Benvinguts al Repositori Digital de la UPF

Visualitzant Articles (Departament de Ciències Experimentals i de la Salut) per títol

Visualitzant Articles (Departament de Ciències Experimentals i de la Salut) per títol

Ordena per: Ordre: Resultats:

  • Tilgner, Hagen, 1980-; Knowles, David G.; Johnson, Rory; Davis, Carrie A.; Chakrabortty, Sudipto; Djebali, Sarah; Curado, Joao; Snyder, Michael; Gingeras, Thomas R.; Guigó Serra, Roderic (Cold Spring Harbor Laboratory Press (CSHL Press), 2012)
    Splicing remains an incompletely understood process. Recent findings suggest that chromatin structure participates in its regulation. Here, we analyze the RNA from subcellular fractions obtained through RNA-seq in the cell ...
  • Sabbaghi Mehrjardi, Mohammad Ali; Gil Gómez, Gabriel; Guardia Laguarta, Cristina; Servitja Tormo, Sonia; Arpí Llucià, Oriol; Menendez Romero, Silvia; Arumí, Montserrat; Serrano, Laia; Salido Galeote, Marta; Muntasell i Castellví, Aura, 1972-; Martínez-García, Maria; Tusquets, Ignasi; Rovira Guerín, Ana; Albanell Mestres, Joan (American Association for Cancer Research (AACR), 2017)
    Purpose: Trastuzumab-emtansine (T-DM1) is a standard treatment in advanced HER2-positive breast cancer. However, resistance inevitably occurs. We aimed to identify mechanisms of acquired T-DM1 resistance.Experimental Design: ...
  • Argente, Jesús; Flores, Raquel; Gutiérrez Arumí, Armand; Verma, Bhupendra; Martos Moreno, Gabriel Á; Cuscó Martí, Ivon, 1973-; Oghabian, Ali; Chowen, Julie A.; Frilander, Mikko J; Pérez Jurado, Luis Alberto (Wiley-VCH Verlag, 2014)
    The molecular basis of a significant number of cases of isolated growth hormone deficiency remains unknown. We describe three sisters affected with severe isolated growth hormone deficiency and pituitary hypoplasia caused ...
  • Trussart, Marie, 1985-; Yus, Eva; Martínez, Sira; Baù, Davide; Tahara, Yuhei O.; Pengo, Thomas; Widjaja, Michael; Kretschmer, Simon; Swoger, Jim; Djordjevic, Steven P.; Turnbull, Lynne; Whitchurch, Cynthia B.; Miyata, Makoto; Martí Renom, Marc A.; Lluch-Senar, Maria 1982-; Serrano Pubull, Luis, 1982- (Nature Publishing Group, 2017)
    DNA-binding proteins are central regulators of chromosome organization; however, in genome-reduced bacteria their diversity is largely diminished. Whether the chromosomes of such bacteria adopt defined three-dimensional ...
  • Lluch-Senar, Maria 1982-; Delgado, Javier; Chen, Wei-Hua; Lloréns Rico, Verónica, 1989-; O’Reilly, Francis J.; Wodke, Judith A.H.; Unal, E. Besray; Yus, Eva; Martínez, Sira; Nichols, Robert J.; Ferrar, Tony; Vivancos Prellezo, Ana; Schmeisky, Arne; Stülke, Jörg; Noort, Vera van; Gavin, Anne-Claude; Bork, Peer; Serrano Pubull, Luis, 1982- (Wiley Blackwell, 2015)
    Identifying all essential genomic components is critical for the assembly of minimal artificial life. In the genome-reduced bacterium Mycoplasma pneumoniae, we found that small ORFs (smORFs; < 100 residues), accounting for ...
  • Hernández Acosta, Astrid; Baños i Díez, Josep Eladi; Llop, Cristina; Farré Albaladejo, Magí (Public Library of Science (PLoS), 2014)
    Aim: Lack of knowledge concerning the nature of placebo and why it is necessary may influence the participation of patients in clinical trials. The objective of the present study is to review how placebo is described in ...
  • Fontanillas, Eric; E. Hood, Michael; Badouin, Hélène; Petit, Elsa; Barbe, Valérie; Gouzy, Jérôme; Vienne, Damien M. de; Aguileta, Gabriela; Poulain, Julie; Wincker, Patrick; Chen, Zehua; Toh, Su San; Cuomo, Christina A.; Perlin, Michael H.; Gladieux, Pierre; Giraud, Tatiana (Oxford University Press, 2015)
    Dimorphic mating-type chromosomes in fungi are excellent models for understanding the genomic consequences of recombination suppression. Their suppressed recombination and reduced effective population size are expected to ...
  • Agustín Pavón, Carmen; Mielcarek, Michael; Garriga-Canut, Mireia; Isalan, Mark (BioMed Central, 2016)
    BACKGROUND: Synthetic zinc finger (ZF) proteins can be targeted to desired DNA sequences and are useful tools for gene therapy. We recently developed a ZF transcription repressor (ZF-KOX1) able to bind to expanded DNA ...
  • Álvarez Lerma, Francisco; Marin Corral, Judith; Vila, Clara; Masclans Enviz, Joan Ramon; González de Molina, Francisco Javier; Martín Loeches, Ignacio; Barbadillo, Sandra; Rodríguez, Alejandro; H1N1 GETGAG/SEMICYUC Study Group (BioMed Central, 2016)
    Background: Patients infected with influenza A (H1N1)pdm09 virus requiring admission to the ICU remain an important source of mortality during the influenza season. The objective of the study was to assess the impact of a ...
  • Aso Pérez, Ester; Maldonado, Rafael, 1961-; Murtra, Patricia; Balerio, Graciela N.; Berrendero Díaz, Fernando, 1971- (Wiley-Blackwell, 2004)
    The possible interactions between Delta9-tetrahydrocannabinol (THC) and nicotine remain unclear in spite of the current association of cannabis and tobacco in humans. The aim of the present study was to explore the ...
  • Salgado Mendialdúa, Victòria; Aguirre Plans, Joaquim; Guney, Emre; Reig-Viader, Rita; Maldonado, Rafael, 1961-; Bayés, Angels; Oliva Miguel, Baldomero; Ozaita Mintegui, Andrés, 1969- (Elsevier, 2018)
    Cannabis is the most consumed illicit drug worldwide. Its principal psychoactive component, Δ9-tetrahydrocannabinol (THC), affects multiple brain functions, including cognitive performance, by modulating cannabinoid type-1 ...
  • Perera, Gayan; Pedersen, Lars; Ansel, David; Alexander, Myriam; Arrighi, H. Michael; Avillach, Paul; Foskett, Nadia; Gini, Rosa; Gordon, Mark F.; Gungabissoona, Usha; Mayer, Miguel Ángel, 1960-; Novak, Gerald; Rijnbeek, Peter; Trifirò, Gianluca; van der Lei, Johan; Visser, Pieter J.; Stewart, Robert (Elsevier, 2018)
    INTRODUCTION: The European Medical Information Framework consortium has assembled electronic health record (EHR) databases for dementia research. We calculated dementia prevalence and incidence in 25 million persons from ...
  • Lobón, Irene; Tucci, Serena; de Manuel, Marc; Ghirotto, Silvia; Benazzo, Andrea; Prado Martínez, Javier, 1987-; Lorente-Galdós, Belén, 1981-; Nam, Kiwoong; Dabad, Marc; Hernández Rodríguez, Jéssica, 1983-; Comas, David, 1969-; Navarro i Cuartiellas, Arcadi, 1969-; Schierup, Mikkel H.; Andrés Morán, Aida; Barbujani, Guido; Hvilsom, Christina; Marquès i Bonet, Tomàs, 1975- (Oxford University Press, 2016)
    The genus Pan is the closest genus to our own and it includes two species, Pan paniscus (bonobos) and Pan troglodytes (chimpanzees). The later is constituted by four subspecies, all highly endangered. The study of the Pan ...
  • Freedman, Adam H.; Lorente-Galdós, Belén, 1981-; Ramírez, Oscar; Novembre, John (Public Library of Science (PLoS), 2016)
    Controlling for background demographic effects is important for accurately identifying loci that have recently undergone positive selection. To date, the effects of demography have not yet been explicitly considered when ...
  • Soria, Ivana; Quattrocchi, Valeria; Langellotti, Cecilia; Gammella, Mariela; Digiacomo Sebastian; Garcia de la Torre, Beatriz; Andreu Martínez, David; Montoya, Maria; Sobrino, Francisco; Blanco, Esther; Zamorano, Patricia (Public Library of Science (PLoS), 2017)
    Foot-and-mouth disease virus (FMDV) causes a highly contagious disease in cloven-hoofed animals. A synthetic vaccine candidate consisting of dendrimeric peptides harbouring two copies of a B-epitope [VP1(136–154)] linked ...
  • Dueñas-Espín, Iván, 1979-; Demeyer, Heleen; Gimeno Santos, Elena, 1980-; Polkey, Michael I.; Hopkinson, Nicholas S.; Rabinovich, Roberto A.; Dobbels, Fabienne; Karlsson, Niklas; Troosters, Thierry; García Aymerich, Judith (Dove Medical Press, 2016)
    BACKGROUND: The role of anxiety and depression in the physical activity (PA) of patients with COPD is controversial. We prospectively assessed the effect of symptoms of anxiety and depression on PA in COPD patients. METHODS: ...
  • Rodríguez Pizà, Ignasi; Raya Chamorro, Ángel; Aran, Begoña; Veiga, Anna; Izpisúa Belmonte, J. C.; Barri, Pere N.; Muñoz, Yolanda; Consiglio, Antonella (Springer, 2010)
    We report here the legislative issues related to/nembryo research and human embryonic stem cell (hESC)/nresearch in Spain and the derivation of nine hESC lines at/nthe Center of Regenerative Medicine in Barcelona. You ...
  • Hampel, K.G.; Rocamora Zúñiga, Rodrigo Alberto; Quesada, C.M. (Elsevier, 2017)
    INTRODUCTION: Sudden unexpected death in epilepsy (SUDEP) is the most frequent cause of premature death in epileptic patients. Most SUDEP events occur at night and frequently go unnoticed; the exact pathophysiological ...
  • Stafoggia, Massimo; Basagaña Flores, Xavier; Forastiere, Francesco; MED-PARTICLES Study Group (National Institute of Environmental Health Sciences, 2016)
    BACKGROUND: Evidence on the association between short-term exposure to desert dust and health outcomes is controversial. OBJECTIVES: We aimed to estimate the short-term effects of particulate matter ≤ 10 μm (PM10) on ...
  • Muiños Gimeno, Margarita; Montfort, Magda; Bayés, Mònica; Estivill, Xavier, 1955-; Espinosa Parrilla, Yolanda (Nature Publishing Group, 2010)
    MicroRNAs (miRNA) are recognized posttranscriptional gene repressors involved in the control of almost every biological process. Allelic variants in these regions may be an important source of phenotypic diversity and ...