• Cerebral oxidative metabolism mapping in four genetic mouse models of anxiety and mood disorders

  Matrov, Denis; Kaart, Tanel; Lanfumey, Laurence; Maldonado, Rafael, 1961-; Sharp, Trevor; Tordera, Rosa M.; Kelly, Paul A.; Deakin, Bill; Harro, Jaanus (Elsevier, 2018)

  The psychopathology of depression is highly complex and the outcome of studies on animal models is divergent. In order to find brain regions that could be metabolically distinctively active across a variety of mouse ...
• Adolescent alcohol use and parental and adolescent socioeconomic position in six European cities

  Bosque Prous, Marina, 1984-; Kuipers, Mirte A. G.; Espelt Hernández, Albert, 1981-; Richter, Matthias; Rimpelä, Arja; Perelman, Julian; Federico, Bruno; Brugal i Puig, M. Teresa; Lorant, Vincent; Kunst, Anton E. (BioMed Central, 2017)

  BACKGROUND: Many risk behaviours in adolescence are socially patterned. However, it is unclear to what extent socioeconomic position (SEP) influences adolescent drinking in various parts of Europe. We examined how alcohol ...
• Comparative analysis of single-cell RNA sequencing methods

  Ziegenhain, Christoph; Vieth, Beate I.H.; Parekh, Swati; Reinius, Björn; Guillaumet-Adkins, Amy; Smets, Martha; Leonhardt, Heinrich; Heyn, Holger; Hellmann, Ines; Enard, Wolfgang (Elsevier, 2017)

  Single-cell RNA sequencing (scRNA-seq) offers new possibilities to address biological and medical questions. However, systematic comparisons of the performance of diverse scRNA-seq protocols are lacking. We generated data ...
• Not all H3K4 Methylations are created equal: Mll2/COMPASS dependency in primordial germ cell specification

  Hu, Deqing; Gao, Xin; Cao, Kaixiang; Morgan, Marc Alard J.; Mas Martín, Glòria; Smith, Edwin R.; Volk, Andrew G.; Bartom, Elizabeth T.; Crispino, John D.; Di Croce, Luciano; Shilatifard, Ali (Elsevier, 2017)

  The spatiotemporal regulation of gene expression is central for cell-lineage specification during embryonic development and is achieved through the combinatorial action of transcription factors/co-factors and epigenetic ...
• Drosophila dorsal closure: An orchestra of forces to zip shut the embryo

  Hayes, Peran; Solon, Jérôme (Elsevier, 2017)

  Dorsal closure, a late-embryogenesis process, consists in the sealing of an epidermal gap on the dorsal side of the Drosophila embryo. Because of its similarities with wound healing and neural tube closure in humans, it ...
• The tilt-dependent potential of mean force of a pair of DNA oligomers from all-atom molecular dynamics simulations

  Cortini, Ruggero; Cheng, Xiaolin; Smith, Jeremy C. (IOP Publishing, 2017)

  Electrostatic interactions between DNA molecules have been extensively studied experimentally and theoretically, but several aspects (e.g. its role in determining the pitch of the cholesteric DNA phase) still remain unclear. ...
• Shared oncogenic pathways implicated in both virus-positive and UV-induced merkel cell carcinomas

  González Vela, María Del Carmen; Derdak, Sophia; Beltran, Sergi; Gut, Marta; Gut, Ivo Glynne; Vaqué, José Pedro (Elsevier, 2017)

  Merkel cell carcinoma (MCC) is a highly malignant neuroendocrine tumor of the skin whose molecular pathogenesis is not completely understood, despite the role that Merkel cell polyomavirus can play in 55-90% of cases. To ...
• The Ol1mpiad: concordance of behavioural faculties of stage 1 and stage 3 Drosophila larvae

  Almeida Carvalho, Maria J.; Braun, Andreas, 1983-; Louis, Matthieu; Zlatic, Marta (Company of Biologists, 2017)

  Mapping brain function to brain structure is a fundamental task for neuroscience. For such an endeavour, the Drosophila larva is simple enough to be tractable, yet complex enough to be interesting. It features about 10,000 ...
• Socioeconomic and ethnic inequalities in exposure to air and noise pollution in London

  Tonne, Cathryn; Milà, Carles; Fecht, Daniela; Alvarez, Mar; Gulliver, John; Smith, James; Beevers, Sean; Anderson, Hugh Ross; Kelly, Frank (Elsevier, 2018)

  BACKGROUND: Transport-related air and noise pollution, exposures linked to adverse health outcomes, varies within cities potentially resulting in exposure inequalities. Relatively little is known regarding inequalities in ...
• Development of a source-exposure matrix for occupational exposure assessment of electromagnetic fields in the INTEROCC study

  Vila Rodríguez, Javier, 1974-; Bowman, Joseph D.; Figuerola, Jordi; Moriña, David; Kincl, Laurel; Richardson, Lesley; Cardis, Elisabeth (Nature Publishing Group, 2017)

  To estimate occupational exposures to electromagnetic fields (EMF) for the INTEROCC study, a database of source-based measurements extracted from published and unpublished literature resources had been previously constructed. ...
• Gene expression changes in blood RNA after swimming in a chlorinated pool

  Salas, Lucas A.; Font Ribera, Laia; Bustamante Pineda, Mariona; Sumoy, Lauro; Grimalt Obrador, Joan; Bonnin, Sarah; Aguilar Morón, María A.; Mattlin, Heidi; Hummel, Manuela; Ferrer Del Alamo, Ana; Kogevinas, Manolis; Villanueva Belmonte, Cristina (Elsevier, 2017)

  Exposure to disinfection by-products (DBP) such as trihalomethanes (THM) in swimming pools has been linked to adverse health effects in humans, but their biological mechanisms are unclear. We evaluated short-term changes ...
• Prenatal and postnatal exposure to NO2 and child attentional function at 4-5 years of age

  Sentís, Alexis; Sunyer Deu, Jordi; Dalmau Bueno, Albert; Andiarena, Ainara; Ballester Díez, Ferran; Cirach, Marta; Estarlich, Marisa; Fernández-Somoano, Ana; Ibarluzea, Jesús; Íñiguez, Carmen; Lertxundi, Aitana; Tardón, Adonina; Nieuwenhuijsen, Mark J.; Vrijheid, Martine; Guxens Junyent, Mònica (Elsevier, 2017)

  BACKGROUND: Prenatal and postnatal exposure to air pollution has been linked to cognitive impairment in children, but very few studies have assessed its association with attentional function. OBJECTIVES: To evaluate the ...
• Clustering of Drosophila housekeeping promoters facilitates their expression

  Corrales Berjano, Marc, 1984-; Rosado, Aránzazu; Cortini, Ruggero; van Arensbergen, Joris; van Steensel, Bas; Filion, Guillaume (Cold Spring Harbor Laboratory Press (CSHL Press), 2017)

  Housekeeping genes of animal genomes cluster in the same chromosomal regions. It has long been suggested that this organization contributes to their steady expression across all the tissues of the organism. Here, we show ...
• Peptide selection for targeted protein quantitation

  Chiva, Cristina; Sabido Aguade, Eduard (American Chemical Society (ACS), 2017)

  Targeted proteomics methods in their different flavors rely on the use of a few peptides as proxies for protein quantitation, which need to be specified either prior to or after data acquisition. However, in contrast with ...
• What is targeted proteomics? A concise revision of targeted acquisition and targeted data analysis in mass spectrometry

  Borràs, Eva; Sabido Aguade, Eduard (Wiley, 2017)

  Targeted proteomics has gained significant popularity in mass spectrometry-based protein quantification as a method to detect proteins of interest with high sensitivity, quantitative accuracy and reproducibility. However, ...
• Transcription factors orchestrate dynamic interplay between genome topology and gene regulation during cell reprogramming

  Stadhouders, Ralph; Vidal Ocabo, Enrique; Serra, François; Di Stefano, Bruno, 1984-; Le Dily, François; Quilez Oliete, Javier; Gómez, Antonio; Collombet, Samuel; Berenguer, Clara; Cuartero, Yasmina; Hecht, Jochen; Filion, Guillaume; Beato, Miguel; Martí Renom, Marc A.; Graf, T. (Thomas) (Nature Publishing Group, 2018)

  Chromosomal architecture is known to influence gene expression, yet its role in controlling cell fate remains poorly understood. Reprogramming of somatic cells into pluripotent stem cells (PSCs) by the transcription factors ...
• In vivo binding of PRDM9 reveals interactions with noncanonical genomic sites

  Grey, Corinne; Clément, Julie A.J.; Buard, Jerome; Leblanc, Benjamin; Gut, Ivo Glynne; Gut, Marta; Duret, Laurent; de Massy, Bernard D. (BioMed Central, 2017)

  In mouse and human meiosis, DNA double-strand breaks (DSBs) initiate homologous recombination and occur at specific sites called hotspots. The localization of these sites is determined by the sequence-specific DNA binding ...
• Role of DOR in neuronal plasticity changes promoted by food-seeking behaviour

  Mancino, Samantha, 1987-; Mendonça Netto, Sueli; Martín García, Elena, 1975-; Maldonado, Rafael, 1961- (Wiley, 2017)

  Several lines of evidence support that food overconsumption may be related to the role of the endogenous opioid system in the control of food palatability. The opioid system, and particularly the delta opioid receptor ...
• Extinction and reinstatement of an operant responding maintained by food in different models of obesity

  Burokas, Aurelijus, 1982-; Martín García, Elena, 1975-; Espinosa-Carrasco, José; Erb, Ionas; McDonald, Jerome; Notredame, Cedric; Dierssen, Mara; Maldonado, Rafael, 1961- (Wiley-Blackwell, 2018)

  A major problem in treating obesity is the high rate of relapse to abnormal food-taking habits after maintaining an energy balanced diet. Alterations of eating behavior such as compulsive-like behavior and lack of self-control ...
• Muscle regeneration potential and satellite cell activation profile during recovery following hindlimb immobilization in mice

  Guitart, Maria; Lloreta, Josep, 1958-; Mañas-García, Laura; Barreiro Portela, Esther (Wiley, 2018)

  Reduced muscle activity leads to muscle atrophy and function loss in patients and animal models. Satellite cells (SCs) are postnatal muscle stem cells that play a pivotal role in skeletal muscle regeneration following ...

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