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Visualitzant Articles (Departament de Medicina i Ciències de la Vida) per títol

Visualitzant Articles (Departament de Medicina i Ciències de la Vida) per títol

Ara mostrant els elements 1318-1337 de 5354

Development and evaluation of culture media based on extracts of the cyanobacterium Arthrospira platensis

Kheirabadi, Elaheh; Macía, Javier (Frontiers, 2022)

Continuous advances in the fields of industrial biotechnology and pharmacy require the development of new formulations of culture media based on new nutrient sources. These new sources must be sustainable, high yielding, ...
Development and validation of AMANDA, a new algorithm for selecting highly relevant regions in Molecular Interaction Fields

Durán Alcaide, Ángel; Martínez, Guillermo C.; Pastor Maeso, Manuel (American Chemical Society (ACS), 2008)

Descriptors based on Molecular Interaction Fields (MIF) are highly suitable for drug discovery, but their size (thousands of variables) often limits their application in practice. Here we describe a simple and fast ...
Development and validation of an electronic daily control score for asthma (e-DASTHMA): a real-world direct patient data study

Sousa Pinto, Bernardo; Antó i Boqué, Josep Maria; Bousquet, Jean (Elsevier, 2023)

Background: Validated questionnaires are used to assess asthma control over the past 1-4 weeks from reporting. However, they do not adequately capture asthma control in patients with fluctuating symptoms. Using the Mobile ...
Development and validation of combined symptom-medication scores for allergic rhinitis

Sousa Pinto, Bernardo; Antó i Boqué, Josep Maria; Bousquet, Jean (Wiley, 2022)

Background: Validated combined symptom-medication scores (CSMSs) are needed to investigate the effects of allergic rhinitis treatments. This study aimed to use real-life data from the MASK-air® app to generate and validate ...
Development and validation of the EspaiJove.net Mental Health Literacy (EMHL) test for spanish adolescents

Castellvi Obiols, Pere; Casañas Sánchez, Rocío; Arfuch, Victoria-Mailen; Gil Moreno, Juan José; Torres Torres, María; García Forero, Carlos; Ruiz-Castañeda, Dyanne; Alonso Caballero, Jordi; Lalucat-Jo, Lluís (MDPI, 2020)

There is evidence of the effectiveness of implementing mental health literacy (MHL) programs. However, there are substantial limitations in the instruments available for measuring MHL. This study aimed to develop and ...
Development of a catheter-based technique for endoluminal radiofrequency sealing of pancreatic duct

Ewertowska, Elżbieta; Andaluz, Anna; Moll, Xavier; Aguilar, Adrià; Garcia, Felix; Fondevila, Dolors; Quesada Diez, Rita; Trujillo Guillén, Macarena; Burdío Pinilla, Fernando; Berjano, Enrique J. (Taylor & Francis, 2019)

introduction: Endoluminal sealing of the pancreatic duct by glue or sutures facilitates the management of the pancreatic stump. Our objective was to develop a catheter-based alternative for endoluminal radiofrequency (RF) ...
Development of a cross-cultural deprivation index in five European countries

Guillaume, Elodie; Pornet, Carole; Dejardin, Olivier; Launay, Ludivine; Lillini, Roberto; Vercelli, Marina; Marí-Dell'Olmo, Marc; Fernández Fontelo, Amanda; Borrell i Thió, Carme; Ribeiro, Ana Isabel; de Pina, Maria Fatima; Mayer, Alexandra; Delpierre, Cyrille; Rachet, Bernard; Launoy, Guy (BMJ Publishing Group, 2016)

Background Despite a concerted policy effort in Europe, social inequalities in health are a persistent problem. Developing a standardised measure of socioeconomic level across Europe will improve the understanding of the ...
Development of a dendrimeric peptide-based approach for the differentiation of animals vaccinated with FlagT4G against classical swine fever from infected pigs

Bohórquez, José Alejandro; Defaus, Sira; Rosell, Rosa; Pérez-Simó, Marta; Alberch, Mònica; Gladue, Douglas P.; Borca, Manuel V.; Andreu Martínez, David; Ganges, Lliliane (MDPI, 2021)

Classical swine fever virus (CSFV) causes a viral disease of high epidemiological and economical significance that affects domestic and wild swine. Control of the disease in endemic countries is based on live-attenuated ...
Development of a registration system for genetic counsellors and nurses in health-care services in Europe.

Paneque, Milena; Moldovan, Ramona; Cordier, Christophe; Serra Juhé, Clara, 1984-; Feroce, Irene; Lambert, Debby; Bjørnevoll, Inga; Skirton, Heather (Nature Publishing Group, 2016)
Development of a source-exposure matrix for occupational exposure assessment of electromagnetic fields in the INTEROCC study

Vila Rodríguez, Javier, 1974-; Bowman, Joseph D.; Figuerola, Jordi; Moriña, David; Kincl, Laurel; Richardson, Lesley; Cardis, Elisabeth (Nature Publishing Group, 2017)

To estimate occupational exposures to electromagnetic fields (EMF) for the INTEROCC study, a database of source-based measurements extracted from published and unpublished literature resources had been previously constructed. ...
Development of an infrastructure for the prediction of biological endpoints in industrial environments. Lessons learned at the eTOX Project

Pastor Maeso, Manuel; Quintana, Jordi; Sanz, Ferran (Frontiers Media, 2018)

In silico methods are increasingly being used for assessing the chemical safety of substances, as a part of integrated approaches involving in vitro and in vivo experiments. A paradigmatic example of these strategies is ...
Development of breast cancer spheroids to evaluate cytotoxic response to an anticancer peptide

Cavaco, Marco; Fraga, Patrícia; Valle, Javier; Andreu Martínez, David; Castanho, Miguel A.R.B.; Neves, Vera (MDPI, 2021)

Breast cancer (BC) is the most commonly diagnosed cancer in women and one of the most common causes of cancer-related deaths. Despite intense research efforts, BC treatment still remains challenging. Improved drug development ...
Development of fluorescent probes that target serotonin 5-HT2B receptors

Azuaje, Jhonny; López, Paula; Iglesias, Alba; de la Fuente, Rocío Ailim; Pérez Rubio, José M.; García, Diego; Maciej Stępniewski, Tomasz; García Mera, Xerardo; Brea, José; Selent, Jana; Pérez Sala, Dolores; Castro, Marián; Loza, María I.; Sotelo, Eddy (Nature Publishing Group, 2017)

Some 5-HT2B fluorescent probes were obtained by tagging 1-(2,5-dimethoxy-4-iodophenyl)-propan-2-amine (DOI) with a subset of fluorescent amines. Some of the resulting fluorescent ligands showed excellent affinity and ...
Development of pranoprofen loaded nanostructured lipid carriers to improve its release and therapeutic efficacy in skin inflammatory disorders

Rincón, María; Calpena, Ana C.; Fábrega, María José; Garduño-Ramírez, María L.; Espina, Marta; Rodríguez-Lagunas, María J.; García, María L.; Abrego, Guadalupe (MDPI, 2018)

Pranoprofen (PF)-loaded nanostructured lipid carriers (NLCs), prepared using a high-pressure homogenization method, have been optimized and characterized to improve the biopharmaceutical profile of the drug. The optimized ...
Development of the adaptive NK cell response to human cytomegalovirus in the context ofaging

López-Botet, Miguel; Muntasell i Castellví, Aura, 1972-; Martínez-Rodriguez, José E.; López-Montañés, María; Costa-García, Marcel; Pupuleku, Aldi, 1985- (Elsevier, 2016)

Human cytomegalovirus (HCMV) establishes a highly prevalent life-long latent infection. Though generally subclinical, HCMV infection may have severe consequences during fetal development and in immunocompromised individuals. ...
The development of the MeDALL core questionnaires for a harmonized follow-up assessment of eleven European birth cohorts on asthma and allergies

Hohmann, Cynthia; Pinart, Mariona; Torrent Quetglas, Maties; Esplugues, Ana; Sunyer Deu, Jordi; Antó i Boqué, Josep Maria; Keil, Thomas; The MeDALL Study Group (Karger (S. Karger AG), 2014)

Background: Numerous birth cohorts have been initiated in the world over the past 30 years using heterogeneous methods to assess the incidence, course and risk factors of asthma and allergies. The aim of the present work ...
Developmental regulation of X-chromosome inactivation

Payer, Bernhard (Elsevier, 2016)

With the emergence of sex-determination by sex chromosomes, which differ in composition and number between males and females, appeared the need to equalize X-chromosomal gene dosage between the sexes. Mammals have devised ...
Developmental RNA-Seq transcriptomics of haploid germ cells and spermatozoa uncovers novel pathways associated with teleost spermiogenesis

Castro-Arnau, Júlia; Chauvigné, François; Gómez-Garrido, Jèssica; Esteve-Codina, Anna; Dabad, Marc; Alioto, Tyler; Finn, Roderick Nigel; Cerdà, Joan (Nature Research, 2022)

In non-mammalian vertebrates, the molecular mechanisms involved in the transformation of haploid germ cells (HGCs) into spermatozoa (spermiogenesis) are largely unknown. Here, we investigated this process in the marine ...
Developmental trajectories in primary schoolchildren using n-back task.

López Vicente, Mònica, 1988-; Forns i Guzman, Joan, 1981-; Suades González, Elisabet; Esnaola, Mikel; García Esteban, Raquel; Álvarez Pedrerol, Mar; Júlvez Calvo, Jordi; Burgaleta Díaz, Miguel, 1981-; Sebastián Gallés, Núria; Sunyer Deu, Jordi (Frontiers, 2016)

BACKGROUND: Neuropsychological instruments to assess cognitive trajectories during childhood in epidemiological studies are needed. This would improve neurodevelopment characterization in order to identify its potential ...
DGCR8 HITS-CLIP reveals novel functions for the Microprocessor

Macias, Sara; Plass Pórtulas, Mireya, 1982-; Stajuda, Agata; Michlewski, Gracjan; Eyras Jiménez, Eduardo; Cáceres, Javier F. (Nature Research, 2012)

The Drosha-DGCR8 complex (Microprocessor) is required for microRNA (miRNA) biogenesis. DGCR8 recognizes the RNA substrate, whereas Drosha functions as the endonuclease. Using high-throughput sequencing and cross-linking ...