• Common aspects influencing the translocation of SERS to biomedicine

  Tsoutsi, Dionysia; Sanles-Sobrido, Marcos; Cabot, Andreu; Rivera Gil, Pilar (Bentham Science Publishers, 2018)

  In this review, we introduce the reader the analytical technique, surface-enhanced Raman scattering motivated by the great potential we believe this technique have in biomedicine. We present the advantages and limitations ...
• The INO80 complex activates the transcription of S phase genes in a cell cycle regulated manner

  Knezevic, Iva, 1984-; González Medina, Alberto; Gaspa, Laura; Hidalgo Hernando, Elena; Ayté del Olmo, José (Wiley, 2018)

  Chromatin structure is an essential factor in the proper regulation of DNA repair, DNA replication and transcription. The INO80 complex and the SWR complex have been shown to play a fundamental role in transcription ...
• Delta9-tetrahydrocannabinol modulates the proteasome system in the brain

  Salgado Mendialdúa, Victòria; Aguirre Plans, Joaquim; Guney, Emre; Reig-Viader, Rita; Maldonado, Rafael, 1961-; Bayés, Angels; Oliva Miguel, Baldomero; Ozaita Mintegui, Andrés, 1969- (Elsevier, 2018)

  Cannabis is the most consumed illicit drug worldwide. Its principal psychoactive component, Δ9-tetrahydrocannabinol (THC), affects multiple brain functions, including cognitive performance, by modulating cannabinoid type-1 ...
• Methylphenidate attenuates the cognitive and mood alterations observed in mbnl2 knockout mice and reduces mcroglia overexpression

  Ramon-Duaso, Carla; Gener, Thomas; Consegal, Marta; Fernández-Avilés, Cristina; Gallego, Juan José; Castarlenas, Laura; Swanson, Maurice S.; Torre Fornell, Rafael de la; Maldonado, Rafael, 1961-; Puig Velasco, María Victoria; Robledo, Patricia, 1958- (Oxford University Press, 2018)

  Myotonic dystrophy type 1 (DM1) is a multisystem disorder affecting muscle and central nervous system (CNS) function. The cellular mechanisms underlying CNS alterations are poorly understood and no useful treatments exist ...
• PharmaTrek: a semantic web explorer for open innovation in multitarget drug discovery

  Carrascosa Baena, María Carmen, 1972-; Massaguer, Oriol L.; Mestres i López, Jordi (Wiley-VCH Verlag, 2012)
• Comparative analysis of miRNA expression during the development of insects of different metamorphosis modes and germband types

  Ylla Bou, Guillem, 1990-; Piulachs i Bagà, M. Dolors; Bellés, Xavier, 1952- (BioMed Central, 2017)

  BACKGROUND: Do miRNAs contribute to specify the germ-band type and the body structure in the insect embryo? Our goal was to address that issue by studying the changes in miRNA expression along the ontogeny of the German ...
• The microRNA toolkit of insects

  Ylla Bou, Guillem, 1990-; Fromm, Bastian; Piulachs i Bagà, M. Dolors; Bellés, Xavier, 1952- (Taylor & Francis (Routledge), 2016)

  Is there a correlation between miRNA diversity and levels of organismic complexity? Exhibiting extraordinary levels of morphological and developmental complexity, insects are the most diverse animal class on earth. Their ...
• Evolución de la DMO durante el tratamiento con inhibidores de aromatasa y su relación con el gen CYP11A1: estudio prospectivo de la cohorte B-ABLE

  Rodríguez Sanz, Maria, 1984-; Prieto-Alhambra, Daniel; Servitja Tormo, Sonia; Garcia Giralt, Natàlia; Garrigos, L.; Albanell Mestres, Joan; Martinez-García, Maria; González, I.; Martos, Tamara; Díez Pérez, Adolfo; Tusquets Trias de Bes, Ignacio; Nogués Solán, Xavier (Sociedad Española de Investigación Ósea y del Metabolismo Mineral, 2015)

  Objetivos: El objetivo del estudio fue analizar los cambios en la densidad mineral ósea (DMO) a lo largo del tratamiento con inhibidores de aromatasa (IA) en la práctica clínica y evaluar la asociación entre el gen CYP11A1 ...
• Estudio del patrón de expresión de microRNAs en el hueso osteoporótico

  Garcia Giralt, Natàlia; Ugarte Corbalán, Laura de, 1988-; Yoskovitz, Guy; Güerri Fernández, Roberto; Grinberg, Daniel; Nogués Solán, Xavier; Mellibovsky, Leonardo; Balcells, Susana; Díez Pérez, Adolfo (Sociedad Española de Investigación Ósea y del Metabolismo Mineral (SEIOMM), 2016)

  Objetivos: Identificar microRNAs (miRNAs) diferencialmente expresados en muestras óseas con fractura osteoporótica respecto a huesos sanos. Material y métodos: Se extrajo RNA total a partir de hueso trabecular fresco del ...
• A source-based measurement database for occupational exposure assessment of electromagnetic fields in the INTEROCC study: a literature review approach

  Vila Rodríguez, Javier, 1974-; Bowman, Joseph D.; Richardson, Lesley; Kincl, Laurel; Conover, Dave L.; McLean, Dave; Mann, Simon; Vecchia, Paolo; van Tongeren, Martie; Cardis, Elisabeth (Oxford University Press, 2016)

  INTRODUCTION: To date, occupational exposure assessment of electromagnetic fields (EMF) has relied on occupation-based measurements and exposure estimates. However, misclassification due to between-worker variability remains ...
• Mex3a marks a slowly dividing subpopulation of Lgr5+ intestinal stem cells

  Barriga de Vicente, Francisco Martín, 1983-; Montagni, Elisa, 1984-; Mana, Miyeko; Méndez Lago, María; Hernando-Momblona, Xavier; Sevillano, Marta; Guillaumet-Adkins, Amy; Rodríguez Esteban, Gustavo; Buczacki, Simon J.A.; Gut, Marta; Heyn, Holger; Winton, Douglas J.; Yilmaz, Omer H.; Attolini, Camille Stephan-Otto; Gut, Ivo Glynne; Batlle Gómez, Eduard (Elsevier, 2017)

  Highly proliferative Lgr5+ stem cells maintain the intestinal epithelium and are thought to be largely homogeneous. Although quiescent intestinal stem cell (ISC) populations have been described, the identity and features ...
• Clustered mutation signatures reveal that error-prone DNA repair targets mutations to active genes

  Supek, Fran; Lehner, Ben, 1978- (Elsevier, 2017)

  Many processes can cause the same nucleotide change in a genome, making the identification of the mechanisms causing mutations a difficult challenge. Here, we show that clustered mutations provide a more precise fingerprint ...
• omiXcore: a web server for prediction of protein interactions with large RNA

  Armaos, Alexandros; Cirillo, Davide; Tartaglia, Gian Gaetano (Oxford University Press, 2017)

  SUMMARY: Here we introduce omiXcore, a server for calculations of protein binding to large RNAs (> 500 nucleotides). Our webserver allows (i) use of both protein and RNA sequences without size restriction, (ii) pre-compiled ...
• Dual MET and ERBB inhibition overcomes intratumor plasticity in osimertinib-resistant-advanced non-small-cell lung cancer (NSCLC)

  Martinez-Marti, Alex; Felip, Enriqueta; Matito, Judit; Mereu, Elisabetta; Navarro, A.; Cedrés, S.; Pardo, N.; Martines de Castro, Ana; Remon, Jordi; Miquel, J.M.; Guillaumet-Adkins, Amy; Nadal, E.; Rodríguez Esteban, Gustavo; Arqués, O.; Fasani, R.; Nuciforo, Paolo G.; Heyn, Holger; Villanueva, A.; Palmer, Héctor G.; Vivancos Prellezo, Ana (Oxford University Press, 2017)

  BACKGROUND: Third-generation epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) such as osimertinib are the last line of targeted treatment of metastatic non-small-cell lung cancer (NSCLC) EGFR-mutant ...
• Civilians in World War II and DSM-IV mental disorders: results from the World Mental Health Survey Initiative

  Frounfelker, Rochelle; Gilman, Stephen E.; Betancourt, Theresa S.; Aguilar Gaxiola, Sergio; Alonso Caballero, Jordi; Bromet, Evelyn J.; Bruffaerts, Ronny; De Girolamo, Giovanni; Gluzman, Semyon; Gureje, Oye; Karam, Elie G.; Lee, Sing; Lépine, Jean-Pierre; Ono, Yutaka; Pennell, Beth-Ellen; Popovici, Daniela G.; ten Have, Margreet; Kessler, Ronald C.; WHO World Mental Health Survey Collaborators (Springer, 2018)

  PURPOSE: Understanding the effects of war on mental disorders is important for developing effective post-conflict recovery policies and programs. The current study uses cross-sectional, retrospectively reported data collected ...
• Prevalence of asthma-like symptoms with ageing

  Jarvis, Debbie; Antó i Boqué, Josep Maria; Zock, Jan-Paul; Burney, Peter (BMJ Publishing Group, 2016)

  BACKGROUND: Change in the prevalence of asthma-like symptoms in populations of ageing adults is likely to be influenced by smoking, asthma treatment and atopy. METHODS: The European Community Respiratory Health Survey ...
• Mutation Spectrum in the CACNA1A Gene in 49 Patients with Episodic Ataxia

  Sintas, Cèlia; Carreño, Oriel; Fernández Castillo, Noelia; Corominas, Roser; Vila Pueyo, Marta; Toma, Claudio; Cuenca-León, Ester; Barroeta, Isabel; Roig, Carles; Volpini, Victor; Macaya, Alfons; Cormand, Bru (Nature Publishing Group, 2017)

  Episodic ataxia is an autosomal dominant ion channel disorder characterized by episodes of imbalance and incoordination. The disease is genetically heterogeneous and is classified as episodic ataxia type 2 (EA2) when it ...
• How cells respond to environmental cues - insights from bio-functionalized substrates

  Ruprecht, Verena; Monzo, Pascale; Ravasio, Andrea; Yue, Zhang; Makhija, Ekta; Strale, Pierre Olivier; Gauthier, Nils; Shivashankar, G. V.; Studer, Vincent; Albiges-Rizo, Corinne; Viasnoff, Virgile (Company of Biologists, 2017)

  Biomimetic materials have long been the (he)art of bioengineering. They usually aim at mimicking in vivo conditions to allow in vitro culture, differentiation and expansion of cells. The past decade has witnessed a ...
• Prognostic impact of CD133 expression in Endometrial Cancer Patients

  Mancebo Moreno, Gemma; Sole-Sedeno, J.M.; Pino, O.; Miralpeix, E.; Mojal, Sergio; Garrigos, L.; Lloveras Rubio, Belen; Navarro Medrano, Pilar; Gibert, Joan; Lorenzo Perez, Marta; Aran, Iris; Carreras Collado, Ramón; Alameda Quitllet, Fransesc (Nature Publishing Group, 2017)

  To assess the impact of CD133 expression on the prognosis of endometrioid endometrial carcinoma (EEC). We retrospectively assessed CD133 expression in tissue microarray of 116 surgically treated FIGO I-III EEC. Tumors with ...
• Recent positive selection has acted on genes encoding proteins with more interactions within the whole human interactome

  Luisi, Pierre, 1985-; Alvarez-Ponce, David; Pybus Oliveras, Marc, 1985-; Fares, Mario A.; Bertranpetit, Jaume, 1952-; Laayouni, Hafid, 1968- (Oxford University Press, 2015)

  Genes vary in their likelihood to undergo adaptive evolution. The genomic factors that determine adaptability, however, remain poorly understood. Genes function in the context of molecular networks, with some occupying ...

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