Benvinguts al Repositori Digital de la UPF

Visualitzant Articles (Departament de Ciències Experimentals i de la Salut) per títol

Visualitzant Articles (Departament de Ciències Experimentals i de la Salut) per títol

Ordena per: Ordre: Resultats:

  • Domínguez Frutos, Elena; López Hernández, Iris; Vendrell, Víctor; Neves, Joana; Gallozzi, Micaela; Gutsche, Katja; Quintana, Laura; Sharpe, James; Knoepfler, Paul S.; Eisenman, Robert N.; Trumpp, Andreas; Giráldez, Fernando; Schimmang, Thomas (Society for Neuroscience, 2011)
    Myc family members play crucial roles in regulating cell proliferation, size, and differentiation during organogenesis. Both N-myc and c-myc are expressed throughout inner ear development. To address their function in the ...
  • Calleja Conde, Javier; Echeverry Alzate, Víctor; Giné, Elena; Bühler, Kora Mareen; Nadal, Roser; Maldonado, Rafael, 1961-; Rodríguez de Fonseca, Fernando; Gual, Antoni; López Moreno, José A. (Wiley, 2016)
    BACKGROUND AND PURPOSE: The opioid antagonist nalmefene (selincro®) was approved for alcohol-related disorders by the European Medicines Agency in 2013. However, there have been no studies regarding the effectiveness of ...
  • Muntasell, Aura; López-Botet, M. (Miguel) (American Association for Cancer Research, 2016)
    The report by Curti et al. highlightsthe potential of NK cell-based adoptive cellular immunotherapy in oncology,currently boosted by advances in the knowledge on NK cell biology and in their ex-vivo GMP manipulation.Several ...
  • Cagan, Alexander; Theunert, Christoph; Laayouni, Hafid, 1968-; Santpere, Gabriel; Pybus Oliveras, Marc, 1985-; Casals López, Ferran; Prüfer, Kay; Navarro i Cuartiellas, Arcadi, 1969-; Marquès i Bonet, Tomàs, 1975-; Bertranpetit, Jaume, 1952-; Andrés Morán, Aida (Oxford University Press, 2016)
    Natural selection is crucial for the adaptation of populations to their environments. Here, we present the first global study of natural selection in the Hominidae (humans and great apes) based on genome-wide information ...
  • Taskov, Kalin; Chapple, Charles E.; Kryukov, Gregory V.; Castellano Hereza, Sergi; Lobanov, Alexei V.; Korotkov, Konstantin V.; Guigó Serra, Roderic; Gladyshev, Vadim N. (Oxford University Press, 2005)
    Selenocysteine (Sec) is co-translationally inserted into selenoproteins in response to codon UGA with the help of the selenocysteine insertion sequence (SECIS) element. The number of selenoproteins in animals varies, with ...
  • Grosdidier, Solène; Ferrer, Antoni; Faner, Rosa; Piñero González, Janet, 1977-; Roca, Josep; García Cosio, Borja; Agustí, Alvar; Gea Guiral, Joaquim; Sanz, Ferran; Furlong, Laura I., 1971- (BioMed Central, 2014)
    Background: Patients with chronic obstructive pulmonary disease (COPD) often suffer concomitant disorders that worsen significantly their health status and vital prognosis. The pathogenic mechanisms underlying COPD ...
  • Avena-Koenigsberger, Andrea; Goñi, Joaquín; Solé Vicente, Ricard, 1962-; Sporns, Olaf (Royal Society, 2015)
    The structure of complex networks has attracted much attention in recent years. It has been noted that many real-world examples of networked systems share a set of common architectural features. This raises important ...
  • Casas, Caty; Isus, Laura; Herrando Grabulosa, Mireia; Mancuso, Francesco M.; Borrás, Eva; Sabido Aguade, Eduard; Forés, Joaquim; Aloy, Patrick, 1972- (Nature Publishing Group, 2015)
    Neurodegenerative processes are preceded by neuronal dysfunction and synaptic disconnection. Disconnection between spinal motoneuron (MN) soma and synaptic target leads either to a retrograde degenerative process or to a ...
  • Klus, Petr, 1985-; Cirillo, Davide; Botta Orfila, Teresa; Tartaglia, Gian Gaetano (Nature Publishing Group, 2015)
    It has been reported that genes up-regulated in cancer are often down-regulated in neurodegenerative disorders and vice versa. The fact that apparently unrelated diseases share functional pathways suggests a link between ...
  • Cirillo, Davide; Agostini, Federico, 1985-; Klus, Petr, 1985-; Marchese, Domenica, 1986-; Rodríguez, Silvia; Bolognesi, Benedetta; Tartaglia, Gian Gaetano (Cold Spring Harbor Laboratory Press (CSHL Press), 2013)
    Increasing evidence indicates that RNA plays an active role in a number of neurodegenerative diseases. We recently introduced a theoretical framework, catRAPID, to predict the binding ability of protein and RNA molecules. ...
  • Basagaña Flores, Xavier; Esnaola, Mikel; Rivas, Ioar; Amato, Fulvio; Álvarez Pedrerol, Mar; Forns i Guzman, Joan, 1981-; López Vicente, Mònica, 1988-; Pujol Martí, Jesús; Nieuwenhuijsen, Mark J.; Querol, Xavier; Sunyer Deu, Jordi (National Institute of Environmental Health Sciences, 2016)
    BACKGROUND: A few studies have reported associations between traffic-related air pollution exposure at schools and cognitive development. The role of PM components or sources other than traffic on cognitive development has ...
  • Villanueva Cañas, José Luis, 1984-; Ruiz Orera, Jorge, 1988-; Agea, M. Isabel; Gallo, Maria; Andreu Martínez, David; Albà Soler, Mar (Oxford University Press, 2017)
    The birth of genes that encode new protein sequences is a major source of evolutionary innovation. However, we still understand relatively little about how these genes come into being and which functions they are selected ...
  • Busquets Garcia, Arnau, 1985-; Maldonado, Rafael, 1961-; Ozaita Mintegui, Andrés, 1969- (Elsevier, 2014)
    Fragile X syndrome is the most common monogenetic form of intellectual disability and is a leading cause of autism. This syndrome is produced by the reduced transcription of the fragile X mental retardation (FMR1) gene, ...
  • García Garcerà, Marc; Garcia Etxebarria, Koldo; Coscollà, Mireia; Latorre, Amparo; Calafell i Majó, Francesc (Public Library of Science (PLoS), 2013)
    In the last decade, an extensive effort has been made to characterize the human microbiota, due to its clinical and economic interests. However, a metagenomic approach to the skin microbiota is hampered by the high proportion ...
  • Melé Messeguer, Marta, 1982-; Javed, Asif; Pybus Oliveras, Marc, 1985-; Calafell i Majó, Francesc; Parida, Laxmi; Bertranpetit, Jaume, 1952-; The Genographic Consortium (Public Library of Science (PLoS), 2010)
    Recombination is one of the main forces shaping genome diversity, but the information it generates is often overlooked. A recombination event creates a junction between two parental sequences that may be transmitted to the ...
  • Gómez Grau, Marta; Albaigès, Júlia; Casas, Josefina; Auladell, Carme; Dierssen, Mara; Vilageliu, Lluïsa; Grinberg, Daniel (Nature Publishing Group, 2017)
    Niemann-Pick disease type C (NPC) is a rare neurovisceral disease caused mainly by mutations in the NPC1 gene. This autosomal recessive lysosomal disorder is characterised by the defective lysosomal secretion of cholesterol ...
  • Dias, Susana A.; Freire, Joao Miguel; Pérez-Peinado, Clara; Domingues, Marco M.; Gaspar, Diana; Vale, Nuno; Gomes, Paula; Andreu Martínez, David; Henriques, Sónia T.; Castanho, Miguel A.R.B.; Veiga, Ana Salomé (Frontiers, 2017)
    The increasing prevalence of multidrug-resistant bacteria urges the development of new antibacterial agents. With a broad spectrum activity, antimicrobial peptides have been considered potential antibacterial drug leads. ...
  • Serrano Munuera, Carmen; Corral Juan, Marc; Stevanin, Giovanni; San Nicolás, Hector; Roig, Carles; Corral, Jordi; Campos, Berta; Jorge, Laura de; Morcillo Suárez, Carlos; Navarro i Cuartiellas, Arcadi, 1969-; Forlani, Sylvie; Durr, Alexandra; Kulisevsky, Jaime J.; Brice, Alexis; Sánchez, Ivelisse; Volpini, Victor; Matilla Dueñas, Antoni (American Institute of Physics (AIP), 2013)
    IMPORTANCE: To provide clinical and genetic diagnoses for patients' conditions, it is important to identify and characterize the different subtypes of spinocerebellar ataxia (SCA). OBJECTIVE: To clinically and genetically ...
  • Tellechea, Mónica; Buxadé Fortuny, Maria; Tejedor Vaquero, Sonia; Aramburu, José (Aramburu Beltrán); López Rodríguez, M. Cristina (American Association of Immunologists - AAI, 2018)
    Macrophages are exquisite sensors of tissue homeostasis that can rapidly switch between pro- and anti-inflammatory or regulatory modes to respond to perturbations in their microenvironment. This functional plasticity ...
  • Berrendero Díaz, Fernando, 1971-; Mendizábal, Victoria; Robledo, Patricia, 1958-; Galeote González, Lola; Bilkei Gorzo, Andras; Zimmer, Andreas; Maldonado, Rafael, 1961- (Society for Neuroscience, 2005)
    It has been shown previously that the endogenous opioid system may be involved in the behavioral effects of nicotine. In the present study, the participation of endogenous enkephalins on nicotine responses has been ...