• Thromboembolic, cardiovascular and overall mortality risks of aromatase inhibitors, compared with tamoxifen treatment: an outpatient-register-based retrospective cohort study

  Pineda-Moncusí, Marta; Garcia Giralt, Natàlia; Díez Pérez, Adolfo; Tusquets Trias de Bes, Ignacio; Servitja Tormo, Sonia; Albanell Mestres, Joan; Prieto-Alhambra, Daniel; Nogués Solan, Francesc Xavier (SAGE Publications, 2020)

  Background: Tamoxifen (TAM) and aromatase inhibitor (AI) therapies have been associated with increased risk of thromboembolic and cardiovascular events, respectively, in addition to other side effects. This study analysed ...
• Evolutionary and functional patterns of shared gene neighbourhood in fungi

  Marcet Houben, Marina; Gabaldón Estevan, Juan Antonio, 1973- (Nature Research, 2019)

  Gene clusters comprise genomically co-localized and potentially co-regulated genes that tend to be conserved across species. In eukaryotes, multiple examples of metabolic gene clusters are known, particularly among fungi ...
• Impact of a telemedicine program on the reduction in the emission of atmospheric pollutants and journeys by road

  Vidal Alaball, Josep; Franch Parella, Jordi; López Seguí, Francesc; Garcia Cuyàs, Francesc; Mendioroz Peña, Jacobo (MDPI, 2019)

  This retrospective study evaluates the effect of a telemedicine program developed in the central Catalan region in lowering the environmental footprint by reducing the emission of atmospheric pollutants, thanks to a reduction ...
• Influence of childhood asthma and allergies on occupational exposure in early adulthood: a prospective cohort study

  Dumas, Orianne; Le Moual, Nicole; Lowe, Adrian J.; Lodge, Caroline J.; Zock, Jan-Paul; Kromhout, Hans; Erbas, Bircan; Perret, Jennifer L.; Dharmage, Shyamali C.; Benke, Geza; Abramson, Michael J. (MDPI, 2019)

  We aimed to determine whether history of asthma/allergies in childhood was associated with avoidance of jobs with exposure to asthmagens in early adulthood. The Melbourne Atopic Cohort Study recruited 620 children at high ...
• Oral health-related quality of life in native and immigrant populations in the PELFI study in Spain

  Agudelo Suárez, Andrés A; Vivares Builes, Annie M.; Muñoz Pino, Natalia; Martínez Martínez, José Miguel, 1974-; Reid, Alison; Ronda-Pérez, Elena (MDPI, 2019)

  Quality of life and its relationship to oral health is an important consideration in the determinants of health of vulnerable groups. The aim of this study is to assess oral health-related quality of life (OHRQoL) and its ...
• Population health inequalities across and within european metropolitan areas through the lens of the EURO-HEALTHY Population Health Index

  Costa, Claudia; Santana, Paula; Dimitroulopoulou, Sani; Burström, Bo; Borrell i Thió, Carme; Schweikart, Jürgen; Dzúrová, Dagmar; Zangarini, Nicolás; Katsouyanni, Klea; Deboseree, Patrick; Freitas, Ângela; Mitsakou, Christina; Samoli, Evangelia; Vardoulakis, Sotiris; Marí Dell'Olmo, Marc, 1978-; Gotsens Miquel, Mercè, 1983-; Lustigova, Michala; Corman, Diana; Costa, Giuseppe (MDPI, 2019)

  The different geographical contexts seen in European metropolitan areas are reflected in the uneven distribution of health risk factors for the population. Accumulating evidence on multiple health determinants point to the ...
• Self-reported sleep disturbance from road, rail and aircraft noise: exposure-response relationships and effect modifiers in the SiRENE study

  Brink, Mark; Schäffer, Beat; Vienneau, Danielle; Pieren, Reto; Foraster Pulido, Maria, 1984-; Eze, Ikenna C.; Rudzik, Franziska; Thiesse, Laurie; Cajochen, Christian; Probst-Hensch, Nicole; Röösli, Martin; Wunderli, Jean Marc (MDPI, 2019)

  This survey investigates the cross-sectional association between nighttime road, rail and aircraft noise exposure and the probability to be highly sleep disturbed (%HSD), as measured by self-report in postal and online ...
• DNA methylation in inflammatory pathways modifies the association between BMI and adult-onset non-atopic asthma

  Jeong, Ayoung; Imboden, Medea; Ghantous, Akram; Novoloaca, Alexei; Carsin, Anne-Elie; Kogevinas, Manolis; Schindler, Christian; Lovison, Gianfranco; Herceg, Zdenko; Cuenin, Cyrille; Vermeulen, Roel; Jarvis, Deborah; Amaral, André F.S.; Kronenberg, Florian; Vineis, Paolo; Probst-Hensch, Nicole (MDPI, 2019)

  A high body mass (BMI) index has repeatedly been associated with non-atopic asthma, but the biological mechanism linking obesity to asthma is still poorly understood. We aimed to test the hypothesis that inflammation and/or ...
• Our lives in boxes: perceived community mediators between housing insecurity and health using a PHOTOVOICE approach

  Vásquez-Vera, Hugo, 1982-; Fernández, Ana; Novoa Pardo, Ana María; Delgado, Lucía; Barcala, Joaquín; Macías, Carlos; Borrell i Thió, Carme; Photovoice Working Group of Public Health Agency of Barcelona (BioMed Central, 2019)

  Background: While the negative effects of housing insecurity on health are well known, the mechanisms and mediators of these effects have been less well studied. The aim of this study is to identify perceived mediators ...
• Trends in mortality inequalities in an urban area: the influence of immigration

  Rodríguez Sanz, Maica, 1974-; Gotsens Miquel, Mercè, 1983-; Marí Dell'Olmo, Marc, 1978-; Borrell i Thió, Carme (BioMed Central, 2019)

  Background: Nearly 20% of the population in Barcelona is foreign-born and this percentage rises to up to 40% in some neighborhoods. Consequently, migration health patterns may play an important role in trends in socioeconomic ...
• Dissecting the effects of selection and mutation on genetic diversity in three wood white (Leptidea) butterfly species

  Talla, Venkat; Soler, Lucile; Kawakami, Takeshi; Dincă, Vlad; Vila, Roger; Friberg, Magne; Wiklund, Christer; Backström, Niclas (Oxford University Press, 2019)

  The relative role of natural selection and genetic drift in evolution is a major topic of debate in evolutionary biology. Most knowledge spring from a small group of organisms and originate from before it was possible to ...
• ReorientExpress: reference-free orientation of nanopore cDNA reads with deep learning

  Ruiz Reche, Angel; Srivastava, Akanksha; Indi, Joel A.; de la Rubia, Ivan; Eyras Jiménez, Eduardo (BioMed Central, 2019)

  We describe ReorientExpress, a method to perform reference-free orientation of transcriptomic long sequencing reads. ReorientExpress uses deep learning to correctly predict the orientation of the majority of reads, and in ...
• A phase 3 study to compare delafloxacin with moxifloxacin for the treatment of adults with community-acquired bacterial pneumonia (DEFINE-CABP)

  Horcajada Gallego, Juan Pablo; Salata, Robert A.; Álvarez-Sala, Rodolfo; Nitu, Floarea Mimi; Lawrence, Laura; Quintas, Megan; Cheng, Chun-Yen; Cammarata, Sue; DEFINE-CABP Study Group (Oxford University Press, 2020)

  Background: The clinical and economic burden of community-acquired bacterial pneumonia (CABP) is significant and is anticipated to increase as the population ages and pathogens become more resistant. Delafloxacin is a ...
• Associations of sickness absence for pain in the low back, neck and shoulders with wider propensity to pain

  Coggon, David; Serra, Consol; Harcombe, Helen (BMJ Publishing Group, 2020)

  Objectives: To explore the association of sickness absence ascribed to pain at specific anatomical sites with wider propensity to musculoskeletal pain. Methods: As part of the CUPID (Cultural and Psychosocial Influences ...
• The relation of CUN-BAE Index with Body Mass Index and waist circumference in adults aged 50 to 85 Years: the MCC-Spain Study

  Davila-Batista, Veronica; Romaguera Bosch, Dora; Castaño Vinyals, Gemma; Kogevinas, Manolis; Martín Sánchez, Vicente; McC-Spain Study Group (MDPI, 2020)

  Backgound: Traditional anthropometrics such as body mass index (BMI) or waist circumference (WC) do not fully capture the complex biology of body fat (BF) in the elderly. The Clinica Universidad de Navarra-Body Adiposity ...
• The dietary inflammatory index and chronic lymphocytic leukaemia in the MCC Spain Study

  Flores, José Carlos; Gracia Lavedan, Esther; Romaguera Bosch, Dora; Gimeno Vázquez, Eva; Kogevinas, Manolis; Castaño Vinyals, Gemma; Casabonne, Delphine (MDPI, 2020)

  Chronic inflammation plays a role in the development of chronic lymphocytic leukaemia (CLL), and diet might modulate chronic inflammation. This study aims to evaluate the association between the dietary inflammatory index ...
• Association between polyphenol intake and breast Cancer risk by menopausal and hormone receptor status

  Vitelli-Storelli, Facundo; Castaño Vinyals, Gemma; Kogevinas, Manolis; Martín Sánchez, Vicente (MDPI, 2020)

  There is limited evidence of phenolic compounds acting as protective agents on several cancer types, including breast cancer (BC). Nevertheless, some polyphenol classes have not been investigated and there is a lack of ...
• NeAT: a nonlinear analysis toolbox for neuroimaging

  Casamitjana, Adrià; Vilaplana, Verónica; Puch, Santi; Aduriz, Asier; López, Carlos; Operto, Grégory; Cacciaglia, Raffaele; Falcón, Carles; Molinuevo, José Luis; Domingo Gispert, Juan; Alzheimer’s Disease Neuroimaging Initiative (SpringerOpen, 2020)

  NeAT is a modular, flexible and user-friendly neuroimaging analysis toolbox for modeling linear and nonlinear effects overcoming the limitations of the standard neuroimaging methods which are solely based on linear models. ...
• Guidelines and definitions for research on epithelial-mesenchymal transition

  Yang, Jing; García de Herreros, Antonio; Sheng, Guojun; EMT International Association (TEMTIA) (Nature Research, 2020)

  Epithelial-mesenchymal transition (EMT) encompasses dynamic changes in cellular organization from epithelial to mesenchymal phenotypes, which leads to functional changes in cell migration and invasion. EMT occurs in a ...
• The Conserved Non-Coding Sequence 2 (CNS2) enhances CD69 transcription through cooperation between the transcription factors Oct1 and RUNX1

  Fontela, Miguel G.; Notario, Laura; Alari-Pahissa, Elisenda; Lorente, Elena; Lauzurica, Pilar (MDPI, 2019)

  The immune regulatory receptor CD69 is expressed upon activation in all types of leukocytes and is strongly regulated at the transcriptional level. We previously described that, in addition to the CD69 promoter, there are ...

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