• Impact of antibiotic resistance on outcomes of neutropenic cancer patients with Pseudomonas aeruginosa bacteraemia (IRONIC study): study protocol of a retrospective multicentre international study

  Albasanz-Puig, Adaia; Montero, Maria Milagro; Carratalà, Jordi; IRONIC study group (BMJ Publishing Group, 2019)

  INTRODUCTION: Pseudomonas aeruginosa (PA) has historically been one of the major causes of severe sepsis and death among neutropenic cancer patients. There has been a recent increase of multidrug-resistant PA (MDRPA) ...
• Incisional hernia recurrence after open elective repair: expertise in abdominal wall surgery matters

  Pereira Rodríguez, José Antonio; Bravo-Salva, Alejandro; Montcusí Ventura, Blanca; Pérez-Farre, Silvia; Fresno de Prado, L.; López-Cano, Manuel (BioMed Central, 2019)

  BACKGROUND: Recurrence after incisional hernia repair is one of the major problems related with this operation. Our objective is to analyze the influence of abdominal wall surgery expertise in the results of the open ...
• Consistent inverse correlation between DNA methylation of the first intron and gene expression across tissues and species

  Anastasiadi, Dafni, 1986-; Esteve-Codina, Anna; Piferrer, Francesc (BioMed Central, 2018)

  Background: DNA methylation is one of the main epigenetic mechanisms for the regulation of gene expression in eukaryotes. In the standard model, methylation in gene promoters has received the most attention since it is ...
• Mutations in L-type amino acid transporter-2 support SLC7A8 as a novel gene involved in age-related hearing loss

  Espino Guarch, Meritxell; Fons-Llitjós, Mariona; Murillo-Cuesta, Silvia; Errasti-Murugarren, Ekaitz; Celaya, Adelaida M.; Girotto, Giorgia; Vuckovic, Dragana; Mezzavilla, Massimo; Vilches, Clara (eLife, 2018)

  Age-related hearing loss (ARHL) is the most common sensory deficit in the elderly. The disease has a multifactorial etiology with both environmental and genetic factors involved being largely unknown. SLC7A8/SLC3A2 heterodimer ...
• High levels of histones promote whole-genome-duplications and trigger a Swe1(WEE1)-dependent phosphorylation of Cdc213(CDK1)

  Maya Miles, Douglas; Peñate, Xenia; Sanmartín Olmo, Trinidad; Jourquin, Frederic; Muñoz Centeno, Maria Cruz; Mendoza, Manuel (Mendoza Palomares); Simon, Marie-Noelle; Chávez, Sebastián; Geli, Vincent (eLife, 2018)

  Whole-genome duplications (WGDs) have played a central role in the evolution of genomes and constitute an important source of genome instability in cancer. Here, we show in Saccharomyces cerevisiae that abnormal accumulations ...
• Two consecutive microtubule-based epithelial seaming events mediate dorsal closure in the scuttle fly Megaselia abdita

  Fraire-Zamora, Juan José; Jaeger, Johannes, 1973-; Solon, Jérôme (eLife, 2018)

  Evolution of morphogenesis is generally associated with changes in genetic regulation. Here, we report evidence indicating that dorsal closure, a conserved morphogenetic process in dipterans, evolved as the consequence of ...
• Prevention and management of musculoskeletal pain in nursing staff by a multifaceted intervention in the workplace: design of a cluster randomized controlled trial with effectiveness, process and economic evaluation (INTEVAL_Spain)

  Serra, Consol; Soler-Font, Mercè; García, Ana María; Peña, Pilar; Vargas-Prada Figueroa, Sergio, 1976 -; Ramada Rodilla, José María, 1961-; Ramada Rodilla, José María, 1961- (BioMed Central, 2019)

  BACKGROUND: Musculoskeletal pain (MSP) is the leading cause of years lived with disability. In consequence, to reduce MSP and its associated sickness absence is a major challenge. Previous interventions have been developed ...
• Labor market situation after an episode of sickness absence due to malignant neoplasia. Evidence from a Spanish cohort

  Lear-Claveras, Ana; Ubalde López, Mònica, 1972-; Serra Saurina, Laura (BioMed Central, 2019)

  BACKGROUND: Due to the progress in screening and cancer treatments, survivor's prognosis has improved enabling a more likely return to work. However, return to work after a cancer diagnosis may be complex because of an ...
• Early outcomes of kidney transplantation from elderly donors after circulatory death (GEODAS study).

  Pérez-Saez , María José; Pascual Santos, Julio; Portolés, José; GEODAS Group (BioMed Central, 2019)

  BACKGROUND: Spain has dramatically increased the number of controlled circulatory death donors (cDCD). The initial selection criteria for considering cDCD for kidney transplantation (KT) have been expanded progressively, ...
• Determinants of international variation in the prevalence of disabling wrist and hand pain

  Coggon David; Serra, Consol; Harcombe, Helen (BioMed Central, 2019)

  BACKGROUND: Previous research has indicated that wide international variation in the prevalence of disabling low back pain among working populations is largely driven by factors predisposing to musculoskeletal pain more ...
• Childhood generalized specific phobia as an early marker of internalizing psychopathology across the lifespan: results from the World Mental Health Surveys

  de Vries, Ymkje Anna; Alonso Caballero, Jordi; de Jonge, Peter (BioMed Central, 2019)
• The genetic landscape of a physical interaction

  Diss, Guillaume; Lehner, Ben, 1978- (eLife, 2018)

  A key question in human genetics and evolutionary biology is how mutations in different genes combine to alter phenotypes. Efforts to systematically map genetic interactions have mostly made use of gene deletions. However, ...
• Quantification of gene expression patterns to reveal the origins of abnormal morphogenesis

  Martínez Abadías, Neus; Mateu-Estivill, Roger; Sastre-Tomas, Jaume; Motch Perrine, Susan; Yoon, Melissa; Robert Moreno, Alexandre; Swoger, Jim; Russo, Lucia; Kawasaki, Kazuhiko (eLife, 2018)

  The earliest developmental origins of dysmorphologies are poorly understood in many congenital diseases. They often remain elusive because the first signs of genetic misregulation may initiate as subtle changes in gene ...
• Sensorimotor pathway controlling stopping behavior during chemotaxis in the Drosophila melanogaster larva

  Tastekin, Ibrahim, 1986-; Khandelwal, Avinash, 1987-; Tadres, David; Fessner, Nico D.; Truman, James W.; Zlatic, Marta; Cardona, Albert; Louis, Matthieu (eLife, 2018)

  Sensory navigation results from coordinated transitions between distinct behavioral programs. During chemotaxis in the Drosophila melanogaster larva, the detection of positive odor gradients extends runs while negative ...
• Endogenous mobilization of bone-marrow cells into the murine retina induces fusion-mediated reprogramming of müller glia cells

  Pesaresi, Martina; Bonilla-Pons, Sergi A.; Simonte, Giacoma, 1984-; Sanges, Daniela; Di Vicino, Umberto; Cosma, Maria Pia, 1970- (Elsevier, 2018)

  Müller glial cells (MGCs) represent the most plastic cell type found in the retina. Following injury, zebrafish and avian MGCs can efficiently re-enter the cell cycle, proliferate and generate new functional neurons. The ...
• Adherens junction length during tissue contraction is controlled by the mechanosensitive activity of actomyosin and junctional recycling

  Sumi, Angughali Aheto, 1986-; Hayes, D. Peran, 1983-; D'Angelo, Arturo; Colombelli, Julien; Salbreux, Guillaume; Dierkes, Kai; Solon, Jérôme (Elsevier, 2018)

  During epithelial contraction, cells generate forces to constrict their surface and, concurrently, fine-tune the length of their adherens junctions to ensure force transmission. While many studies have focused on understanding ...
• Measuring and modeling interventions in aging

  Stroustrup, Nicholas (Elsevier, 2018)

  Many dietary, pharmaceutical, and genetic interventions have been found to increase the lifespan of laboratory animals. Several are now being explored for clinical application. To understand the physiologic action and ...
• Prediction of PD-L1 inhibition effects for HIV-infected individuals

  Zheltkova, Valerya; Argilaguet Marqués, Jordi, 1977-; Peligero Cruz, Cristina, 1986-; Bocharov, Gennady A.; Meyerhans, Andreas (Public Library of Science (PLoS), 2019)

  The novel therapies with immune checkpoint inhibitors hold great promises for patients with chronic virus infections and cancers. This is based mainly on the partial reversal of the exhausted phenotype of antigen-specific ...
• GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI

  Couto Alves, Alexessander; Estivill, Xavier, 1955-; Sunyer Deu, Jordi; Early Growth Genetics (EGG) Consortium (American Association for the Advancement of Science (AAAS), 2019)

  Early childhood growth patterns are associated with adult health, yet the genetic factors and the developmental stages involved are not fully understood. Here, we combine genome-wide association studies with modeling of ...
• Factores sociodemográficos y laborales relacionados con la exposición laboral a riesgos psicosociales por ocupación en España. Proyecto MatEmESp.

  González-Galarzo, M. Carmen; Ronda-Pérez, Elena; Benavides, Fernando G. (Fernando García); García, Ana M. (Societat Catalana de Salut Laboral, 2019)

  Objetivo: El objetivo del estudio es describir el nivel de exposición a riesgos psicosociales por ocupación en población laboral española y analizar su relación con condiciones de empleo y características sociodemográficas. ...

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