Benvinguts al Repositori Digital de la UPF

Visualitzant Articles (Departament de Ciències Experimentals i de la Salut) per títol

Visualitzant Articles (Departament de Ciències Experimentals i de la Salut) per títol

Ordena per: Ordre: Resultats:

  • Santpere Baró, Gabriel, 1981-; Darre, Fleur; Blanco, Soledad; Alcami, Antonio; Villoslada, Pablo; Albà Soler, Mar; Navarro i Cuartiellas, Arcadi, 1969- (Oxford University Press, 2014)
    Most people in the world (∼90%) are infected by the Epstein–Barr virus (EBV), which establishes itself permanently in B cells. Infection by EBV is related to a number of diseases including infectious mononucleosis, multiple ...
  • Beshiri, Michael L.; Islam, Abul, 1978-; DeWaal, Dannielle C.; Richter, William F.; Love, Jennifer; López Bigas, Núria; Benevolenskaya, Elizaveta V. (MYJoVE Corporation, 2010)
    Recruitment of transcriptional and epigenetic factors to their targets is a key step in their regulation. Prominently featured in recruitment are the protein domains that bind to specific histone modifications. One such ...
  • Fadhlaoui-Zid, Karima; Haber, Marc, 1980-; Martínez Cruz, Begoña; Zalloua, Pierre A.; Elgaaied, Amel Benammar; Comas, David, 1969- (Public Library of Science (PLoS), 2013)
    The geostrategic location of North Africa as a crossroad between three continents and as a stepping-stone outside Africa has evoked anthropological and genetic interest in this region. Numerous studies have described the ...
  • Corvelo, André; Hallegger, Martina; Smith, Christopher, W. J.; Eyras Jiménez, Eduardo (Public Library of Science (PLoS), 2010)
    The branch point (BP) is one of the three obligatory signals required for pre-mRNA splicing. In mammals, the degeneracy of the motif combined with the lack of a large set of experimentally verified BPs complicates the task ...
  • Rosendahl, Jonas; Real, Francisco X.; Sahin-Tóth, Miklós (BMJ Publishing Group, 2018)
    Objective: Alcohol-related pancreatitis is associated with a disproportionately large number of hospitalisations among GI disorders. Despite its clinical importance, genetic susceptibility to alcoholic chronic pancreatitis ...
  • Beaumont, Robin N.; Espinosa Díaz, Ana; Kogevinas, Manolis; Estivill, Xavier, 1955- (Oxford University Press, 2018)
    Genome-wide association studies of birth weight have focused on fetal genetics, whereas relatively little is known about the role of maternal genetic variation. We aimed to identify maternal genetic variants associated ...
  • Jerković, Ivana; Ibrahim, Daniel Murad; Andrey, Guillaume; Haas, Stefan A.; Hansen, Peter; Janetzki, Catrin; González Navarrete, Irene, 1983-; Robinson, Peter N.; Hecht, Jochen; Mundlos, Stefan (Public Library of Science (PLoS), 2017)
    Homeotic genes code for key transcription factors (HOX-TFs) that pattern the animal body plan. During embryonic development, Hox genes are expressed in overlapping patterns and function in a partially redundant manner. In ...
  • Marenne, Gaëlle; Real, Francisco X.; Rothman, Nathaniel; Rodríguez Santiago, Benjamín; Pérez Jurado, Luis Alberto; Kogevinas, Manolis; García Closas, Montserrat; Silverman, Debra T.; Chanock, Stephen J.; Génin, Emmanuelle; Malats i Riera, Núria (BioMed Central, 2012)
    BACKGROUND: Structural variations such as copy number variants (CNV) influence the expression of different phenotypic traits. Algorithms to identify CNVs through SNP-array platforms are available. The ability to evaluate ...
  • Cheung, Joseph; Estivill, Xavier, 1955-; Khaja, Razi; MacDonald, Jeffrey R; Lau, Ken; Tsui, Lap-Chee; Scherer, Stephen W. (BioMed Central, 2003)
    Background: Previous studies have suggested that recent segmental duplications, which are often involved in chromosome rearrangements underlying genomic disease, account for some 5% of the human genome. We have developed ...
  • Haber, Marc, 1980-; Gauguier, Dominique; Youhanna, Sonia; Patterson, Nick; Moorjani, Priya; Botigué, Laura R; Platt, Daniel E.; Matisoo Smith, Elizabeth; Soria Hernanz, David F; Wells, R. Spencer; Bertranpetit, Jaume, 1952-; Tyler-Smith, Chris; Comas, David, 1969-; Zalloua, Pierre A. (Public Library of Science (PLoS), 2013)
    The Levant is a region in the Near East with an impressive record of continuous human existence and major cultural developments since the Paleolithic period. Genetic and archeological studies present solid evidence placing ...
  • Morales, Eva; Vilahur Chiaraviglio, Nadia, 1982-; Salas Díaz, Lucas Andrés, 1980-; Motta, Valeria; Fernandez, Mariana F.; Murcia, Mario; Llop, Sabrina; Tardón, Adonina; Fernandez-Tardon, Guillermo; Santa Marina, Loreto; Gallastegui, Mara; Bollati, Valentina; Estivill, Xavier, 1955-; Olea, Nicolás; Sunyer Deu, Jordi; Bustamante Pineda, Mariona (Oxford University Press, 2016)
    BACKGROUND: We conducted an epigenome-wide association study (EWAS) of DNA methylation in placenta in relation to maternal tobacco smoking during pregnancy and examined whether smoking-induced changes lead to low birthweight. ...
  • Savol, Andrej J.; Wang, Peggy I.; Jeon, Yesu; Colognori, David; Yildirim, Eda; Pinter, Stefan F.; Payer, Bernhard, 1975-; Lee, Jeannie T.; Sadreyev, Ruslan Ilyasovich (Public Library of Science (PLoS), 2017)
    In mammals, monoallelic gene expression can result from X-chromosome inactivation, genomic imprinting, and random monoallelic expression (RMAE). Epigenetic regulation of RMAE is not fully understood. Here we analyze allelic ...
  • Klein, Alison P.; Real, Francisco X.; Amundadottir, Laufey T. (Nature Publishing Group, 2018)
    In 2020, 146,063 deaths due to pancreatic cancer are estimated to occur in Europe and the United States combined. To identify common susceptibility alleles, we performed the largest pancreatic cancer GWAS to date, including ...
  • Yin, Xianyong; Estivill, Xavier, 1955-; Liu, Jianjun (Nature Publishing Group, 2015)
    Psoriasis is a common inflammatory skin disease with complex genetics and different degrees of prevalence across ethnic populations. Here we present the largest trans-ethnic genome-wide meta-analysis (GWMA) of psoriasis ...
  • Bofill-De Ros, Xavier; Santos, Mónica; Vila-Casadesús, Maria; Villanueva, Eneko; Andreu Somavilla, Núria; Dierssen, Mara; Fillat i Fonts, Cristina (BioMed Central, 2015)
    Background. Down syndrome (DS) or trisomy 21 is the result of a genetic dosage imbalance that translates in a broad clinical spectrum. A major challenge in the study of DS is the identification of functional genetic elements ...
  • Aterido, Adrià; Julià, Antonio; Ferrándiz, Carlos; Puig, Lluís; Fonseca Capdevila, Eduardo; Fernández-López, Emilia; Dauden, Esteban; Sánchez-Carazo, José Luís; López-Estebaranz, José Luís; Moreno-Ramírez, David; Vanaclocha, Francisco; Herrera, Enrique; Cueva, Pablo de la; Dand, Nick; Palau, Núria; Alonso, Arnald; López-Lasanta, María; Tortosa, Raül; García-Montero, Andrés; Codó, Laia; Gelpí, Josep Lluís; Bertranpetit, Jaume, 1952-; Absher, Devin; Capon, Francesca; Myers, Richard M.; Barker, Jonathan N.; Marsal, Sara (Elsevier, 2016)
    Psoriasis is a chronic inflammatory disease with a complex genetic architecture. To date, the psoriasis heritability is only partially explained. However, there is increasing evidence that the missing heritability in ...
  • Calvo, Isabel A.; Gabrielli, Natalia, 1978-; Iglesias Baena, Iván; García Santamarina, Sarela, 1978-; Hoe, Kwang-Lae; Kim, Dong Uk; Sansó Martínez, Miriam, 1979-; Zuin, Alice, 1978-; Pérez, Pilar; Ayté del Olmo, José; Hidalgo Hernando, Elena (Public Library of Science (PLoS), 2009)
    Background: An excess of caffeine is cytotoxic to all eukaryotic cell types. We aim to study how cells become tolerant to a/ntoxic dose of this drug, and the relationship between caffeine and oxidative stress pathways./n ...
  • García Rodríguez, Patricia; Encinar del Dedo, Javier; Ayté del Olmo, José; Hidalgo Hernando, Elena (American Society for Biochemistry and Molecular Biology (ASBMB), 2016)
    In response to environmental cues, the mitogen-activated protein kinase Sty1-driven signaling cascade activates hundreds of genes to induce a robust anti-stress cellular response in fission yeast. Thus, upon stress imposition ...
  • Sadd, Ben M.; Cámara, Francisco; Guigó Serra, Roderic; Mariotti, Marco, 1984-; Santesmasses Ruiz, Didac, 1978-; Worley, Kim C. (BioMed Central, 2015)
    BACKGROUND: The shift from solitary to social behavior is one of the major evolutionary transitions. Primitively eusocial bumblebees are uniquely placed to illuminate the evolution of highly eusocial insect societies. ...
  • Mattle-Greminger, Maja P.; Bilgin Sonay, Tugce; Nater, Alexander; Pybus Oliveras, Marc, 1985-; Desai, Tariq; de Valles-Ibáñez, Guillem; Casals López, Ferran; Scally, Aylwyn; Bertranpetit, Jaume, 1952-; Marquès i Bonet, Tomàs, 1975-; Van Schaik, Carel P.; Anisimova, Maria; Krützen, Michael (BioMed Central, 2018)
    Background: Integrating demography and adaptive evolution is pivotal to understanding the evolutionary history and conservation of great apes. However, little is known about the adaptive evolution of our closest relatives, ...