Elion; Lotan Pompan, Maya; Weinberger, Adina; Segal, Eran; Carey, Lucas, 1980- (Cold Spring Harbor Laboratory Press (CSHL Press), 2017)
    Transcription factors (TFs) are key mediators that propagate extracellular and intracellular signals through to changes in gene expression profiles. However, the rules by which promoters decode the amount of active TF into ...
  • Menashe, Idan; Real, Francisco X.; Kogevinas, Manolis; Serra, Consol; Lloreta Trull, Josep, 1958-; Rothman, Nathaniel (Public Library of Science (PLoS), 2012)
    Pathway analysis of genome-wide association studies (GWAS) offer a unique opportunity to collectively evaluate genetic variants with effects that are too small to be detected individually. We applied a pathway analysis to ...

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