• The regulation of Net1/Cdc14 by the Hog1 MAPK upon osmostress unravels a new mechanism regulating mitosis

  Jiménez, Javier; Queralt Badia, Ethel; Posas Garriga, Francesc; Nadal Clanchet, Eulàlia de (Taylor & Francis, 2020)

  During evolution, cells have developed a plethora of mechanisms to optimize survival in a changing and unpredictable environment. In this regard, they have evolved networks that include environmental sensors, signaling ...
• The GATA3 X308_Splice breast cancer mutation is a hormone context-dependent oncogenic driver

  Hruschka, Natascha; Andreu Martínez, David; Real, Francisco X.; Martinelli, Paola (Nature Research, 2020)

  As the catalog of oncogenic driver mutations is expanding, it becomes clear that alterations in a given gene might have different functions and should not be lumped into one class. The transcription factor GATA3 is a ...
• Sex-biased patterns shaped the genetic history of Roma

  García-Fernández, Carla; Font-Porterias, Neus; Kučinskas, Vaidutis; Sukarova-Stefanovska, Emilija; Pamjav, Horolma; Makukh, Halyna; Dobón Berenguer, Begoña, 1987-; Bertranpetit, Jaume, 1952-; Netea, Mihai G; Calafell i Majó, Francesc; Comas, David, 1969- (Nature Research, 2020)

  The Roma population is a European ethnic minority characterized by recent and multiple dispersals and founder effects. After their origin in South Asia around 1,500 years ago, they migrated West. In Europe, they diverged ...
• A fully integrated machine learning scan of selection in the chimpanzee genome

  Nye, Jessica, 1986-; Mondal, Mayukh, 1989-; Bertranpetit, Jaume, 1952-; Laayouni, Hafid, 1968- (Oxford University Press, 2020)

  After diverging, each chimpanzee subspecies has been the target of unique selective pressures. Here, we employ a machine learning approach to classify regions as under positive selection or neutrality genome-wide. The ...
• Sox17 controls emergence and remodeling of Nestin-expressing coronary vessels

  González Hernández, Sara; Gómez, Manuel J.; Sánchez Cabo, Fátima; Méndez Ferrer, Simón; Muñoz Cánoves, Pura, 1962-; Isern, Joan (American Hearth Association, 2020)

  Rationale: The molecular mechanisms underlying the formation of coronary arteries during development and during cardiac neovascularization after injury are poorly understood. However, a detailed description of the relevant ...
• Immune cell subtypes and cytokines in lung tumor microenvironment: influence of COPD

  Tang, Jun; Ramis Cabrer, Daniel, 1993-; Curull Serrano, Víctor; Wang, Xuejie; Qin, Liyun; Mateu Jiménez, Mercè, 1990-; Duran Jordà, Xavier, 1974-; Pijuan Andujar, Lara; Rodríguez-Fuster, Alberto; Aguiló Espases, Rafael; Barreiro Portela, Esther (MDPI, 2020)

  Background: The immune microenvironment plays a role in tumorigenesis. Chronic Obstructive Pulmonary Disease (COPD) is an independent risk factor for lung cancer (LC). We hypothesized that immune profile characterized by ...
• The hippo pathway transducers YAP1/TEAD induce acquired resistance to trastuzumab in HER2-Positive breast cancer

  González-Alonso, Paula; Arpí Llucià, Oriol; Rovira Guerín, Ana; Albanell Mestres, Joan; Rojo, Federico (MDPI, 2020)

  Trastuzumab is the first-line targeted therapeutic drug for HER2-positive breast cancer, leading to improved overall survival. However, acquired resistance inevitably occurs. We aimed to identify, quantify, and assess the ...
• Health inequity in workers of Latin America and the Caribbean

  Silva Peñaherrera, Michael; López Ruiz, María, 1982-; Merino Salazar, Pamela Alexandra, 1978-; Gómez García, Antonio Ramón; Benavides, Fernando G. (Fernando García) (BioMed Central, 2020)

  Background: Latin America and the Caribbean (LAC) is the world's most inequitable region in terms of wealth distribution. The full scale of social inequalities in health has been hidden by the lack of reliable data. This ...
• Digital transformation of health and care to sustain Planetary Health: The MASK proof-of-concept for airway diseases-POLLAR symposium under the auspices of Finland's Presidency of the EU, 2019 and MACVIA-France, Global Alliance against Chronic Respiratory Diseases (GARD, WH0) demonstration project, Reference Site Collaborative Network of the European Innovation Partnership on Active and Healthy Ageing

  Bousquet, Jean; Antó i Boqué, Josep Maria; Basagaña Flores, Xavier; Laune, Daniel (BioMed Central, 2020)

  In December 2019, a conference entitled "Europe That Protects: Safeguarding Our Planet, Safeguarding Our Health" was held in Helsinki. It was co-organized by the Finnish Institute for Health and Welfare, the Finnish ...
• A demonstration project of Global Alliance against Chronic Respiratory Diseases: Prediction of interactions between air pollution and allergen exposure-the Mobile Airways Sentinel NetworK-Impact of air POLLution on Asthma and Rhinitis approach

  Sofiev, Mikhail; Bédard, Annabelle, 1986-; Basagaña Flores, Xavier; Antó i Boqué, Josep Maria; Bousquet, Jean (Wolters Kluwer (LWW), 2020)

  This review analyzes the state and recent progress in the field of information support for pollen allergy sufferers. For decades, information available for the patients and allergologists consisted of pollen counts, which ...
• Immunohistochemistry-based taxonomical classification of bladder cancer predicts response to neoadjuvant chemotherapy

  Font, Albert; Doménech, Montserrat; Benítez, Raquel; Rava, Marta; Marqués, Miriam; Ramírez, José L.; Pineda, Silvia; Domínguez Rodríguez, Miriam; Gago, José L.; Badal, Josep; Carrato, Cristina; López, Héctor; Quer, Ariadna; Castellano, Daniel; Malats i Riera, Núria; Real, Francisco X. (MDPI, 2020)

  Background: Platinum-based neoadjuvant chemotherapy (NAC) increases the survival of patients with organ-confined urothelial bladder cancer (UBC). In retrospective studies, patients with basal/squamous (BASQ)-like tumors ...
• Catalonia Suicide Risk Code Epidemiology (CSRC-Epi) study: protocol for a population-representative nested case-control study of suicide attempts in Catalonia, Spain

  Mortier, Philippe; Vilagut Saiz, Gemma, 1975-; Puértolas Gracia, Beatriz; De Inés Trujillo, Ana; Alayo, Itxaso; Ballester, Laura; Blasco Cubedo, Maria Jesús; Elices, Matilde; Gómez Sánchez, Javier; Martín Sánchez, Mario; Pérez Solá, Victor; Alonso Caballero, Jordi; CODIRISC Epidemiology Study Group (BMJ Publishing Group, 2020)

  Introduction: Suicide attempts represent an important public health burden. Centralised electronic health record (EHR) systems have high potential to provide suicide attempt surveillance, to inform public health action ...
• Chronic pain after groin hernia repair: pain characteristics and impact on quality of life

  Bande, David; Moltó, Luis; Pereira Rodríguez, José Antonio; Montes Pérez, Antonio (BioMed Central, 2020)

  Background: Chronic postsurgical pain (CPSP) after hernia repair research has mainly relied on unconfirmed self-reporting. We aimed to describe confirmed CPSP incidence, management, and quality of life (QoL) in a 2-year ...
• The genome sequence of the grape phylloxera provides insights into the evolution, adaptation, and invasion routes of an iconic pest

  Rispe, Claude; Fernández, Rosa; Gabaldón Estevan, Juan Antonio, 1973-; Guigó Serra, Roderic; Ripoll Cladellas, Aida; Tagu, Denis (BioMed Central, 2020)

  Background: Although native to North America, the invasion of the aphid-like grape phylloxera Daktulosphaira vitifoliae across the globe altered the course of grape cultivation. For the past 150 years, viticulture relied ...
• The EU-ToxRisk method documentation, data processing and chemical testing pipeline for the regulatory use of new approach methods

  Krebs, Alice; Pastor Maeso, Manuel; Leist, Marcel (Springer, 2020)

  Hazard assessment, based on new approach methods (NAM), requires the use of batteries of assays, where individual tests may be contributed by different laboratories. A unified strategy for such collaborative testing is ...
• Intermittent explosive disorder subtypes in the general population: association with comorbidity, impairment and suicidality

  Scott, Kate M.; Alonso Caballero, Jordi; de Jonge, P.; World Mental Health Surveys collaborators (Cambridge University Press, 2020)

  Aims: Intermittent explosive disorder (IED) is characterised by impulsive anger attacks that vary greatly across individuals in severity and consequence. Understanding IED subtypes has been limited by lack of large, general ...
• The LifeCycle Project-EU child cohort network: a federated analysis infrastructure and harmonized data of more than 250,000 children and parents

  Jaddoe, Vincent W. V.; Sunyer Deu, Jordi; Duijts, Liesbeth; LifeCycle Project Group (SpringerOpen, 2020)

  Early life is an important window of opportunity to improve health across the full lifecycle. An accumulating body of evidence suggests that exposure to adverse stressors during early life leads to developmental adaptations, ...
• Long-term greenspace exposure and progression of arterial stiffness: the whitehall II cohort study

  Keijzer, Carmen de, 1992-; Foraster Pulido, Maria, 1984-; Basagaña Flores, Xavier; Tonne, Cathryn; Alonso Garcia, Lucia; Valentín, Antònia; Kivimäki, Mika; Nieuwenhuijsen, Mark J.; Alonso Caballero, Jordi; Antó i Boqué, Josep Maria; Singh-Manoux, Archana; Sunyer Deu, Jordi; Dadvand, Payam (National Institute of Environmental Health Sciences (NIEHS), 2020)

  Background: Arterial stiffness, and its progression with age, is an important indicator of cardiovascular aging. Greenspace exposure may protect against arterial stiffness by promoting physical activity, fostering social ...
• Designing functionally versatile, highly immunogenic peptide-based multiepitopic vaccines against foot-and-mouth disease virus

  Defaus, Sira; Forner, Mar; Cañas Arranz, Rodrigo; de León, Patricia; Bustos, María J.; Rodríguez Pulido, Miguel; Blanco, Esther; Sobrino, Francisco; Andreu Martínez, David (MDPI, 2020)

  A broadly protective and biosafe vaccine against foot-and-mouth disease virus (FMDV) remains an unmet need in the animal health sector. We have previously reported solid protection against serotype O FMDV afforded by ...
• Characterization of partially ordered states in the intrinsically disordered N-terminal domain of p53 using millisecond molecular dynamics simulations

  Herrera Nieto, Pablo; Pérez, Adrià; De Fabritiis, Gianni (Nature Research, 2020)

  The exploration of intrinsically disordered proteins in isolation is a crucial step to understand their complex dynamical behavior. In particular, the emergence of partially ordered states has not been explored in depth. ...

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