Benvinguts al Repositori Digital de la UPF

Visualitzant Articles (Departament de Ciències Experimentals i de la Salut) per títol

Visualitzant Articles (Departament de Ciències Experimentals i de la Salut) per títol

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  • Domedel Puig, Núria; Rué, Pau; Pons, Antonio J.; García Ojalvo, Jordi (Public Library of Science (PLoS), 2011)
    Living systems are capable of processing multiple sources of information simultaneously. This is true even at the cellular level, where not only coexisting signals stimulate the cell, but also the presence of fluctuating ...
  • Seoane, Luís F., 1985-; Solé Vicente, Ricard, 1962- (Royal Society, 2018)
    Despite the obvious advantage of simple life forms capable of fast replication, different levels of cognitive complexity have been achieved by living systems in terms of their potential to cope with environmental uncertainty. ...
  • Espejo Herrera, Nadia Carminia, 1983-; Gràcia Lavedan, Esther; Font Ribera, Laia; Castaño Vinyals, Gemma; Kogevinas, Manolis; Villanueva Belmonte, Cristina (Environmental Health Perspectives, 2016)
    BACKGROUND: Ingested nitrate leads to endogenous formation of N-nitroso compounds that are breast carcinogens in animals, but human evidence is limited. OBJECTIVE: We evaluated ingested nitrate as a risk factor for breast ...
  • Inglés Esteve, Julia; Morales, Mònica; Dalmases Massegú, Alba, 1982-; Garcia Carbonell, Ricard; Jené i Sanz, Alba, 1984-; López Bigas, Núria; Iglesias Coma, Mar; Ruiz Herguido, Cristina; Rovira Guerín, Ana; Rojo, Federico; Albanell Mestres, Joan; Gomis, Roger R.; Bigas Salvans, Anna; Espinosa Blay, Lluís (Public Library of Science (PLoS), 2012)
    14-3-3σ is frequently lost in human breast cancers by genetic deletion or promoter methylation. We have now investigated the involvement of 14-3-3σ in the termination of NF-κB signal in mammary cells and its putative role ...
  • Chaves Pozo, Elena; Valero, Yulema; Esteve-Codina, Anna; Gómez Garrido, Jèssica; Dabad, Marc; Alioto, Tyler; Meseguer, José; Esteban, María Ángeles; Cuesta, Alberto (Nature Publishing Group, 2017)
    Nervous necrosis virus (NNV) causes high mortalities in several marine species. We aimed to evaluate the innate cell-mediated cytotoxic (CMC) activity of head-kidney leucocytes (HKLs) isolated from naïve European sea bass ...
  • Briggs, Katharine; Cases, Montserrat; Heard, David J.; Pastor Maeso, Manuel; Pognan, François; Sanz, Ferran; Schwab, Christof H.; Steger-Hartmann, Thomas; Sutter, Andreas; Watson, David K.; Wichard, Jörg (MDPI, 2012)
    There is a widespread awareness that the wealth of preclinical toxicity data that the pharmaceutical industry has generated in recent decades is not exploited as efficiently as it could be. Enhanced data availability for ...
  • Junier, Ivan; Unal, E. Besray; Yus, Eva; Lloréns Rico, Verónica, 1989-; Serrano Pubull, Luis, 1982- (Elsevier, 2016)
    Coordination of transcription in bacteria occurs at supra-operonic scales, but the extent, specificity, and mechanisms of such regulation are poorly understood. Here, we tackle this problem by profiling the transcriptome ...
  • Ramon, Maria Antonia; Ferrer, Jaume; Gimeno Santos, Elena, 1980-; Donaire González, David; Rodríguez, Esther; Balcells Vilarnau, Eva, 1967-; De Batlle, Jordi; Benet, Marta; Guerra, Stefano; Sauleda Roig, Jaume; Ferrer, Antoni-Lluc, 1942-; Farrero, Eva; Gea Guiral, Joaquim; Barberà, Joan Albert; Agustí, Alvar; Rodríguez Roisin, Robert; Antó i Boqué, Josep Maria; García Aymerich, Judith; PAC-COPD Study Group (Wiley, 2016)
    BACKGROUND AND OBJECTIVE: Exercise capacity decline is a predictor of mortality in patients with chronic obstructive pulmonary disease (COPD). Static pulmonary hyperinflation is a key determinant of exercise performance, ...
  • Sarlabous, Leonardo; Torres, Abel; Fiz, José Antonio; Martínez-Llorens, Juana Mª; Gea Guiral, Joaquim; Jané, Raimon (Public Library of Science (PLoS), 2017)
    There is a lack of instruments for assessing respiratory muscle activation during the breathing cycle in clinical conditions. The aim of the present study was to evaluate the usefulness of the respiratory muscle mechanomyogram ...
  • Codina i Solà, Marta, 1988-; Rodríguez Santiago, Benjamín; Homs Raubert, Aïda, 1983-; Santoyo-Lopez, Javier; Rigau, Maria; Aznar Laín, Gemma; Campo Casanelles, Miguel del, 1966-; Gener, Blanca; Gabau, Elisabeth; Botella, María Pilar; Gutiérrez Arumi, Armand, 1980-; Antiñolo, Guillermo; Pérez Jurado, Luis Alberto; Cuscó Martí, Ivon, 1973- (BioMed Central, 2015)
    BACKGROUND: Autism spectrum disorders (ASD) are a group of neurodevelopmental disorders with high heritability. Recent findings support a highly heterogeneous and complex genetic etiology including rare de novo and inherited ...
  • Karube, Kennosuke; Rubio Pérez, Carlota, 1990-; Tamborero Noguera, David; Salar Silvestre, Antonio; Colomo Saperas, Luis Alberto; López Bigas, Núria; Miyoshi, Hiroaki (Nature Publishing Group, 2018)
    Genome studies of diffuse large B-cell lymphoma (DLBCL) have revealed a large number of somatic mutations and structural alterations. However, the clinical significance of these alterations is still not well defined. In ...
  • Engin, H Billur; Güney, Emre, 1983-; Keskin, Ozlem; Oliva Miguel, Baldomero; Gursoy, Attila (Public Library of Science (PLoS), 2013)
    Blocking specific protein interactions can lead to human diseases. Accordingly, protein interactions and the structural knowledge on interacting surfaces of proteins (interfaces) have an important role in predicting the ...
  • Pineda, Silvia; Real, Francisco X.; Kogevinas, Manolis; Carrato, Alfredo; Chanock, Stephen J.; Malats i Riera, Núria; Van Steen, Kristel (Public Library of Science, 2015)
    Omics data integration is becoming necessary to investigate the genomic mechanisms involved in complex diseases. During the integration process, many challenges arise such as data heterogeneity, the smaller number of ...
  • Hernández-Roldán, Juan L.; Dapporto, Leonardo; Dincă, Vlad; Vicente, Juan C.; Hornett, Emily A.; Šíchová, Jindra; Lukhatanov, Vladimir A.; Talavera, Gerard; Vila, Roger (Wiley, 2016)
  • Imanishi, Tadashi; Eyras Jiménez, Eduardo; Sugano, Sumio (Public Library of Science (PLoS), 2004)
    The human genome sequence defines our inherent biological potential; the realization of the biology encoded therein requires knowledge of the function of each gene. Currently, our knowledge in this area is still limited. ...
  • Pérez Llamas, Christian, 1976-; Gundem, Gunes; López Bigas, Núria (Oxford University Press, 2011)
    Recently, we created IntOGen, a resource to integrate a large amount of cancer genomic data. IntOGen aims at facilitating the detection of the most recurrent alterations that drive tumorigenesis. It collates, annotates and ...
  • Ballana Guix, Ester; González Ruiz, Juan Ramón; Bosch Pagès, Nina; Estivill, Xavier, 1955- (BioMed Central, 2007)
    Background: Copy number variants (CNVs) account for a significant proportion of normal phenotypic variation and may have an important role in human pathological variation. The α-defensin cluster on human chromosome 8p23.1 ...
  • Mokkink, Lidwine B.; Terwee, Caroline B.; Gibbons, Elisabeth; Stratford, Paul W.; Alonso Caballero, Jordi; Patrick, Donald L.; Knol, Dirk L.; Bouter, Lex M.; De Vet, Henrica C. W. (BioMed Central, 2010)
    Background: The COSMIN checklist is a tool for evaluating the methodological quality of studies on measurement properties of health-related patient-reported outcomes. The aim of this study is to determine the inter-rater ...
  • Stojanovski, Klement; Ferrar, Tony; Benisty, Hannah; Uschner, Friedemann; Delgado, Javier; Jimenez, Javier; Solé, Carme; Nadal Clanchet, Eulàlia de; Klipp, Edda; Posas Garriga, Francesc; Serrano Pubull, Luis, 1982-; Kiel, Christina (Elsevier, 2017)
    The understanding of interaction dynamics in signaling pathways can shed light on pathway architecture and provide insights into targets for intervention. Here, we explored the relevance of kinetic rate constants of a key ...
  • Herrmann, Madeleine; Ruprecht, Klemens; Sauter, Marlies; Martinez, Javier P.; van Heteren, Pearl; Glas, Michael; Best, Barbara; Meyerhans, Andreas; Roemer, Klaus; Mueller-Lantzsch, Nikolaus (Elsevier, 2010)
    Retrovirus replication critically depends on a dynamic interplay between retroviral and host proteins. We report on the binding of the surface subunit (glycoprotein 120 (gp120)) of the human immunodeficiency virus type 1 ...