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Browsing Articles (Departament de Ciències Experimentals i de la Salut) by Title

Browsing Articles (Departament de Ciències Experimentals i de la Salut) by Title

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  • Fernández-Fernández, José Manuel, 1967-; Tomás Mestres, Marta; Vázquez Gómez, Esther; Orio, Patricio; Latorre, Ramón; Sentí Clapés, Mariano; Marrugat de la Iglesia, Jaume; Valverde, M. A. (Miguel Ángel), 1963- (American Society for Clinical Investigation, 2004)
    Hypertension is the most prevalent risk factor for cardiovascular diseases, present in almost 30% of adults. A key element in the control of vascular tone is the large-conductance, Ca(2+)-dependent K(+) (BK) channel. The ...
  • Mani, Haresh; Climent, Fina; Colomo Saperas, Luis Alberto; Pittaluga, Stefania; Raffeld, Mark; Jaffe, Elaine S. (Lippincott Williams & Wilkins, 2010)
    Lymphomas of the gall bladder and extrahepatic bile ducts are exceedingly rare. We present the clinicopathological features of 19 cases from our files; 14 patients had primary lymphoma (13 involving gall bladder and 1 ...
  • Crombach, Anton; Wotton, Karl R.; Jiménez Guri, Eva; Jaeger, Johannes, 1973- (Oxford University Press, 2016)
    Developmental gene networks implement the dynamic regulatory mechanisms that pattern and shape the organism. Over evolutionary time, the wiring of these networks changes, yet the patterning outcome is often preserved, a ...
  • Zhong, Yi; Wang, Zheng; Fu, Baojin; Pan, Fan; Yachida, Shinichi; Dhara, Mousumi; Albesiano, Emilia; Li, Li; Naito, Yoshiki; Vilardell, Felip; Cummings, Christopher; Martinelli, Paola; Li, Ang; Yonescu, Raluca; Ma, Qingyong; Griffin, Constance A; Real, Francisco X.; Iacobuzio Donahue, Christine A (Public Library of Science (PLoS), 2011)
    Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal disease characterized by late diagnosis and treatment resistance. Recurrent genetic alterations in defined genes in association with perturbations of developmental ...
  • Martinelli, Paola; Carrillo, Enrique; Cox, Trevor; Sainz, Bruno Jr; Dusetti, Nelson; Greenhalf, William; Rinaldi, Lorenzo, 1986-; Costello, Eithne; Ghaneh, Paula; Malats i Riera, Núria; Büchler, Markus; Pajic, Marina; Biankin, Andrew V; Iovanna, Juan; Neoptolemos, John; Real, Francisco X. (BMJ Publishing Group, 2017)
    BACKGROUND AND AIMS: The role of GATA factors in cancer has gained increasing attention recently, but the function of GATA6 in pancreatic ductal adenocarcinoma (PDAC) is controversial. GATA6 is amplified in a subset of ...
  • Lopes, Pedro; Nunes, Tiago; Campos, David; Furlong, Laura I., 1971-; Bauer-Mehren, Anna; Sanz, Ferran; Carrascosa Baena, María Carmen, 1972-; Mestres i López, Jordi; Kors, Jan A.; Singh, Barat; van Mulligen, Erik M.; van der Lei, Johan; Diallo, Gayo; Avillach, Paul; Ahlberg Helgee, Ernst; Boyer, Scott; Díaz, Carlos; Oliveira, José Luis (Public Library of Science (PLoS), 2013)
    Pharmacovigilance plays a key role in the healthcare domain through the assessment, monitoring and discovery of interactions amongst drugs and their effects in the human organism. However, technological advances in this ...
  • Olesti Muñoz, Eulàlia; Pujadas Bastardes, Mitona; Papaseit Fontanet, Esther; Pérez Mañá, Clara; Pozo Mendoza, Óscar J., 1975-; Farré Albaladejo, Magí; Torre Fornell, Rafael de la (Oxford University Press, 2017)
    Increasing consumption has been observed among young people of new psychoactive substances, including synthetic cathinone derivatives. The most well known of these is mephedrone whose use has been related to acute intoxication ...
  • Shackleton, Cedric; Pozo Mendoza, Óscar J., 1975-; Marcos del Águila, Josep, 1971- (Endocrine Society, 2018)
    Gas chromatography/mass spectrometry (GC/MS) has been used for steroid analysis since the 1960s. The advent of protective derivatization, capillary columns, and inexpensive electron ionization bench-top single quadrupole ...
  • Sansó Martínez, Miriam, 1979-; Vargas Pérez, Itzel; Quintales, Luis; Antequera, Francisco; Ayté del Olmo, José; Hidalgo Hernando, Elena (Oxford University Press, 2011)
    In the fission yeast, the MAP kinase Sty1 and the transcription factor Atf1 regulate up to 400 genes in response to environmental signals, and both proteins have been shown to bind to their promoters in a stress-dependent ...
  • Degenkolbe, Elisa; König, Jana; Zimmer, Julia; Walther, Maria; Reißner, Carsten; Nickel, Joachim; Plöger, Frank; Raspopovic, Jelena, 1984-; Sharpe, James; Dathe, Katarina; Hecht, Jacqueline T.; Mundlos, Stefan; Doelken, Sandra C.; Seemann, Petra (Public Library of Science (PLoS), 2013)
    Growth and Differentiation Factor 5 (GDF5) is a secreted growth factor that belongs to the Bone Morphogenetic Protein (BMP) family and plays a pivotal role during limb development. GDF5 is a susceptibility gene for ...
  • Boronat i Llop, Susanna, 1965-; García Santamarina, Sarela, 1978-; Hidalgo Hernando, Elena (Taylor & Francis (Routledge), 2015)
    Oxidative modifications in proteins have been traditionally considered as hallmarks of damage by oxidative stress and aging. However, oxidants can generate a huge variety of reversible and irreversible modifications in ...
  • Terré, Berta; Piergiovanni, Gabriele; Segura-Bayona, Sandra; Gil Gómez, Gabriel; Youssef, Sameh A.; Attolini, Camille Stephan-Otto; Wilsch-Bräuninger, Michaela; Jung, Carole; Rojas Mendoza, Ana Maria; Marjanovi c, Marko; Knobel, Philip A.; Palenzuela, Lluís; López-Rovira, Teresa; Forrow, Stephen; Huttner, Wieland B.; Valverde, M. A. (Miguel Ángel), 1963-; de Bruin, Alain; Costanzo, Vincenzo; Stracker, Travis (EMBO Press, 2016)
    The generation of multiciliated cells (MCCs) is required for the proper function of many tissues, including the respiratory tract, brain, and germline. Defects in MCC development have been demonstrated to cause a subclass ...
  • Frankish, Adam; Carbonell Sala, Silvia; Lagarde, Julien; Guigó Serra, Roderic (Oxford University Press, 2019)
    The accurate identification and description of the genes in the human and mouse genomes is a fundamental requirement for high quality analysis of data informing both genome biology and clinical genomics. Over the last 15 ...
  • Harrow, Jennifer; Denoeud, France; Frankish, Adam; Reymond, Alexandre; Chen, Chao-Kung; Chrast, Jacqueline; Lagarde, Julien; Gilbert, James; Storey, Roy; Swarbreck, David; Rossier, Colette; Ucla, Catherine; Hubbard, Tim J.; Antonarakis, Stylianos E.; Guigó Serra, Roderic (BioMed Central, 2006)
    Background: The GENCODE consortium was formed to identify and map all protein-coding genes within the ENCODE regions. This was achieved by a combination of initial manual/nannotation by the HAVANA team, experimental ...
  • Harrow, Jennifer; Tanzer, Andrea; Guigó Serra, Roderic; Hubbard, Tim J. (Cold Spring Harbor Laboratory Press (CSHL Press), 2012)
    The GENCODE Consortium aims to identify all gene features in the human genome using a combination of computational analysis, manual annotation, and experimental validation. Since the first public release of this annotation ...
  • Miranda-Mendizábal, Andrea; Castellvi Obiols, Pere; Parés Badell, O.; Alayo, Itxaso; Almenara, José; Alonso, I.; Blasco Cubedo, Maria Jesus; Blasco Cubedo, Maria Jesus; Cebrià, Ana Isabel; Gabilondo Cuéllar, Andrea; Gili, M.; Lagares, Carolina; Piqueras, José Antonio; Rodríguez Jimenez, T.; Rodríguez-Marín, Jesús; Roca, Miquel; Soto-Sanz, Victoria; Vilagut Saiz, Gemma, 1975-; Alonso Caballero, Jordi (Springer, 2019)
    OBJECTIVES: To assess the association between gender and suicide attempt/death and identify gender-specific risk/protective factors in adolescents/young adults. METHODS: Systematic review (5 databases until January 2017). ...
  • Campos-Serna, Javier, 1974-; Ronda-Pérez, Elena; Artazcoz Lazcano, Lucía, 1963-; Moen, Bente E; Benavides, Fernando G. (Fernando García) (BioMed Central, 2013)
    Gender inequalities exist in work life, but little is known about their presence in relation to factors examined in occupation health settings. The aim of this study was to identify and summarize the working and employment ...
  • Dobón Berenguer, Begoña, 1987-; Montanucci, Ludovica, 1978-; Peretó, Juli; Bertranpetit, Jaume, 1952-; Laayouni, Hafid, 1968- (BioMed Central, 2019)
    Background: Determining the factors involved in the likelihood of a gene being under adaptive selection is still a challenging goal in Evolutionary Biology. Here, we perform an evolutionary analysis of the human metabolic ...
  • Salas, Lucas A.; Font Ribera, Laia; Bustamante Pineda, Mariona; Sumoy Van Dyck, Lauro; Grimalt Obrador, Joan; Bonnin, Sarah; Aguilar Morón, María A.; Mattlin, Heidi; Hummel, Manuela; Ferrer Del Alamo, Ana; Kogevinas, Manolis; Villanueva Belmonte, Cristina (Elsevier, 2017)
    Exposure to disinfection by-products (DBP) such as trihalomethanes (THM) in swimming pools has been linked to adverse health effects in humans, but their biological mechanisms are unclear. We evaluated short-term changes ...
  • Buxadé Fortuny, Maria; Lunazzi, Giulia; Minguillón Pedreño, Jordi; Iborra, Salvador; Berga-Bolaños, Rosa; Del Val, Margarita; Aramburu, José (Aramburu Beltrán); López Rodríguez, M. Cristina (Rockefeller University Press, 2012)
    Toll-like receptors (TLRs) engage networks of transcriptional regulators to induce genes essential for antimicrobial immunity. We report that NFAT5, previously characterized as an osmostress responsive factor, regulates ...

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