• Prediction of PD-L1 inhibition effects for HIV-infected individuals

  Zheltkova, Valerya; Argilaguet Marqués, Jordi, 1977-; Peligero Cruz, Cristina, 1986-; Bocharov, Gennady A.; Meyerhans, Andreas (Public Library of Science (PLoS), 2019)

  The novel therapies with immune checkpoint inhibitors hold great promises for patients with chronic virus infections and cancers. This is based mainly on the partial reversal of the exhausted phenotype of antigen-specific ...
• GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI

  Couto Alves, Alexessander; Estivill, Xavier, 1955-; Sunyer Deu, Jordi; Early Growth Genetics (EGG) Consortium (American Association for the Advancement of Science (AAAS), 2019)

  Early childhood growth patterns are associated with adult health, yet the genetic factors and the developmental stages involved are not fully understood. Here, we combine genome-wide association studies with modeling of ...
• Factores sociodemográficos y laborales relacionados con la exposición laboral a riesgos psicosociales por ocupación en España. Proyecto MatEmESp.

  González-Galarzo, M. Carmen; Ronda-Pérez, Elena; Benavides, Fernando G. (Fernando García); García, Ana M. (Societat Catalana de Salut Laboral, 2019)

  Objetivo: El objetivo del estudio es describir el nivel de exposición a riesgos psicosociales por ocupación en población laboral española y analizar su relación con condiciones de empleo y características sociodemográficas. ...
• Next-generation ARIA care pathways for rhinitis and asthma: a model for multimorbid chronic diseases

  Bousquet, Jean; Antó i Boqué, Josep Maria; García Aymerich, Judith; MASK study group (BioMed Central, 2019)

  Background: In all societies, the burden and cost of allergic and chronic respiratory diseases are increasing rapidly. Most economies are struggling to deliver modern health care effectively. There is a need to support the ...
• Association of maternal iodine status with child IQ: a meta-analysis of individual participant data

  Levie, Deborah; Korevaar, Tim I. M.; Bath, Sarah C.; Murcia, Mario; Dineva, Mariana; Llop, Sabrina; Espada, Mercedes; van Herwaarden, Antonius E.; de Rijke, Yolanda B.; Ibarluzea, Jesús; Sunyer Deu, Jordi; Tiemeier, Henning; Rayman, Margaret P.; Guxens Junyent, Mònica; Peeters, Robin P. (Oxford University Press, 2019)

  Context: Although the consequences of severe iodine deficiency are beyond doubt, the effects of mild to moderate iodine deficiency in pregnancy on child neurodevelopment are less well established. Objective: To study the ...
• Reconstruction of apo A2A receptor activation pathways reveal ligand-competent intermediates and state-dependent cholesterol hotspots

  Lovera, Silvia; Cuzzolin, Alberto; Kelm, Sebastian; De Fabritiis, Gianni; Sands, Zara A. (Nature Research, 2019)

  G-protein coupled receptors (GPCRs) play a pivotal role in transmitting signals at the cellular level. Structural insights can be exploited to support GPCR structure-based drug discovery endeavours. Despite advances in ...
• Maternal circulating Vitamin D3 levels during pregnancy and behaviour across childhood

  López Vicente, Mònica, 1988-; Sunyer Deu, Jordi; Lertxundi, Nerea; González, Llúcia; Rodríguez Dehli, Cristina; Espada Sáenz-Torre, Mercedes; Vrijheid, Martine; Tardón, Adonina; Llop, Sabrina; Torrent Quetglas, Maties; Ibarluzea, Jesús; Guxens Junyent, Mònica (Nature Research, 2019)

  Vitamin D deficiency during critical periods of development could lead to persistent brain alterations. We aimed to assess the association between maternal vitamin D3, the major circulatory form of vitamin D, at pregnancy ...
• Distribution of local ancestry and evidence of adaptation in admixed populations

  Secolin, Rodrigo; Mas Sandoval, Àlex, 1989-; Arauna, Lara R; Torres, Fábio R.; de Araujo, Tânia K.; Santos, Marilza L.; Rocha, Cristiane S.; Carvalho, Benilton S.; Cendes, Fernando; Lopes-Cendes, Iscia; Comas, David, 1969- (Nature Research, 2019)

  Admixed American populations have different global proportions of European, Sub-Saharan African, and Native-American ancestry. However, individuals who display the same global ancestry could exhibit remarkable differences ...
• Cellular heterogeneity results from indirect effects under metabolic tradeoffs

  Ollé-Vila, Aina; Solé Vicente, Ricard, 1962- (Royal Society, 2019)

  The emergence and maintenance of multicellularity requires the coexistence of diverse cellular populations displaying cooperative relationships. This enables long-term persistence of cellular consortia, particularly under ...
• European Roma groups show complex West Eurasian admixture footprints and a common South Asian genetic origin

  Font-Porterias, Neus; Arauna, Lara R; Poveda, Alaitz; Bianco, Erica; Rebato, Esther; Prata, Maria Joao; Calafell i Majó, Francesc; Comas, David, 1969- (Public Library of Science (PLoS), 2019)

  The Roma population is the largest transnational ethnic minority in Europe, characterized by a linguistic, cultural and historical heterogeneity. Comparative linguistics and genetic studies have placed the origin of European ...
• Gcn5-mediated acetylation at MBF-regulated promoters induces the G1/S transcriptional wave

  González Medina, Alberto, 1990-; Hidalgo Hernando, Elena; Ayté del Olmo, José (Oxford University Press, 2019)

  In fission yeast, MBF-dependent transcription is inactivated at the end of S phase through a negative feedback loop that involves the co-repressors, Yox1 and Nrm1. Although this repression system is well known, the molecular ...
• Urothelial organoids originating from Cd49fhigh mouse stem cells display Notch-dependent differentiation capacity

  Santos, Catarina P.; Lapi, Eleonora; Martínez de Villarreal, Jaime; Álvaro-Espinosa, Laura; Fernández-Barral, Asunción; Barbáchano, Antonio; Domínguez, Orlando; Laughney, Ashley M.; Megías, Diego; Muñoz, Alberto; Real, Francisco X. (Nature Research, 2019)

  Understanding urothelial stem cell biology and differentiation has been limited by the lack of methods for their unlimited propagation. Here, we establish mouse urothelial organoids that can be maintained uninterruptedly ...
• Association of exposure to ambient air pollution with thyroid function during pregnancy

  Ghassabian, Akhgar; Pierotti, Livia; Julvez, Jordi; Vrijheid, Martine; Sunyer Deu, Jordi; Guxens Junyent, Mònica (American Medical Association, 2019)

  Importance: Air pollutants interact with estrogen nuclear receptors, but their effect on thyroid signaling is less clear. Thyroid function is of particular importance for pregnant women because of the thyroid’s role in ...
• A2A receptor homodimer-disrupting sequence efficiently delivered by a protease-resistant, cyclic CPP vector

  Gallo, Maria; Navarro, Gemma; Franco, Rafael; Andreu Martínez, David (MDPI, 2019)

  G-protein-coupled receptors associate into dimers/oligomers whose function is not well understood. One approach to investigate this issue is to challenge oligomerization by peptides replicating transmembrane domains and ...
• Return to the sea, get huge, beat cancer: an analysis of cetacean genomes including an asssembly for the humpback whale (megaptera novaeangliae)

  Tollis, Marc; Robbins, Jooke; Webb, Andrew E.; Kuderna, Lukas F.K.; Caulin, Aleah F.; Garcia, Jacinda D.; Bèrubè, Martine; Pourmand, Nader; Marquès i Bonet, Tomàs, 1975-; O'Connell, Mary J.; Palsbøll, Per J.; Maley, Carlo C. (Oxford University Press, 2019)

  Cetaceans are a clade of highly specialized aquatic mammals that include the largest animals that have ever lived. The largest whales can have ∼1,000× more cells than a human, with long lifespans, leaving them theoretically ...
• MICU1 confers protection from MCU-dependent manganese toxicity

  Wettmarshausen, Jennifer; Goh, Valerie; Huang, Kai-Ting; Arduino, Daniela M.; Tripathi, Utkarsh; Leimpek, Anja; Cheng, Yiming; Pittis, Alexandros, 1982-; Gabaldón Estevan, Juan Antonio, 1973-; Mokranjac, Dejana; Hajnóczky, György; Perocchi, Fabiana (Elsevier, 2018)

  The mitochondrial calcium uniporter is a highly selective ion channel composed of species- and tissue-specific subunits. However, the functional role of each component still remains unclear. Here, we establish a synthetic ...
• Impaired spermatogenesis, muscle, and erythrocyte function in U12 intron splicing-defective Zrsr1 mutant mice

  Horiuchi, Keiko; Papasaikas, Panagiotis; Valcárcel, J. (Juan); Gutiérrez-Adán, Alfonso (Elsevier, 2018)

  The U2AF35-like ZRSR1 has been implicated in the recognition of 3' splice site during spliceosome assembly, but ZRSR1 knockout mice do not show abnormal phenotypes. To analyze ZRSR1 function and its precise role in RNA ...
• An integrative study of protein-RNA condensates identifies scaffolding RNAs and reveals players in fragile X-associated tremor/ataxia syndrome

  Cid-Samper, Fernando; Gelabert-Baldrich, Mariona; Lang, Benjamin; Lorenzo Gotor, Maria de las Nieves; Ponti, Riccardo delli; Severijnen, Lies-Anne W.F.M.; Bolognesi, Benedetta; Gelpi, Ellen; Hukema, Renate K.; Botta Orfila, Teresa; Tartaglia, Gian Gaetano (Elsevier, 2018)

  Recent evidence indicates that specific RNAs promote the formation of ribonucleoprotein condensates by acting as scaffolds for RNA-binding proteins (RBPs). We systematically investigated RNA-RBP interaction networks to ...
• Systems level expression correlation of Ras GTPase regulators

  Besray Unal, E.; Kiel, Christina; Benisty, Hannah; Campbell, Andrew; Pickering, Karen; Blüthgen, Nils; Sansom, Owen J.; Serrano Pubull, Luis, 1982- (BioMed Central, 2018)

  Background: Proteins of the ubiquitously expressed core proteome are quantitatively correlated across multiple eukaryotic species. In addition, it was found that many protein paralogues exhibit expression anticorrelation, ...
• FUS phase separation is modulated by a molecular chaperone and methylation of arginine cation-π interactions

  Qamar, Seema; Tartaglia, Gian Gaetano; St George-Hyslop, Peter (Elsevier, 2018)

  Reversible phase separation underpins the role of FUS in ribonucleoprotein granules and other membrane-free organelles and is, in part, driven by the intrinsically disordered low-complexity (LC) domain of FUS. Here, we ...

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