Benvinguts al Repositori Digital de la UPF

Visualitzant Articles (Departament de Ciències Experimentals i de la Salut) per títol

Visualitzant Articles (Departament de Ciències Experimentals i de la Salut) per títol

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  • Parra Farré, Genís; Reymond, Alexandre; Dabbouseh, Noura; Dermitzakis, Emmanuouil T.; Thomson, Timothy M.; Antonarakis, Stylianos E.; Guigó Serra, Roderic (Cold Spring Harbor Laboratory Press-CSHL Press, 2006)
    The “one-gene, one-protein” rule, coined by Beadle and Tatum, has been fundamental to molecular biology. The rule implies that the genetic complexity of an organism depends essentially on its gene number. The discovery, ...
  • Sonay, Tugce Bilgin; Carvalho, Tiago Loureiro de, 1987-; Robinson, Mark D.; Greminger, Maja P.; Krützen, Michael; Comas, David, 1969-; Highnam, Gareth; Mittelman, David; Sharp, Andrew J.; Marquès i Bonet, Tomàs, 1975-; Wagner, Andreas (Cold Spring Harbor Laboratory Press (CSHL Press), 2015)
    Tandem repeats (TRs) are stretches of DNA that are highly variable in length and mutate rapidly. They are thus an important source of genetic variation. This variation is highly informative for population and conservation ...
  • Santos, António J. M.; Nogueira, Cristina; Ortega Bellido, María; Malhotra, Vivek (Rockefeller University Press, 2016)
    Procollagens, pre-chylomicrons, and pre–very low-density lipoproteins (pre-VLDLs) are too big to fit into conventional COPII-coated vesicles, so how are these bulky cargoes exported from the endoplasmic reticulum (ER)? We ...
  • Kamdem Toukam, Donatien; Tenbusch, Matthias; Stang, Alexander; Temchura, Vladimir; Storcksdieck Genannt Bonsmann, Michael; Grewe, Bastian; Koch, Stefanie; Meyerhans, Andreas; Nichinda, Godwin; Kaptue, Lazare; Überla, Klaus (Public Library of Science (PLoS), 2012)
    Although human immunodeficiency type 1 (HIV-1) infection induces strong antibody responses to the viral envelope glycoprotein (Env) only a few of these antibodies possess the capacity to neutralize a broad range of strains. ...
  • Rué, Laura; Bañez Coronel, Mónica; Creus-Muncunill, Jordi; Giralt, Albert; Alcalá-Vida, Rafael; Mentxaka, Gartze; Kagerbauer, Birgit; Zomeño-Abellán, M. Teresa; Aranda, Zeus; Venturi, Veronica; Pérez-Navarro, Esther; Estivill, Xavier, 1955-; Martí, Eulàlia (American Society for Clinical Investigation, 2016)
    Huntington's disease (HD) is a polyglutamine disorder caused by a CAG expansion in the Huntingtin (HTT) gene exon 1. This expansion encodes a mutant protein whose abnormal function is traditionally associated with HD ...
  • Busquets Garcia, Arnau, 1985-; Gomis González, Maria; Guegan, Thomas, 1983-; Agustín Pavón, Carmen; Pastor, Antonio; Mato, Susana; Pérez Samartín, A.; Matute, Carlos; Torre Fornell, Rafael de la; Dierssen, Mara; Maldonado, Rafael, 1961-; Ozaita Mintegui, Andrés, 1969- (Nature Publishing Group, 2013)
    Fragile X syndrome (FXS), the most common monogenic cause of inherited intellectual disability and autism, is caused by the silencing of the FMR1 gene, leading to the loss of fragile X mental retardation protein (FMRP), a ...
  • Engelken, Johannes; Brinkmann, Henner; Adamska, Iwona (BioMed Central, 2010)
    Background: The extended light-harvesting complex (LHC) protein superfamily is a centerpiece of eukaryotic photosynthesis, comprising the LHC family and several families involved in photoprotection, like the LHC-like and ...
  • Chang, Jia-Ming, 1978-; Di Tommaso, Paolo; Lefort, Vincent; Gascuel, Olivier; Notredame, Cedric (Oxford University Press, 2015)
    This article introduces the Transitive Consistency Score (TCS) web server; a service making it possible to estimate the local reliability of protein multiple sequence alignments (MSAs) using the TCS index. The evaluation ...
  • O'Connor, Giselle; Piñero Casas, Maria; Basagaña Flores, Xavier; López Vicente, Mònica, 1988-; Davand, Payam; Torrent Quetglas, Maties; Martínez-Murciano, David; García Esteban, Raquel; Marinelli, Marcella; Sunyer Deu, Jordi; Júlvez Calvo, Jordi (Elsevier, 2016)
    This study is aiming to evaluate the association between television viewing during childhood and long-term adolescent neuropsychological outcomes and the potential explanatory pathways. This is a longitudinal study based ...
  • Fernando, Carol A.; Conrad, Patricia A.; Bartels, Cynthia F.; Marquès i Bonet, Tomàs, 1975-; To, Michael; Balow, Stephanie A.; Nakamura, Yukio; Warman, Matthew L. (Wiley, 2010)
    The six mammalian CCN genes (Cyr61, CTGF, Nov, WISP1, WISP2, WISP3) encode a family of secreted, cysteine-rich, multimodular proteins having roles in cell proliferation, adhesion, migration, and differentiation during ...
  • Kuchina, Anna; Espinar, Lorena; Cagatay, Tolga; Balbin, Alejandro O.; Zhang, Fang; Alvarado, Alma; García Ojalvo, Jordi; Süel, Gürol M. (Nature Publishing Group, 2011)
    Multipotent differentiation, where cells adopt one of several possible fates, occurs in diverse systems ranging from bacteria to mammals. This decision-making process is driven by multiple differentiation programs that ...
  • Jedynak, Maciej; Pons, Antonio J.; García Ojalvo, Jordi; Goodfellow, Marc (Elsevier, 2017)
    Macroscopic models of brain networks typically incorporate assumptions regarding the characteristics of afferent noise, which is used to represent input from distal brain regions or ongoing fluctuations in non-modelled ...
  • Ponomarenko, Julia; Garrido, Romina; Roderic, Guigo (Public Library of Science (PLoS), 2017)
  • Duran Jordà, Xavier, 1974-; Martínez Martínez, José Miguel, 1974-; Benavides, Fernando G. (Fernando García) (Ministerio de Sanidad y Consumo, 2012)
    Fundamentos: La incapacidad permanente (IP) es un problema de salud laboral en el que intervienen factores laborales, sanitarios o legales, los cuales han variado en España a lo largo de los últimos años. El objetivo del ...
  • Gutiérrez Sacristán, Alba; Bravo Serrano, Àlex, 1984-; Portero Tresserra, Marta; Valverde Granados, Olga; Leis Machin, Angela; Mayer, Miguel Ángel, 1960-; Warnault, Vincent; Sanz, Ferran; Furlong, Laura I., 1971- (Oxford University Press, 2017)
    Psychiatric disorders constitute one of the main causes of disability worldwide. During the past years, considerable research has been conducted on the genetic architecture of such diseases, although little understanding ...
  • Touriño Raposo, Clara; Zimmer, Andreas; Valverde Granados, Olga (Public Library of Science (PLoS), 2010)
    The majority of MDMA (ecstasy) recreational users also consume cannabis. Despite the rewarding effects that both drugs have, they induce several opposite pharmacological responses. MDMA causes hyperthermia, oxidative stress ...
  • Zhang, Zhaiyi; Falaleeva, Marina; Agranat-Tamir, Lily; Pagès Pinós, Amadís; Eyras Jiménez, Eduardo; Sperling, Joseph; Sperling, Ruth; Stamm, Stefan (Springer Verlag, 2013)
    The serotonin receptor 2C (HTR2C) gene encodes a G protein-coupled receptor that is exclusively expressed in neurons. Here, we report that the 5' untranslated region of the receptor pre-mRNA as well as its hosted miRNAs ...
  • Sakae, Diana Yae; Martín García, Elena, 1975-; Gutiérrez Cuesta, Javier; Maldonado, Rafael, 1961-; El Mestikawy, Salah (Nature Publishing Group, 2015)
    Tonically active cholinergic interneurons (TANs) from the nucleus accumbens (NAc) are centrally involved in reward behavior. TANs express a vesicular glutamate transporter referred to as VGLUT3 and thus use both acetylcholine ...
  • Molinuevo, José Luis; Gramunt, Nina; Domingo Gispert, Juan; Fauria, Karine; Esteller, Manel; Minguillon, Carolina; Sánchez Benavides, Gonzalo; Huesa, Gema; Morán, Sebastián; Dal-Ré, Rafael; Camí, Jordi, 1952- (Elsevier, 2016)
    Introduction: The preclinical phase of Alzheimer's disease (AD) is optimal for identifying early pathophysiological events and developing prevention programs, which are shared aims of the ALFA project, including the ALFA ...
  • Astle, William J.; Garrido Martín, Diego; Guigó Serra, Roderic; Soranzo, Nicole (Elsevier, 2016)
    Many common variants have been associated with hematological traits, but identification of causal genes and pathways has proven challenging. We performed a genome-wide association analysis in the UK Biobank and INTERVAL ...