• Metabolomics predicts the pharmacological profile of new psychoactive substances

  Olesti Muñoz, Eulàlia, 1991-; De Toma, Ilario; Ramaekers, Johannes G.; Brunt, Tibor M.; Carbó Banús, Marcel·lí; Fernández-Avilés, Cristina; Robledo, Patricia, 1958-; Farré Albaladejo, Magí; Dierssen, Mara; Pozo Mendoza, Óscar J.; Torre Fornell, Rafael de la (SAGE Publications, 2019)

  BACKGROUND: The unprecedented proliferation of new psychoactive substances (NPS) threatens public health and challenges drug policy. Information on NPS pharmacology and toxicity is, in most cases, unavailable or very limited ...
• Epigenome-wide meta-analysis of DNA methylation and childhood asthma

  Reese, Sarah E.; Ruiz Arenas, Carlos, 1990-; Antó i Boqué, Josep Maria; London, Stephanie J. (Elsevier, 2019)

  Epigenetic mechanisms, including methylation, can contribute to childhood asthma. Identifying DNA methylation profiles in asthmatic patients can inform disease pathogenesis. OBJECTIVE: We sought to identify differential ...
• Análisis de los problemas relacionados con los medicamentos en un hospital de tercer nivel de Barcelona

  Ferránzez Quirante, Olivia; Casañ, Borja; Grau Cerrato, Santiago; Louro, Javier; Salas Sanchez, Esther; Castells, Xavier; Sala Serra, Maria (Elsevier, 2019)

  OBJECTIVE: To describe drug-related problems identified in hospitalized patients and to assess physicians' acceptance rate of pharmacists' recommendations. METHODS: Retrospective observational study that included all ...
• A comprehensive proteomics-based interaction screen that links DYRK1A to RNF169 and to the DNA damage response

  Roewenstrunk, Julia Maria, 1981-; Di Vona, Chiara, 1981-; Chen, Jie; Borràs, Eva; Dong, Chao; Arató, Krisztina, 1981-; Sabidó Aguadé, Eduard, 1981-; Huen, Michael S. Y.; Luna Gargantilla, Susana de la (Nature Research, 2019)

  Dysregulation of the DYRK1A protein kinase has been associated with human disease. On the one hand, its overexpression in trisomy 21 has been linked to certain pathological traits of Down syndrome, while on the other, ...
• Labelled regulatory elements are pervasive features of the macrophage genome and are dynamically utilized by classical and alternative polarization signals

  Horvath, Attila; Daniel, Bence; Szeles, Lajos; Cuaranta-Monroy, Ixchelt; Czimmerer, Zsolt; Ozgyin, Lilla; Steiner, Laszlo; Kiss, Mate; Simandi, Zoltan; Poliska, Szilard; Giannakis, Nikolas; Raineri, Emanuele; Gut, Ivo Glynne; Nagy, Benedek; Nagy, Laszlo (Oxford University Press, 2019)

  The concept of tissue-specific gene expression posits that lineage-determining transcription factors (LDTFs) determine the open chromatin profile of a cell via collaborative binding, providing molecular beacons to ...
• Binless normalization of Hi-C data provides significant interaction and difference detection independent of resolution

  Spill, Yannick G.; Castillo Andreo, David; Vidal, Enrique; Marti-Renom, Marc A. (Nature Research, 2019)

  Chromosome conformation capture techniques, such as Hi-C, are fundamental in characterizing genome organization. These methods have revealed several genomic features, such as chromatin loops, whose disruption can have ...
• The fitness cost and benefit of phase-separated protein deposits

  Sanchez de Groot, Natalia; Torrent, Marc; Ravarani, Charles N.J.; Trusina, Ala; Ventura, Salvador; Babu, M. Madan (Wiley-VCH Verlag, 2019)

  Phase separation of soluble proteins into insoluble deposits is associated with numerous diseases. However, protein deposits can also function as membrane-less compartments for many cellular processes. What are the fitness ...
• RNA as a key factor in driving or preventing self-assembly of the TAR DNA-binding protein 43

  Zacco, Elsa; Graña-Montes, Ricardo; Martin, Stephen R.; Sanchez de Groot, Natalia; Alfano, Caterina; Tartaglia, Gian Gaetano; Pastore, Annalisa (Elsevier, 2019)

  Amyotrophic lateral sclerosis and frontotemporal lobar degeneration are incurable motor neuron diseases associated with muscle weakness, paralysis and respiratory failure. Accumulation of TAR DNA-binding protein 43 (TDP-43) ...
• BKV clearance time correlates with exhaustion state and T-cell receptor repertoire shape of BKV-specific T-cells in renal transplant patients

  Stervbo, Ulrik; Nienen, Mikalai; Weist, Benjamin J. D.; Kuchenbecker, Leon; Hecht, Jochen; Wehler, Patrizia; Westhoff, Timm H.; Reinke, Petra; Babel, Nina (Frontiers Media, 2019)

  Reactivation of the BK polyomavirus is known to lead to severe complications in kidney transplant patients. The current treatment strategy relies on decreasing the immunosuppression to allow the immune system to clear the ...
• Whole-genome sequencing of the opportunistic yeast pathogen candida inconspicua uncovers its hybrid origin

  Mixão, Verónica; Perez Hansen, Antonio; Saus Martínez, Ester; Boekhout, Teun; Lass-Florl, Cornelia; Gabaldón Estevan, Juan Antonio, 1973- (Frontiers Media, 2019)

  Fungal infections such as those caused by Candida species are increasingly common complications in immunocompromised patients. The list of causative agents of candidiasis is growing and comprises a set of emerging species ...
• Transcriptomics-based screening identifies pharmacological inhibition of hsp90 as a means to defer aging

  Janssens, Georges E.; Lin, Xin-Xuan; Millán Ariño, Lluís, 1984-; Kavšek, Alan; Sen, Ilke; Seinstra, Renée I.; Stroustrup, Nicholas; Nollen, Ellen A. A.; Riedel, Christian G. (Elsevier, 2019)

  Aging strongly influences human morbidity and mortality. Thus, aging-preventive compounds could greatly improve our health and lifespan. Here we screened for such compounds, known as geroprotectors, employing the power of ...
• JARID1B expression and its function in DNA damage repair are tightly regulated by miRNAs in breast cancer

  Mocavini, Ivano; Pippa, Simone; Licursi, Valerio; Paci, Paola; Trisciuoglio, Daniela; Mannironi, Cecilia; Presutti, Carlo; Negri, Rodolfo (Wiley Open Access, 2019)

  JARID1B/KDM5B histone demethylase's mRNA is markedly overexpressed in breast cancer tissues and cell lines and the protein has been shown to have a prominent role in cancer cell proliferation and DNA repair. However, the ...
• Bistable emergence of oscillations in growing Bacillus subtilis biofilms

  Martínez Corral, Rosa; Liu, Jintao; Süel, Gürol M.; García Ojalvo, Jordi (National Academy of Sciences, 2018)

  Biofilm communities of Bacillus subtilis bacteria have recently been shown to exhibit collective growth-rate oscillations mediated by electrochemical signaling to cope with nutrient starvation. These oscillations emerge ...
• Constant-Murley Score: systematic review and standardized evaluation in different shoulder pathologies

  Vrotsou, Kalliopi; Ávila Pacheco, Mónica Marcela, 1984-; Machón, Mónica; Mateo-Abad, Maider; Pardo Cladellas, Yolanda; Garin Boronat, Olatz, 1979-; Zaror, Carlos; González, Nerea; Escobar, Antonio; Cuéllar, Ricardo (SpringerOpen, 2018)

  PURPOSE: The objective of this study was to evaluate the psychometric properties of the Constant-Murley Score (CMS) in various shoulder pathologies, based on a systematic review and expert standardized evaluations. METHODS: ...
• Validity of the EQ-5D-5L and reference norms for the Spanish population

  Hernandez, Gimena; Garin Boronat, Olatz, 1979-; Pardo, Yolanda; Vilagut Saiz, Gemma, 1975-; Pont Acuña, Àngels; Suárez, Mónica; Neira, Montse; Rajmil Rajmil, Luis Alberto; Gorostiza, Inigo; Ramallo-Fariña, Yolanda; Cabases, Juan; Alonso Caballero, Jordi; Ferrer Forés, Maria Montserrat (Springer, 2018)

  BACKGROUND AND OBJECTIVE: The EuroQol 5 dimensions 5 levels (EQ-5D-5L) is the new version of EQ-5D, developed to improve its discriminatory capacity. This study aims to evaluate the construct validity of the Spanish version ...
• Change in functioning outcomes as a predictor of the course of depression: a 12-month longitudinal study

  Forero, Carlos G.; Olariu, Elena, 1984-; Álvarez López, Pilar; Castro-Rodriguez, José-Ignacio; Blasco Cubedo, Maria Jesus; Vilagut Saiz, Gemma, 1975-; Alonso Caballero, Jordi; INSAyD Investigators (Springer, 2018)

  PURPOSE: Functioning is a necessary diagnostic criterion for depression, and thus routinely assessed in depressive patients. While it is highly informative of disorder severity, its change has not been tested for prognostic ...
• A living liquid crystal dissected

  García Ojalvo, Jordi (Nature Research, 2019)

  A large-scale imaging study has tracked thousands of bacteria living in three-dimensional biofilms. This technical tour de force reveals the importance of mechanical interactions between cells for building local and global ...
• Magnesium flux modulates ribosomes to increase bacterial survival

  Lee, Dong-yeon D.; Galera Laporta, Letícia, 1985-; Bialecka-Fornal, Maja; Moon, Eun Chae; Shen, Zhouxin; Briggs, Steven P.; García Ojalvo, Jordi; Süel, Gürol M. (Elsevier, 2019)

  Bacteria exhibit cell-to-cell variability in their resilience to stress, for example, following antibiotic exposure. Higher resilience is typically ascribed to "dormant" non-growing cellular states. Here, by measuring ...
• Deficiency in p53 is required for doxorubicin induced transcriptional activation of NF-κB target genes in human breast cancer

  Dalmases Massegú, Alba, 1982-; González González, Irene; Menendez Romero, Silvia; Arpí Llucià, Oriol; Corominas Torres, Josep Maria; Servitja Tormo, Sonia; Tusquets, Ignasi; Chamizo, Cristina; Rincón, Raúl; Espinosa Blay, Lluís; Bigas Salvans, Anna; Eroles, Pilar; Furriol, Jessica; Lluch, Ana; Rovira Guerín, Ana; Albanell Mestres, Joan; Rojo, Federico (Impact Journals, 2014)

  NF-кB has been linked to doxorubicin resistance in breast cancer patients. NF-кB nuclear translocation and DNA binding in doxorubicin treated-breast cancer cells have been extensively examined; however its functional ...
• Chlorination disinfection by-products in drinking water and congenital anomalies: review and meta-analyses

  Nieuwenhuijsen, Mark J.; Martinez Murciano, David; Grellier, James; Bennett, James; Best, Nicky; Iszatt, Nina; Vrijheid, Martine; Toledano, Mireille B. (National Institute of Environmental Health Sciences (NIEHS), 2009)

  OBJECTIVES: The aim of this study was to review epidemiologic evidence, provide summary risk estimates of the association between exposure to chlorination disinfection by-products (DBPs) and congenital anomalies, and provide ...

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