Benvinguts al Repositori Digital de la UPF

Visualitzant Articles (Departament de Ciències Experimentals i de la Salut) per títol

Visualitzant Articles (Departament de Ciències Experimentals i de la Salut) per títol

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  • Costa, Daniel; Castelo Valdueza, Robert (Nature Publishing Group, 2016)
    BACKGROUND: The fetal inflammatory response (FIR) in placental membranes to an intrauterine infection often precedes premature birth raising neonatal mortality and morbidity. However, the precise molecular events behind ...
  • Martínez-Mármol, Ramón; Comes, Núria; Styrczewska, Katarzyna; Pérez Verdaguer, Mireia; Vicente García, Rubén, 1978-; Pujadas, Lluís; Soriano, Eduardo; Sorkin, Alexander; Felipe, Antonio (Springer, 2016)
    The potassium channel Kv1.3 plays roles in immunity, neuronal development and sensory discrimination. Regulation of Kv1.3 by kinase signaling has been studied. In this context, EGF binds to specific receptors (EGFR) and ...
  • Gayà Vidal, Magdalena; Albà Soler, Mar (BioMed Central, 2014)
    Background: The recent increase in human polymorphism data, together with the availability of genome sequences from several primate species, provides an unprecedented opportunity to investigate how natural selection has ...
  • Piñero González, Janet, 1977-; Berenstein, Ariel José; González-Pérez, Abel; Chernomoretz, Ariel; Furlong, Laura I., 1971- (Nature Publishing group, 2016)
    Characterizing the behavior of disease genes in the context of biological networks has the potential to shed light on disease mechanisms, and to reveal both new candidate disease genes and therapeutic targets. Previous ...
  • Bocharov, Gennady A.; Argilaguet, Jordi; Meyerhans, Andreas (Hindawi, 2015)
    Virus infections represent complex biological systems governed by multiple-level regulatory processes of virus replication and host immune responses. Understanding of the infection means an ability to predict the systems ...
  • Kharraz, Yacine; Guerra, Joana; Pessina, Patrizia; Serrano, Antonio L.; Muñoz Cánoves, Pura, 1962- (Hindawi, 2014)
    Fibrosis is the aberrant deposition of extracellular matrix (ECM) components during tissue healing leading to loss of its architecture and function. Fibrotic diseases are often associated with chronic pathologies and occur ...
  • Cheng, Chao; Alexander, Roger; Min, Renqiang; Leng, Jing; Yip, Kevin Y.; Rozowsky, Joel S.; Yan, Koon-Kiu; Dong, Xianjun; Djebali, Sarah; Ruan, Yijun; Davis, Carrie A.; Carninci, Piero; Lassmann, Timo; Gingeras, Thomas R.; Guigó Serra, Roderic; Birney, Ewan; Weng, Zhiping; Snyder, Michael; Gerstein, Mark B. (Cold Spring Harbor Laboratory Press (CSHL Press), 2012)
    Statistical models have been used to quantify the relationship between gene expression and transcription factor (TF) binding signals. Here we apply the models to the large-scale data generated by the ENCODE project to study ...
  • Thornicroft, Graham; Alonso Caballero, Jordi; Kessler, Ronald C. (Royal College of Psychiatrists, 2017)
    BACKGROUND: Major depressive disorder (MDD) is a leading cause of disability worldwide. AIMS: To examine the: (a) 12-month prevalence of DSM-IV MDD; (b) proportion aware that they have a problem needing treatment and who ...
  • Pryszcz, Leszek Piotr, 1985-; Németh, Tibor; Gácser, Attila; Gabaldón Estevan, Juan Antonio, 1973- (Oxford University Press, 2013)
    Invasive candidiasis is the most commonly reported invasive fungal infection worldwide. Although Candida albicans remains the main cause, the incidence of emerging Candida species, such as C. parapsilosis is increasing. ...
  • Pryszcz, Leszek Piotr, 1985-; Németh, Tibor; Gácser, Attila; Gabaldón Estevan, Juan Antonio, 1973- (Oxford University Press, 2013)
    Invasive candidiasis is the most commonly reported invasive fungal infection worldwide. Although Candida albicans remains the main cause, the incidence of emerging Candida species, such as C. parapsilosis is increasing. ...
  • Boattini, Alessio; Martínez Cruz, Begoña; Sarno, Stefania; Harmant, Christine; Useli, Antonella; Sanz, Paula; Yang-Yao, Daniele; Manry, Jeremy; Ciani, Graziella; Luiselli, Donata; Quintana Murci, Lluis; Comas, David, 1969-; Pettener, Davide; Genographic Consortium (Public Library of Science (PLoS), 2013)
    Located in the center of the Mediterranean landscape and with an extensive coastal line, the territory of what is today Italy has played an important role in the history of human settlements and movements of Southern Europe ...
  • Martínez-Useros, Javier; Georgiev Hristov, Tihomir; Fernández Aceñero, María Jesús; Borrero-Palacios, Aurea; Indacochea Cusirramos, Alberto; Guerrero Jijon, Santiago Xavier; Li, Weiyao; Cebrián, Arancha; del Pulgar, Teresa Gómez; Puime Otín, Alberto; Puerto Nevado, Laura del; Rodríguez Remírez, María; Pérez, Núria; Celdrán Uriarte, Ángel; Gebauer, Fátima; García-Foncillas, Jesús (Public Library of Science (PLoS), 2017)
    Pancreatic ductal adenocarcinoma is an aggressive form of pancreatic cancer and the fourth leading cause of cancer-related death. When possible, curative approaches are based on surgical resection, though not every patient ...
  • Wurth, Laurence; Papasaikas, Panagiotis; Olmeda, David; Bley, Nadine; Calvo, Guadalupe T.; Guerrero Jijon, Santiago Xavier; Cerezo-Wallis, Daniela; Martínez-Useros, Javier; García-Fernández, María; Hüttelmaier, Stefan; Soengas, María S.; Gebauer, Fátima (Elsevier, 2016)
    RNA binding proteins (RBPs) modulate cancer progression through poorly understood mechanisms. Here we show that the RBP UNR/CSDE1 is overexpressed in melanoma tumors and promotes invasion and metastasis. iCLIP sequencing, ...
  • Ullastres, Anna; Farré, Marta; Capilla, Laia; Ruiz Herrera, Aurora (BioMed Central, 2014)
    Background: By reshuffling genomes, structural genomic reorganizations provide genetic variation on which natural selection can work. Understanding the mechanisms underlying this process has been a long-standing question ...
  • Miravet Verde, Samuel; Ferrar, Tony; Espadas, Guadalupe; Mazzolini, Rocco; Gharrab, Anas; Sabidó Aguadé, Eduard, 1981-; Serrano Pubull, Luis, 1982-; Lluch-Senar, Maria 1982- (Wiley Open Access, 2019)
    Identification of small open reading frames (smORFs) encoding small proteins (≤ 100 amino acids; SEPs) is a challenge in the fields of genome annotation and protein discovery. Here, by combining a novel bioinformatics tool ...
  • Durán, Elisa; Djebali, Sarah; González, Santi; Flores, Oscar; Mercader Bigas, Josep Maria; Guigó Serra, Roderic; Torrents, David; Soler López, Montserrat; Orozco, Modesto (Oxford University Press, 2013)
    Although protein recognition of DNA motifs in promoter regions has been traditionally considered as a critical regulatory element in transcription, the location of promoters, and in particular transcription start sites ...
  • Raguz Nakin, Zrinka; Seisenbacher, Gerhard; Posas Garriga, Francesc; Sauer, Uwe (BioMed Central, 2016)
    Background: Coordinated through a complex network of kinases and phosphatases, protein phosphorylation regulates essentially all cellular processes in eukaryotes. Recent advances in proteomics enable detection of thousands ...
  • Valls, Gabriela; Codina, Montserrat; Miller, Rachel K.; Valle Pérez, Beatriz del; Vinyoles, Meritxell; Caelles Franch, Carme; McCrea, Pierre D.; García de Herreros, Antonio; Duñach, Mireia (Company of Biologists, 2012)
    A role for Rac1 GTPase in canonical Wnt signaling has recently been demonstrated, showing that it is required for β-catenin translocation to the nucleus. In this study, we investigated the mechanism of Rac1 stimulation by ...
  • Nieuwenhuijsen, Mark J. (BioMed Central, 2016)
    Background: The majority of people live in cities and urbanization is continuing worldwide. Cities have long been known to be society’s predominant engine of innovation and wealth creation, yet they are also a main source ...
  • Jungfleisch, Jennifer, 1986-; Blasco Moreno, Bernat, 1986-; Díez Antón, Juana, 1962- (MDPI, 2016)
    Positive-strand RNA viruses have evolved multiple strategies to not only circumvent the hostile decay machinery but to trick it into being a priceless collaborator supporting viral RNA translation and replication. In this ...