Benvinguts al Repositori Digital de la UPF

Visualitzant Articles (Departament de Ciències Experimentals i de la Salut) per data de publicació

Visualitzant Articles (Departament de Ciències Experimentals i de la Salut) per data de publicació

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  • Kalaydjieva, Luba; Gresham, David; Calafell i Majó, Francesc (BioMed Central, 2001)
    Background: Data provided by the social sciences as well as genetic research suggest that the 8-10 million Roma (Gypsies) who live in Europe today are best described as a conglomerate of genetically isolated founder ...
  • Wiehe, Thomas; Gebauer-Jung, Steffi; Mitchell-Olds, Thomas; Guigó Serra, Roderic (Cold Spring Harbor Laboratory Press-CSHL Press, 2001)
    Conventional methods of gene prediction rely on the recognition of DNA-sequence signals, the coding potential or the comparison of a genomic sequence with a cDNA, EST, or protein database. Reasons for limited accuracy in ...
  • Ghozland, Sandy; Matthes, Hans W. D.; Simonin, Frederic; Filliol, Dominique; Kieffer, Brigitte L.; Maldonado, Rafael, 1961- (Society for Neuroscience, 2002)
    Repeated THC administration produces motivational and somatic/nadaptive changes leading to dependence in rodents. To/ninvestigate the molecular basis for cannabinoid dependence/nand its possible relationship with the ...
  • Muñoz López, Francisco José, 1964-; Opazo, Carlos; Gil Gómez, Gabriel; Tapia, Gladys; Fernández, Virginia; Valverde, M. A. (Miguel Ángel), 1963-; Inestrosa, Nibaldo C. (Society for Neuroscience, 2002)
    Amyloid β-peptide (Aβ) fibril deposition on cerebral vessels produces cerebral amyloid angiopathy that appears in the majority of Alzheimer's disease patients. An early onset of a cerebral amyloid angiopathy variant called ...
  • Sunyer Deu, Jordi; Herrero, Carmen; Ozalla, Dolores; Sala, Maria; Ribas Fitó, Núria; Grimalt Obrador, Joan; Basagaña Flores, Xavier (BioMed Central, 2002)
    Background: Porphyria cutanea tarda (PCT) is caused by hexachlorobenzene (HCB) in several species of laboratory mammals, but the human evidence is contradictory. In a study among adults of a population highly exposed to ...
  • Berrendero Díaz, Fernando, 1971-; Kieffer, Brigitte L.; Maldonado, Rafael, 1961- (Society for Neuroscience, 2002)
    The involvement of μ-opioid receptors in different behavioral responses elicited by nicotine was explored by using μ-opioid receptor knock-out mice. The acute antinociceptive responses induced by nicotine in the tail-immersion ...
  • Maldonado, Rafael, 1961-; Rodríguez de Fonseca, Fernando (Society for Neuroscience, 2002)
    The use of cannabis sativa preparations as recreational drugs can be traced back to the earliest civilizations. However, animal models of cannabinoid addiction allowing the exploration of neural correlates of cannabinoid ...
  • Cheung, Joseph; Estivill, Xavier, 1955-; Khaja, Razi; MacDonald, Jeffrey R; Lau, Ken; Tsui, Lap-Chee; Scherer, Stephen W (BioMed Central, 2003)
    Background: Previous studies have suggested that recent segmental duplications, which are often involved in chromosome rearrangements underlying genomic disease, account for some 5% of the human genome. We have developed ...
  • Coma Camprodón, Mireia; Vicente García, Rubén, 1978-; Busquets, Silvia; Carbó, Neus; Tamkun, Michael M.; López Soriano, Francisco J.; Argilés, Josep M.; Felipe, Antonio (Elsevier, 2003)
    Cancer-induced cachexia affects most advanced cancer patients. It is characterized by anorexia, profound metabolic dysfunctions, and severe neurological disorders. Here we show that voltage-gated potassium channel (Kv) ...
  • Parra Farré, Genís; Agarwal, Pankaj; Abril Ferrando, Josep Francesc; Wiehe, Thomas; Fickett, James W.; Guigó Serra, Roderic (Cold Spring Harbor Laboratory Press-CSHL Press, 2003)
    The completion of the sequencing of the mouse genome promises to help predict human genes with greater accuracy. While current ab initio gene prediction programs are remarkably sensitive (i.e., they predict at least a ...
  • Guerra, Carmen; Mijimolle, Nieves; Dhawahir, Alma; Dubus, Pierre; Barradas, Marta; Serrano, Manuel; Campuzano Uceda, María Victoria; Barbacid, Mariano (Elsevier, 2003)
    We have targeted a K-ras allele in mouse embryonic stem (ES) cells to express a K-Ras(V12) oncoprotein along with a marker protein (beta-geo) from a single bicistronic transcript. Expression of this oncogenic allele requires ...
  • Guigó Serra, Roderic (Centre de Supercomputació de Catalunya, 2003)
  • García Martínez, Montse; Schiaffino, Anna; Fernández, Esteve; Martí, Mercè; Saltó i Cerezuela, Esteve; Pérez Albarracín, Glòria; Peris, Mercè; Borrell i Thió, Carme; Nieto, F. Javier; Borràs, Josep M. (BioMed Central, 2003)
    Background: The aim of this report is to describe the main characteristics of the design, including response rates, of the Cornella Health Interview Survey Follow-up Study. Methods: The original cohort consisted of 2,500 ...
  • Huang, Hui; Winter, Eitan E; Wang, Huajun; Weinstock, Keith G; Xing, Heming; Goodstadt, Leo; Stenson, Peter D; Cooper, David N; Smith, Douglas; Albà Soler, Mar; Ponting, Chris P; Fechtel, Kim (BioMed Central, 2004)
    Background: Model organisms have contributed substantially to our understanding of the etiology of human disease as well as having assisted with the development of new treatment modalities. The availability of the human, ...
  • Fernández-Fernández, José Manuel, 1967-; Tomás Mestres, Marta; Vázquez Gómez, Esther; Orio, Patricio; Latorre, Ramón; Sentí Clapés, Mariano; Marrugat de la Iglesia, Jaume; Valverde, M. A. (Miguel Ángel), 1963- (American Society for Clinical Investigation, 2004)
    Hypertension is the most prevalent risk factor for cardiovascular diseases, present in almost 30% of adults. A key element in the control of vascular tone is the large-conductance, Ca(2+)-dependent K(+) (BK) channel. The ...
  • Imanishi, Tadashi; Eyras Jiménez, Eduardo; Sugano, Sumio (Public Library of Science (PLoS), 2004)
    The human genome sequence defines our inherent biological potential; the realization of the biology encoded therein requires knowledge of the function of each gene. Currently, our knowledge in this area is still limited. ...
  • Vicente García, Rubén, 1978-; Coma Camprodón, Mireia; Busquets, Silvia; Moore Carrasco, Rodrigo; López Soriano, Francisco J.; Argilés, Josep M.; Felipe, Antonio (Elsevier, 2004)
    TNF-alpha, generated during the systemic inflammatory response, triggers a wide range of biological activities that mediate the neurologic manifestations associated with cancer and infection. Since this cytokine regulates ...
  • Albà Soler, Mar; Guigó Serra, Roderic (Cold Spring Harbor Laboratory Press-CSHL Press, 2004)
    Amino acid tandem repeats, also called homopolymeric tracts, are extremely abundant in eukaryotic proteins. To gain insight into the genome-wide evolution of these regions in mammals, we analyzed the repeat content in a ...
  • Fiz, José Antonio; Jané, Raimon; Torres, Abel; Morera, Josep; Galdiz, Batxi; Gea Guiral, Joaquim; Grassino, Alejandro (BioMed Central, 2004)
    Background: Non-invasive monitoring of respiratory muscle function is an area of increasing research interest, resulting in the appearance of new monitoring devices, one of these being piezoelectric contact sensors. The ...
  • González Neira, Anna; Calafell i Majó, Francesc; Navarro i Cuartiellas, Arcadi, 1969-; Lao Grueso, Oscar, 1976-; Cann, Howard M.; Comas, David, 1969-; Bertranpetit, Jaume, 1952- (BioMed Central, 2004)
    Recent studies of haplotype diversity in a number of genomic regions have suggested that long stretches of DNA are preserved in the same chromosome, with little evidence of recombination events. The knowledge of the extent ...