• Metabolic flux is a determinant of the evolutionary rates of enzyme-encoding genes

  Colombo, Martino; Laayouni, Hafid, 1968-; Invergo, Brandon M., 1982-; Bertranpetit, Jaume, 1952-; Montanucci, Ludovica, 1978- (Wiley-VCH Verlag, 2014)

  Relationships between evolutionary rates and gene properties on a genomic, functional, pathway, or system level are being explored to unravel the principles of the evolutionary process. In particular, functional network ...
• Nonhepatosplenic γδ T-cell lymphomas represent a spectrum of aggressive cytotoxic T-cell lymphomas with a mainly extranodal presentation

  Garcia-Herrera, Adriana; Song, Joo Y.; Chuang, Shih-Sung; Villamor, Neus; Colomo Saperas, Luis Alberto; Pittaluga, Stefania; Alvaro, Tomas; Rozman, Maria; Anda Gonzalez, Jazmin de; Arrunategui, Ana Maria; Fernandez, Eva; Gonzalvo, Elena; Estrach, Teresa; Colomer, Dolors; Raffeld, Mark; Gaulard, Philippe; Campo, Elias; Jaffe, Elaine S.; Martinez, Antonio (Lippincott Williams & Wilkins, 2011)

  γδ T cells represent a minor T-cell subset that is mainly distributed in mucosal surfaces. Two distinct lymphomas derived from these cells have been recognized: hepatosplenic γδ T-cell lymphoma (HSTL) and primary cutaneous ...
• Activity-based probes for monitoring postproline protease activity

  Sabidó Aguadé, Eduard, 1981-; Tarragó, Teresa; Niessen, Sherry; Cravatt, Benjamin F.; Giralt, Ernest (Wiley-VCH Verlag, 2009)

  Postproline proteases constitute a subset of serine proteases involved in the regulation of many signaling events and are emerging as promising therapeutic targets for prevalent diseases, such as diabetes and cancer. ...
• Gall bladder and extrahepatic bile duct lymphomas: clinicopathological observations and biological implications

  Mani, Haresh; Climent, Fina; Colomo Saperas, Luis Alberto; Pittaluga, Stefania; Raffeld, Mark; Jaffe, Elaine S. (Lippincott Williams & Wilkins, 2010)

  Lymphomas of the gall bladder and extrahepatic bile ducts are exceedingly rare. We present the clinicopathological features of 19 cases from our files; 14 patients had primary lymphoma (13 involving gall bladder and 1 ...
• IG/MYC rearrangements are the main cytogenetic alteration in plasmablastic lymphomas

  Valera, Alexandra; Balagué, Olga; Colomo Saperas, Luis Alberto; Martínez García, Antonio; Delabie, Jan; Taddesse-Heath, Lekidelu; Jaffe, Elaine S.; Campo, Elias (Lippincott Williams & Wilkins, 2010)

  Plasmablastic lymphoma (PBL) is an aggressive lymphoma characterized by a terminally differentiated B-cell phenotype that usually occurs in the immunocompromised or elderly patients. Although the clinical and pathologic ...
• Traffic-related air pollution, APOEε4 status, and neurodevelopmental outcomes among school children enrolled in the BREATHE project (Catalonia, Spain)

  Alemany, Silvia; Vilor Tejedor, Natàlia, 1988-; García Esteban, Raquel; Bustamante Pineda, Mariona; Dadvand, Payam; Esnaola, Mikel; Mortamais, Marion; Forns i Guzman, Joan, 1981-; van Drooge, Barend L.; Álvarez Pedrerol, Mar; Grimalt Obrador, Joan; Rivas, Ioar; Querol, Xavier; Pujol Martí, Jesús, 1981-; Sunyer Deu, Jordi (National Institute of Environmental Health Sciences (NIEHS), 2018)

  BACKGROUND: Traffic-related air pollution is emerging as a risk factor for Alzheimer's disease (AD) and impaired brain development. Individual differences in vulnerability to air pollution may involve the ε4 allele of ...
• Evaluation of the impact of ambient temperatures on occupational injuries in Spain

  Martínez Solanas, Èrica, 1982-; López Ruiz, María, 1982-; Wellenius, Gregory A.; Gasparrini, Antoni; Sunyer Deu, Jordi; Benavides, Fernando G.(Fernando García); Basagaña Flores, Xavier (National Institute of Environmental Health Sciences (NIEHS), 2018)

  BACKGROUND: Extreme cold and heat have been linked to an increased risk of occupational injuries. However, the evidence is still limited to a small number of studies of people with relatively few injuries and with a limited ...
• Evaluating the association between artificial light-at-night exposure and breast and prostate cancer risk in Spain (MCC-Spain study).

  Garcia-Saenz, Ariadna; Espinosa Díaz, Ana; Valentín, Antònia; Castaño Vinyals, Gemma; Kogevinas, Manolis (National Institute of Environmental Health Sciences (NIEHS), 2018)

  BACKGROUND: Night shift work, exposure to light at night (ALAN) and circadian disruption may increase the risk of hormone-dependent cancers. OBJECTIVES: We evaluated the association of exposure to ALAN during sleeping time ...
• Pregnenolone can protect the brain from cannabis intoxication

  Vallée, Monique; Martín García, Elena, 1975-; Maldonado, Rafael, 1961-; Piazza, Pier Vincenzo (American Association for the Advancement of Science (AAAS), 2014)

  Pregnenolone is considered the inactive precursor of all steroid hormones, and its potential functional effects have been largely uninvestigated. The administration of the main active principle of Cannabis sativa (marijuana), ...
• Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia

  Puente, Xosé S.; Escaramís, Geòrgia; Bassaganyas Bars, Laia, 1985-; Tubio, José M. C.; Tornador Antolin, Cristian, 1979-; Himmelbauer, Heinz; Castillo Andreo, Esther; Dohm, Juliane C.; Guigó Serra, Roderic; Estivill, Xavier, 1955-; Campo, Elias (Nature Research, 2011)

  Chronic lymphocytic leukaemia (CLL), the most frequent leukaemia in adults in Western countries, is a heterogeneous disease with variable clinical presentation and evolution. Two major molecular subtypes can be distinguished, ...
• Common variants at 12q15 and 12q24 are associated with infant head circumference

  Taal, H. Rob; Guxens Junyent, Mònica; Sunyer Deu, Jordi; Estivill, Xavier, 1955-; Jaddoe, Vincent W. V. (Nature Research, 2012)

  To identify genetic variants associated with head circumference in infancy, we performed a meta-analysis of seven genome-wide association studies (GWAS) (N = 10,768 individuals of European ancestry enrolled in pregnancy ...
• DGCR8 HITS-CLIP reveals novel functions for the Microprocessor

  Macias, Sara; Plass Pórtulas, Mireya, 1982-; Stajuda, Agata; Michlewski, Gracjan; Eyras Jiménez, Eduardo; Cáceres, Javier F. (Nature Research, 2012)

  The Drosha-DGCR8 complex (Microprocessor) is required for microRNA (miRNA) biogenesis. DGCR8 recognizes the RNA substrate, whereas Drosha functions as the endonuclease. Using high-throughput sequencing and cross-linking ...
• Multiple Kv1.5 targeting to membrane surface microdomains

  Martínez-Mármol, Ramón; Villalonga, Núria; Solé, Laura; Vicente García, Rubén, 1978-; Tamkun, Michael M.; Soler, Concepció; Felipe, Antonio (Wiley-VCH Verlag, 2008)

  Surface expression of voltage-dependent K(+) channels (Kv) has a pivotal role in leukocyte physiology. Although little is known about the physiological role of lipid rafts, these microdomains concentrate signaling molecules ...
• Microorganisms resistant to conventional antimicrobials in acute exacerbations of chronic obstructive pulmonary disease

  Estirado Vera, Cristina; Ceccato, Adrian; Guerrero, Monica; Huerta, Arturo; Cilloniz, Catia; Vilaró, Olivia; Gabarrús, Albert; Gea Guiral, Joaquim; Crisafulli, Ernesto; Soler, Nestor; Torres, Antoni (BioMed Central, 2018)

  Background: Antimicrobial treatment for acute exacerbations of chronic obstructive pulmonary disease (AECOPD) remains controversial. In some cases AECOPD are caused by microorganisms that are resistant to treatments ...
• Alkylphenolic compounds and risk of breast and prostate cancer in the MCC-Spain study

  Peremiquel-Trillas, Paula; Tusquets Trias de Bes, Ignacio; Castaño Vinyals, Gemma; Kogevinas, Manolis; Costas, Laura (Elsevier, 2019)

  BACKGROUND: Alkylphenolic compounds are chemicals with endocrine disrupting properties that have been widely used in industry with important changes in their usage over time. Few epidemiologic studies have evaluated the ...
• Green and blue spaces and physical functioning in older adults: Longitudinal analyses of the Whitehall II study

  de Keijzer, Carmen; Tonne, Cathryn; Sabia, Severine; Basagaña Flores, Xavier; Valentín, Antònia; Singh-Manoux, Archana; Antó i Boqué, Josep Maria; Alonso Caballero, Jordi; Nieuwenhuijsen, Mark J.; Sunyer Deu, Jordi; Dadvand, Payam (Elsevier, 2019)

  There is increasing evidence of the health benefits of exposure to natural environments, including green and blue spaces. The association with physical functioning and its decline at older age remains to be explored. The ...
• Weather and gastrointestinal disease in Spain: A retrospective time series regression study

  Morral, Clara; Martínez Solanas, Èrica, 1982-; Villanueva Belmonte, Cristina; Basagaña Flores, Xavier (Elsevier, 2018)

  BACKGROUND: A few studies in high-income countries have investigated the relationship between ambient temperature and/or precipitation and the occurrence of gastroenteritis. In most of the cases, hot temperatures and heavy ...
• Phosphorylation and proteasome recognition of the mRNA-Binding protein Cth2 facilitates yeast adaptation to iron deficiency

  Romero, Antonia M.; Martínez Pastor, Mar; Du, Gang; Solé, Carme; Carlos, María; Vergara, Sandra V.; Sanvisens, Nerea; Wohlschlegel, James A.; Toczyski, David P.; Posas Garriga, Francesc; Nadal Clanchet, Eulàlia de; Martínez-Pastor, María T.; Thiele, Dennis J.; Puig, Sergi (American Society for Microbiology, 2018)

  Iron is an indispensable micronutrient for all eukaryotic organisms due to its participation as a redox cofactor in many metabolic pathways. Iron imbalance leads to the most frequent human nutritional deficiency in the ...
• Chromatic transitions in the emergence of syntax networks

  Corominas Murtra, Bernat; Sànchez Fibla, Martí; Valverde, Sergi; Solé Vicente, Ricard, 1962- (Royal Society, 2018)

  The emergence of syntax during childhood is a remarkable example of how complex correlations unfold in nonlinear ways through development. In particular, rapid transitions seem to occur as children reach the age of two, ...
• Response to growth hormone in patients with RNPC3 mutations

  Martos Moreno, Gabriel A.; Travieso-Suárez, Lourdes; Pozo-Román, Jesús; Muñoz-Calvo, María T.; Chowen, Julie A.; Frilander, Mikko J.; Pérez Jurado, Luis Alberto; Hawkins, Federico G.; Argente, Jesús (Wiley-Blackwell, 2018)

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