• The genetic landscape of a physical interaction

  Diss, Guillaume; Lehner, Ben, 1978- (eLife, 2018)

  A key question in human genetics and evolutionary biology is how mutations in different genes combine to alter phenotypes. Efforts to systematically map genetic interactions have mostly made use of gene deletions. However, ...
• Quantification of gene expression patterns to reveal the origins of abnormal morphogenesis

  Martínez Abadías, Neus; Mateu-Estivill, Roger; Sastre-Tomas, Jaume; Motch Perrine, Susan; Yoon, Melissa; Robert Moreno, Alexandre; Swoger, Jim; Russo, Lucia; Kawasaki, Kazuhiko (eLife, 2018)

  The earliest developmental origins of dysmorphologies are poorly understood in many congenital diseases. They often remain elusive because the first signs of genetic misregulation may initiate as subtle changes in gene ...
• Sensorimotor pathway controlling stopping behavior during chemotaxis in the Drosophila melanogaster larva

  Tastekin, Ibrahim, 1986-; Khandelwal, Avinash, 1987-; Tadres, David; Fessner, Nico D.; Truman, James W.; Zlatic, Marta; Cardona, Albert; Louis, Matthieu (eLife, 2018)

  Sensory navigation results from coordinated transitions between distinct behavioral programs. During chemotaxis in the Drosophila melanogaster larva, the detection of positive odor gradients extends runs while negative ...
• Endogenous mobilization of bone-marrow cells into the murine retina induces fusion-mediated reprogramming of müller glia cells

  Pesaresi, Martina; Bonilla-Pons, Sergi A.; Simonte, Giacoma, 1984-; Sanges, Daniela; Di Vicino, Umberto; Cosma, Maria Pia, 1970- (Elsevier, 2018)

  Müller glial cells (MGCs) represent the most plastic cell type found in the retina. Following injury, zebrafish and avian MGCs can efficiently re-enter the cell cycle, proliferate and generate new functional neurons. The ...
• Adherens junction length during tissue contraction is controlled by the mechanosensitive activity of actomyosin and junctional recycling

  Sumi, Angughali Aheto, 1986-; Hayes, D. Peran, 1983-; D'Angelo, Arturo; Colombelli, Julien; Salbreux, Guillaume; Dierkes, Kai; Solon, Jérôme (Elsevier, 2018)

  During epithelial contraction, cells generate forces to constrict their surface and, concurrently, fine-tune the length of their adherens junctions to ensure force transmission. While many studies have focused on understanding ...
• Measuring and modeling interventions in aging

  Stroustrup, Nicholas (Elsevier, 2018)

  Many dietary, pharmaceutical, and genetic interventions have been found to increase the lifespan of laboratory animals. Several are now being explored for clinical application. To understand the physiologic action and ...
• Determinants of international variation in the prevalence of disabling wrist and hand pain

  Coggon David; Serra, Consol; Harcombe, Helen (BioMed Central, 2019)

  BACKGROUND: Previous research has indicated that wide international variation in the prevalence of disabling low back pain among working populations is largely driven by factors predisposing to musculoskeletal pain more ...
• Childhood generalized specific phobia as an early marker of internalizing psychopathology across the lifespan: results from the World Mental Health Surveys

  de Vries, Ymkje Anna; Alonso Caballero, Jordi; de Jonge, Peter (BioMed Central, 2019)
• Prediction of PD-L1 inhibition effects for HIV-infected individuals

  Zheltkova, Valerya; Argilaguet Marqués, Jordi, 1977-; Peligero Cruz, Cristina, 1986-; Bocharov, Gennady A.; Meyerhans, Andreas (Public Library of Science (PLoS), 2019)

  The novel therapies with immune checkpoint inhibitors hold great promises for patients with chronic virus infections and cancers. This is based mainly on the partial reversal of the exhausted phenotype of antigen-specific ...
• GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI

  Couto Alves, Alexessander; Estivill, Xavier, 1955-; Sunyer Deu, Jordi; Early Growth Genetics (EGG) Consortium (American Association for the Advancement of Science (AAAS), 2019)

  Early childhood growth patterns are associated with adult health, yet the genetic factors and the developmental stages involved are not fully understood. Here, we combine genome-wide association studies with modeling of ...
• Factores sociodemográficos y laborales relacionados con la exposición laboral a riesgos psicosociales por ocupación en España. Proyecto MatEmESp.

  González-Galarzo, M. Carmen; Ronda-Pérez, Elena; Benavides, Fernando G. (Fernando García); García, Ana M. (Societat Catalana de Salut Laboral, 2019)

  Objetivo: El objetivo del estudio es describir el nivel de exposición a riesgos psicosociales por ocupación en población laboral española y analizar su relación con condiciones de empleo y características sociodemográficas. ...
• Next-generation ARIA care pathways for rhinitis and asthma: a model for multimorbid chronic diseases

  Bousquet, Jean; Antó i Boqué, Josep Maria; García Aymerich, Judith; MASK study group (BioMed Central, 2019)

  Background: In all societies, the burden and cost of allergic and chronic respiratory diseases are increasing rapidly. Most economies are struggling to deliver modern health care effectively. There is a need to support the ...
• Association of maternal iodine status with child IQ: a meta-analysis of individual participant data

  Levie, Deborah; Korevaar, Tim I. M.; Bath, Sarah C.; Murcia, Mario; Dineva, Mariana; Llop, Sabrina; Espada, Mercedes; van Herwaarden, Antonius E.; de Rijke, Yolanda B.; Ibarluzea, Jesús; Sunyer Deu, Jordi; Tiemeier, Henning; Rayman, Margaret P.; Guxens Junyent, Mònica; Peeters, Robin P. (Oxford University Press, 2019)

  Context: Although the consequences of severe iodine deficiency are beyond doubt, the effects of mild to moderate iodine deficiency in pregnancy on child neurodevelopment are less well established. Objective: To study the ...
• Reconstruction of apo A2A receptor activation pathways reveal ligand-competent intermediates and state-dependent cholesterol hotspots

  Lovera, Silvia; Cuzzolin, Alberto; Kelm, Sebastian; De Fabritiis, Gianni; Sands, Zara A. (Nature Research, 2019)

  G-protein coupled receptors (GPCRs) play a pivotal role in transmitting signals at the cellular level. Structural insights can be exploited to support GPCR structure-based drug discovery endeavours. Despite advances in ...
• Maternal circulating Vitamin D3 levels during pregnancy and behaviour across childhood

  López Vicente, Mònica, 1988-; Sunyer Deu, Jordi; Lertxundi, Nerea; González, Llúcia; Rodríguez Dehli, Cristina; Espada Sáenz-Torre, Mercedes; Vrijheid, Martine; Tardón, Adonina; Llop, Sabrina; Torrent Quetglas, Maties; Ibarluzea, Jesús; Guxens Junyent, Mònica (Nature Research, 2019)

  Vitamin D deficiency during critical periods of development could lead to persistent brain alterations. We aimed to assess the association between maternal vitamin D3, the major circulatory form of vitamin D, at pregnancy ...
• Distribution of local ancestry and evidence of adaptation in admixed populations

  Secolin, Rodrigo; Mas Sandoval, Àlex, 1989-; Arauna, Lara R; Torres, Fábio R.; de Araujo, Tânia K.; Santos, Marilza L.; Rocha, Cristiane S.; Carvalho, Benilton S.; Cendes, Fernando; Lopes-Cendes, Iscia; Comas, David, 1969- (Nature Research, 2019)

  Admixed American populations have different global proportions of European, Sub-Saharan African, and Native-American ancestry. However, individuals who display the same global ancestry could exhibit remarkable differences ...
• Cellular heterogeneity results from indirect effects under metabolic tradeoffs

  Ollé-Vila, Aina; Solé Vicente, Ricard, 1962- (Royal Society, 2019)

  The emergence and maintenance of multicellularity requires the coexistence of diverse cellular populations displaying cooperative relationships. This enables long-term persistence of cellular consortia, particularly under ...
• European Roma groups show complex West Eurasian admixture footprints and a common South Asian genetic origin

  Font-Porterias, Neus; Arauna, Lara R; Poveda, Alaitz; Bianco, Erica; Rebato, Esther; Prata, Maria Joao; Calafell i Majó, Francesc; Comas, David, 1969- (Public Library of Science (PLoS), 2019)

  The Roma population is the largest transnational ethnic minority in Europe, characterized by a linguistic, cultural and historical heterogeneity. Comparative linguistics and genetic studies have placed the origin of European ...
• Gcn5-mediated acetylation at MBF-regulated promoters induces the G1/S transcriptional wave

  González Medina, Alberto, 1990-; Hidalgo Hernando, Elena; Ayté del Olmo, José (Oxford University Press, 2019)

  In fission yeast, MBF-dependent transcription is inactivated at the end of S phase through a negative feedback loop that involves the co-repressors, Yox1 and Nrm1. Although this repression system is well known, the molecular ...
• Urothelial organoids originating from Cd49fhigh mouse stem cells display Notch-dependent differentiation capacity

  Santos, Catarina P.; Lapi, Eleonora; Martínez de Villarreal, Jaime; Álvaro-Espinosa, Laura; Fernández-Barral, Asunción; Barbáchano, Antonio; Domínguez, Orlando; Laughney, Ashley M.; Megías, Diego; Muñoz, Alberto; Real, Francisco X. (Nature Research, 2019)

  Understanding urothelial stem cell biology and differentiation has been limited by the lack of methods for their unlimited propagation. Here, we establish mouse urothelial organoids that can be maintained uninterruptedly ...

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