• Adaptive features of natural killer cells in multiple sclerosis

  Moreira Villanueva, Antía; Alari-Pahissa, Elisenda; Munteis Olivas, Elvira; Vera, Andrea; Zabalza, Ana; Llop, Mireia; Villarrubia, Noelia; Costa García, Marcel, 1989-; Álvarez-Lafuente, Roberto; Villar, Luisa Maria; López-Botet, M. (Miguel); Martínez-Rodriguez, José E. (Frontiers, 2019)

  Human cytomegalovirus (HCMV) has been recently related with a lower susceptibility to multiple sclerosis (MS). HCMV promotes an adaptive development of NK cells bearing the CD94/NKG2C receptor with a characteristic phenotypic ...
• Dynamics of microRNA expression during mouse prenatal development

  Rahmanian, Sorena; Guigó Serra, Roderic; Mortazavi, Ali (Cold Spring Harbor Laboratory Press (CSHL Press), 2019)

  MicroRNAs (miRNAs) play a critical role as posttranscriptional regulators of gene expression. The ENCODE Project profiled the expression of miRNAs in an extensive set of organs during a time-course of mouse embryonic ...
• Association between long-term air pollution exposure and DNA methylation: The REGICOR study

  Sayols, Sergi; Fernández Sanlés, Alba; Prats Uribe, Albert; Subirana Cachinero, Isaac; Plusquin, Michelle; Künzli, Nino; Marrugat de la Iglesia, Jaume; Basagaña Flores, Xavier; Elosua Llanos, Roberto (Elsevier, 2019)

  INTRODUCTION: Limited evidence suggests that epigenetic mechanisms may partially mediate the adverse effects of air pollution on health. Our aims were to identify new genomic loci showing differential DNA methylation ...
• Association of residential air pollution, noise, and greenspace with initial ischemic stroke severity

  Vivanco Hidalgo, Rosa María; Avellaneda Gómez, Carla; Dadvand, Payam; Cirach, Marta; Ois Santiago, Angel Javier; Gómez González, Alejandra; Rodríguez-Campello, Ana; Ceballos, Pablo de; Basagaña Flores, Xavier; Zabalza, Ana; Cuadrado Godia, Elisa; Sunyer Deu, Jordi; Roquer, Jaume; Wellenius, Gregory A. (Elsevier, 2019)

  BACKGROUND AND PURPOSE: A number of environmental risk factors of acute ischemic stroke have been identified, but few studies have evaluated the influence of the outdoor environment on stroke severity. We assessed the ...
• Association between early life exposure to air pollution and working memory and attention

  Rivas, Ioar; Basagaña Flores, Xavier; Cirach, Marta; López Vicente, Mònica, 1988-; Suades González, Elisabet; García Esteban, Raquel; Álvarez Pedrerol, Mar; Dadvand, Payam; Sunyer Deu, Jordi (National Institute of Environmental Health Sciences (NIEHS), 2019)

  Background: Although previous studies have reported negative associations between exposure to air pollution and cognition, studies of the effects of prenatal and postnatal exposures in early childhood have been limited. ...
• Predictors of personal exposure to black carbon among women in southern semi-rural Mozambique

  Curto Tirado, Ariadna, 1987-; Donaire González, David; Manacaf, Maria N.; González, Raquel; Sacoor, Charfudin; Rivash, Ioar; Gascon, Mireia; Wellenius, Gregory A.; Querol, Xavier; Sunyer Deu, Jordi; Macetef, Eusébio; Menéndez, Clara; Tonn, Cathryn (Elsevier, 2019)

  Sub-Saharan Africa (SSA) has the highest proportion of people using unclean fuels for household energy, which can result in products of incomplete combustion that are damaging for health. Black carbon (BC) is a useful ...
• Toenail concentrations of trace elements and occupational history in pancreatic cancer

  Camargo, Judit; Pumarega Rodríguez, José Antonio; Alguacil, Juan; Sanz-Gallén, Pere; Gasull Panadès, Magda; Delclos, George L.; Amaral, André F.S.; Porta Serra, Miquel (Elsevier, 2019)

  Background: Some occupations potentially entailing exposure to cadmium, arsenic, lead, selenium, nickel, and chromium have been associated with an increased risk of exocrine pancreatic cancer (EPC), but no studies have ...
• Hybridization and emergence of virulence in opportunistic human yeast pathogens

  Mixão, Verónica; Gabaldón Estevan, Juan Antonio, 1973- (Wiley, 2018)

  Hybridization between different species can result in the emergence of new lineages and adaptive phenotypes. Occasionally, hybridization in fungal organisms can drive the appearance of opportunistic lifestyles or shifts ...
• Misidentification of genome assemblies in public databases: The case of Naumovozyma dairenensis and proposal of a protocol to correct misidentifications

  Stavrou, Aimilia A.; Mixão, Verónica; Boekhout, Teun; Gabaldón Estevan, Juan Antonio, 1973- (Wiley, 2018)

  Online sequence databases such as NCBI GenBank serve as a tremendously useful platform for researchers to share and reuse published data. However, submission systems lack control for errors such as organism misidentification, ...
• Eicosanoid biosynthesis influences the virulence of Candida parapsilosis

  Chakraborty, Tanmoy; Thuer, Ernst, 1986-; Heijink, Marieke; Tóth, Renáta; Bodai, László; Vágvölgyi, Csaba; Giera, Martin; Gabaldón Estevan, Juan Antonio, 1973-; Gácser, Attila (Taylor & Francis, 2018)

  Lipid mediators, derived from arachidonic acid metabolism, play an important role in immune regulation. The functions of bioactive eicosanoids range from modulating cytokine signaling and inflammasome formation to ...
• A de novo FOXP1 truncating mutation in a patient originally diagnosed as C syndrome

  Urreizti, Roser; Damanti, Sarah; Esteve, Carla; Franco Valls, Héctor; Castilla-Vallmanya, Laura; Tonda, Raúl; Cormand, Bru; Vilageliu, Lluïsa; Opitz, John M.; Neri, Giovanni; Grinberg, Daniel; Balcells, Susana (Nature Research, 2018)

  De novo FOXP1 mutations have been associated with intellectual disability (ID), motor delay, autistic features and a wide spectrum of speech difficulties. C syndrome (Opitz C trigonocephaly syndrome) is a rare and genetically ...
• Investigation of Candida parapsilosis virulence regulatory factors during host-pathogen interaction

  Tóth, Renáta; Cabral, Vitor; Thuer, Ernst, 1986-; Bohner, Flóra; Németh, Tibor; Papp, Csaba; Nimrichter, Leonardo; Molnár, Gergő; Vágvölgyi, Csaba; Gabaldón Estevan, Juan Antonio, 1973-; Nosanchuk, Joshua D.; Gácser, Attila (Nature Research, 2018)

  Invasive candidiasis is among the most life-threatening infections in patients in intensive care units. Although Candida albicans is the leading cause of candidaemia, the incidence of Candida parapsilosis infections is ...
• Deciphering the mechanism of action of 089, a compound impairing the fungal cell cycle

  Stefanini, Irene; Rizzetto, Lisa; Rivero, Damariz; Carbonell, Silvia; Gut, Marta; Heath, Simon; Gut, Ivo Glynne; Trabocchi, Andrea; Guarna, Antonio; Ben Ghazzi, Nagwa; Bowyer, Paul; Kapushesky, Misha; Cavalieri, Duccio (Nature Research, 2018)

  Fungal infections represent an increasingly relevant clinical problem, primarily because of the increased survival of severely immune-compromised patients. Despite the availability of active and selective drugs and of ...
• Chromatin remodeling in Drosophila preblastodermic embryo extract

  Šatović, Eva; Font Mateu, Jofre, 1977-; Carbonell, Albert; Beato, Miguel; Azorín Marín, Fernando (Nature Research, 2018)

  Chromatin is known to undergo extensive remodeling during nuclear reprogramming. However, the factors and mechanisms involved in this remodeling are still poorly understood and current experimental approaches to study it ...
• Knock-down of AHCY and depletion of adenosine induces DNA damage and cell cycle arrest

  Belužić, Lucija; Grbeša, Ivana; Belužić, Robert; Park, Jong Hoon; Kong, Hyun Kyung; Kopjar, Nevenka; Espadas, Guadalupe; Sabidó Aguadé, Eduard, 1981-; Lepur, Adriana; Rokić, Filip; Jerić, Ivanka; Brkljačić, Lidija; Vugrek, Oliver (Nature Research, 2018)

  Recently, functional connections between S-adenosylhomocysteine hydrolase (AHCY) activity and cancer have been reported. As the properties of AHCY include the hydrolysis of S-adenosylhomocysteine and maintenance of the ...
• Somatic alterations compromised molecular diagnosis of DOCK8 hyper-IgE syndrome caused by a novel intronic splice site mutation

  Hagl, Beate; Spielberger, Benedikt D.; Thoene, Silvia; Bonnal, Sophie; Mertes, Christian; Winter, Christof; Nijman, Isaac J.; Verduin, Shira; Eberherr, Andreas C.; Puel, Anne; Schindler, Detlev; Ruland, Jürgen; Meitinger, Thomas; Gagneur, Julien; Orange, Jordan S.; van Gijn, Marielle E.; Renner, Ellen D. (Nature Research, 2018)

  In hyper-IgE syndromes (HIES), a group of primary immunodeficiencies clinically overlapping with atopic dermatitis, early diagnosis is crucial to initiate appropriate therapy and prevent irreversible complications. ...
• Labyrinthopeptins exert broad-spectrum antiviral activity through lipid-binding-mediated virolysis

  Prochnow, Hans; Prado Martínez, Javier, 1987-; Meyerhans, Andreas; Brönstrup, Mark (American Society for Microbiology, 2019)

  To counteract the serious health threat posed by known and novel viral pathogens, drugs that target a variety of viruses through a common mechanism have attracted recent attention due to their potential in treating ...
• Functional analysis of human pathological semen samples in an oocyte cytoplasmic ex vivo system

  Amargant i Riera, Farners, 1990-; García, Désirée; Barragán, Montserrat; Vassena, Rita; Vernos, Isabelle, 1959- (Nature Research, 2018)

  Human fertilization and embryo development involve a wide range of critical processes that determine the successful development of a new organism. Although Assisted Reproduction Technologies (ART) may help solve infertility ...
• tarsal-less is expressed as a gap gene but has no gap gene phenotype in the moth midge Clogmia albipunctata

  Jiménez Guri, Eva; Wotton, Karl R.; Jaeger, Johannes, 1973- (Royal Society, 2018)

  Gap genes are involved in segment determination during early development of the vinegar fly Drosophila melanogaster and other dipteran insects (flies, midges and mosquitoes). They are expressed in overlapping domains along ...
• nextPARS: parallel probing of RNA structures in Illumina

  Saus Martínez, Ester; Willis, Jesse R.; Pryszcz, Leszek Piotr, 1985-; Hafez, Ahmed; Llorens, Carlos; Himmelbauer, Heinz; Gabaldón Estevan, Juan Antonio, 1973- (Cold Spring Harbor Laboratory Press (CSHL Press), 2018)

  RNA molecules play important roles in virtually every cellular process. These functions are often mediated through the adoption of specific structures that enable RNAs to interact with other molecules. Thus, determining ...

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