Benvinguts al Repositori Digital de la UPF

Visualitzant Articles (Departament de Ciències Experimentals i de la Salut) per títol

Visualitzant Articles (Departament de Ciències Experimentals i de la Salut) per títol

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  • Uzkudun, Manu; Marcon, Luciano, 1983-; Sharpe, James (Wiley Blackwell, 2015)
    Parameter optimization coupled with model selection is a convenient approach to infer gene regulatory networks from experimental gene expression data, but so far it has been limited to single cells or static tissues where ...
  • Agirre Ortiz de Guzmán, Eneritz, 1983-; Eyras Jiménez, Eduardo (BioMed Central, 2011)
    Recent advances in high-throughput sequencing have facilitated the genome-wide studies of small non-coding RNAs (sRNAs). Numerous studies have highlighted the role of various classes of sRNAs at different levels of gene ...
  • Liñeiro, Eva; Chiva, Cristina; Cantoral, Jesús M.; Sabido Aguade, Eduard; Fernández-Acero, Francisco Javier (Elsevier, 2016)
    Phosphorylation is one of the main post-translational modification (PTM) involved in signaling network in the ascomycete Botrytis cinerea, one of the most relevant phytopathogenic fungus. The data presented in this article ...
  • Cardoso, Graça; Xavier, Miguel; Vilagut Saiz, Gemma, 1975-; Petukhova, Maria; Alonso, Jordi; Kessler, Ronald C.; Caldas-de-Almeida, José Miguel (Royal College of Psychiatrists, 2017)
    BACKGROUND: One important aspect of the societal burden of mental disorders is the extent to which these problems cause disability. AIMS: To assess days out of role associated with commonly occurring mental disorders in ...
  • Mall, Sumaya; Lund, Crick; Vilagut Saiz, Gemma, 1975-; Alonso Caballero, Jordi; Williams, David R.; Stein, Dan J. (Springer, 2015)
    Background: Both mental and physical disorders can result in role limitation, such as ‘days out of role’, which have an important impact on national productivity losses. This paper analyses data from the South African ...
  • Andrade, Laura Helena; Baptista, Marcos C.; Alonso Caballero, Jordi; Petukhova, Maria; Bruffaerts, Ronny; Kessler, Ronald C.; Silveira, Camila M.; Siu, Erica R.; Wang, Yuan-Pang; Viana, Maria Carmen (Hospital das Clínicas, Faculty of Medicine, University of São Paulo, 2013)
    OBJECTIVES: To investigate the relative importance of common physical and mental disorders with regard to the number of days out-of-role (DOR; number of days for which a person is completely unable to work or carry out ...
  • Ehmke, Nadja; Hecht, Jochen; Kornak, Uwe (Elsevier, 2017)
    Gorlin-Chaudhry-Moss syndrome (GCMS) is a dysmorphic syndrome characterized by coronal craniosynostosis and severe midface hypoplasia, body and facial hypertrichosis, microphthalmia, short stature, and short distal phalanges. ...
  • Carbonell Ballestero, Max, 1988-; García Ramallo, Eva; Montañez, Raúl; Rodríguez Caso, Carlos; Macía, Javier (Oxford University Press, 2016)
    Synthetic biology seeks to envision living cells as a matter of engineering. However, increasing evidence suggests that the genetic load imposed by the incorporation of synthetic devices in a living organism introduces a ...
  • Duch, Alba; Nadal Clanchet, Eulàlia de; Posas Garriga, Francesc (Elsevier, 2013)
    Transcription during S phase needs to be spatially and temporally regulated to prevent collisions between the transcription and replication machineries. Cells have evolved a number of mechanisms to make both processes ...
  • Bekpen, Cemalettin; Marquès i Bonet, Tomàs, 1975-; Alkan, Can; Antonacci, Francesca; Leogrande, Maria Bruna; Ventura, Mario; Kidd, Jeffrey M.; Siswara, Priscillia; Howard, Jonathan C.; Eichler, Evan E. (Public Library of Science (PLoS), 2009)
    Immunity-related GTPases (IRG) play an important role in defense against intracellular pathogens. One member of this gene family in humans, IRGM, has been recently implicated as a risk factor for Crohn's disease. We analyzed ...
  • Bosch Fusté, Elena; Laayouni, Hafid, 1968-; Morcillo Suárez, Carlos; Casals López, Ferran; Moreno Estrada, Andrés; Ferrer Admetlla, Anna; Gardner, Michelle; Rosa, Araceli; Comas, David, 1969-; Graffelman, Jan; Calafell i Majó, Francesc; Bertranpetit, Jaume, 1952- (BioMed Central, 2009)
    Background: It is well known that the pattern of linkage disequilibrium varies between human populations, with remarkable geographical stratification. Indirect association studies routinely exploit linkage disequilibrium ...
  • Meyer, Markus; Plass Pórtulas, Mireya, 1982-; Pérez Valle, Jorge; Eyras Jiménez, Eduardo; Vilardell, Josep (Elsevier, 2011)
    Poor understanding of the spliceosomal mechanisms to select intronic 3' ends (3'ss) is a major obstacle to deciphering eukaryotic genomes. Here, we discern the rules for global 3'ss selection in yeast. We show that, in ...
  • de la Cruz Peña, María Jose; Martínez Hernández, Francisco; García Heredia, Inmaculada; Lluesma Gómez, Mónica; Fornas Carreño, Oscar; Martínez García, Manuel (MDPI, 2018)
    Single-cell genomics has unveiled the metabolic potential of dominant microbes inhabiting different environments, including the human body. The lack of genomic information for predominant microbes of the human body, such ...
  • Salat Canela, Clàudia; Paulo Mirasol, Esther, 1984-; Sánchez Mir, Laura; Carmona, Mercè; Ayté del Olmo, José; Oliva Miguel, Baldomero; Hidalgo Hernando, Elena (American Society for Biochemistry and Molecular Biology (ASBMB), 2017)
    Adaptation to stress triggers the most dramatic shift in gene expression in fission yeast (Schizosaccharomyces pombe), and this response is driven by signaling via the MAPK Sty1. Upon activation, Sty1 accumulates in the ...
  • Mallorquí-Bagué, Nuria; Fagundo, Ana B.; Jiménez Murcia, Susana; Torre Fornell, Rafael de la; Baños, Rosa M.; Botella, Cristina; Casanueva, Felipe F.; Crujeiras, Ana B.; Fernández García, José C.; Fernández Real, Jose M.; Frühbeck, Gema; Granero, Roser; Rodríguez, Amaia; Tolosa-Sola, Iris; Ortega, Francisco J.; Tinahones, Francisco J.; Alvarez-Moya, Eva; Ochoa, Cristian; Menchón, José M.; Fernández Aranda, Fernando (Public Library of Science (PLoS) , 2016)
    INTRODUCTION: Addictions are associated with decision making impairments. The present study explores decision making in Substance use disorder (SUD), Gambling disorder (GD) and Obesity (OB) when assessed by Iowa Gambling ...
  • Aparicio i Prat, Estel, 1986-; Arnan Ros, Carme; Sala, Ilaria; Bosch Roca, Núria; Guigó Serra, Roderic; Johnson, Rory (BioMed Central, 2015)
    Background. CRISPR genome-editing technology makes it possible to quickly and cheaply delete non-protein-coding regulatory elements. We present a vector system adapted for this purpose called DECKO (Double Excision CRISPR ...
  • Tilgner, Hagen, 1980-; Knowles, David G.; Johnson, Rory; Davis, Carrie A.; Chakrabortty, Sudipto; Djebali, Sarah; Curado, Joao; Snyder, Michael; Gingeras, Thomas R.; Guigó Serra, Roderic (Cold Spring Harbor Laboratory Press (CSHL Press), 2012)
    Splicing remains an incompletely understood process. Recent findings suggest that chromatin structure participates in its regulation. Here, we analyze the RNA from subcellular fractions obtained through RNA-seq in the cell ...
  • Sabbaghi Mehrjardi, Mohammad Ali; Gil Gómez, Gabriel; Guardia Laguarta, Cristina; Servitja Tormo, Sonia; Arpí Llucià, Oriol; Menendez Romero, Silvia; Arumí, Montserrat; Serrano, Laia; Salido Galeote, Marta; Muntasell i Castellví, Aura, 1972-; Martínez-García, Maria; Tusquets, Ignasi; Rovira Guerín, Ana; Albanell Mestres, Joan (American Association for Cancer Research (AACR), 2017)
    Purpose: Trastuzumab-emtansine (T-DM1) is a standard treatment in advanced HER2-positive breast cancer. However, resistance inevitably occurs. We aimed to identify mechanisms of acquired T-DM1 resistance.Experimental Design: ...
  • Argente, Jesús; Flores, Raquel; Gutiérrez Arumí, Armand; Verma, Bhupendra; Martos Moreno, Gabriel Á; Cuscó Martí, Ivon, 1973-; Oghabian, Ali; Chowen, Julie A.; Frilander, Mikko J; Pérez Jurado, Luis Alberto (Wiley-VCH Verlag, 2014)
    The molecular basis of a significant number of cases of isolated growth hormone deficiency remains unknown. We describe three sisters affected with severe isolated growth hormone deficiency and pituitary hypoplasia caused ...
  • Trussart, Marie, 1985-; Yus, Eva; Martínez, Sira; Baù, Davide; Tahara, Yuhei O.; Pengo, Thomas; Widjaja, Michael; Kretschmer, Simon; Swoger, Jim; Djordjevic, Steven P.; Turnbull, Lynne; Whitchurch, Cynthia B.; Miyata, Makoto; Martí Renom, Marc A.; Lluch-Senar, Maria 1982-; Serrano Pubull, Luis, 1982- (Nature Publishing Group, 2017)
    DNA-binding proteins are central regulators of chromosome organization; however, in genome-reduced bacteria their diversity is largely diminished. Whether the chromosomes of such bacteria adopt defined three-dimensional ...