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Browsing Articles (Departament de Ciències Experimentals i de la Salut) by Title

Browsing Articles (Departament de Ciències Experimentals i de la Salut) by Title

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  • Pineda, Silvia; Milne, Roger L.; Calle, M. Luz; Rothman, Nathaniel; López De Maturana, Evangelina; Herranz, Jesús; Kogevinas, Manolis; Chanock, Stephen J.; Tardón, Adonina; Márquez, Mirari; Guey, Lin T.; García Closas, Montserrat; Lloreta Trull, Josep, 1958-; Baum, Erin; González Neira, Anna; Carrato, Alfredo; Navarro i Cuartiellas, Arcadi, 1969-; Silverman, Debra T.; Real, Francisco X.; Malats i Riera, Núria (Public Library of Science (PLoS), 2014)
    Introduction: Germline variants in TP63 have been consistently associated with several tumors, including bladder cancer, indicating the importance of TP53 pathway in cancer genetic susceptibility. However, variants in other ...
  • Robledo, Patricia, 1958-; Martín García, Elena, 1975-; Aso Pérez, Ester; Maldonado, Rafael, 1961- (Bentham Science Publishers, 2014)
    The pathophysiological mechanisms underlying depression are still poorly understood. An initial hypothesis postulated to explain the substrates of depression was based on the involvement of monoaminergic systems. This early ...
  • Gebauer, Fátima; Hentze, Matthias W. (American Association for the Advancement of Science (AAAS), 2016)
    Comment on Comparative genetics. Systematic discovery of cap-independent translation sequences in human and viral genomes. [Science. 2016]
  • Vlasova, Anna; Capella Gutiérrez, Salvador Jesús, 1985-; Erb, Ionas; Cámara, Francisco; Prieto Barja, Pablo, 1986-; Kedra, Darek; González Navarrete, Irene, 1983-; Cozzuto, Luca; Gómez Garrido, Jèssica; Aguilar Morón, María A.; Andreu Somavilla, Núria; Zehnsdorf, Maik; Alioto, Tyler; Notredame, Cedric; Gabaldón Estevan, Juan Antonio, 1973-; Guigó Serra, Roderic (BioMed Central, 2016)
    Background: Legumes are the third largest family of angiosperms and the second most important crop class. Legume genomes have been shaped by extensive large-scale gene duplications, including an approximately 58 million ...
  • Pryszcz, Leszek Piotr, 1985-; Németh, Tibor; Gácser, Attila; Gabaldón Estevan, Juan Antonio, 1973- (Oxford University Press, 2014)
    The Candida parapsilosis species complex comprises a group of emerging human pathogens of varying virulence. This complex was recently subdivided into three different species: C. parapsilosis sensu stricto, C. metapsilosis, ...
  • Carreté Muñoz, Laia, 1990-; Ksiezopolska, Ewa; Gómez-Molero, Emilia; Angoulvant, Adela; Bader, Olivier; Fairhead, Cécile; Gabaldón Estevan, Juan Antonio, 1973- (Frontiers, 2019)
    Candida glabrata is an opportunistic fungal pathogen that currently ranks as the second most common cause of candidiasis. Although the mechanisms underlying virulence and drug resistance in C. glabrata are now starting to ...
  • Cruz, Fernando; Julca, Irene; Gómez Garrido, Jèssica; Loska, Damian; Marcet Houben, Marina; Cano, Emilio; Galán Sicilia, Beatriz; Frias, Leonor; Ribeca, Paolo; Derdak, Sophia; Gut, Marta; Sánchez Fernández, Manuel; García, Jose Luis; Gut, Ivo Glynne; Vargas Gómez, Pablo; Alioto, Tyler; Gabaldón Estevan, Juan Antonio, 1973- (BioMed Central, 2016)
    Background: The Mediterranean olive tree (Olea europaea subsp. europaea) was one of the first trees to be domesticated and is currently of major agricultural importance in the Mediterranean region as the source of olive ...
  • Freedman, Adam H; Lorente-Galdós, Belén, 1981-; Ramírez, Oscar; Marquès i Bonet, Tomàs, 1975-; Novembre, John (Public Library of Science (PLoS), 2014)
    To identify genetic changes underlying dog domestication and reconstruct their early evolutionary history, we generated high-quality genome sequences from three gray wolves, one from each of the three putative centers of ...
  • Ballester, Ana Rosa; Marcet Houben, Marina; Levin, Elena; Sela, Noa; Selma Lázaro, Cristina; Carmona, Lourdes; Wisniewski, Michael; Droby, Samir; González Candelas, Luis; Gabaldón Estevan, Juan Antonio, 1973- (APS Press, 2015)
    The relationship between secondary metabolism and infection in pathogenic fungi has remained largely elusive. The genus Penicillium comprises a group of plant pathogens with varying host specificities and with the ability ...
  • Ecker, Simone; Merkel, Angelika; BLUEPRINT Consortium; Paul, Dirk S. (BioMed Central, 2017)
    Background: A healthy immune system requires immune cells that adapt rapidly to environmental challenges. This phenotypic plasticity can be mediated by transcriptional and epigenetic variability. Results: We apply a novel ...
  • Santpere Baró, Gabriel, 1981-; Darre, Fleur; Blanco, Soledad; Alcami, Antonio; Villoslada, Pablo; Albà Soler, Mar; Navarro i Cuartiellas, Arcadi, 1969- (Oxford University Press, 2014)
    Most people in the world (∼90%) are infected by the Epstein–Barr virus (EBV), which establishes itself permanently in B cells. Infection by EBV is related to a number of diseases including infectious mononucleosis, multiple ...
  • Beshiri, Michael L.; Islam, Abul, 1978-; DeWaal, Dannielle C.; Richter, William F.; Love, Jennifer; López Bigas, Núria; Benevolenskaya, Elizaveta V. (MYJoVE Corporation, 2010)
    Recruitment of transcriptional and epigenetic factors to their targets is a key step in their regulation. Prominently featured in recruitment are the protein domains that bind to specific histone modifications. One such ...
  • Fadhlaoui-Zid, Karima; Haber, Marc, 1980-; Martínez Cruz, Begoña; Zalloua, Pierre A.; Elgaaied, Amel Benammar; Comas, David, 1969- (Public Library of Science (PLoS), 2013)
    The geostrategic location of North Africa as a crossroad between three continents and as a stepping-stone outside Africa has evoked anthropological and genetic interest in this region. Numerous studies have described the ...
  • Corvelo, André; Hallegger, Martina; Smith, Christopher, W. J.; Eyras Jiménez, Eduardo (Public Library of Science (PLoS), 2010)
    The branch point (BP) is one of the three obligatory signals required for pre-mRNA splicing. In mammals, the degeneracy of the motif combined with the lack of a large set of experimentally verified BPs complicates the task ...
  • Rosendahl, Jonas; Real, Francisco X.; Sahin-Tóth, Miklós (BMJ Publishing Group, 2018)
    Objective: Alcohol-related pancreatitis is associated with a disproportionately large number of hospitalisations among GI disorders. Despite its clinical importance, genetic susceptibility to alcoholic chronic pancreatitis ...
  • Beaumont, Robin N.; Espinosa Díaz, Ana; Kogevinas, Manolis; Estivill, Xavier, 1955- (Oxford University Press, 2018)
    Genome-wide association studies of birth weight have focused on fetal genetics, whereas relatively little is known about the role of maternal genetic variation. We aimed to identify maternal genetic variants associated ...
  • Jerković, Ivana; Ibrahim, Daniel Murad; Andrey, Guillaume; Haas, Stefan A.; Hansen, Peter; Janetzki, Catrin; González Navarrete, Irene, 1983-; Robinson, Peter N.; Hecht, Jochen; Mundlos, Stefan (Public Library of Science (PLoS), 2017)
    Homeotic genes code for key transcription factors (HOX-TFs) that pattern the animal body plan. During embryonic development, Hox genes are expressed in overlapping patterns and function in a partially redundant manner. In ...
  • Marenne, Gaëlle; Real, Francisco X.; Rothman, Nathaniel; Rodríguez Santiago, Benjamín; Pérez Jurado, Luis Alberto; Kogevinas, Manolis; García Closas, Montserrat; Silverman, Debra T.; Chanock, Stephen J.; Génin, Emmanuelle; Malats i Riera, Núria (BioMed Central, 2012)
    BACKGROUND: Structural variations such as copy number variants (CNV) influence the expression of different phenotypic traits. Algorithms to identify CNVs through SNP-array platforms are available. The ability to evaluate ...
  • Cheung, Joseph; Estivill, Xavier, 1955-; Khaja, Razi; MacDonald, Jeffrey R; Lau, Ken; Tsui, Lap-Chee; Scherer, Stephen W. (BioMed Central, 2003)
    Background: Previous studies have suggested that recent segmental duplications, which are often involved in chromosome rearrangements underlying genomic disease, account for some 5% of the human genome. We have developed ...
  • Haber, Marc, 1980-; Gauguier, Dominique; Youhanna, Sonia; Patterson, Nick; Moorjani, Priya; Botigué, Laura R; Platt, Daniel E.; Matisoo Smith, Elizabeth; Soria Hernanz, David F; Wells, R. Spencer; Bertranpetit, Jaume, 1952-; Tyler-Smith, Chris; Comas, David, 1969-; Zalloua, Pierre A. (Public Library of Science (PLoS), 2013)
    The Levant is a region in the Near East with an impressive record of continuous human existence and major cultural developments since the Paleolithic period. Genetic and archeological studies present solid evidence placing ...

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