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Browsing Articles (Departament de Ciències Experimentals i de la Salut) by Title

Browsing Articles (Departament de Ciències Experimentals i de la Salut) by Title

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  • Porcari, Riccardo; Proukakis, Christos; Waudby, Christopher A.; Bolognesi, Benedetta; Mangione, P. Patrizia; Paton, Jack F. S.; Mullin, Stephen; Cabrita, Lisa D.; Penco, Amanda; Relini, Annalisa; Verona, Guglielmo; Vendruscolo, Michele; Stoppini, Monica; Tartaglia, Gian Gaetano; Camilloni, Carlo; Christodoulou, John; Schapira, Anthony H. V.; Bellotti, Vittorio (American Society for Biochemistry and Molecular Biology, 2015)
    The conversion of α-synuclein from its intrinsically disordered monomeric state into the fibrillar cross-β aggregates characteristically present in Lewy bodies is largely unknown. The investigation of α-synuclein variants ...
  • Warringer, Jonas; Hult, Malin; Regot Rodríguez de Mier, Sergi; Posas Garriga, Francesc; Sunnerhagen, Per (American Society for Cell Biology, 2010)
    Cellular responses to environmental changes occur on different levels. We investigated the translational response of yeast cells after mild hyperosmotic shock by isolating mRNA associated with multiple ribosomes (polysomes) ...
  • Ruiz Roig, Clàudia; Noriega Esteban, Núria; Duch, Alba; Posas Garriga, Francesc; Nadal Clanchet, Eulàlia de (American Society for Cell Biology, 2012)
    Cells modulate expression of nuclear genes in response to alterations in mitochondrial function, a response termed retrograde (RTG) regulation. In budding yeast, the RTG pathway relies on Rtg1 and Rtg3 basic helix-loop-helix ...
  • Martins, Telma S.; Pereira, Clara; Canadell, David; Vilaça, Rita; Teixeira, Vítor; Moradas Ferreira, Pedro; Nadal Clanchet, Eulàlia de; Posas Garriga, Francesc; Costa, Vítor M.V. (Elsevier, 2018)
    Iron acquisition systems have to be tightly regulated to assure a continuous supply of iron, since it is essential for survival, but simultaneously to prevent iron overload that is toxic to the cells. In budding yeast, the ...
  • Niell, Núria; Larriba, María Jesús; Ferrer Mayorga, Gemma; Sánchez Pérez, Isabel; Cantero, Ramón; Real, Francisco X.; Peso, Luis Del; Muñoz, Alberto; González Sancho, José Manuel (Wiley, 2018)
    Colorectal cancer results from the malignant transformation of colonic epithelial cells. Stromal fibroblasts are the main component of the tumour microenvironment, and play an important role in the progression of this and ...
  • Flores de los Heros, África, 1985-; Maldonado, Rafael, 1961-; Berrendero Díaz, Fernando, 1971- (Elsevier, 2014)
    BACKGROUND: Cannabis is the most widely used illicit drug in the world. Although there is a high prevalence of users who seek treatment for cannabis dependence, no accepted pharmacologic treatment is available to facilitate ...
  • Flores de los Heros, África, 1985-; Valls Comamala, Victòria, 1987-; Costa, Giulia; Saravia, Rocío; Maldonado, Rafael, 1961-; Berrendero Díaz, Fernando, 1971- (Nature Publishing Group, 2014)
    Anxiety disorders are often associated with an inability to extinguish learned fear responses. The hypocretin/orexin system is involved in the regulation of emotional states and could also participate in the consolidation ...
  • Plaza-Zabala, Ainhoa, 1982-; Maldonado, Rafael, 1961-; Berrendero Díaz, Fernando, 1971- (Springer, 2012)
    Hypocretins (also known as orexins) are hypothalamic neuropeptides involved in the regulation of sleep/wake states and feeding behavior. Recent studies have also demonstrated an important role for the hypocretin/orexin ...
  • Di Tommaso, Paolo; Palumbo, Emilio; Chatzou, Maria, 1985-; Prieto Barja, Pablo, 1986-; Heuer, Michael L.; Notredame, Cedric (PeerJ Inc., 2015)
    Genomic pipelines consist of several pieces of third party software and, because of their experimental nature, frequent changes and updates are commonly necessary thus raising serious deployment and reproducibility issues. ...
  • Hernández Rodríguez, Jéssica, 1983-; Arandjelovic, Mimi; Lester, Jack; Filippo, Cesare de; Weihmann, Antje; Meyer, Matthias; Angedakin, Samuel; Casals López, Ferran; Navarro i Cuartiellas, Arcadi, 1969-; Vigilant, Linda; Kühl, Hjalmar S.; Langergraber, Kevin; Boesch, Christophe; Hughes, David; Marquès i Bonet, Tomàs, 1975- (Wiley-Blackwell, 2018)
    Target-capture approach has improved over the past years, proving to be very efficient tool for selectively sequencing genetic regions of interest. These methods have also allowed the use of noninvasive samples such as ...
  • Schleyer, Michael; Reid, Samuel F.; Pamir, Evren; Saumweber, Timo; Paisios, Emmanouil; Davies, Alexander; Gerber, Bertram; Louis, Matthieu (Cold Spring Harbor Laboratory Press, 2015)
    How do animals adaptively integrate innate with learned behavioral tendencies? We tackle this question using chemotaxis as a paradigm. Chemotaxis in the Drosophila larva largely results from a sequence of runs and oriented ...
  • Li, Xin; Guigó Serra, Roderic; Montgomery, Stephen B.; Genotype-Tissue Expression (GTEx) Consortium (Nature Publishing Group, 2017)
    Rare genetic variants are abundant in humans and are expected to contribute to individual disease risk. While genetic association studies have successfully identified common genetic variants associated with susceptibility, ...
  • Montano, Valeria; Marcari, Veronica; Pavanello, Mariano; Anyaele, Okorie; Comas, David, 1969-; Destro Bisol, Giovanni; Batini, Chiara (BioMed Central, 2013)
    Background: When studying the genetic structure of human populations, the role of cultural factors may be difficult to ascertain due to a lack of formal models. Linguistic diversity is a typical example of such a situation. ...
  • Canova, Cristina; Antó i Boqué, Josep Maria; Zock, Jan-Paul; Jarvis, Deborah (European Respiratory Society, 2013)
    No large study has described the seasonal variation in asthma attacks in population-based asthmatics in whom sensitisation to allergen has been measured. 2,637 young adults with asthma living in 15 countries reported the ...
  • Gascon Merlos, Mireia, 1984-; Guxens Junyent, Mònica; Vrijheid, Martine; Torrent Quetglas, Maties; Ibarluzea, Jesús; Fano, Eduardo; Llop, Sabrina; Ballester Díez, Ferran; Fernandez, Mariana F.; Tardón, Adonina; Fernández-Somoano, Ana; Sunyer Deu, Jordi (Elsevier, 2017)
    BACKGROUND: In 2003 the INMA-INfancia y Medio Ambiente (Environment and Childhood) project, a Spanish national network of birth cohorts including more than 3500 participants, was set up with the aim to assess the health ...
  • Knezevic, Iva, 1984-; González Medina, Alberto; Gaspa, Laura; Hidalgo Hernando, Elena; Ayté del Olmo, José (Wiley, 2018)
    Chromatin structure is an essential factor in the proper regulation of DNA repair, DNA replication and transcription. The INO80 complex and the SWR complex have been shown to play a fundamental role in transcription ...
  • Brack, Andrew S.; Muñoz Cánoves, Pura, 1962- (BioMed Central, 2016)
    Skeletal muscle has a remarkable capacity to regenerate by virtue of its resident stem cells (satellite cells). This capacity declines with aging, although whether this is due to extrinsic changes in the environment and/or ...
  • Hernando Herráez, Irene, 1985-; Heyn, Holger; Fernández Callejo, Marcos; Vidal, Enrique; Fernández Bellon, Hugo; Prado Martínez, Javier, 1987-; Sharp, Andrew J.; Esteller, Manel; Marquès i Bonet, Tomàs, 1975- (Oxford University Press, 2015)
    Despite the increasing knowledge about DNA methylation, the understanding of human epigenome evolution is in its infancy. Using whole genome bisulfite sequencing we identified hundreds of differentially methylated regions ...
  • Merlos-Suárez, Anna; Barriga de Vicente, Francisco Martín, 1983-; Jung, Peter; Iglesias Coma, Mar; Céspedes, María Virtudes; Rossell, David; Sevillano, Marta; Hernando-Momblona, Xavier; Silva-Diz, Victoria da; Muñoz, Purificación; Clevers, Hans; Sancho, Elena; Mangues, Ramon; Batlle Gómez, Eduard (Elsevier, 2011)
    A frequent complication in colorectal cancer (CRC) is regeneration of the tumor after therapy. Here, we report that a gene signature specific for adult intestinal stem cells (ISCs) predicts disease relapse in CRC patients. ...
  • Brbić, Maria; Piškorec, Martija; Vidulin, Vedrana; Krisko, Anita; Šmuc, Tomislav; Supek, Fran (Oxford University Press, 2016)
    Bacteria and Archaea display a variety of phenotypic traits and can adapt to diverse ecological niches. However, systematic annotation of prokaryotic phenotypes is lacking. We have therefore developed ProTraits, a resource ...

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