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Browsing Articles (Departament de Ciències Experimentals i de la Salut) by Title

Browsing Articles (Departament de Ciències Experimentals i de la Salut) by Title

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  • Fu, Marcela; Fernández, Esteve; Martínez Sánchez, Jose María; Pascual, José A.; Schiaffino, Anna; Agudo, Antoni; Ariza, Carles; Borràs, Josep M.; Samet, Jonathan M. (BioMed Central, 2009)
    Background/nCharacterizing and comparing the determinant of cotinine concentrations in different populations should facilitate a better understanding of smoking patterns and addiction. This study describes and characterizes ...
  • Gundem, Gunes; López Bigas, Núria (BioMed Central, 2012)
    Background: Adaptation to stress signals in the tumor microenvironment is a crucial step towards carcinogenic phenotype. The adaptive alterations attained by cells to withstand different types of insults are collectively ...
  • Dotu, Ivan; Scott I. Adamson; Coleman, Benjamin; Fournier, Cyril; Ricart Altimiras, Emma; Eyras Jiménez, Eduardo; Chuang, Jeffrey H. (Public Library of Science (PLoS), 2018)
    RNA-protein binding is critical to gene regulation, controlling fundamental processes including splicing, translation, localization and stability, and aberrant RNA-protein interactions are known to play a role in a wide ...
  • Saint-Léger, Adélaïde; Bello Cabrera, Carla; Dans, Pablo D.; Gabriel Torres, Adrian; Novoa, Eva Maria; Camacho, Noelia; Orozco, Modesto; Kondrashov, Fyodor A., 1979-; Ribas de Pouplana, Lluís (American Association for the Advancement of Science (AAAS), 2016)
    Understanding the principles that led to the current complexity of the genetic code is a central question in evolution. Expansion of the genetic code required the selection of new transfer RNAs (tRNAs) with specific ...
  • Pulido-Quetglas, Carlos; Aparicio i Prat, Estel, 1986-; Arnan Ros, Carme; Polidori, Taisia; Hermoso Pulido, Antonio; Palumbo, Emilio; Ponomarenko, Julia; Guigó Serra, Roderic; Johnson, Rory (Public Library of Science (PLoS), 2017)
    CRISPR-Cas9 technology can be used to engineer precise genomic deletions with pairs of single guide RNAs (sgRNAs). This approach has been widely adopted for diverse applications, from disease modelling of individual loci, ...
  • Bousquet, Jean; Antó i Boqué, Josep Maria; Mercier, J. (BioMedCentral, 2016)
    Action Plan B3 of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) focuses on the integrated care of chronic diseases. Area 5 (Care Pathways) was initiated using chronic respiratory diseases ...
  • Azzaoui, Kamal; Jacoby, Edgar; Senger, Stefan; Cuadrado Rodríguez, Emiliano; Loza, Mabel; Zdrazil, Barbara; Pinto, Marta; Williams, Antony J.; Torre, Victor de la; Mestres i López, Jordi; Pastor Maeso, Manuel; Taboureau, Olivier; Rarey, Matthias; Chichester, Christine; Pettifer, Steve; Blomberg, Niklas; Harland, Lee; Williams-Jones, Bryn; Ecker, Gerhard F. (Elsevier, 2013)
    Molecular information systems play an important part in modern data-driven drug discovery. They do not only support decision making but also enable new discoveries via association and inference. In this review, we outline ...
  • Balcells Aribau, Georgina, 1987-; Pozo Mendoza, Óscar J., 1975-; Esquivel López, Argitxu; Kotronoulas, Aristotelis; Joglar Tamargo, Jesús; Segura Noguera, Jordi; Ventura Alemany, Rosa (Elsevier, 2015)
    In order to improve the detection capabilities of anabolic androgenic steroids (AAS) in sports, a liquid chromatography-tandem mass spectrometry (LC-MS/MS) screening method for the simultaneous detection of AAS phase I and ...
  • Vilagut Saiz, Gemma, 1975-; Forero, Carlos G.; Barbaglia, María Gabriela, 1979-; Alonso Caballero, Jordi (Public Library of Science, 2016)
    OBJECTIVE: We aimed to collect and meta-analyse the existing evidence regarding the performance of the Center for Epidemiologic Studies Depression (CES-D) for detecting depression in general population and primary care ...
  • Monfort Mercader, Núria, 1983-; Martínez, Laura; Bergés Casas, Rosa Leonor; Segura Noguera, Jordi; Ventura Alemany, Rosa (Wiley, 2015)
    A fast screening method for the detection of more than 60 stimulants in urine was developed. The method consisted of a dilution of the urine (1:5 v/v) and analysis by ultra high performance liquid chromatography coupled ...
  • Carreño, Oriel; Corominas, Roser; Serra Pascual, Selma A., 1981-; Sintas, Cèlia; Fernández Castillo, Noelia; Vila Pueyo, Marta; Toma, Claudio; Gené, Gemma; Pons, Roser; Llaneza, Miguel; Sobrido, María Jesús; Grinberg, Daniel; Valverde, M. A. (Miguel Ángel), 1963-; Fernández-Fernández, José Manuel, 1967-; Macaya, Alfons; Cormand, Bru (Wiley, 2013)
    Hemiplegic migraine (HM) is a rare and severe subtype of autosomal dominant migraine, characterized by a complex aura including some degree of motor weakness. Mutations in four genes (CACNA1A, ATP1A2, SCN1A and PRRT2) have ...
  • Alsina i Español, Berta; Whitfield, Tanya T. (Elsevier, 2017)
    The vertebrate inner ear is a precision sensory organ, acting as both a microphone to receive sound and an accelerometer to detect gravity and motion. It consists of a series of interlinked, fluid-filled chambers containing ...
  • Agostini, Federico, 1985-; Cirillo, Davide; Delli Ponti, Riccardo; Tartaglia, Gian Gaetano (BioMed Central, 2014)
    BACKGROUND: The large amount of data produced by high-throughput sequencing poses new computational challenges. In the last decade, several tools have been developed for the identification of transcription and splicing ...
  • Viscardi, Lucas Henriques; Paixão-Côrtes, Vanessa Rodrigues; Comas, David, 1969-; Salzano, Francisco Mauro; Rovaris, Diego; Bau, Claiton Dotto; Amorim, Carlos Eduardo G.; Bortolini, Maria Cátira (UNLISTED PUBLISHER, 2018)
    Hominin evolution is characterized by adaptive solutions often rooted in behavioral and cognitive changes. If balancing selection had an important and long-lasting impact on the evolution of these traits, it can be ...
  • Mariotti, Marco, 1984-; Lobanov, Alexei V.; Guigó Serra, Roderic; Gladyshev, Vadim N. (Oxford University Press, 2013)
    Selenoproteins are proteins containing an uncommon amino acid selenocysteine (Sec). Sec is inserted by a specific translational machinery that recognizes a stem-loop structure, the SECIS element, at the 3' UTR of selenoprotein ...
  • Guerrero, Lucia; Marco Ferreres, Raquel; Serrano, Antonio L.; Arredondo, Juan J.; Cervera, Margarita (Elsevier, 2010)
    Although tight quantitative control of gene expression is required to ensure that organs and tissues function correctly, the transcriptional mechanisms underlying this process still remain poorly understood. Here, we ...
  • Pegueroles Queralt, Maria Cinta; Gabaldón Estevan, Juan Antonio, 1973- (BioMed Central, 2016)
    Background: Metazoans transcribe many long non-coding RNAs (lncRNAs) that are poorly conserved and whose function remains unknown. This has raised the questions of what fraction of the predicted lncRNAs is actually functional, ...
  • Martínez-Sánchez, Jose M.; Ballbé, Montse; Pérez-Ortuño, Raúl; Fu, Marcela; Sureda, Xisca; Pascual Esteban, José A.; Peruga, Armando; Fernández, Esteve (Elsevier, 2018)
    OBJECTIVE: To assess the levels of a tobacco-specific nitrosamine (NNAL) in non-smokers passively exposed to the second-hand aerosol (SHA) emitted from users of electronic cigarettes (e-cigarettes). METHOD: We conducted ...
  • Hartasánchez Frenk, Diego Andrés, 1982-; Brasó-Vives, Marina; Fuentes-Díaz, Juanma; Vallés-Codina, Oriol; Navarro i Cuartiellas, Arcadi, 1969- (Oxford University Press, 2016)
    SUMMARY: SeDuS is the first flexible and user-friendly forward-in-time simulator of patterns of molecular evolution within segmental duplications undergoing interlocus gene conversion and crossover. SeDuS introduces known ...
  • Nye, Jessica; Laayouni, Hafid, 1968-; Kuhlwilm, Martin; Mondal, Mayukh, 1989-; Marquès i Bonet, Tomàs, 1975-; Bertranpetit, Jaume, 1952- (Oxford University Press, 2018)
    During the demographic history of the Pan clade, there has been gene-flow between species, likely >200,000 years ago. Bonobo haplotypes in three subspecies of chimpanzee have been identified to be segregating in modern-day ...

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