• Obesity is associated with shorter telomeres in 8 year-old children

  Clemente Batalha Pardal, Diana, 1990-; Maitre, Léa; Bustamante Pineda, Mariona; Chatzi, Leda; Roumeliotaki, Theano; Fossati, Serena; Grazuleviciene, Regina; Gützkow, Kristine B.; Lepeule, Johanna; Martens, Dries S.; McEachan, Rosemary R.C.; Meltzer, Helle Margrete; Petraviciene, Inga; Slama, Rémy; Tamayo-Uria, Ibon; Urquiza, José M.; Vafeiadi, Marina, 1983-; Wright, John; Nawrot, Tim S.; Vrijheid, Martine (Nature Research, 2019)

  Telomere length is considered a biomarker of biological aging. Shorter telomeres and obesity have both been associated with age-related diseases. To evaluate the association between various indices of obesity with leukocyte ...
• Integrated single-base resolution maps of transcriptome, sRNAome and methylome of Tomato yellow leaf curl virus (TYLCV) in tomato

  Piedra Aguilera, Álvaro; Jiao, Chen; Luna, Ana P.; Villanueva, Francisco; Dabad, Marc; Esteve-Codina, Anna; Díaz Pendón, Juan A.; Fei, Zhangjun; Bejarano, Eduardo R.; Castillo, Araceli G. (Nature Research, 2019)

  Geminiviruses are plant ssDNA viruses that replicate through dsDNA intermediates and form minichromosomes which carry the same epigenetic marks as the host chromatin. During the infection, geminiviruses are targets of the ...
• High degree of polyclonality hinders somatic mutation calling in lung brush samples of COPD cases and controls

  Thun, Gian Andri; Derdak, Sophia; Castro Giner, Francesc; Apunte Ramos, Katherine; Águeda, Lidia; Gut, Marta; Gut, Ivo Glynne (Nature Research, 2019)

  Chronic obstructive pulmonary disease (COPD) is induced by cigarette smoking and characterized by inflammation of airway tissue. Since smokers with COPD have a higher risk of developing lung cancer than those without, we ...
• Controlled ploidy reduction of pluripotent 4n cells generates 2n cells during mouse embryo development

  Frade, João; Nakagawa, Shoma; Cortes, Paola; Di Vicino, Umberto; Romo Saladrigas, Neus, 1982-; Lluis Viñas, Frederic; Cosma, Maria Pia, 1970- (American Association for the Advancement of Science (AAAS), 2019)

  Cells with high ploidy content are common in mammalian extraembryonic and adult tissues. Cell-to-cell fusion generates polyploid cells during mammalian development and tissue regeneration. However, whether increased ploidy ...
• Protein-assisted RNA fragment docking (RnaX) for modeling RNA-protein interactions using ModelX

  Delgado Blanco, Javier; Radusky, Leandro; Cianferoni, Damiano; Serrano Pubull, Luis, 1982- (National Academy of Sciences, 2019)

  RNA-protein interactions are crucial for such key biological processes as regulation of transcription, splicing, translation, and gene silencing, among many others. Knowing where an RNA molecule interacts with a target ...
• CRISPR editing of sftb-1/SF3B1 in Caenorhabditis elegans allows the identification of synthetic interactions with cancer-related mutations and the chemical inhibition of splicing

  Serrat Farran, Xènia, 1993-; Kukhtar, Dmytro; Cornes Maragliano, Eric, 1987-; Esteve-Codina, Anna; Benlloch, Helena; Cecere, Germano; Cerón Madrigal, Julián (Public Library of Science (PLoS), 2019)

  SF3B1 is the most frequently mutated splicing factor in cancer. Mutations in SF3B1 likely confer clonal advantages to cancer cells but they may also confer vulnerabilities that can be therapeutically targeted. SF3B1 cancer ...
• Recurrent somatic mutations reveal new insights into consequences of mutagenic processes in cancer

  Stobbe, Miranda D.; Thun, Gian Andri; Diéguez Docampo, Andrea; Oliva, Meritxell; Whalley, Justin P.; Raineri, Emanuele; Gut, Ivo Glynne (Public Library of Science (PLoS), 2019)

  The sheer size of the human genome makes it improbable that identical somatic mutations at the exact same position are observed in multiple tumours solely by chance. The scarcity of cancer driver mutations also precludes ...
• Reconstruction of protein domain evolution using single-cell amplified genomes of uncultured choanoflagellates sheds light on the origin of animals

  López Escardó, David, 1988-; Grau Bové, Xavier; Guillaumet-Adkins, Amy; Gut, Marta; Sieracki, Michael E.; Ruiz Trillo, Iñaki (Royal Society, 2019)

  Understanding the origins of animal multicellularity is a fundamental biological question. Recent genome data have unravelled the role that co-option of pre-existing genes played in the origin of animals. However, there ...
• The glucocorticoid receptor interferes with progesterone receptor-dependent genomic regulation in breast cancer cells

  Ogara, Maria F.; Rodríguez Seguí, Santiago A.; Marini, Melisa; Silvina Nacht, Ana; Stortz, Martin; Levi, Valeria; Presman, Diego M.; Vicent, Guillermo Pablo; Pecci, Adali (Oxford University Press, 2019)

  The glucocorticoid and progesterone receptors (GR and PR) are closely related members of the steroid receptor family. Despite sharing similar structural and functional characteristics; the cognate hormones display very ...
• Super-resolution microscopy reveals how histone tail acetylation affects DNA compaction within nucleosomes in vivo

  Otterstrom, Jason; Castells García, Àlvaro, 1991-; Vicario, Chiara; Gómez García, Pablo; Cosma, Maria Pia, 1970-; Lakadamyali, Melike (Oxford University Press, 2019)

  Chromatin organization is crucial for regulating gene expression. Previously, we showed that nucleosomes form groups, termed clutches. Clutch size correlated with the pluripotency grade of mouse embryonic stem cells and ...
• The mutational landscape of a prion-like domain

  Bolognesi, Benedetta; Faure, Andre J.; Seuma, Mireia; Schmiedel, Jörn M.; Tartaglia, Gian Gaetano; Lehner, Ben, 1978- (Nature Research, 2019)

  Insoluble protein aggregates are the hallmarks of many neurodegenerative diseases. For example, aggregates of TDP-43 occur in nearly all cases of amyotrophic lateral sclerosis (ALS). However, whether aggregates cause ...
• Engaging chromatin: PRC2 structure meets function

  Chammas, Paul, 1992-; Mocavini, Ivano; Di Croce, Luciano (Nature Research, 2020)

  Polycomb repressive complex 2 (PRC2) is a key epigenetic multiprotein complex involved in the regulation of gene expression in metazoans. PRC2 is formed by a tetrameric core that endows the complex with histone methyltransferase ...
• The bivalent genome: characterization, structure, and regulation

  Blanco, Enrique; González Ramírez, Mar; Alcaine Colet, Anna, 1992-; Aranda Aragón, Sergio; Di Croce, Luciano (Elsevier, 2020)

  An intricate molecular machinery is at the core of gene expression regulation in every cell. During the initial stages of organismal development, the coordinated activation of diverse transcriptional programs is crucial ...
• Spatially clustered loci with multiple enhancers are frequent targets of HIV-1 integration

  Lucic, Bojana; Chen, Heng-Chang; Kuzman, Maja; Zorita, Eduard; Wegner, Julia; Minneker, Vera; Wang, Wei; Fronza, Raffaele; Laufs, Stefanie; Schmidt, Manfred; Stadhouders, Ralph; Roukos, Vassilis; Vlahovicek, Kristian; Filion, Guillaume; Lusic, Marina (Nature Research, 2019)

  HIV-1 recurrently targets active genes and integrates in the proximity of the nuclear pore compartment in CD4+ T cells. However, the genomic features of these genes and the relevance of their transcriptional activity for ...
• Using single-cell transcriptomics to understand functional states and interactions in microbial eukaryotes

  Ku, Chuan; Sebé-Pedrós, Arnau (Royal Society, 2019)

  Understanding the diversity and evolution of eukaryotic microorganisms remains one of the major challenges of modern biology. In recent years, we have advanced in the discovery and phylogenetic placement of new eukaryotic ...
• Origin and evolution of eukaryotic transcription factors

  de Mendoza, Alex; Sebé-Pedrós, Arnau (Elsevier, 2019)

  Transcription factors (TFs) have a central role in genome regulation directing gene transcription through binding specific DNA sequences. Eukaryotic genomes encode a large diversity of TF classes, each defined by unique ...
• Resumen ejecutivo de ARIA 2019: Vías integradas de atención para la rinitis alérgica en Argentina, España y México

  Ivancevich, Juan Carlos; Antó i Boqué, Josep Maria; Bousquet, Jean (Colegio Mexicano de Inmunología Clínica y Alergia, A.C., 2019)

  El impacto sanitario y económico de las enfermedades alérgicas está aumentando rápidamente y se necesitan cambios en las estrategias para su manejo. Su influencia reduce al menos en un tercio la capacidad de desempeño ...
• Accurate detection of m6A RNA modifications in native RNA sequences

  Liu, Huanle; Begik, Oguzhan; Lucas, Morghan C.; Ramirez, Jose Miguel; Mason, Christopher E.; Wiener, David; Schwartz, Schraga; Mattick, John S.; Smith, Martin A.; Novoa, Eva Maria (Nature Research, 2019)

  The epitranscriptomics field has undergone an enormous expansion in the last few years; however, a major limitation is the lack of generic methods to map RNA modifications transcriptome-wide. Here, we show that using direct ...
• A tunable dual-input system for on-demand dynamic gene expression regulation

  Pedone, Elisa, 1985-; Postiglione, Lorena; Aulicino, Francesco, 1987-; Rocca, Dan L.; Montes Olivas, Sandra; Khazim, Mahmoud; di Bernardo, Diego; Cosma, Maria Pia, 1970-; Marucci, Lucia (Nature Research, 2019)

  Cellular systems have evolved numerous mechanisms to adapt to environmental stimuli, underpinned by dynamic patterns of gene expression. In addition to gene transcription regulation, modulation of protein levels, dynamics ...
• From single drug targets to synergistic network pharmacology in ischemic stroke

  Casas, Ana I.; Hassan, Ahmed; Larsen, Simon J.; Gomez-Rangel, Vanessa; Elbatreek, Mahmoud; Kleikers, Pamela W. M.; Guney, Emre; Egea, Javier; López, Manuela G.; Baumbach, Jan; Schmidt, Harald H.H.W. (National Academy of Sciences, 2019)

  Drug discovery faces an efficacy crisis to which ineffective mainly single-target and symptom-based rather than mechanistic approaches have contributed. We here explore a mechanism-based disease definition for network ...

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