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Browsing Articles (Departament de Ciències Experimentals i de la Salut) by Title

Browsing Articles (Departament de Ciències Experimentals i de la Salut) by Title

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  • Pertsovskaya, Inna; Abad Adan, Elena; Domedel Puig, Núria; García Ojalvo, Jordi; Villoslada, Pablo (BioMed Central, 2013)
    Background: Interferon-beta (IFN-beta) activates the immune response through the type I IFN signaling pathway. IFN-beta is important in the response to pathogen infections and is used as a therapy for Multiple Sclerosis. ...
  • Smit, Lidwien AM; Kogevinas, Manolis; Antó i Boqué, Josep Maria; Bouzigon, Emmanuelle; González Ruiz, Juan Ramón; Moual, Nicole Le; Kromhout, Hans; Carsin, Anne-Elie; Pin, Isabelle; Jarvis, Deborah; Vermeulen, Roel; Janson, Christer; Heinrich, Joachim; Gut, Ivo Glynne; Lathrop, Mark; Valverde, M. A. (Miguel Ángel), 1963-; Demenais, Florence; Kauffmann, Francine (BioMed Central, 2012)
    Background: Transient receptor potential (TRP) vanilloid and ankyrin cation channels are activated by various noxious chemicals and may play an important role in the pathogenesis of cough. The aim was to study the influence ...
  • Barardi, Alessandro; García Ojalvo, Jordi; Mazzoni, Alberto (Public Library of Science (PLoS), 2016)
    The thalamus is a key brain element in the processing of sensory information. During the sleep and awake states, this brain area is characterized by the presence of two distinct dynamical regimes: in the sleep state activity ...
  • Díez Antón, Juana, 1962-; Jungfleisch, Jennifer, 1986- (Taylor & Francis (Routledge), 2017)
    Viruses are powerful tools to uncover cellular processes. Through viral studies we have recently identified a novel translational control mechanism that involves the DEAD-box helicase Dhh1/DDX6 and RNA folding within coding ...
  • Ruiz-Orera, Jorge; Verdaguer-Grau, Pol; Villanueva Cañas, José Luis, 1984-; Messeguer, Xavier; Albà Soler, Mar (Springer, 2018)
    Accumulating evidence indicates that some protein-coding genes have originated de novo from previously non-coding genomic sequences. However, the processes underlying de novo gene birth are still enigmatic. In particular, ...
  • Maslon, Magdalena M.; Heras, Sara R.; Bellora Pereyra, Nicolás; Eyras Jiménez, Eduardo; Cáceres, Javier F. (eLife, 2014)
    The shuttling serine/arginine rich (SR) protein SRSF1 (previously known as SF2/ASF) is a splicing regulator that also activates translation in the cytoplasm. In order to dissect the gene network that is translationally ...
  • McGrath, John J.; Alonso Caballero, Jordi; Kessler, Ronald C.; The WHO World Mental Health (WMH) Survey Initiative (Royal College of Psychiatrists, 2017)
    Traumatic events are associated with increased risk of psychotic experiences, but it is unclear whether this association is explained by mental disorders prior to psychotic experience onset .Aims:To investigate the ...
  • Kessler, Ronald C.; Alonso Caballero, Jordi; Koenen, Karestan C. (Taylor & Francis (Routledge), 2017)
    BACKGROUND: Although post-traumatic stress disorder (PTSD) onset-persistence is thought to vary significantly by trauma type, most epidemiological surveys are incapable of assessing this because they evaluate lifetime PTSD ...
  • Alonso Caballero, Jordi; WHO World Mental Health Survey Collaborators (Wiley, 2018)
    Background: Anxiety disorders are a major cause of burden of disease. Treatment gaps have been described, but a worldwide evaluation is lacking. We estimated, among individuals with a 12‐month DSM‐IV (where DSM is Diagnostic ...
  • Decara, Juan M.; Pavón, Francisco Javier; Suárez, Juan; Romero-Cuevas, Miguel; Baixeras, Elena; Vázquez, Mariam; Rivera, Patricia; Gavito, Ana L.; Almeida Cotrim, Bruno; Joglar Tamargo, Jesús; Torre Fornell, Rafael de la; Rodríguez de Fonseca, Fernando; Serrano, Antonia (Company of Biologists, 2015)
    Fatty liver disease is one of the main hepatic complications associated with obesity. To date, there are no effective treatments for this pathology apart from the use of classical fibrates. In this study, we have characterized ...
  • Bosch de Basea i Gómez, Magda, 1982-; Salotti, Jane A.; Pearce, Mark S.; Muchart, Jordi; Riera, Luis; Barber, Ignasi; Pedraza, Salvador; Pardina, Marina; Capdevila, Antoni; Espinosa Díaz, Ana; Cardis, Elisabeth (Springer, 2016)
    BACKGROUND: Although there are undeniable diagnostic benefits of CT scanning, its increasing use in paediatric radiology has become a topic of concern regarding patient radioprotection. OBJECTIVE: To assess the rate of CT ...
  • NCD Risk Factor Collaboration (NCD-RisC); Sunyer Deu, Jordi (Elsevier, 2016)
    Background: Underweight and severe and morbid obesity are associated with highly elevated risks of adverse health outcomes. We estimated trends in mean body-mass index (BMI), which characterises its population distribution, ...
  • Puigpinós i Riera, Rosa; Borrell i Thió, Carme; Ferreira Antunes, José Leopoldo; Azlor, Enric; Pasarín i Rua, M. Isabel; Serral Cano, Gemma, 1973-; Pons i Vigués, Mariona; Rodríguez Sanz, Maica; Fernández Muñoz, Esteve (BioMed Central, 2009)
    Background: The objective of this study was to assess trends in cancer mortality by educational level in Barcelona from 1992 to 2003. Methods: The study population comprised Barcelona inhabitants aged 20 years or older. ...
  • Izaguirre, Victor; Fernández-Fernández, José Manuel, 1967-; Ceña, Valentin; González García, Carmen (Elsevier, 1997)
    Nicotine-induced ATP secretion from chromaffin cells was blocked by imipramine and desipramine. This blocking action took place on both, fast and slow, components of ATP secretion. Exposure of chromaffin cells to nicotine ...
  • Font Ribera, Laia; Colomer Cotta, Jordi; Gómez Gutiérrez, Anna; Villanueva Belmonte, Cristina (Elsevier, 2017)
    Bottled water consumption is increasing worldwide, despite its huge economic and environmental cost. We aim to describe personal and tap water quality determinants of bottled water use in the city of Barcelona. This ...
  • Oleksiewicz, Urszula; Gładych, Marta; Raman, Ayush T.; Heyn, Holger; Mereu, Elisabetta; Chlebanowska, Paula; Andrzejewska, Anastazja; Sozańska, Barbara; Samant, Neha; Fąk, Katarzyna; Auguścik, Paulina; Kosiński, Marcin; Wróblewska, Joanna P.; Tomczak, Katarzyna; Kulcenty, Katarzyna; Płoski, Rafał; Biecek, Przemysław; Esteller, Manel; Shah, Parantu K.; Rai, Kunal; Wiznerowicz, Maciej (Elsevier, 2017)
    Reprogramming to induced pluripotent stem cells (iPSCs) and differentiation of pluripotent stem cells (PSCs) are regulated by epigenetic machinery. Tripartite motif protein 28 (TRIM28), a universal mediator of Krüppel-associated ...
  • Mitrovic, Sandra; Nogueira, Cristina; Cantero Recasens, Gerard, 1984-; Kiefer, Kerstin, 1986-; Fernández-Fernández, José Manuel, 1967-; Popoff, Jean-François; Casano, Laetitia; Bard, Frederic A.; Gómez, Raul; Valverde, M. A. (Miguel Ángel), 1963-; Malhotra, Vivek (eLife, 2013)
    Mucin 5AC (MUC5AC) is secreted by goblet cells of the respiratory tract and, surprisingly, also expressed de novo in mucus secreting cancer lines. siRNA-mediated knockdown of 7343 human gene products in a human colonic ...
  • Alpizar, Yeranddy A.; Boonen, Brett; Sánchez, Alicia; Jung, Carole; López-Requena, Alejandro; Naert, Robbe; Steelant, Brecht; Luyts, Katrien; Plata, Cristina; Vooght, Vanessa De; Vanoirbeek, Jeroen A.J.; Meseguer, Victor M.; Voets, Thomas; Alvarez, Julio L.; Hellings, Peter W.; Hoet, Peter H.M.; Nemery, Benoit; Valverde, M. A. (Miguel Ángel), 1963-; Talavera, Karel (Nature Publishing Group, 2017)
    Lipopolysaccharides (LPS), the major components of the wall of gram-negative bacteria, trigger powerful defensive responses in the airways via mechanisms thought to rely solely on the Toll-like receptor 4 (TLR4) immune ...
  • Guerra, Carmen; Mijimolle, Nieves; Dhawahir, Alma; Dubus, Pierre; Barradas, Marta; Serrano, Manuel; Campuzano Uceda, María Victoria; Barbacid, Mariano (Elsevier, 2003)
    We have targeted a K-ras allele in mouse embryonic stem (ES) cells to express a K-Ras(V12) oncoprotein along with a marker protein (beta-geo) from a single bicistronic transcript. Expression of this oncogenic allele requires ...
  • Hernández, Jordi; Bechara, Elias; Schlesinger, Doerte; Delgado, Javier; Serrano Pubull, Luis, 1982-; Valcárcel, J. (Juan) (Wiley-Blackwell, 2016)
    RBM10 is an RNA binding protein and alternative splicing regulator frequently mutated in lung adenocarcinomas. Recent results indicate that RBM10 inhibits proliferation of lung cancer cells by promoting skipping of exon 9 ...

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