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Browsing Articles (Departament de Ciències Experimentals i de la Salut) by Title

Browsing Articles (Departament de Ciències Experimentals i de la Salut) by Title

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  • Romero, Lucia; Cano, Jordi; Gomis-Tena, Julio; Trenor, Beatriz; Sanz, Ferran; Pastor Maeso, Manuel; Saiz, Javier (American Chemical Society (ACS), 2018)
    Drug-induced proarrhythmicity is a major concern for regulators and pharmaceutical companies. For novel drug candidates, the standard assessment involves the evaluation of the potassium hERG channels block and the in vivo ...
  • Vafeiadi, Marina, 1983-; Agramunt, Silvia; Papadopoulou, Eleni, 1985-; Besselink, Harrie; Mathianaki, Kleopatra; Karakosta, Polyxeni; Spanaki, Ariana; Koutis, Antonis; Chatzi, Leda; Vrijheid, Martine; Kogevinas, Manolis (National Institute of Environmental Health Sciences (NIEHS), 2013)
    BACKGROUND: Anogenital distance in animals is used as a measure of fetal androgen action. Prenatal exposure to dioxins and dioxin-like compounds in rodents causes reproductive changes in male offspring and decreases ...
  • Vilahur Chiaraviglio, Nadia, 1982-; Fernandez, Mariana F.; Bustamante Pineda, Mariona; Ramos, Rosa; Forns i Guzman, Joan, 1981-; Ballester Díez, Ferran; Murcia, Mario; Riaño, Isolina; Ibarluzea, Jesús; Olea, Nicolás; Sunyer Deu, Jordi (Elsevier, 2014)
    BACKGROUND: To date, no epidemiological studies have explored the impact and persistence of in utero exposure to mixtures of xenoestrogens on the developing brain. We aimed to assess whether the cumulative effect of ...
  • Grey, Corinne; Clément, Julie A.J.; Buard, Jerome; Leblanc, Benjamin; Gut, Ivo Glynne; Gut, Marta; Duret, Laurent; de Massy, Bernard D. (BioMed Central, 2017)
    In mouse and human meiosis, DNA double-strand breaks (DSBs) initiate homologous recombination and occur at specific sites called hotspots. The localization of these sites is determined by the sequence-specific DNA binding ...
  • Niu, Dong; Wei, Hong-Jiang; Lin, Lin; George, Haydy; Wang, Tao; Lee, I-Hsiu; Zhao, Hong-Ye; Wang, Yong; Kan, Yinan; Shrock, Ellen; Lesha, Emal; Wang, Gang; Luo, Yonglun; Qing, Yubo; Jiao, Deling; Zhao, Heng; Zhou, Xiaoyang; Wang, Shouqi; Wei, Hong-Jiang; Güell Cargol, Marc; Church, George M.; Yang, Luhan (American Association for the Advancement of Science (AAAS), 2017)
    Xenotransplantation is a promising strategy to alleviate the shortage of organs for human transplantation. In addition to the concerns about pig-to-human immunological compatibility, the risk of cross-species transmission ...
  • Zaballa, Elena; Martínez Martínez, José Miguel, 1974-; Duran Jordà, Xavier, 1974-; Alberti, Constança; Gimeno Ruiz de Porras, David; Benavides, Fernando G. (Fernando García) (BioMed Central, 2016)
    Background: To examine the differences in the incidence of registered sickness absence by type of employment contract in a large representative sample of salaried workers in Spain in 2009. Method: A study of 653,264 salaried ...
  • Benavides, Fernando G. (Fernando García); Zaballa, Elena; Duran Jordà, Xavier, 1974-; Sánchez Niubò, Albert; Gimeno Ruiz de Porras, David (Societat Catalana de Salut Laboral, 2017)
    Objetivo: La gestión de la incapacidad temporal por contingencias comunes (ITcc) en España se centra más en el control de su duración que en prevenir su incidencia. El objetivo de este trabajo es proporcionar valores de ...
  • Alonso Caballero, Jordi; Vilagut Saiz, Gemma, 1975-; Rojas-Farreras, Sonia; Kessler, Ronald C. (Cambridge University Press, 2011)
    BACKGROUND: The methodology commonly used to estimate disease burden, featuring ratings of severity of individual conditions, has been criticized for ignoring co-morbidity. A methodology that addresses this problem is ...
  • Cubillos, Carolina; García de la Torre, Beatriz; Bárcena, Juan; Andreu Martínez, David; Sobrino, Francisco; Blanco, Esther (BioMed Central, 2012)
    Background: Foot-and-mouth disease virus (FMDV) causes an economically important and highly contagious disease of cloven-hoofed animals. FMD control in endemic regions is implemented using chemically inactivated whole-virus ...
  • Bosch Morató, Mònica, 1986-; Iriondo, Cinta; Guivernau Almazán, Biuse, 1988-; Valls Comamala, Victòria, 1987-; Vidal, Noemí; Olivé, Montse; Querfurth, Henry; Muñoz López, Francisco José, 1964- (Impact Journals, 2016)
    GNE myopathy is an autosomal recessive muscular disorder of young adults characterized by progressive skeletal muscle weakness and wasting. It is caused by a mutation in the UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine ...
  • Paul, Dirk S.; Heath, Simon; Gut, Marta; Gut, Ivo Glynne; Leslie, R. David (Nature Publishing Group, 2016)
    The incidence of type 1 diabetes (T1D) has substantially increased over the past decade, suggesting a role for non-genetic factors such as epigenetic mechanisms in disease development. Here we present an epigenome-wide ...
  • Biarnés Pérez, Marc, 1973-; Arias, Luis; Alonso Caballero, Jordi; García, Míriam; Hijano, Míriam; Rodríguez, Anabel; Serrano, Anna; Badal, Josep; Muhtaseb, Hussein; Verdaguer, Paula; Monés, Jordi (Monés Carilla) (Elsevier Science, 2015)
    PURPOSE: To define the role of increased fundus autofluorescence (FAF), a surrogate for lipofuscin content, as a risk factor for progression of geographic atrophy (GA). DESIGN: Prospective natural history cohort study, the ...
  • Váraljai, Renáta; Islam, Abul, 1978-; Beshiri, Michael L.; Rehman, Jalees; López Bigas, Núria; Benevolenskaya, Elizaveta V. (Cold Spring Harbor Laboratory Press (CSHL Press), 2015)
    The retinoblastoma tumor suppressor protein pRb restricts cell growth through inhibition of cell cycle progression. Increasing evidence suggests that pRb also promotes differentiation, but the mechanisms are poorly understood, ...
  • Águila, Sonia; Martínez-Martínez, Irene; Dichiara, Gilda; Gutiérrez Gallego, Ricardo, 1968-; Navarro-Fernández, José; Vicente, Vicente; Corral, Javier (Public Library of Science (PLoS), 2014)
    The inefficient glycosylation of consensus sequence on N135 in antithrombin explains the two glycoforms of this key anticoagulant serpin found in plasma: α and β, with four and three N-glycans, respectively. The lack of ...
  • Gallego, Xavier; Murtra, Patricia; Zamalloa, Teresa; Canals, Josep Maria; Pineda, Joseba; Amador Arjona, Alejandro; Maldonado, Rafael, 1961-; Dierssen, Mara (Frontiers, 2010)
    Panic disorder is a highly prevalent neuropsychiatric disorder that shows co-occurrence with substance abuse. Here, we demonstrate that TrkC, the high-affinity receptor for neurotrophin-3, is a key molecule involved in ...
  • Biton, Anne; Bernard-Pierrot, Isabelle; Lou, Yinjun; Krucker, Clémentine; Chapeaublanc, Elodie; Rubio Pérez, Carlota, 1990-; López Bigas, Núria; Kamoun, Aurélie; Neuzillet, Yann; Gestraud, Pierre; Grieco, Luca; Rebouissou, Sandra; deReyniès, Aurélien; Benhamou, Simone; Lebret, Thierry; Southgate, Jennifer; Barillot, Emmanuel; Allory, Yves; Zinovyev, Andrei; Radvanyi, François (Elsevier, 2014)
    Extracting relevant information from large-scale data offers unprecedented opportunities in cancerology. We applied independent component analysis (ICA) to bladder cancer transcriptome data sets and interpreted the components ...
  • Abelló Sumpsi, Gina, 1980-; Khatri, Safia; Radosevic, Marija, 1978-; Scotting, Paul; Giráldez, Fernando; Alsina i Español, Berta (Elsevier, 2010)
    The development of neural tissue starts with the activation of early neural genes such as the SoxB1 transcription factors, which are expressed in response to signaling molecules. Neural progenitors in the inner ear are ...
  • Cabrera-León, Andrés; Daponte, Antonio; Mateo, Inmaculada; Arroyo-Borrell, Elena; Bartoll, Xavier; Bravo, María José; Domínguez-Berjón, María Felicitas; Renart, Gemma; Álvarez-Dardet, Carlos; Marí Dell'Olmo, Marc, 1978-; Bolívar Muñoz, Julia; Saez, Marc; Escribà-Agüir, Vicenta; Palència Fernàndez, Laia; López, Maria José; Saurina, Carme; Puig i Barrachina, Vanessa, 1980-; Martín, Unai; Gotsens Miquel, Mercè, 1983-; Borrell i Thió, Carme; Serra Saurina, Laura; Sordo, Luis; Bacigalupe, Amaia; Rodríguez Sanz, Maica; Pérez Albarracín, Glòria; Espelt Hernández, Albert, 1981-; Ruiz-Canela, Miguel; Bernal, Mariola (Elsevier, 2017)
    Objetivo: Proporcionar indicadores para evaluar, en España y en sus comunidades autónomas, el impacto sobre la salud, sus determinantes sociales y las desigualdades en salud del contexto social y de la crisis económica más ...
  • Selent, Jana; Sanz, Ferran; Pastor Maeso, Manuel; De Fabritiis, Gianni (Public Library of Science (PLoS), 2010)
    G-protein coupled receptors, the largest family of proteins in the human genome, are involved in many complex signal transduction pathways, typically activated by orthosteric ligand binding and subject to allosteric ...
  • García Subirats, Irene, 1982-; Vargas, Ingrid; Mogollón Pérez, Amparo Susana; Paepe, Pierre de; Ferreira da Silva, Mª Rejane; Unger, Jean Pierre; Borrell i Thió, Carme; Vázquez, María Luisa (BioMed Central, 2014)
    INTRODUCTION: Health system reforms are undertaken with the aim of improving equity of access to health care. Their impact is generally analyzed based on health care utilization, without distinguishing between levels of ...

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