• RNA as a key factor in driving or preventing self-assembly of the TAR DNA-binding protein 43

  Zacco, Elsa; Graña-Montes, Ricardo; Martin, Stephen R.; Sanchez de Groot, Natalia; Alfano, Caterina; Tartaglia, Gian Gaetano; Pastore, Annalisa (Elsevier, 2019)

  Amyotrophic lateral sclerosis and frontotemporal lobar degeneration are incurable motor neuron diseases associated with muscle weakness, paralysis and respiratory failure. Accumulation of TAR DNA-binding protein 43 (TDP-43) ...
• BKV clearance time correlates with exhaustion state and T-cell receptor repertoire shape of BKV-specific T-cells in renal transplant patients

  Stervbo, Ulrik; Nienen, Mikalai; Weist, Benjamin J. D.; Kuchenbecker, Leon; Hecht, Jochen; Wehler, Patrizia; Westhoff, Timm H.; Reinke, Petra; Babel, Nina (Frontiers Media, 2019)

  Reactivation of the BK polyomavirus is known to lead to severe complications in kidney transplant patients. The current treatment strategy relies on decreasing the immunosuppression to allow the immune system to clear the ...
• Whole-genome sequencing of the opportunistic yeast pathogen candida inconspicua uncovers its hybrid origin

  Mixão, Verónica; Perez Hansen, Antonio; Saus Martínez, Ester; Boekhout, Teun; Lass-Florl, Cornelia; Gabaldón Estevan, Juan Antonio, 1973- (Frontiers Media, 2019)

  Fungal infections such as those caused by Candida species are increasingly common complications in immunocompromised patients. The list of causative agents of candidiasis is growing and comprises a set of emerging species ...
• Transcriptomics-based screening identifies pharmacological inhibition of hsp90 as a means to defer aging

  Janssens, Georges E.; Lin, Xin-Xuan; Millán Ariño, Lluís, 1984-; Kavšek, Alan; Sen, Ilke; Seinstra, Renée I.; Stroustrup, Nicholas; Nollen, Ellen A. A.; Riedel, Christian G. (Elsevier, 2019)

  Aging strongly influences human morbidity and mortality. Thus, aging-preventive compounds could greatly improve our health and lifespan. Here we screened for such compounds, known as geroprotectors, employing the power of ...
• JARID1B expression and its function in DNA damage repair are tightly regulated by miRNAs in breast cancer

  Mocavini, Ivano; Pippa, Simone; Licursi, Valerio; Paci, Paola; Trisciuoglio, Daniela; Mannironi, Cecilia; Presutti, Carlo; Negri, Rodolfo (Wiley Open Access, 2019)

  JARID1B/KDM5B histone demethylase's mRNA is markedly overexpressed in breast cancer tissues and cell lines and the protein has been shown to have a prominent role in cancer cell proliferation and DNA repair. However, the ...
• Bistable emergence of oscillations in growing Bacillus subtilis biofilms

  Martínez Corral, Rosa; Liu, Jintao; Süel, Gürol M.; García Ojalvo, Jordi (National Academy of Sciences, 2018)

  Biofilm communities of Bacillus subtilis bacteria have recently been shown to exhibit collective growth-rate oscillations mediated by electrochemical signaling to cope with nutrient starvation. These oscillations emerge ...
• Constant-Murley Score: systematic review and standardized evaluation in different shoulder pathologies

  Vrotsou, Kalliopi; Ávila Pacheco, Mónica Marcela, 1984-; Machón, Mónica; Mateo-Abad, Maider; Pardo Cladellas, Yolanda; Garin Boronat, Olatz, 1979-; Zaror, Carlos; González, Nerea; Escobar, Antonio; Cuéllar, Ricardo (SpringerOpen, 2018)

  PURPOSE: The objective of this study was to evaluate the psychometric properties of the Constant-Murley Score (CMS) in various shoulder pathologies, based on a systematic review and expert standardized evaluations. METHODS: ...
• Validity of the EQ-5D-5L and reference norms for the Spanish population

  Hernandez, Gimena; Garin Boronat, Olatz, 1979-; Pardo, Yolanda; Vilagut Saiz, Gemma, 1975-; Pont Acuña, Àngels; Suárez, Mónica; Neira, Montse; Rajmil Rajmil, Luis Alberto; Gorostiza, Inigo; Ramallo-Fariña, Yolanda; Cabases, Juan; Alonso Caballero, Jordi; Ferrer Forés, Maria Montserrat (Springer, 2018)

  BACKGROUND AND OBJECTIVE: The EuroQol 5 dimensions 5 levels (EQ-5D-5L) is the new version of EQ-5D, developed to improve its discriminatory capacity. This study aims to evaluate the construct validity of the Spanish version ...
• Change in functioning outcomes as a predictor of the course of depression: a 12-month longitudinal study

  Forero, Carlos G.; Olariu, Elena, 1984-; Álvarez López, Pilar; Castro-Rodriguez, José-Ignacio; Blasco Cubedo, Maria Jesus; Vilagut Saiz, Gemma, 1975-; Alonso Caballero, Jordi; INSAyD Investigators (Springer, 2018)

  PURPOSE: Functioning is a necessary diagnostic criterion for depression, and thus routinely assessed in depressive patients. While it is highly informative of disorder severity, its change has not been tested for prognostic ...
• A living liquid crystal dissected

  García Ojalvo, Jordi (Nature Research, 2019)

  A large-scale imaging study has tracked thousands of bacteria living in three-dimensional biofilms. This technical tour de force reveals the importance of mechanical interactions between cells for building local and global ...
• Magnesium flux modulates ribosomes to increase bacterial survival

  Lee, Dong-yeon D.; Galera Laporta, Letícia, 1985-; Bialecka-Fornal, Maja; Moon, Eun Chae; Shen, Zhouxin; Briggs, Steven P.; García Ojalvo, Jordi; Süel, Gürol M. (Elsevier, 2019)

  Bacteria exhibit cell-to-cell variability in their resilience to stress, for example, following antibiotic exposure. Higher resilience is typically ascribed to "dormant" non-growing cellular states. Here, by measuring ...
• Deficiency in p53 is required for doxorubicin induced transcriptional activation of NF-κB target genes in human breast cancer

  Dalmases Massegú, Alba, 1982-; González González, Irene; Menendez Romero, Silvia; Arpí Llucià, Oriol; Corominas Torres, Josep Maria; Servitja Tormo, Sonia; Tusquets, Ignasi; Chamizo, Cristina; Rincón, Raúl; Espinosa Blay, Lluís; Bigas Salvans, Anna; Eroles, Pilar; Furriol, Jessica; Lluch, Ana; Rovira Guerín, Ana; Albanell Mestres, Joan; Rojo, Federico (Impact Journals, 2014)

  NF-кB has been linked to doxorubicin resistance in breast cancer patients. NF-кB nuclear translocation and DNA binding in doxorubicin treated-breast cancer cells have been extensively examined; however its functional ...
• Chlorination disinfection by-products in drinking water and congenital anomalies: review and meta-analyses

  Nieuwenhuijsen, Mark J.; Martinez Murciano, David; Grellier, James; Bennett, James; Best, Nicky; Iszatt, Nina; Vrijheid, Martine; Toledano, Mireille B. (National Institute of Environmental Health Sciences (NIEHS), 2009)

  OBJECTIVES: The aim of this study was to review epidemiologic evidence, provide summary risk estimates of the association between exposure to chlorination disinfection by-products (DBPs) and congenital anomalies, and provide ...
• Ambient air pollution and risk of congenital anomalies: a systematic review and meta-analysis

  Vrijheid, Martine; Martinez Murciano, David; Manzanares, Sandra; Dadvand, Payam; Schembari, Anna, 1982-; Rankin, Judith; Nieuwenhuijsen, Mark J. (National Institute of Environmental Health Sciences (NIEHS), 2011)

  OBJECTIVE: We systematically reviewed epidemiologic studies on ambient air pollution and congenital anomalies and conducted meta-analyses for a number of air pollutant-anomaly combinations. DATA SOURCES AND EXTRACTION: ...
• European birth cohorts for environmental health research

  Vrijheid, Martine; Casas Sanahuja, Maribel; Kogevinas, Manolis; Nieuwenhuijsen, Mark J. (National Institute of Environmental Health Sciences (NIEHS), 2012)

  BACKGROUND: Many pregnancy and birth cohort studies investigate the health effects of early-life environmental contaminant exposure. An overview of existing studies and their data is needed to improve collaboration, ...
• Traffic-related air pollution, oxidative stress genes, and asthma (ECHRS)

  Castro Giner, Francesc; Künzli, Nino; Jacquemin Leonard, Bénédicte; Forsberg, Bertil; Cid Ibeas, Rafael de; Sunyer Deu, Jordi; Jarvis, Deborah; Briggs, David; Vienneau, Danielle; Norbäck, Dan; Gonzalez, Juan Ramon; Guerra, Stefano; Janson, Christer; Antó i Boqué, Josep Maria; Wjst, Matthias; Heinrich, Joachim; Estivill, Xavier, 1955-; Kogevinas, Manolis (National Institute of Environmental Health Sciences (NIEHS), 2009)

  BACKGROUND: Traffic-related air pollution is related with asthma, and this association may be modified by genetic factors. OBJECTIVES: We investigated the role of genetic polymorphisms potentially modifying the association ...
• Association between long-term exposure to traffic-related air pollution and subclinical atherosclerosis: the REGICOR study

  Rivera, Marcela, 1982-; Basagaña Flores, Xavier; Aguilera Jiménez, Inmaculada, 1977-; Foraster Pulido, Maria, 1984-; Agis, David; Groot, Eric de; Pérez Grau, Laura; Mendez, Michelle A.; Bouso, Laura; Targa, Jaume; Ramos, Rafel; Sala, Joan; Marrugat de la Iglesia, Jaume; Elosua Llanos, Roberto; Künzli, Nino (National Institute of Environmental Health Sciences (NIEHS), 2013)

  BACKGROUND: Epidemiological evidence of the effects of long-term exposure to air pollution on the chronic processes of atherogenesis is limited. OBJECTIVE: We investigated the association of long-term exposure to traffic-related ...
• Self-amplifying pulsatile protein dynamics without positive feedback

  Martínez Corral, Rosa; Raimundez, Elba; Lin, Yihan; Elowitz, Michael B.; García Ojalvo, Jordi (Elsevier, 2018)

  Many proteins exhibit dynamic activation patterns in the form of irregular pulses. Such behavior is typically attributed to a combination of positive and negative feedback loops in the underlying regulatory network. However, ...
• Metabolic basis of brain-like electrical signalling in bacterial communities

  Martínez Corral, Rosa, 1991-; Liu, Jintao; Prindle, Arthur; Süel, Gürol M.; García Ojalvo, Jordi (Royal Society, 2019)

  Information processing in the mammalian brain relies on a careful regulation of the membrane potential dynamics of its constituent neurons, which propagates across the neuronal tissue via electrical signalling. We recently ...
• Pigmentation phototype and prostate and breast cancer in a select Spanish population-A Mendelian randomization analysis in the MCC-Spain study

  Gómez-Acebo, Inés; Castaño Vinyals, Gemma; Kogevinas, Manolis; Llorca, Javier (Public Library of Science (PLoS), 2018)

  INTRODUCTION: Phototype has been associated with an increased risk of prostate cancer, and it is yet unknown if it is related to other hormone-dependent cancers, such as breast cancer or whether this association could be ...

View more