• A consensus molecular classification of muscle-invasive bladder cancer

  Kamoun, Aurélie; Real, Francisco X.; Bladder Cancer Molecular Taxonomy Group (Elsevier, 2019)

  Background: Muscle-invasive bladder cancer (MIBC) is a molecularly diverse disease with heterogeneous clinical outcomes. Several molecular classifications have been proposed, but the diversity of their subtype sets impedes ...
• The mechanism of action of pepR, a viral-derived peptide, against Staphylococcus aureus biofilms

  Pinto, Sandra N.; Dias, Susana A.; Cruz, Ana F.; Mil-Homens, Dalila; Fernandes, Fabio; Valle, Javier; Andreu Martínez, David; Prieto, Manuel; Castanho, Miguel A.R.B.; Coutinho, Ana; Salomé Veiga, Ana (Oxford University Press, 2019)

  Objectives: To investigate the mechanism of action at the molecular level of pepR, a multifunctional peptide derived from the Dengue virus capsid protein, against Staphylococcus aureus biofilms. Methods: Biofilm mass, ...
• The role of C-reactive protein levels on the association of physical activity with lung function in adults

  Fuertes, Elaine; Carsin, Anne-Elie; Garcia-Larsen, Vanessa; Guerra, Stefano; Pin, Isabelle; Leynaert, Bénédicte; Accordini, Simone; Martínez-Moratalla, Jesús; Antó i Boqué, Josep Maria; Urrutia, Isabel; Le Gouellec, Audrey; Heinrich, Joachim; Gislason, Thorarinn; Jõgi, Rain; Janson, Christer; Jarvis, Debbie; García Aymerich, Judith (Public Library of Science (PLoS), 2019)

  Objective: Regular physical activity may be associated with improved lung function via reduced systemic inflammation, although studies exploring this mechanism are rare. We evaluated the role of C-reactive protein in blood, ...
• Accuracy of online survey assessment of mental disorders and suicidal thoughts and behaviors in Spanish university students. Results of the WHO World Mental Health- International College Student initiative

  Ballester, Laura; Alayo, Itxaso; Vilagut Saiz, Gemma, 1975-; Blasco Cubedo, Maria Jesús; Mortier, Philippe; Alonso Caballero, Jordi; UNIVERSAL study group (Public Library of Science (PLoS), 2019)

  Objective: To assess the accuracy of WMH-ICS online screening scales for evaluating four common mental disorders (Major Depressive Episode[MDE], Mania/Hypomania[M/H], Panic Disorder[PD], Generalized Anxiety Disorder[GAD]) ...
• Generation of the antioxidant hydroxytyrosol from tyrosol present in beer and red wine in a randomized clinical trial

  Soldevila-Domenech, Natalia; Boronat Rigol, Anna; Mateus Rodriguez, Julian Andrés; Diaz-Pellicer, Patricia; Matilla, Iris; Pérez-Otero, Marta; Aldea-Perona, Ana; Torre Fornell, Rafael de la (MDPI, 2019)

  Beer and wine contains the simple phenol tyrosol (TYR) which is endogenously converted into hydroxytyrosol (HT), one of the strongest dietary antioxidants, by CYP2A6 and CYP2D6 polymorphic enzymes. We investigated in humans ...
• Altered neocortical dynamics in a mouse model of Williams-Beuren syndrome

  Dasilva, Miguel; Navarro-Guzman, Alvaro; Ortiz Romero, Paula; Camassa, Alessandra; Muñoz-Cespedes, Alberto; Campuzano Uceda, María Victoria; Sanchez-Vives, Maria V. (Springer, 2019)

  Williams-Beuren syndrome (WBS) is a rare neurodevelopmental disorder characterized by moderate intellectual disability and learning difficulties alongside behavioral abnormalities such as hypersociability. Several structural ...
• Processive recoding and metazoan evolution of selenoprotein P: up to 132 UGAs in molluscs

  Baclaocos, Janinah; Santesmasses Ruiz, Didac, 1978-; Mariotti, Marco, 1984-; Bierla, Katarzyna; Vetick, Michael B.; Lynch, Sharon; McAllen, Rob; Mackrill, John J.; Loughran, Gary; Guigó Serra, Roderic; Szpunar, Joanna; Copeland, Paul R.; Gladyshev, Vadim N.; Atkins, John F. (Elsevier, 2019)

  Selenoproteins typically contain a single selenocysteine, the 21st amino acid, encoded by a context-redefined UGA. However, human selenoprotein P (SelenoP) has a redox-functioning selenocysteine in its N-terminal domain ...
• Insight into the antifungal mechanism of action of human RNase N-terminus derived peptides

  Salazar, Vivian A.; Arranz-Trullén, Javier; Prats-Ejarque, Guillem; Torrent, Marc; Andreu Martínez, David; Pulido, David; Boix, Ester (MDPI, 2019)

  Candida albicans is a polymorphic fungus responsible for mucosal and skin infections. Candida cells establish themselves into biofilm communities resistant to most currently available antifungal agents. An increase of ...
• Protocol for measuring compulsive-like feeding behavior in mice

  Fructuoso, Marta; Espinosa-Carrasco, José; Erb, Ionas; Notredame, Cedric; Dierssen, Mara (Bio-protocol, 2019)

  Obesity is an important health problem with a strong environmental component that is acquiring pandemic proportion. The high availability of caloric dense foods promotes overeating potentially causing obesity. Animal models ...
• Reconstructed lost native american populations from eastern Brazil are shaped by differential jê/tupi ancestry

  Mas Sandoval, Àlex, 1989-; Arauna, Lara R; Gouveia, Mateus H.; Barreto, Mauricio L.; Horta, Bernardo L.; Lima-Costa, Maria Fernanda; Pereira, Alexandre C.; Salzano, Francisco Mauro; Hünemeier, Tábita; Tarazona-Santos, Eduardo; Bortolini, Maria Cátira; Comas, David, 1969- (Oxford University Press, 2019)

  After the colonization of the Americas by Europeans and the consequent Trans-Atlantic Slave Trade, most Native American populations in eastern Brazil disappeared or went through an admixture process that configured a ...
• N-of-1 clinical trials in nutritional interventions directed at improving cognitive function

  Soldevila-Domenech, Natalia; Boronat Rigol, Anna; Langohr, Klaus; Torre Fornell, Rafael de la (Frontiers, 2019)

  Longer life expectancy has led to an increase in the prevalence of age-related cognitive decline and dementia worldwide. Due to the current lack of effective treatment for these conditions, preventive strategies represent ...
• Effects of prenatal exposure to particulate matter air pollution on corpus callosum and behavioral problems in children

  Mortamais, Marion; Pujol Martí, Jesús, 1981-; Martínez-Vilavella, Gerard; Fenoll, Raquel; Reynes, Christelle; Sabatier, Robert; Rivas, Ioar; Forns i Guzman, Joan, 1981-; Vilor Tejedor, Natàlia, 1988-; Alemany, Silvia; Cirach, Marta; Alvarez-Pedrerol, Mar; Nieuwenhuijsen, Mark J.; Sunyer Deu, Jordi (Elsevier, 2019)

  Objective: Air pollution (AP) may affect neurodevelopment, but studies about the effects of AP on the growing human brain are still scarce. We aimed to investigate the effects of prenatal exposure to AP on lateral ventricles ...
• Monitoring cytosolic H2O2 fluctuations arising from altered plasma membrane gradients or from mitochondrial activity

  Carmona, Mercè; de Cubas, Laura; Bautista, Eric; Moral-Blanch, Marta; Medrano-Fernández, Iria; Sitia, Roberto; Boronat i Llop, Susanna, 1965-; Ayté del Olmo, José; Hidalgo Hernando, Elena (Nature Research, 2019)

  Genetically encoded probes monitoring H2O2 fluctuations in living organisms are key to decipher redox signaling events. Here we use a new probe, roGFP2-Tpx1.C169S, to monitor pre-toxic fluctuations of peroxides in fission ...
• Identification of ubiquitin-proteasome system components affecting the degradation of the transcription factor Pap1

  Marte, Luis; Boronat i Llop, Susanna, 1965-; García Santamarina, Sarela, 1978-; Ayté del Olmo, José; Kitamura, Kenji; Hidalgo Hernando, Elena (Elsevier, 2019)

  Signaling cascades respond to specific inputs, but also require active interventions to be maintained in their basal/inactive levels in the absence of the activating signal(s). In a screen to search for protein quality ...
• Live-cell structural biology to solve biological mechanisms: the case of the exocyst

  Irastorza-Azcarate, Ibai; Castaño-Díez, Daniel; Devos, Damien P.; Gallego, Oriol (Elsevier, 2019)

  Historically, structural biology has been largely centered on in vitro approaches as the dominant technique to obtain indispensable high-resolution data. In situ structural biology is now poised to contribute with ...
• Ten simple rules for providing optimal administrative support to research teams

  Garrido, Romina; Trowbridge, Casandra A.; Tamura, Nana (Public Library of Science (PLoS), 2019)
• Prenatal and postnatal exposure to air pollution and emotional and aggressive symptoms in children from 8 European birth cohorts

  Jorcano, Ainhoa; Lubczynska, Malgorzata Joanna; Pierotti, Livia; Sunyer Deu, Jordi; Guxens Junyent, Mònica (Elsevier, 2019)

  Background: The association between air pollution exposure and emotional and behavioural problems in children is unclear. We aimed to assess prenatal and postnatal exposure to several air pollutants and child's depressive ...
• Conformational sensors and domain swapping reveal structural and functional differences between β-arrestin isoforms

  Ghosh, Eshan; Dwivedi, Hemlata; Baidya, Mithu; Srivastava, Ashish; Kumari, Punita; Stepniewski, Tomek; Kim, Hee Ryung; Lee, Mi-Hye; van Gastel, Jaana; Chaturvedi, Madhu; Roy, Debarati; Pandey, Shubhi; Maharana, Jagannath; Guixà González, Ramon, 1978-; Luttrell, Louis M.; Chung, Ka Young; Dutta, Somnath; Selent, Jana; Shukla, Arun K. (Elsevier, 2019)

  Desensitization, signaling, and trafficking of G-protein-coupled receptors (GPCRs) are critically regulated by multifunctional adaptor proteins, β-arrestins (βarrs). The two isoforms of βarrs (βarr1 and 2) share a high ...
• Sex-specific incidence of asthma, rhinitis and respiratory multimorbidity before and after puberty onset: individual participant meta-analysis of five birth cohorts collaborating in MeDALL

  Hohmann, Cynthia; Keller, Theresa; Gehring, Ulrike; Wijga, Alet; Standl, Marie; Kull, Inger; Bergström, Anna; Lehmann, Irina; von Berg, Andrea; Heinrich, Joachim; Lau, Susanne; Wahn, Ulrich; Maier, Dieter; Antó i Boqué, Josep Maria; Bousquet, Jean; Smit, Henriëtte A.; Keil, Thomas; Roll, Stephanie (BMJ Publishing Group, 2019)

  Introduction To understand the puberty-related sex shift in the prevalence of asthma and rhinitis as single entities and as respiratory multimorbidities, we investigated if there is also a sex-specific and puberty-related ...
• Gene connectivity and enzyme evolution in the human metabolic network

  Dobón Berenguer, Begoña, 1987-; Montanucci, Ludovica, 1978-; Peretó, Juli; Bertranpetit, Jaume, 1952-; Laayouni, Hafid, 1968- (BioMed Central, 2019)

  Background: Determining the factors involved in the likelihood of a gene being under adaptive selection is still a challenging goal in Evolutionary Biology. Here, we perform an evolutionary analysis of the human metabolic ...

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