• Protein kinase C-gamma knockout mice show impaired hippocampal short-term memory while preserved long-term memory

  Gomis González, Maria, 1988-; Galera López, Lorena; Ten-Blanco, Marc; Busquets Garcia, Arnau, 1985-; Cox, Thomas; Maldonado, Rafael, 1961-; Ozaita Mintegui, Andrés, 1969- (Springer, 2020)

  The brain encodes, stores, and retrieves relevant information in the form of memories that are classified as short-term (STM) and long-term memories (LTM) depending on the interval between acquisition and retrieval. It is ...
• The conventional isoproterenol-induced heart failure model does not consistently mimic the diaphragmatic dysfunction observed in patients

  Cabrera-Aguilera, Ignacio; Falcones, Bryan; Calvo-Fernández, Alicia; Benito Villabriga, Begoña; Barreiro Portela, Esther; Gea Guiral, Joaquim; Farré, Ramon; Almendros, Isaac; Farré López, Núria (Public Library of Science (PLoS), 2020)

  Heart failure (HF) impairs diaphragm function. Animal models realistically mimicking HF should feature both the cardiac alterations and the diaphragmatic dysfunction characterizing this disease. The isoproterenol-induced ...
• CTCF is dispensable for immune cell transdifferentiation but facilitates an acute inflammatory response

  Stik, Grégoire; Vidal, Enrique; Barrero, Mercedes; Cuartero, Sergi; Vila-Casadesús, Maria; Mendieta-Esteban, Julen; Tian, Tian V.; Choi, Jinmi; Berenguer, Clara; Abad, Amaya; Borsari, Beatrice; Le Dily, François; Cramer, Patrick; Martí Renom, Marc A.; Stadhouders, Ralph; Graf, T. (Thomas) (Nature Research, 2020)

  Three-dimensional organization of the genome is important for transcriptional regulation1-7. In mammals, CTCF and the cohesin complex create submegabase structures with elevated internal chromatin contact frequencies, ...
• Perspectives on ENCODE

  Encode Project Consortium; Snyder, Michael; Myers, Richard M. (Nature Research, 2020)

  The Encylopedia of DNA Elements (ENCODE) Project launched in 2003 with the long-term goal of developing a comprehensive map of functional elements in the human genome. These included genes, biochemical regions associated ...
• Functional annotation of human long noncoding RNAs via molecular phenotyping

  Ramilowski, Jordan A.; Borsari, Beatrice; Garrido Martín, Diego, 1992-; Muñoz-Aguirre, Manuel; Nurtdinov, Ramil; Guigó Serra, Roderic; Carninci, Piero (Cold Spring Harbor Laboratory Press (CSHL Press), 2020)

  Long noncoding RNAs (lncRNAs) constitute the majority of transcripts in the mammalian genomes, and yet, their functions remain largely unknown. As part of the FANTOM6 project, we systematically knocked down the expression ...
• Expanded encyclopaedias of DNA elements in the human and mouse genomes

  Encode Project Consortium; Moore, Jill E.; Guigó Serra, Roderic; Weng, Zhiping (Nature Research, 2020)

  The human and mouse genomes contain instructions that specify RNAs and proteins and govern the timing, magnitude, and cellular context of their production. To better delineate these elements, phase III of the Encyclopedia ...
• Assessment of the impact of media coverage on COVID-19-related Google Trends data: infodemiology study

  Sousa Pinto, Bernardo; Antó, Aram; Czarlewski, Wienia; Antó i Boqué, Josep Maria; Almeida Fonseca, João; Bousquet, Jean (JMIR Publications, 2020)

  Background: The influence of media coverage on web-based searches may hinder the role of Google Trends (GT) in monitoring coronavirus disease (COVID-19). Objective: The aim of this study was to assess whether COVID-19-related ...
• How do molecular dynamics data complement static structural data of GPCRs

  Torrens Fontanals, Mariona; Stepniewski, Tomasz Maciej, 1988-; Aranda García, David; Morales Pastor, Adrián; Medel Lacruz, Brian; Selent, Jana (MDPI, 2020)

  G protein-coupled receptors (GPCRs) are implicated in nearly every physiological process in the human body and therefore represent an important drug targeting class. Advances in X-ray crystallography and cryo-electron ...
• A limited set of transcriptional programs define major cell types

  Breschi, Alessandra, 1988-; Muñoz-Aguirre, Manuel; Wucher, Valentin; Davis, Carrie A.; Garrido Martín, Diego, 1992-; Djebali, Sarah; Gillis, Jesse; Pervouchine, Dmitri D.; Vlasova, Anna; Dobin, Alexander; Zaleski, Chris; Drenkow, Jorg; Danyko, Cassidy; Scavelli, Alexandra; Reverter, Ferran; Snyder, Michael; Gingeras, Thomas R.; Guigó Serra, Roderic (Cold Spring Harbor Laboratory Press (CSHL Press), 2020)

  We have produced RNA sequencing data for 53 primary cells from different locations in the human body. The clustering of these primary cells reveals that most cells in the human body share a few broad transcriptional programs, ...
• Sources of stress and their associations with mental disorders among college students: results of the World Health Organization World Mental Health Surveys International College Student Initiative

  Karyotaki, Eirini; Cuijpers, Pim; Albor, Yesica; Alonso Caballero, Jordi; Auerbach, Randy P.; Bantjes, Jason; Bruffaerts, Ronny; Ebert, David Daniel; Hasking, Penelope; Kiekens, Glenn; Lee, Sue; McLafferty, Margaret; Mak, Arthur; Mortier, Philippe; Sampson, Nancy A.; Stein, Dan J.; Vilagut Saiz, Gemma, 1975-; Kessler, Ronald C.; WHO World Mental Health Survey Collaborators (Frontiers, 2020)

  The college years are stressful for many students. Identifying the sources of stress and their relative importance in leading to clinically significant emotional problems may assist in the development of targeted stress ...
• Comorbidity within mental disorders: a comprehensive analysis based on 145 990 survey respondents from 27 countries

  McGrath, John J.; Alonso Caballero, Jordi; de Jonge, P. (Cambridge University Press, 2020)

  Aims: Epidemiological studies indicate that individuals with one type of mental disorder have an increased risk of subsequently developing other types of mental disorders. This study aimed to undertake a comprehensive ...
• Essential roles of cohesin STAG2 in mouse embryonic development and adult tissue homeostasis

  De Koninck, Magali; Lapi, Eleonora; Badía Careaga, Claudio; Cossío, Itziar; Giménez-Llorente, Daniel; Rodríguez-Corsino, Miriam; Andrada, Elena; Hidalgo, Andrés; Manzanares, Miguel; Real, Francisco X.; Losada, Ana (Elsevier, 2020)

  Cohesin mediates sister chromatid cohesion and 3D genome folding. Two versions of the complex carrying STAG1 or STAG2 coexist in somatic vertebrate cells. STAG2 is commonly mutated in cancer, and germline mutations have ...
• The regulation of Net1/Cdc14 by the Hog1 MAPK upon osmostress unravels a new mechanism regulating mitosis

  Jiménez, Javier; Queralt Badia, Ethel; Posas Garriga, Francesc; Nadal Clanchet, Eulàlia de (Taylor & Francis, 2020)

  During evolution, cells have developed a plethora of mechanisms to optimize survival in a changing and unpredictable environment. In this regard, they have evolved networks that include environmental sensors, signaling ...
• The GATA3 X308_Splice breast cancer mutation is a hormone context-dependent oncogenic driver

  Hruschka, Natascha; Andreu Martínez, David; Real, Francisco X.; Martinelli, Paola (Nature Research, 2020)

  As the catalog of oncogenic driver mutations is expanding, it becomes clear that alterations in a given gene might have different functions and should not be lumped into one class. The transcription factor GATA3 is a ...
• Sex-biased patterns shaped the genetic history of Roma

  García-Fernández, Carla; Font-Porterias, Neus; Kučinskas, Vaidutis; Sukarova-Stefanovska, Emilija; Pamjav, Horolma; Makukh, Halyna; Dobón Berenguer, Begoña, 1987-; Bertranpetit, Jaume, 1952-; Netea, Mihai G; Calafell i Majó, Francesc; Comas, David, 1969- (Nature Research, 2020)

  The Roma population is a European ethnic minority characterized by recent and multiple dispersals and founder effects. After their origin in South Asia around 1,500 years ago, they migrated West. In Europe, they diverged ...
• A fully integrated machine learning scan of selection in the chimpanzee genome

  Nye, Jessica, 1986-; Mondal, Mayukh, 1989-; Bertranpetit, Jaume, 1952-; Laayouni, Hafid, 1968- (Oxford University Press, 2020)

  After diverging, each chimpanzee subspecies has been the target of unique selective pressures. Here, we employ a machine learning approach to classify regions as under positive selection or neutrality genome-wide. The ...
• Sox17 controls emergence and remodeling of Nestin-expressing coronary vessels

  González Hernández, Sara; Gómez, Manuel J.; Sánchez Cabo, Fátima; Méndez Ferrer, Simón; Muñoz Cánoves, Pura, 1962-; Isern, Joan (American Hearth Association, 2020)

  Rationale: The molecular mechanisms underlying the formation of coronary arteries during development and during cardiac neovascularization after injury are poorly understood. However, a detailed description of the relevant ...
• Immune cell subtypes and cytokines in lung tumor microenvironment: influence of COPD

  Tang, Jun; Ramis Cabrer, Daniel, 1993-; Curull Serrano, Víctor; Wang, Xuejie; Qin, Liyun; Mateu Jiménez, Mercè, 1990-; Duran Jordà, Xavier, 1974-; Pijuan Andujar, Lara; Rodríguez-Fuster, Alberto; Aguiló Espases, Rafael; Barreiro Portela, Esther (MDPI, 2020)

  Background: The immune microenvironment plays a role in tumorigenesis. Chronic Obstructive Pulmonary Disease (COPD) is an independent risk factor for lung cancer (LC). We hypothesized that immune profile characterized by ...
• The hippo pathway transducers YAP1/TEAD induce acquired resistance to trastuzumab in HER2-Positive breast cancer

  González-Alonso, Paula; Arpí Llucià, Oriol; Rovira Guerín, Ana; Albanell Mestres, Joan; Rojo, Federico (MDPI, 2020)

  Trastuzumab is the first-line targeted therapeutic drug for HER2-positive breast cancer, leading to improved overall survival. However, acquired resistance inevitably occurs. We aimed to identify, quantify, and assess the ...
• Health inequity in workers of Latin America and the Caribbean

  Silva Peñaherrera, Michael; López Ruiz, María, 1982-; Merino Salazar, Pamela Alexandra, 1978-; Gómez García, Antonio Ramón; Benavides, Fernando G. (Fernando García) (BioMed Central, 2020)

  Background: Latin America and the Caribbean (LAC) is the world's most inequitable region in terms of wealth distribution. The full scale of social inequalities in health has been hidden by the lack of reliable data. This ...

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