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Browsing Articles (Departament de Ciències Experimentals i de la Salut) by Title

Browsing Articles (Departament de Ciències Experimentals i de la Salut) by Title

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  • Martínez-Useros, Javier; Georgiev Hristov, Tihomir; Fernández Aceñero, María Jesús; Borrero-Palacios, Aurea; Indacochea Cusirramos, Alberto; Guerrero Jijon, Santiago Xavier; Li, Weiyao; Cebrián, Arancha; del Pulgar, Teresa Gómez; Puime Otín, Alberto; Puerto Nevado, Laura del; Rodríguez Remírez, María; Pérez, Núria; Celdrán Uriarte, Ángel; Gebauer, Fátima; García-Foncillas, Jesús (Public Library of Science (PLoS), 2017)
    Pancreatic ductal adenocarcinoma is an aggressive form of pancreatic cancer and the fourth leading cause of cancer-related death. When possible, curative approaches are based on surgical resection, though not every patient ...
  • Wurth, Laurence; Papasaikas, Panagiotis; Olmeda, David; Bley, Nadine; Calvo, Guadalupe T.; Guerrero Jijon, Santiago Xavier; Cerezo-Wallis, Daniela; Martínez-Useros, Javier; García-Fernández, María; Hüttelmaier, Stefan; Soengas, María S.; Gebauer, Fátima (Elsevier, 2016)
    RNA binding proteins (RBPs) modulate cancer progression through poorly understood mechanisms. Here we show that the RBP UNR/CSDE1 is overexpressed in melanoma tumors and promotes invasion and metastasis. iCLIP sequencing, ...
  • Agraz-Doblas, Antonio; Bueno, Clara; Bashford-Rogers, Rachael; Roy, Anindita; Schneider, Pauline; Bardini, Michela; Ballerini, Paola; Cazzaniga, Gianni; Moreno, Thaidy; Revilla, Carlos; Gut, Marta; Valsecchi, Maria G.; Roberts, Irene; Pieters, Rob; De Lorenzo, Paola; Varela, Ignacio; Menéndez, Pablo; Stam, Ronald W. (Ferrata Storti Foundation, 2019)
    B-cell acute lymphoblastic leukemia is the commonest childhood cancer. In infants, B-cell acute lymphoblastic leukemia remains fatal, especially in patients with t(4;11), present in ~80% of cases. The pathogenesis of ...
  • Ullastres, Anna; Farré, Marta; Capilla, Laia; Ruiz Herrera, Aurora (BioMed Central, 2014)
    Background: By reshuffling genomes, structural genomic reorganizations provide genetic variation on which natural selection can work. Understanding the mechanisms underlying this process has been a long-standing question ...
  • Miravet Verde, Samuel; Ferrar, Tony; Espadas, Guadalupe; Mazzolini, Rocco; Gharrab, Anas; Sabidó Aguadé, Eduard, 1981-; Serrano Pubull, Luis, 1982-; Lluch-Senar, Maria 1982- (Wiley Open Access, 2019)
    Identification of small open reading frames (smORFs) encoding small proteins (≤ 100 amino acids; SEPs) is a challenge in the fields of genome annotation and protein discovery. Here, by combining a novel bioinformatics tool ...
  • Durán, Elisa; Djebali, Sarah; González, Santi; Flores, Oscar; Mercader Bigas, Josep Maria; Guigó Serra, Roderic; Torrents, David; Soler López, Montserrat; Orozco, Modesto (Oxford University Press, 2013)
    Although protein recognition of DNA motifs in promoter regions has been traditionally considered as a critical regulatory element in transcription, the location of promoters, and in particular transcription start sites ...
  • Raguz Nakin, Zrinka; Seisenbacher, Gerhard; Posas Garriga, Francesc; Sauer, Uwe (BioMed Central, 2016)
    Background: Coordinated through a complex network of kinases and phosphatases, protein phosphorylation regulates essentially all cellular processes in eukaryotes. Recent advances in proteomics enable detection of thousands ...
  • Valls, Gabriela; Codina, Montserrat; Miller, Rachel K.; Valle Pérez, Beatriz del; Vinyoles, Meritxell; Caelles Franch, Carme; McCrea, Pierre D.; García de Herreros, Antonio; Duñach, Mireia (Company of Biologists, 2012)
    A role for Rac1 GTPase in canonical Wnt signaling has recently been demonstrated, showing that it is required for β-catenin translocation to the nucleus. In this study, we investigated the mechanism of Rac1 stimulation by ...
  • Campos-Fumero, Adriana; Delclòs i Clanchet, Jordi, 1956-; Douphrate, David I.; Felknor, Sarah A.; Vargas-Prada, Sergio; Serra, Consol; Coggon, David; Gimeno, David (BMJ Publishing Group, 2016)
    OBJECTIVES: To estimate the prevalence and incidence of upper extremity musculoskeletal pain (UEMP) and related disability among office workers in Costa Rica, Nicaragua and Spain. METHODS: Data from the multinational ...
  • Nieuwenhuijsen, Mark J. (BioMed Central, 2016)
    Background: The majority of people live in cities and urbanization is continuing worldwide. Cities have long been known to be society’s predominant engine of innovation and wealth creation, yet they are also a main source ...
  • Tischer, Christina; Dadvand, Payam; Basagaña Flores, Xavier; Sunyer Deu, Jordi; Antó i Boqué, Josep Maria (Elsevier, 2018)
    Objective: We integratively assessed the effect of different indoor and outdoor environmental exposures early in life on respiratory and allergic health conditions among children from (sub-) urban areas. Methods: This study ...
  • Maitre, Léa; Robinson, Oliver; Martínez, David; Toledano, Mireille B.; Ibarluzea, Jesús; Marina, Loreto Santa; Sunyer Deu, Jordi; Villanueva, Cristina M.; Keun, Hector C.; Vrijheid, Martine; Coen, Muireann (American Chemical Society (ACS), 2018)
    Exposure to environmental pollutants, particularly during pregnancy, can have adverse consequences on child development but little is known about the effects of pollutant mixtures on endogenous metabolism in pregnant women. ...
  • Jungfleisch, Jennifer, 1986-; Blasco Moreno, Bernat, 1986-; Díez Antón, Juana, 1962- (MDPI, 2016)
    Positive-strand RNA viruses have evolved multiple strategies to not only circumvent the hostile decay machinery but to trick it into being a priceless collaborator supporting viral RNA translation and replication. In this ...
  • Erb, Ionas; González-Vallinas Rostes, Juan, 1983-; Bussotti, Giovanni, 1983-; Blanco, Enrique; Eyras Jiménez, Eduardo; Notredame, Cedric (Oxford University Press, 2012)
    We address the challenge of regulatory sequence alignment with a new method, Pro-Coffee, a multiple aligner specifically designed for homologous promoter regions. Pro-Coffee uses a dinucleotide substitution matrix estimated ...
  • Dadvand, Payam; Poursafa, Parinaz; Heshmat, Ramin; Motlagh, Mohammad Esmaeil; Qorbani, Mostafa; Basagaña Flores, Xavier; Kelishadi, Roya (Elsevier, 2018)
    A limited but emerging body of evidence is suggestive for a beneficial association between contact with green spaces and glucose homeostasis in adults; however, such an evidence for children is scarce. We evaluated the ...
  • Dierssen Sotos, Trinidad; Servitja Tormo, Sonia; Gracia Lavedan, Esther; Castaño Vinyals, Gemma; Kogevinas, Manolis; Llorca, Javier (BioMed Central, 2016)
    Background: The relationship between non-steroidal anti-inflammatory drug (NSAID) consumption and breast cancer has been repeatedly studied, although the results remain controversial. Most case-control studies reported ...
  • Maldonado, Rafael, 1961-; Baños i Díez, Josep Eladi; Cabañero Ferri, David (Wiley, 2017)
    Several lines of knockout mice deficient in the genes encoding each component of the endogenous opioid system have been used for decades to clarify the specific role of the different opioid receptors and peptide precursors ...
  • Guigó Serra, Roderic; Myers, Richard M.; Good, Peter J (Public Library of Science (PLoS), 2011)
    The mission of the Encyclopedia of DNA Elements (ENCODE) Project is to enable the scientific and medical communities to interpret the human genome sequence and apply it to understand human biology and improve health. The ...
  • Mayer, Miguel Ángel, 1960-; Gutiérrez Sacristán, Alba; Leis Machin, Angela; De La Peña, Santiago; Sanz, Ferran; Furlong, Laura I., 1971- (IOS Press, 2017)
    Comorbid diseases are an important concern in oncology since they can affect the choice and effectiveness of treatment. What is particularly relevant is the fact that the diagnosis of depression in cancer patients has an ...
  • Baños i Díez, Josep Eladi; Bosch Llonch, Fèlix (Elsevier, 2015)
    Feature films can be powerful teaching tools. However, to ensure successful results, teachers should bear several principles in mind. In this review, we recommend some principles for using films in medical education. We ...

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