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Articles (Departament de Ciències Experimentals i de la Salut)

Articles (Departament de Ciències Experimentals i de la Salut)

 

Articles de recerca, en accés obert, del Departament de Ciències Experimentals i de la Salut de la UPF.

Recent Submissions

  • Mañas-García, Laura; Guitart, Maria; Duran Jordà, Xavier, 1974-; Barreiro Portela, Esther (MDPI, 2020)
    We hypothesized that treatment with pharmacological agents known to increase sirtuin-1 activity (resveratrol and curcumin) may enhance muscle regeneration. In limb muscles of mice (C57BL/6J, 10 weeks) exposed to reloading ...
  • Dierssen, Mara; Fructuoso, Marta; Martínez de Lagrán Cabredo, María; Perluigi, Marzia; Barone, Eugenio (Frontiers, 2020)
    Down syndrome (DS) is the most frequent chromosomal abnormality that causes intellectual disability, resulting from the presence of an extra complete or segment of chromosome 21 (HSA21). In addition, trisomy of HSA21 ...
  • Filion, Guillaume; Cortini, Ruggero; Zorita, Eduard (Frontiers, 2020)
    The increasing throughput of DNA sequencing technologies creates a need for faster algorithms. The fate of most reads is to be mapped to a reference sequence, typically a genome. Modern mappers rely on heuristics to gain ...
  • Martone, Julie; Lisi, Michela; Castagnetti, Francesco; Rosa, Alessandro; Di Carlo, Valerio; Blanco, Enrique; Setti, Adriano; Mariani, Davide; Colantoni, Alessio; Santini, Tiziana; Perone, Lucia; Di Croce, Luciano; Bozzoni, Irene (UNLISTED PUBLISHER, 2020)
    Exon skipping is an effective strategy for the treatment of many Duchenne Muscular Dystrophy (DMD) mutations. Natural exon skipping observed in several DMD cases can help in identifying novel therapeutic tools. Here, we ...
  • Peligero Cruz, Cristina, 1986-; Givony, Tal; Sebé-Pedrós, Arnau; Dobeš, Jan; Kadouri, Noam; Nevo, Shir; Roncato, Francesco; Alon, Ronen; Goldfarb, Yael; Abramson, Jakub (eLife, 2020)
    Foxp3+ regulatory T cells (Tregs) are potent suppressor cells, essential for the maintenance of immune homeostasis. Most Tregs develop in the thymus and are then released into the immune periphery. However, some Tregs ...
  • Touceda-Suárez, María; Kita, Elizabeth M.; Acemel, Rafael D.; Firbas, Panos N.; Magri, Marta S.; Naranjo, Silvia; Tena, Juan J.; Gómez Skarmeta, José Luis; Maeso, Ignacio; Irimia, Manuel (Oxford University Press (OUP), 2020)
    We investigated how the two rounds of whole-genome duplication that occurred at the base of the vertebrate lineage have impacted ancient microsyntenic associations involving developmental regulators (known as genomic ...
  • Fernández, Rosa; Marcet Houben, Marina; Legeai, Fabrice; Richard, Gautier; Robin, Stéphanie; Wucher, Valentin; Pegueroles Queralt, Maria Cinta; Gabaldón Estevan, Juan Antonio, 1973-; Tagu, Denis (Oxford University Press (OUP), 2020)
    Ecology of insects is as wide as their diversity, which reflects their high capacity of adaptation in most of the environments of our planet. Aphids, with over 4,000 species, have developed a series of adaptations including ...
  • Tian, Tian V.; Vidal Ocabo, Enrique; Graf, T. (Thomas); Stik, Grégoire (MyJove Corporation, 2020)
    During mammalian development, cell fates are determined through the establishment of regulatory networks that define the specificity, timing, and spatial patterns of gene expression. Embryoid bodies (EBs) derived from ...
  • Hollmann, Nele Merret; Jagtap, Pravin Kumar Ankush; Masiewicz, Pawel; Guitart, Tanit; Simon, Bernd; Provaznik, Jan; Stein, Frank; Haberkant, Per; Sweetapple, Lara Jayne; Villacorta, Laura; Mooijman, Dylan; Benes, Vladimir; Savitski, Mikhail M.; Gebauer, Fátima; Hennig, Janosch (Elsevier, 2020)
    RNA-binding proteins (RBPs) commonly feature multiple RNA-binding domains (RBDs), which provide these proteins with a modular architecture. Accumulating evidence supports that RBP architectural modularity and adaptability ...
  • Rea, Jessica; Menci, Valentina; Tollis, Paolo; Santini, Tiziana; Armaos, Alexandros, 1989-; Garone, Maria Giovanna; Iberite, Federica; Cipriano, Andrea; Tartaglia, Gian Gaetano; Rosa, Alessandro; Ballarino, Monica; Laneve, Pietro; Caffarelli, Elisa (Nature Research, 2020)
    Neuronal differentiation is a timely and spatially regulated process, relying on precisely orchestrated gene expression control. The sequential activation/repression of genes driving cell fate specification is achieved by ...
  • Boni, Jacopo; Rubio Pérez, Carlota, 1990-; López Bigas, Núria; Fillat i Fonts, Cristina; Luna, Susana de la (MDPI, 2020)
    DYRK (dual-specificity tyrosine-regulated kinases) are an evolutionary conserved family of protein kinases with members from yeast to humans. In humans, DYRKs are pleiotropic factors that phosphorylate a broad set of ...
  • Pérez Soriano, Alexandra; Arnal, Magdalena; Botta Orfila, Teresa; Giraldo, Darly; Fernández, Manel; Compta, Yaroslau; Fernández-Santiago, Ruben; Ezquerra, Mario; Tartaglia, Gian Gaetano; Martí, M. Josep; Catalan multiple system atrophy-registry (CMSAR) (Nature Research, 2020)
    Background: Multiple system atrophy (MSA) is a rare oligodendroglial synucleinopathy of unknown etiopathogenesis including two major clinical variants with predominant parkinsonism (MSA-P) or cerebellar dysfunction (MSA-C). ...
  • Blanco Cabra, Núria; Paetzold, Bernhard, 1981-; Ferrar, Tony; Mazzolini, Rocco; Torrents, Eduard; Serrano Pubull, Luis, 1982-; Lluch-Senar, Maria 1982- (Nature Research, 2020)
    Aggregates of Pseudomonas aeruginosa form a protective barrier against antibiotics and the immune system. These barriers, known as biofilms, are associated with several infectious diseases. One of the main components of ...
  • Vansant, Gerlinde; Chen, Heng-Chang; Zorita, Eduard; Trejbalová, Katerina; Miklík, Dalibor; Filion, Guillaume; Debyser, Zeger (Oxford University Press, 2020)
    HIV-1 persists lifelong in memory cells of the immune system as latent provirus that rebounds upon treatment interruption. Therefore, the latent reservoir is the main target for an HIV cure. Here, we studied the direct ...
  • Reim, Alexander; Ackermann, Roland; Font Mateu, Jofre, 1977-; Kammel, Robert; Beato, Miguel; Nolte, Stefan; Mann, Matthias; Russmann, Christoph; Wierer, Michael, 1982- (Nature Research, 2020)
    Transcription factors (TFs) regulate target genes by specific interactions with DNA sequences. Detecting and understanding these interactions at the molecular level is of fundamental importance in biological and clinical ...
  • Toda, Haruka; Borràs, Eva; Sabidó Aguadé, Eduard, 1981-; del Portillo, Hernando A. (Nature Research, 2020)
    Plasmodium vivax is the most widely distributed human malaria parasite. Previous studies have shown that circulating microparticles during P. vivax acute attacks are indirectly associated with severity. Extracellular ...
  • Alriquet, Marion; Calloni, Giulia; Martínez Limón, Adrián; Delli Ponti, Riccardo, 1987-; Hanspach, Gerd; Hegensbach, Martin; Tartaglia, Gian Gaetano; Vabulas, R. Martin (Oxford University Press (OUP), 2020)
    Post-transcriptional methylation of N6- and N1-adenine can effect transcriptome turnover and translation. Furthermore, the regulatory function of N6-methyladenine (m6A) during heat shock has been uncovered, including the ...
  • Begik, Oguzhan; Lucas, Morghan C.; Liu, Huanle; Ramírez, José Miguel; Mattick, John S.; Novoa, Eva Maria (BioMed Central, 2020)
    Background: RNA modifications play central roles in cellular fate and differentiation. However, the machinery responsible for placing, removing, and recognizing more than 170 RNA modifications remains largely uncharacterized ...
  • Massoni-Badosa, Ramon; Iacono, Giovanni; Moutinho, Catia; Kulis, Marta; Palau, Núria; Marchese, Domenica, 1986-; Rodríguez Ubreva, Javier; Ballestar, Esteban; Rodríguez Esteban, Gustavo; Marsal, Sara; Aymerich, Marta; Colomer, Dolors; Campo, Elias; Julià Cano, Antoni; Martín-Subero, José I.; Heyn, Holger (BioMed Central, 2020)
    Robust protocols and automation now enable large-scale single-cell RNA and ATAC sequencing experiments and their application on biobank and clinical cohorts. However, technical biases introduced during sample acquisition ...
  • Hovhannisyan, Hrant; Saus Martínez, Ester; Ksiezopolska, Ewa; Roberts, Alex J. Hinks; Louis, Edward J.; Gabaldón Estevan, Juan Antonio (Frontiers Media, 2020)
    The formation of interspecific hybrids results in the coexistence of two diverged genomes within the same nucleus. It has been hypothesized that negative epistatic interactions and regulatory interferences between the two ...

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