• White matter hyperintensities mediate gray matter volume and processing speed relationship in cognitively unimpaired participants

  Brugulat Serrat, Anna, 1986-; Salvadó, Glòria; Operto, Grégory; Cacciaglia, Raffaele; Sudre, Carole H.; Grau-Rivera, Oriol; Suárez-Calvet, Marc; Falcón, Carles; Sánchez Benavides, Gonzalo; Gramunt, Nina; Minguillón, Carolina; Fauria, Karine; Barkhof, Frederik; Molinuevo, José Luis; Gispert López, Juan Domingo; ALFA Study (Wiley, 2020)

  White matter hyperintensities (WMH) have been extensively associated with cognitive impairment and reductions in gray matter volume (GMv) independently. This study explored whether WMH lesion volume mediates the relationship ...
• Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age

  Merid, Simon Kebede; Kogevinas, Manolis; Bustamante Pineda, Mariona; Antó i Boqué, Josep Maria; Melén, Erik (BioMed Central, 2020)

  Background: Preterm birth and shorter duration of pregnancy are associated with increased morbidity in neonatal and later life. As the epigenome is known to have an important role during fetal development, we investigated ...
• The evolutionary history of extinct and living lions

  de Manuel, Marc; Marquès i Bonet, Tomàs, 1975-; Gilbert, M Thomas (National Academy of Sciences, 2020)

  Lions are one of the world's most iconic megafauna, yet little is known about their temporal and spatial demographic history and population differentiation. We analyzed a genomic dataset of 20 specimens: two ca. 30,000-y-old ...
• Incapacidad permanente y mortalidad prematura en una cohorte de afiliados a la Seguridad Social en España, 2004-2015

  Serra Saurina, Laura; Ubalde López, Mònica, 1972-; Benavides, Fernando G. (Fernando García) (Elsevier, 2020)

  Objetivo: Describir un sistema de vigilancia y monitorización basado en el análisis de la tasa de incidencia de la incapacidad permanente (IP) y la mortalidad prematura (MP) en una muestra de afiliados/as a la Seguridad ...
• Copy number variants and fixed duplications among 198 rhesus macaques (Macaca mulatta)

  Brasó-Vives, Marina, 1990-; Povolotskaya, Inna, 1986-; Hartasánchez Frenk, Diego Andrés, 1982-; Farré, Xavier; Fernández Callejo, Marcos; Raveendran, Muthuswamy; Harris, R. Alan; Rosene, Douglas L.; Lorente Galdós, Maria Belén; Navarro i Cuartiellas, Arcadi, 1969-; Marquès i Bonet, Tomàs, 1975-; Rogers, Jeffrey; Juan Sopeña, David Alejandro, 1975- (Public Library of Science (PLoS), 2020)

  The rhesus macaque is an abundant species of Old World monkeys and a valuable model organism for biomedical research due to its close phylogenetic relationship to humans. Copy number variation is one of the main sources ...
• Enabling large-scale genome editing at repetitive elements by reducing DNA nicking

  Smith, Cory J.; Castanon, Oscar; Said, Khaled; Volf, Verena; Khoshakhlagh, Parastoo; Hornick, Amanda; Ferreira, Raphael; Wu, Chun-Ting; Güell Cargol, Marc; Garg, Shilpa; Ng, Alex H. M.; Myllykallio, Hannu; Church, George M. (Oxford University Press, 2020)

  To extend the frontier of genome editing and enable editing of repetitive elements of mammalian genomes, we made use of a set of dead-Cas9 base editor (dBE) variants that allow editing at tens of thousands of loci per cell ...
• Extreme differences between human germline and tumor mutation densities are driven by ancestral human-specific deviations

  Heredia Genestar, José María, 1985-; Marquès i Bonet, Tomàs, 1975-; Juan Sopeña, David Alejandro, 1975-; Navarro i Cuartiellas, Arcadi, 1969- (Nature Research, 2020)

  Mutations do not accumulate uniformly across the genome. Human germline and tumor mutation density correlate poorly, and each is associated with different genomic features. Here, we use non-human great ape (NHGA) germlines ...
• Budding yeast complete DNA synthesis after chromosome segregation begins

  Ivanova, Tsvetomira Georgieva, 1978-; Maier, Michael, 1983-; Missarova, Alsu, 1990-; Ziegler-Birling, Céline; Dam, Monica; Gomar-Alba, Mercè; Carey, Lucas, 1980-; Mendoza, Manuel (Mendoza Palomares) (Nature Research, 2020)

  To faithfully transmit genetic information, cells must replicate their entire genome before division. This is thought to be ensured by the temporal separation of replication and chromosome segregation. Here we show that ...
• Gut bacterial ClpB-like gene function is associated with decreased body weight and a characteristic microbiota profile

  Arnoriaga Rodríguez, María; Mayneris Perxachs, Jordi; Burokas, Aurelijus, 1982-; Pérez Brocal, Vicente; Moya, Andrés; Portero Otín, Manuel; Ricart, Wifredo; Maldonado, Rafael, 1961-; Fernández Real, Jose M. (BioMed Central, 2020)

  Background: The chaperone ClpB, a bacterial protein, is a conformational antigen-mimetic of α-melanocyte-stimulating hormone (α-MSH) implicated in body weight regulation in mice. We here investigated the potential associations ...
• Impact of cytomegalovirus infection on B cell differentiation and cytokine production in multiple sclerosis

  Zabalza, Ana; Vera, Andrea; Alari-Pahissa, Elisenda; Munteis Olivas, Elvira; Moreira Villanueva, Antía; Yélamos López, José; Llop, Mireia; López-Botet, M. (Miguel); Martínez Rodríguez, Jose E. (BioMed Central, 2020)

  Background: Human cytomegalovirus (HCMV) infection has been recently associated with a low risk of multiple sclerosis (MS), yet the basis behind this observation remains uncertain. In this study, we aimed to determine in ...
• A novel hydroxylation step in the taxane biosynthetic pathway: A new approach to paclitaxel production by synthetic biology

  Sánchez Muñoz, Raúl, 1990-; Pérez Mata, Edgar; Almagro, Lorena; Cusidó Vidal, Rosa M.; Bonfill Baldrich, Ma. Mercedes; Palazón, Javier; Moyano Claramunt, Elisabet (Frontiers, 2020)

  Engineered plant cell lines have the potential to achieve enhanced metabolite production rates, providing a high-yielding source of compounds of interest. Improving the production of taxanes, pharmacologically valuable ...
• Personal exposure to particulate air pollution and vascular damage in peri-urban South India

  Ranzani, Otavio; Milà, Carles; Sanchez, Margaux; Bhogadi, Santhi; Kulkarni, Bharati; Balakrishnan, Kalpana; Sambandam, Sankar; Sunyer Deu, Jordi; Marshall, Julian D.; Kinra, Sanjay; Tonne, Cathryn (Elsevier, 2020)

  Objective: Air pollution is a leading preventable risk factor for cardiovascular diseases. Previous studies mostly relied on concentrations at residence, which might not represent personal exposure. Personal air pollution ...
• Cord blood DNA methylation reflects cord blood C-reactive protein levels but not maternal levels: a longitudinal study and meta-analysis

  Yeung, Edwina H.; Guan, Weihua; Zeng, Xuehuo; Salas Díaz, Lucas Andrés, 1980-; Mumford, Sunni L.; Prado Bert, Paula de; van Meel, Evelien R.; Malmberg, Anni; Sunyer Deu, Jordi; Duijts, Liesbeth; Felix, Janine Frédérique; Czamara, Darina; Hämäläinen, Esa; Binder, Elisabeth B.; Räikkönen, Katri; Lahti, Jari; London, Stephanie J.; Silver, Robert M.; Schisterman, Enrique F. (BioMed Central, 2020)

  Background: Prenatal inflammation has been proposed as an important mediating factor in several adverse pregnancy outcomes. C-reactive protein (CRP) is an inflammatory cytokine easily measured in blood. It has clinical ...
• Attenuated epigenetic suppression of muscle stem cell necroptosis is required for efficient regeneration of dystrophic muscles

  Sreenivasan, Krishnamoorthy; Ianni, Alessandro; Künne, Carsten; Strilic, Boris; Günther, Stefan; Perdiguero, Eusebio, 1968-; Krüger, Marcus; Spuler, Simone; Offermanns, Stefan; Gómez del Arco, Pablo; Redondo, Juan Miguel; Muñoz Cánoves, Pura, 1962-; Kim, Johnny; Braun, Thomas (Elsevier, 2020)

  Somatic stem cells expand massively during tissue regeneration, which might require control of cell fitness, allowing elimination of non-competitive, potentially harmful cells. How or if such cells are removed to restore ...
• CoDysAn: A telemedicine tool to improve awareness and diagnosis for patients with congenital dyserythropoietic anemia

  Tornador Antolin, Cristian, 1979-; Sánchez Prados, Edgar; Cadenas, Beatriz; Russo, Roberta; Venturi, Veronica; Andolfo, Immacolata; Hernández Rodriguez, Ines; Iolascon, Achille; Sánchez, Mayka (Frontiers, 2019)

  Congenital Dyserythropoietic Anemia (CDA) is a heterogeneous group of hematological disorders characterized by chronic hyporegenerative anemia and distinct morphological abnormalities of erythroid precursors in the bone ...
• Closing the gap between therapeutic use and mode of action in remedial herbs

  Olivés Farrés, Joaquim, 1987-; Mestres i López, Jordi (Frontiers, 2019)

  The ancient tradition of taking parts of a plant or preparing plant extracts for treating certain discomforts and maladies has long been lacking a scientific rationale to support its preparation and still widespread use ...
• License to kill? Domestic cats affect a wide range of native fauna in a highly biodiverse mediterranean country

  Mori, Emiliano; Menchetti, Mattia; Camporesi, Alberto; Cavigioli, Luca; Tabarelli de Fatis, Karol; Girardello, Marco (Frontiers, 2019)

  Amongst domestic animals, the domestic cat, Felis catus, is widely considered to be one of the most serious threats to wildlife conservation. This is particularly evident for island ecosystems, as data for mainland countries ...
• Organophosphate pesticide metabolite concentrations in urine during pregnancy and offspring nonverbal IQ at age 6 years

  Jusko, Todd A.; van den Dries, Michiel; Pronk, Anjoeka; Shaw, Pamela A.; Guxens Junyent, Mònica; Spaan, Suzanne; Jaddoe, Vincent W. V.; Tiemeier, Henning; Longnecker, Matthew P. (National Institute of Environmental Health Sciences (NIEHS), 2019)

  Background: Susceptibility to organophosphate (OP) pesticide neurotoxicity may be greatest during the prenatal period; however, previous studies have produced mixed findings concerning in utero OP pesticide exposure and ...
• Does the oxidative stress play a role in the associations between outdoor air pollution and persistent asthma in adults? Findings from the EGEA study

  Havet, Anaïs; Li, Zhen; Zerimech, Farid; Sanchez, Margaux; Siroux, Valérie; Le Moual, Nicole; Brunekreef, Bert; Künzli, Nino; Jacquemin Leonard, Bénédicte; Varraso, Raphaëlle; Matran, Regis; Nadif, Rachel (BioMed Central, 2019)

  Background: Evidences that oxidative stress plays a role in the associations between outdoor air pollution and asthma are growing. We aimed to study the role of plasma fluorescent oxidation products levels (FlOPs; an ...
• Associations of black carbon with lung function and airway inflammation in schoolchildren

  Paunescu, Alexandra-Cristina; Casas Sanahuja, Maribel; Ferrero, Amparo; Pañella, Pau; Bougas, Nicolas; Beydon, Nicole; Just, Jocelyne; Lezmi, Guillaume; Sunyer Deu, Jordi; Ballester Díez, Ferran; Momas, Isabelle (Elsevier, 2019)

  Background: Few studies have investigated the 24-hour respiratory health effects of personal black carbon (BC) and ultrafine particles (UFP) exposure in schoolchildren. The objective of this study was to investigate these ...

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