• An intergenerational information and communications technology learning project to improve digital skills: user satisfaction evaluation

  López Seguí, Francesc; de San Pedro, Marc; Aumatell Verges, Eva; Simó Algado, Salvador; Garcia Cuyàs, Francesc (JMIR Publications Inc., 2019)

  Background: "Digital Partners" is an intergenerational information and communications technology learning project carried out in the municipalities of Vic and Centelles (Catalonia) from April to May 2018. Within the framework ...
• Perspectives of orthopedic surgeons on the clinical use of bioprinted cartilage: qualitative study

  Salvador Verges, Àngels; Fernández Luque, Luis; Yildirim, Meltem; Salvador i Mata, Bertran; Garcia Cuyàs, Francesc (JMIR Publications Inc., 2019)

  Background: Over the past 60 years, no technique used for treating cartilage disorders has been completely successful. Bioprinting provides a highly anticipated, novel alternative solution to this problem. However, identifying ...
• Diverse families of transposable elements affect the transcriptional regulation of stress-response genes in Drosophila melanogaster

  Villanueva Cañas, José Luis, 1984-; Horvath, Vivien; Aguilera, Laura; González, Josefa (Oxford University Press, 2019)

  Although transposable elements are an important source of regulatory variation, their genome-wide contribution to the transcriptional regulation of stress-response genes has not been studied yet. Stress is a major aspect ...
• APOE-ε4 risk variant for Alzheimer's disease modifies the association between cognitive performance and cerebral morphology in healthy middle-aged individuals

  Cacciaglia, Raffaele; Molinuevo, José Luis; Falcón, Carles; Sánchez Benavides, Gonzalo; Gramunt Fombuena, Nina; Brugulat Serrat, Anna, 1986-; Esteller, Manel; Morán, Sebastián; Fauria, Karine; Gispert López, Juan Domingo; ALFA Study (Elsevier, 2019)

  The APOE-ε4 genotype is the highest genetic risk factor for Alzheimer's disease (AD). In cognitively unimpaired individuals, it has been related to altered brain morphology, function and earlier amyloid beta accumulation. ...
• CSF glial biomarkers YKL40 and sTREM2 are associated with longitudinal volume and diffusivity changes in cognitively unimpaired individuals

  Falcón, Carles; Monté-Rubio, Gemma C.; Grau-Rivera, Oriol; Suárez-Calvet, Marc; Sánchez Valle, Raquel; Rami, Lorena; Bosch, Beatriz; Haass, Christian; Gispert López, Juan Domingo; Molinuevo, José Luis (Elsevier, 2019)

  Cerebrospinal fluid (CSF) YKL40 and sTREM2 are astroglial and microglial activity biomarkers, respectively. We assessed whether CSF YKL40 and sTREM2 baseline levels are associated with longitudinal brain volume and diffusivity ...
• Association analyses identify 31 new risk loci for colorectal cancer susceptibility

  Law, Philip J.; The PRACTICAL consortium; Dunlop, Malcolm G. (Nature Research, 2019)

  Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide, and has a strong heritable basis. We report a genome-wide association analysis of 34,627 CRC cases and 71,379 controls of European ancestry that ...
• Alu insertion polymorphisms shared by Papio baboons and Theropithecus gelada reveal an intertwined common ancestry

  Walker, Jerilyn A.; Baboon Genome Analysis Consortium; Batzer, Mark A. (BioMed Central, 2019)

  Background: Baboons (genus Papio) and geladas (Theropithecus gelada) are now generally recognized as close phylogenetic relatives, though morphologically quite distinct and generally classified in separate genera. Primate ...
• The complete mitogenome of the Eurasian blindsnake Xerotyphlops vermicularis (Reptilia, Typhlopidae)

  Kornilios, Panagiotis (Taylor & Francis, 2019)

  The Eurasian or Greek blindsnake, Xerotyphlops vermicularis, is the only European representative of the infraorder Scolecophidia, a largely understudied group of snakes with a poor record of available mitogenomes. Its ...
• Urbanity and the dynamics of language shift in Galicia

  Mussa Juane, Mariamo; Seoane, Luís F., 1985-; Muñuzuri, Alberto P.; Mira, Jorge (Nature Research, 2019)

  Sociolinguistic phenomena often involve interactions across different scales and result in social and linguistic changes that can be tracked over time. Here, we focus on the dynamics of language shift in Galicia, a bilingual ...
• The determinants of genetic diversity in butterflies

  Mackintosh, Alexander; Laetsch, Dominik R.; Hayward, Alexander; Charlesworth, Brian; Waterfall, Martin; Vila, Roger; Lohse, Konrad (Nature Research, 2019)

  Under the neutral theory, genetic diversity is expected to increase with population size. While comparative analyses have consistently failed to find strong relationships between census population size and genetic diversity, ...
• Evolutionary and functional impact of common polymorphic inversions in the human genome

  Giner Delgado, Carla; Villatoro, Sergi; Lerga Jaso, Jon; Gayà Vidal, Magdalena; Oliva, Meritxell; Castellano Esteve, David; Pantano Rubiño, Lorena, 1982-; Bitarello, Bárbara D.; Izquierdo, David; Noguera, Isaac; Olalde Marquínez, Íñigo, 1987-; Delprat, Alejandra; Blancher, Antoine; Lalueza Fox, Carles, 1965-; Esko, Tõnu; O'Reilly, Paul F.; Andrés Morán, Aida, 1976-; Ferretti, Luca; Puig, Marta; Cáceres Aguilar, Mario (Nature Research, 2019)

  Inversions are one type of structural variants linked to phenotypic differences and adaptation in multiple organisms. However, there is still very little information about polymorphic inversions in the human genome due to ...
• Environmental temperatures shape thermal physiology as well as diversification and genome-wide substitution rates in lizards

  Garcia Porta, Joan; Carranza Gil-Dolz del Castellar, Salvador; Wollenberg Valero, Katharina C. (Nature Research, 2019)

  Climatic conditions changing over time and space shape the evolution of organisms at multiple levels, including temperate lizards in the family Lacertidae. Here we reconstruct a dated phylogenetic tree of 262 lacertid ...
• rs12416605:C>T in MIR938 associates with gastric cancer through affecting the regulation of the CXCL12 chemokine gene

  Torruella Loran, Ignasi, 1987-; Ramirez Viña, María Karla; Zapata Contreras, Daniela; Muñoz, Xavier; Garcia Ramallo, Eva; Bonet, Catalina; Gonzalez, Carlos A.; Sala, Núria; Espinosa Parrilla, Yolanda, 1971-; EPIC gastric cancer working group (Wiley, 2019)

  Background: MicroRNAs are small regulatory RNAs with important roles in carcinogenesis. Genetic variants in these regulatory molecules may contribute to disease. We aim to identify allelic variants in microRNAs as ...
• A unique cluster of roo insertions in the promoter region of a stress response gene in Drosophila melanogaster

  Merenciano, Miriam; Iacometti, Camillo; González, Josefa (BioMed Central, 2019)

  Transposable elements (TEs) are not randomly distributed in the genome. A genome-wide analysis of the D. melanogaster genome found that differences in TE density across 50 kb genomic regions was due both to transposition ...
• A benchmark of transposon insertion detection tools using real data

  Vendrell Mir, Pol; Barteri, Fabio; Merenciano, Miriam; González, Josefa; Casacuberta, Josep M.; Castanera, Raúl (BioMed Central, 2019)

  Background: Transposable elements (TEs) are an important source of genomic variability in eukaryotic genomes. Their activity impacts genome architecture and gene expression and can lead to drastic phenotypic changes. ...
• Genetic affinities of an eradicated European Plasmodium falciparum strain

  de Dios, Toni; van Dorp, Lucy; Gelabert Xirinachs, Pere, 1991-; Carøe, Christian; Sandoval Velasco, Marcela; Fregel, Rosa; Escosa, Raül; Aranda, Carles; Huijben, Silvie; Balloux, François; Gilbert, M Thomas; Lalueza Fox, Carles, 1965- (UNLISTED PUBLISHER, 2019)

  Malaria was present in most of Europe until the second half of the 20th century, when it was eradicated through a combination of increased surveillance and mosquito control strategies, together with cross-border and political ...
• Use of health apps by nurses for professional purposes: web-based survey study

  Mayer, Miguel Ángel, 1960-; Rodríguez Blanco, Octavi; Torrejon, Antonio (JMIR Publications Inc., 2019)

  Background: In the last few years, the number of mobile apps for health professionals has increased exponentially. Nevertheless, there is a lack of knowledge about the professional use, training requirements, and quality ...
• Association of occupational exposure to disinfectants with incidence of chronic obstructive pulmonary disease among US female nurses

  Dumas, Orianne; Varraso, Raphaëlle; Boggs, Krislyn M.; Quinot, Catherine; Zock, Jan-Paul; Henneberger, Paul K.; Speizer, Frank E.; Le Moual, Nicole; Camargo, Carlos A. (American Medical Association, 2019)

  Importance: Exposure to disinfectants in health care workers has been associated with respiratory health outcomes, including asthma. Despite the biological plausibility of an association between disinfectants (irritant ...
• Density of green spaces and cardiovascular risk factors in the city of Madrid: the heart healthy hoods study

  Plans, Elena; Gullón, Pedro; Cebrecos, Alba; Fontán, Mario; Díez, Julia; Nieuwenhuijsen, Mark J.; Franco, Manuel (MDPI, 2019)

  The aim of this study is to evaluate the relationship between the density of green spaces at different buffer sizes (300, 500, 1000 and 1500 m) and cardiovascular risk factors (obesity, hypertension, high cholesterol, and ...
• Is being employed always better for mental wellbeing than being unemployed? Exploring the role of gender and welfare state regimes during the economic crisis

  Cortès-Franch, Imma; Puig Barrachina, Vanessa; Vargas Leguás, Hernán; Arcas, M. Marta; Artazcoz Lazcano, Lucía, 1963- (MDPI, 2019)

  The growth of poor jobs related to economic crisis adds to its increase since the mid-1970s as a result of new forms of flexible employment. In Europe, there is no clear evidence on whether working in a poor-quality job ...

View more