• A unicellular relative of animals generates a layer of polarized cells by actomyosin-dependent cellularization

  Dudin, Omaya; Ondracka, Andrej; Grau Bové, Xavier; Haraldsen, Arthur A. B.; Toyoda, Atsushi; Suga, Hiroshi; Bråte, Jon; Ruiz Trillo, Iñaki (eLife, 2019)

  In animals, cellularization of a coenocyte is a specialized form of cytokinesis that results in the formation of a polarized epithelium during early embryonic development. It is characterized by coordinated assembly of an ...
• The Tudor SND1 protein is an m6A RNA reader essential for replication of Kaposi’s sarcoma-associated herpesvirus

  Baquero Pérez, Belinda; Antanaviciute, Agne; Yonchev, Ivaylo D.; Carr, Ian M.; Wilson, Stuart A.; Whitehouse, Adrian (eLife, 2019)

  N6-methyladenosine (m6A) is the most abundant internal RNA modification of cellular mRNAs. m6A is recognised by YTH domain-containing proteins, which selectively bind to m6A-decorated RNAs regulating their turnover and ...
• Heat tolerance and acclimation capacity in subterranean arthropods living under common and stable thermal conditions

  Pallarés, Susana; Colado, Raquel; Pérez Fernández, Toni; Wesener, Thomas; Ribera, Ignacio; Sánchez Fernández, David (Wiley-Blackwell, 2019)

  Cave-dwelling ectotherms, which have evolved for millions of years under stable thermal conditions, could be expected to have adjusted their physiological limits to the narrow range of temperatures they experience and to ...
• Bacterial communities within Phengaris (Maculinea) alcon caterpillars are shifted following transition from solitary living to social parasitism of Myrmica ant colonies

  Szenteczki, Mark A.; Pitteloud, Camille; Casacci, Luca P.; Kešnerová, Lucie; Whitaker, Melissa R. L.; Engel, Philipp; Vila, Roger; Alvarez, Nadir (Wiley-Blackwell, 2019)

  Bacterial symbionts are known to facilitate a wide range of physiological processes and ecological interactions for their hosts. In spite of this, caterpillars with highly diverse life histories appear to lack resident ...
• Narrow-band imaging and high-definition white-light endoscopy in patients with serrated lesions not fulfilling criteria for serrated polyposis syndrome: a randomized controlled trial with tandem colonoscopy

  Riu Pons, Fausto; Andreu García, Montserrat; Naranjo‐Hans, Dolores; Álvarez-González, Marco Antonio; Seoane, Agustín; Dedeu Cusco, Josep Maria; Barranco Priego, Luis Eugenio; Bessa Caserras, Xavier (BioMed Central, 2020)

  Background: It is unknown whether narrow-band imaging (NBI) could be more effective than high-definition white-light endoscopy (HD-WLE) in detecting serrated lesions in patients with prior serrated lesions > 5 mm not ...
• A prospective study of patient reported urinary incontinence among American, Norwegian and Spanish men 1 year after prostatectomy

  Storås, Anne Holck; Sanda, Martin George; Garin Boronat, Olatz, 1979-; Chang, Peter; Patil, Dattatraya; Crociani, Catrina M.; Suárez, José Francisco; Cvancarova, Milada; Loge, Jon Håvard; Fossà, Sophie Dorothea (Elsevier, 2020)

  Objective: To compare pre- and post-radical prostatectomy (RP) responses in the urinary incontinence domain of Expanded Prostate Cancer Index Composite-26 (EPIC-26) in cohorts from the USA, Norway and Spain. Methods: A ...
• Assessment of the role of Wolbachia in mtDNA paraphyly and the evolution of unisexuality in Calligrapha (Coleoptera: Chrysomelidae)

  Gómez Zurita, Jesús (Wiley-Blackwell, 2019)

  Calligrapha is a New World leaf beetle genus that includes several unisexual species in northeastern North America. Each unisexual species had an independent hybrid origin involving different combinations of bisexual ...
• Upregulation of E93 gene expression acts as the trigger for metamorphosis independently of the threshold size in the beetle tribolium castaneum

  Chafino Aixa, Silvia, 1991-; Ureña, Enric; Casanova, Jordi; Casacuberta Suñer, Elena, 1972-; Franch i Marro, Xavier; Martín, David (Elsevier, 2019)

  Body size in holometabolous insects is determined by the size at which the juvenile larva undergoes metamorphosis to the pupal stage. To undergo larva-pupa transition, larva must reach a critical developmental checkpoint, ...
• Socioeconomic inequalities in suicide mortality in Barcelona during the economic crisis (2006–2016): a time trend study

  López Contreras, Natalia; Rodríguez Sanz, Maica, 1974-; Novoa Pardo, Ana María; Borrell i Thió, Carme; Medallo Muñiz, Jordi; Gotsens Miquel, Mercè, 1983- (BMJ Publishing Group, 2019)

  Objectives: This study aimed to analyse trends in socioeconomic inequalities in suicide mortality in Barcelona before and after the start of the economic crisis that started at the end of 2008, including both individual ...
• Cohort profile: the MCC-Spain follow-up on colorectal, breast and prostate cancers: study design and initial results

  Alonso-Molero, Jéssica; Molina, Antonio J.; Jiménez-Moleón, José Juan; Pérez-Gómez, Beatriz; Martín, Vicente; Moreno, Víctor; Amiano, Pilar; Ardanaz Aicua, Eva; Sanjosé Llongueras, Silvia de; Salcedo-Bellido, Inmaculada; Fernández-Tardón, Guillermo; Alguacil, Juan; Salas, Dolores; Marcos-Gragera, Rafael; Chirlaque, María Dolores; Aragonés, Núria; Castaño Vinyals, Gemma; Pollan, Marina; Kogevinas, Manolis; Llorca, Javier (BMJ Publishing Group, 2019)

  Purpose: Since 2016, the multicase-control study in Spain (MCC-Spain) has focused towards the identification of factors associated with cancer prognosis. Inception cohorts of patients with colorectal, breast and prostate ...
• Rationale and population-based prospective cohort protocol for the disadvantaged populations at risk of decline in eGFR (CO-DEGREE)

  González Quiroz, Marvin; Nitsch, Dorothea; Hamilton, Sophie; O'Callaghan Gordo, Cristina; Saran, Rajiv; Glaser, Jason; Correa Rotter, Ricardo; Jakobsson, Kristina; Singh, Ajay; Gunawardena, Nalika; Levin, Adeera; Remuzzi, Giuseppe; Caplin, Ben; Pearce, Neil E.; DEGREE Study Steering Committee (BMJ Publishing Group, 2019)

  Introduction: A recently recognised form of chronic kidney disease (CKD) of unknown origin (CKDu) is afflicting communities, mostly in rural areas in several regions of the world. Prevalence studies are being conducted in ...
• Prevalence of and risk factors for chronic kidney disease of unknown aetiology in India: secondary data analysis of three population-based cross-sectional studies

  O'Callaghan Gordo, Cristina; Shivashankar, Roopa; Anand, Schuchi; Ghosh, Shreeparna; Glaser, Jason; Gupta, Ruby; Jakobsson, Kristina; Kondal, Dimple; Krishnan, Anand; Mohan, Sailesh; Mohan, Viswanathan; Nitsch, Dorothea; Praveen, P. A.; Tandon, Nikhil; Narayan, K. M. Venkat; Pearce, Neil E.; Caplin, Ben; Prabhakaran, Dorairaj (BMJ Publishing Group, 2019)

  Objectives: To assess whether chronic kidney disease of unknown aetiology (CKDu) is present in India and to identify risk factors for it using population-based data and standardised methods. Design: Secondary data analysis ...
• Factors associated with readmissions in women participating in screening programs and treated for breast cancer: a retrospective cohort study

  Miret, Carme; Domingo, Laia; Louro, Javier; Barata, Teresa; Baré, Marisa; Ferrer, Joana; Carmona-Garcia, Maria Carmen; Castells, Xavier; Sala, Maria (BioMed Central, 2019)

  Background: We aimed to identify the risk factors associated with early, late and long-term readmissions in women diagnosed with breast cancer participating in screening programs. Methods: We performed a multicenter cohort ...
• Genome-wide data from the Bubi of Bioko Island clarifies the Atlantic fringe of the Bantu dispersal

  Gelabert Xirinachs, Pere, 1991-; Ferrando-Bernal, Manuel; de Dios, Toni; Mattorre, Benedetta; Campoy, Elena; Gorostiza, Amaya; Patin, Etienne; González Martín, Antonio; Lalueza Fox, Carles, 1965- (BioMed Central, 2019)

  Background: Bioko is one of the few islands that exist around Africa, the most genetically diverse continent on the planet. The native Bantu-speaking inhabitants of Bioko, the Bubi, are believed to have colonized the island ...
• Prevalence of abnormal Alzheimer's disease biomarkers in patients with subjective cognitive decline: cross-sectional comparison of three European memory clinic samples

  Wolfsgruber, Steffen; Molinuevo, José Luis; Euro-SCD working group (BioMed Central, 2019)

  Introduction: Subjective cognitive decline (SCD) in cognitively unimpaired older individuals has been recognized as an early clinical at-risk state for Alzheimer's disease (AD) dementia and as a target population for future ...
• Tumour characteristics and survivorship in a cohort of breast cancer: the MCC-Spain study

  Gómez-Acebo, Inés; Domingo, Laia; Castaño Vinyals, Gemma; Kogevinas, Manolis; Llorca, Javier (SpringerOpen, 2020)

  Purpose: The objective of this study is to analyse the relative survival with breast cancer in women diagnosed after new treatments were generalised and to ascertain the current effect that tumour characteristics such as ...
• Earliest amyloid and tau deposition modulate the influence of limbic networks during closed-loop hippocampal downregulation

  Skouras, Stavros; Torner, Jordi; Andersson, Patrik; Koush, Yury; Falcon, Carles; Minguillón, Carolina; Fauria, Karine; Alpiste, Francesc; Blenow, Kaj; Zetterberg, Henrik; Gispert López, Juan Domingo; Molinuevo, José Luis; ALFA Study (Oxford University Press, 2020)

  Research into hippocampal self-regulation abilities may help determine the clinical significance of hippocampal hyperactivity throughout the pathophysiological continuum of Alzheimer's disease. In this study, we aimed to ...
• Spatial patterns of white matter hyperintensities associated with Alzheimer’s disease risk factors in a cognitively healthy middle-aged cohort

  Salvadó, Gemma; Brugulat Serrat, Anna, 1986-; Sudre, Carole H.; Grau-Rivera, Oriol; Suárez-Calvet, Marc; Falcón, Carles; Fauria, Karine; Cardoso, M. Jorge; Barkhof, Frederik; Molinuevo, José Luis; Gispert López, Juan Domingo; ALFA Study (BioMed Central, 2019)

  Background: White matter hyperintensities (WMH) of presumed vascular origin have been associated with an increased risk of Alzheimer's disease (AD). This study aims to describe the patterns of WMH associated with dementia ...
• Prediction of amyloid pathology in cognitively unimpaired individuals using voxel-wise analysis of longitudinal structural brain MRI

  Petrone, Paula M.; Casamitjana, Adrià; Falcón, Carles; Artigues, Miquel; Operto, Grégory; Cacciaglia, Raffaele; Molinuevo, José Luis; Vilaplana, Verónica; Gispert López, Juan Domingo; Alzheimer’s Disease Neuroimaging Initiative (BioMed Central, 2019)

  Background: Magnetic resonance imaging (MRI) has unveiled specific alterations at different stages of Alzheimer's disease (AD) pathophysiologic continuum constituting what has been established as "AD signature". To what ...
• Centiloid cut-off values for optimal agreement between PET and CSF core AD biomarkers

  Salvadó, Gemma; Molinuevo, José Luis; Brugulat Serrat, Anna, 1986-; Falcón, Carles; Grau-Rivera, Oriol; Suárez-Calvet, Marc; Pavía Segura, Javier; Niñerola-Baizán, Aida; Perissinotti, Andrés; Lomeña, Francisco; Minguillón, Carolina; Fauria, Karine; Zetterberg, Henrik; Blennow, Kaj; Gispert López, Juan Domingo; Alzheimer’s Disease Neuroimaging Initiative (BioMed Central, 2019)

  Background: The Centiloid scale has been developed to standardize measurements of amyloid PET imaging. Reference cut-off values of this continuous measurement enable the consistent operationalization of decision-making for ...

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