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Browsing Articles (Departament de Medicina i Ciències de la Vida) by Title

Browsing Articles (Departament de Medicina i Ciències de la Vida) by Title

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  • C-edge loops of arrestin function as a membrane anchor
    Lally, Ciara C.M.; Bauer, Brain; Selent, Jana; Sommer, Martha E. (Nature Publishing Group, 2017)
    G-protein-coupled receptors are membrane proteins that are regulated by a small family of arrestin proteins. During formation of the arrestin–receptor complex, arrestin first interacts with the phosphorylated receptor C ...
  • The C-terminus of H-ras as a target for the covalent binding of reactive compounds modulating Ras-dependent pathways
    Oeste, Clara L; Díez Dacal, Beatriz; Bray, Francesca; García de Lacoba, Mario; Torre, Beatriz G. de la; Andreu Martínez, David; Ruiz Sánchez, Antonio J; Pérez Inestrosa, Ezequiel; García Domínguez, Carlota A; Rojas, José M; Pérez Sala, Dolores (Public Library of Science (PLoS), 2011)
    Ras proteins are crucial players in differentiation and oncogenesis and constitute important drug targets. The localization and activity of Ras proteins are highly dependent on posttranslational modifications at their ...
  • C/EBPalpha activates pre-existing and de novo macrophage enhancers during induced pre-B cell transdifferentiation and myelopoiesis
    van Oevelen, Chris; Collombet, Samuel; Vicent, Guillermo Pablo; Hoogenkamp, Maarten; Lepoivre, Cyrille; Badeaux, Aimee; Bussmann, Lars; Sardina, Jose Luis; Thieffry, Denis; Beato, Miguel; Shi, Yang; Bonifer, Constanze; Graf, T. (Thomas) (Elsevier, 2015)
    Transcription-factor-induced somatic cell conversions are highly relevant for both basic and clinical research yet their mechanism is not fully understood and it is unclear whether they reflect normal differentiation ...
  • C/EBPα mediates the growth inhibitory effect of progestins on breast cancer cells
    Nacht, A. Silvina; Ferrari, Roberto; Zaurín Quer, Roser; Scabia, Valentina; Carbonell-Caballero, Jose; Le Dily, François; Quilez Oliete, Javier; Leopoldi, Alexandra; Brisken, Cathrin; Beato, Miguel; Vicent, Guillermo Pablo (EMBO Press, 2019)
    Steroid hormones are key gene regulators in breast cancer cells. While estrogens stimulate cell proliferation, progestins activate a single cell cycle followed by proliferation arrest. Here, we use biochemical and genome-wide ...
  • CAAStools: a toolbox to identify and test Convergent Amino Acid Substitutions
    Barteri, Fabio; Valenzuela, Alejandro; Farré, Xavier; Juan, David; Muntané, Gerard; Esteve Altava, Borja; Navarro i Cuartiellas, Arcadi, 1969- (Oxford University Press, 2023)
    Motivation: Coincidence of Convergent Amino Acid Substitutions (CAAS) with phenotypic convergences allow pinpointing genes and even individual mutations that are likely to be associated with trait variation within their ...
  • Cab45 is required for Ca(2+)-dependent secretory cargo sorting at the trans-Golgi network
    Blume, Julia von; Alleaume, Anne-Marie; Kienzle, Christine; Carreras Sureda, Amado, 1986-; Valverde, M. A. (Miguel Ángel), 1963-; Malhotra, Vivek (Rockefeller University Press, 2012)
    Ca(2+) import into the lumen of the trans-Golgi network (TGN) by the secretory pathway calcium ATPase1 (SPCA1) is required for the sorting of secretory cargo. How is Ca(2+) retained in the lumen of the Golgi, and what is ...
  • Cabbage and fermented vegetables: From death rate heterogeneity in countries to candidates for mitigation strategies of severe COVID-19
    Bousquet, Jean; Antó i Boqué, Josep Maria; Czarlewski, Wienczyslawa; Haahtela, Tari; Fonseca, Susana C.; Iaccarino, Guido; Blain, Hubert; Vidal, Alain; Sheikh, Aziz; Akdis, Cezmi A.; Zuberbier, Torsten; ARIA group (Wiley, 2020)
    Large differences in COVID-19 death rates exist between countries and between regions of the same country. Some very low death rate countries such as Eastern Asia, Central Europe, or the Balkans have a common feature of ...
  • CACNA1A mutations causing early onset ataxia: profiling clinical, dysmorphic and structural-functional findings
    Martínez Monseny, Antonio Federico; Edo, Albert; Casas Alba, Dídac; Izquierdo Serra, Mercè; Bolasell, Mercè; Conejo, David; Martorell, Loreto; Muchart, Jordi; Carrera, Laura; Ortez, Carlos; Nascimento, Andrés; Oliva Miguel, Baldomero; Fernández-Fernández, José Manuel, 1967-; Serrano Masip, Mercedes (MDPI, 2021)
    The CACNA1A gene encodes the pore-forming α1A subunit of the voltage-gated CaV2.1 Ca2+ channel, essential in neurotransmission, especially in Purkinje cells. Mutations in CACNA1A result in great clinical heterogeneity with ...
  • Caenorhabditis elegans processes sensory information to choose between freeloading and self-defense strategies
    Schiffer, Jodie A.; Servello, Francesco A.; Heath, William R.; Amrit, Francis Raj Ghandi; Stumbur, Stephanie V; Eder, Matthias; Martin, Olivier M. F.; Johnsen, Sean B.; Stanley, Julia A.; Tam, Hannah; Brennan, Sara J.; McGowan, Natalie G.; Vogelaar, Abigail L.; Xu, Yuyan; Serkin, William T.; Ghazi, Arjumand; Stroustrup, Nicholas; Apfeld, Javier (eLife, 2020)
    Hydrogen peroxide is the preeminent chemical weapon that organisms use for combat. Individual cells rely on conserved defenses to prevent and repair peroxide-induced damage, but whether similar defenses might be coordinated ...
  • Cafeteria diet induces neuroplastic modifications in the nucleus accumbens mediated by microglia activation
    Gutiérrez Martos, Miriam, 1989-; Girard, Benoît; Mendonça Netto, Sueli; Perroy, Julie; Valjent, Emmanuel; Maldonado, Rafael, 1961-; Martín Sánchez, Miquel, 1971- (Wiley-Blackwell, 2018)
    High-palatable and caloric foods are widely overconsumed due to hedonic mechanisms that prevail over caloric necessities leading to overeating and overweight. The nucleus accumbens (NAc) is a key brain area modulating the ...
  • Calcineurin and mTOR inhibitors have opposing effects on regulatory T cells while reducing regulatory B cell populations in kidney transplant recipients.
    Latorre, Irene; Esteve-Solé, Ana; Redondo Pachón, María Dolores; Giest, Sandra; Argilaguet Marqués, Jordi, 1977-; Álvarez, Sara; Peligero Cruz, Cristina, 1986-; Forstmann, Isabelle; Crespo Barrio, Marta; Pascual Santos, Julio; Meyerhans, Andreas (Elsevier, 2016)
    BACKGROUND: Regulatory B (Breg) and T (Treg) cells represent a biomarker for tolerance in transplant patients. Despite the importance of Treg and Breg in transplantation and the suggested crosstalk between both suppressive ...
  • Calcium supplementation for the prevention of colorectal adenomas: a systematic review and meta-analysis of randomized controlled trials
    Bonovas, Stefanos; Fiorino, Gionata; Lytras, Theodoros, 1987-; Malesci, Alberto; Danese, Silvio (Baishideng Publishing Group, 2016)
    To determine the efficacy of calcium supplementation in reducing the recurrence of colorectal adenomas. We conducted a systematic review and meta-analysis of published studies. We searched PubMed, Scopus, the Cochrane ...
  • Calibrating seed-based heuristics to map short reads with sesame
    Filion, Guillaume; Cortini, Ruggero; Zorita, Eduard (Frontiers, 2020)
    The increasing throughput of DNA sequencing technologies creates a need for faster algorithms. The fate of most reads is to be mapped to a reference sequence, typically a genome. Modern mappers rely on heuristics to gain ...
  • Can digital mobility assessment enhance the clinical assessment of disease severity in Parkinson's disease?
    Kirk, Cameron; Rehman, Rana Zia Ur; Galna, Brook; Alcock, Lisa; Ranciati, Saverio; Palmerini, Luca; García Aymerich, Judith; Hansen, Clint; Schaeffer, Eva; Berg, Daniela; Maetzler, Walter; Rochester, Lynn; Del Din, Silvia; Yarnall, Alison J. (IOS Press, 2023)
    Background: Real-world walking speed (RWS) measured using wearable devices has the potential to complement the Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS III) for motor assessment in ...
  • Can molecular dynamics simulations improve the structural accuracy and virtual screening performance of GPCR models?
    Kapla, Jon; Rodríguez Espigares, Ismael, 1990-; Ballante, Flavio; Selent, Jana; Carlsson, Jens (Public Library of Science (PLoS), 2021)
    The determination of G protein-coupled receptor (GPCR) structures at atomic resolution has improved understanding of cellular signaling and will accelerate the development of new drug candidates. However, experimental ...
  • Can routine primary care records help in detecting suicide risk? A population-based case-control study in Barcelona
    Fradera, Marc; Ouchi, Dan; Prat, Oriol; Morros, Rosa; Martin-Fumadó, Carles; Palao Vidal, Diego J.; Cardoner, Narcís; Campillo, Maria Teresa; Pérez Solá, Victor; Pontes, Caridad (Taylor & Francis, 2022)
    Objectives: To characterize people who died by suicide after having previous contacts with public health system using the data available in a primary care setting. Method: A retrospective, population-based case-control ...
  • Cancer effects of low to moderate doses of ionizing radiation in young people with cancer-predisposing conditions: a systematic review
    Canet, Maelle; Harbron, Richard W.; Thierry-Chef, Isabelle; Cardis, Elisabeth (American Association for Cancer Research (AACR), 2022)
    Moderate to high doses of ionizing radiation (IR) are known to increase the risk of cancer, particularly following childhood exposure. Concerns remain regarding risks from lower doses and the role of cancer-predisposing ...
  • Cancer Genome Interpreter annotates the biological and clinical relevance of tumor alterations
    Tamborero Noguera, David; Rubio Pérez, Carlota, 1990-; Déu Pons, Jordi; Schroeder, Michael Philipp, 1986-; Vivancos Prellezo, Ana; Rovira Guerín, Ana; Tusquets Trias de Bes, Ignacio; Albanell Mestres, Joan; Rodon, Jordi; Tabernero Cartula, Josep; Torres, Carmen de; Dienstmann, Rodrigo; González-Pérez, Abel; López Bigas, Núria (BioMed Central, 2018)
    While tumor genome sequencing has become widely available in clinical and research settings, the interpretation of tumor somatic variants remains an important bottleneck. Here we present the Cancer Genome Interpreter, a ...
  • Cancer LncRNA census reveals evidence for deep functional conservation of long noncoding RNAs in tumorigenesis
    Carlevaro-Fita, Joana; Lanzós, Andrés; Feuerbach, Lars; Hong, Chen; Mas Ponte, David; Pedersen, Jackob S.; PCAWG Drivers and Functional Interpretation Working Group; Johnson, Rory; PCAWG Consortium (Nature Research, 2020)
    Long non-coding RNAs (lncRNAs) are a growing focus of cancer genomics studies, creating the need for a resource of lncRNAs with validated cancer roles. Furthermore, it remains debated whether mutated lncRNAs can drive ...
  • Cancer mortality in an international cohort of reinforced plastics workers exposed to styrene: a reanalysis
    Loomis, Dana; Guha, Neela; Kogevinas, Manolis; Fontana, Vincenzo; Gennaro, Valerio; Kolstad, Henrik A.; McElvenny, Damien Martin; Sallmén, Markku; Saracci, Rodolfo (BMJ Publishing Group, 2019)
    Objective: To investigate the carcinogenicity of styrene by reanalysing data from a previous international cohort study of workers in the reinforced plastics industry. Methods: Mortality from cancers of prior interest was ...

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