• Oil extraction in the Amazon basin and exposure to metals in indigenous populations

  O'Callaghan Gordo, Cristina; Flores, Juan A.; Lizárraga, Pilar; Okamoto, Tami; Papoulias, Diana M.; Barclay, Federica; Orta-Martínez, Martí; Kogevinas, Manolis; Astete, John (Elsevier, 2018)

  Most oil extraction areas in the Peruvian Amazon are within indigenous territories. Poor environmental practices have exposed the indigenous population to metals. We conducted a survey in two indigenous Kukama communities ...
• Health impact assessment of cycling network expansions in European cities

  Mueller, Natalie, 1988-; Rojas Rueda, David, 1979-; Salmon, Maëlle; Martínez, David; Ambros, Albert; Brand, Christian; De Nazelle, Audrey; Dons, Evi; Gaupp-Berghausen, Mailin; Gerike, Regine; Götschi, Thomas; Iacorossi, Francesco; Int Panis, Luc; Kahlmeier, Sonja; Raser, Elisabeth; Nieuwenhuijsen, Mark J.; PASTA consortium (Elsevier, 2018)

  We conducted a health impact assessment (HIA) of cycling network expansions in seven European cities. We modeled the association between cycling network length and cycling mode share and estimated health impacts of the ...
• Thyroid function in early pregnancy, child IQ, and autistic traits: a meta-analysis of individual participant data

  Levie, Deborah; Korevaar, Tim I. M.; Bath, Sarah C.; Dalmau Bueno, Albert; Murcia, Mario; Espada, Mercedes; Dineva, Mariana; Ibarluzea, Jesús; Sunyer Deu, Jordi; Tiemeier, Henning; Rebagliato, Marisa; Rayman, Margaret P.; Peeters, Robin P.; Guxens Junyent, Mònica (Endocrine Society, 2018)

  Context: Low maternal free T4 (FT4) has been associated with poor child neurodevelopment in some single-center studies. Evidence remains scarce for the potential adverse effects of high FT4 and whether associations differ ...
• Metabolomics predicts the pharmacological profile of new psychoactive substances

  Olesti Muñoz, Eulàlia, 1991-; De Toma, Ilario; Ramaekers, Johannes G.; Brunt, Tibor M.; Carbó Banús, Marcel·lí; Fernández-Avilés, Cristina; Robledo, Patricia, 1958-; Farré Albaladejo, Magí; Dierssen, Mara; Pozo Mendoza, Óscar J.; Torre Fornell, Rafael de la (SAGE Publications, 2019)

  BACKGROUND: The unprecedented proliferation of new psychoactive substances (NPS) threatens public health and challenges drug policy. Information on NPS pharmacology and toxicity is, in most cases, unavailable or very limited ...
• Air pollution exposure during fetal life, brain morphology, and cognitive function in school-age children

  Guxens Junyent, Mònica; Lubczynska, Malgorzata Joanna; Muetzel, Ryan L.; Dalmau Bueno, Albert; Jaddoe, Vincent W. V.; Hoek, Gerard; van der Lugt, Aad; Verhulst, Frank C.; White, Tonya; Brunekreef, Bert; Tiemeier, Henning; El Marroun, Hanan (Society of Biological Psychiatry, 2018)

  Background: Air pollution exposure during fetal life has been related to impaired child neurodevelopment, but it is unclear if brain structural alterations underlie this association. The authors assessed whether air pollution ...
• Genetic and epigenetic regulation of YKL-40 in childhood

  Guerra, Stefano; Sunyer Deu, Jordi; Lavi, Iris; Benet, Marta; Bustamante Pineda, Mariona; Carsin, Anne-Elie; Dobaño, Carlota; Guxens Junyent, Mònica; Tischer, Christina; Vrijheid, Martine; Antó i Boqué, Josep Maria; Koppelman, Gerard H. (Elsevier, 2018)

  Background: Circulating levels of the chitinase-like protein YKL-40 are influenced by genetic variation in its encoding gene (chitinase 3–like 1 [CHI3L1]) and are increased in patients with several diseases, including ...
• The dyspnoea-inactivity vicious circle in COPD: development and external validation of a conceptual model

  Ramon, Maria Antonia; Ter Riet, Gerben; Carsin, Anne-Elie; Gimeno Santos, Elena, 1980-; Agustí, Alvar; Antó i Boqué, Josep Maria; Donaire González, David; Ferrer, Jaume; Rodríguez, Esther; Rodríguez Roisin, Robert; Puhan, Milo A.; García Aymerich, Judith (European Respiratory Society, 2018)

  The vicious circle of dyspnoea-inactivity has been proposed, but never validated empirically, to explain the clinical course of chronic obstructive pulmonary disease (COPD). We aimed to develop and validate externally a ...
• Epigenome-wide meta-analysis of DNA methylation and childhood asthma

  Reese, Sarah E.; Ruiz Arenas, Carlos, 1990-; Antó i Boqué, Josep Maria; London, Stephanie J. (Elsevier, 2019)

  Epigenetic mechanisms, including methylation, can contribute to childhood asthma. Identifying DNA methylation profiles in asthmatic patients can inform disease pathogenesis. OBJECTIVE: We sought to identify differential ...
• Análisis de los problemas relacionados con los medicamentos en un hospital de tercer nivel de Barcelona

  Ferránzez Quirante, Olivia; Casañ, Borja; Grau Cerrato, Santiago; Louro, Javier; Salas Sanchez, Esther; Castells, Xavier; Sala Serra, Maria (Elsevier, 2019)

  OBJECTIVE: To describe drug-related problems identified in hospitalized patients and to assess physicians' acceptance rate of pharmacists' recommendations. METHODS: Retrospective observational study that included all ...
• A comprehensive proteomics-based interaction screen that links DYRK1A to RNF169 and to the DNA damage response

  Roewenstrunk, Julia Maria, 1981-; Di Vona, Chiara, 1981-; Chen, Jie; Borràs, Eva; Dong, Chao; Arató, Krisztina, 1981-; Sabidó Aguadé, Eduard, 1981-; Huen, Michael S. Y.; Luna Gargantilla, Susana de la (Nature Research, 2019)

  Dysregulation of the DYRK1A protein kinase has been associated with human disease. On the one hand, its overexpression in trisomy 21 has been linked to certain pathological traits of Down syndrome, while on the other, ...
• Labelled regulatory elements are pervasive features of the macrophage genome and are dynamically utilized by classical and alternative polarization signals

  Horvath, Attila; Daniel, Bence; Szeles, Lajos; Cuaranta-Monroy, Ixchelt; Czimmerer, Zsolt; Ozgyin, Lilla; Steiner, Laszlo; Kiss, Mate; Simandi, Zoltan; Poliska, Szilard; Giannakis, Nikolas; Raineri, Emanuele; Gut, Ivo Glynne; Nagy, Benedek; Nagy, Laszlo (Oxford University Press, 2019)

  The concept of tissue-specific gene expression posits that lineage-determining transcription factors (LDTFs) determine the open chromatin profile of a cell via collaborative binding, providing molecular beacons to ...
• Binless normalization of Hi-C data provides significant interaction and difference detection independent of resolution

  Spill, Yannick G.; Castillo Andreo, David; Vidal, Enrique; Marti-Renom, Marc A. (Nature Research, 2019)

  Chromosome conformation capture techniques, such as Hi-C, are fundamental in characterizing genome organization. These methods have revealed several genomic features, such as chromatin loops, whose disruption can have ...
• The fitness cost and benefit of phase-separated protein deposits

  Sanchez de Groot, Natalia; Torrent, Marc; Ravarani, Charles N.J.; Trusina, Ala; Ventura, Salvador; Babu, M. Madan (Wiley-VCH Verlag, 2019)

  Phase separation of soluble proteins into insoluble deposits is associated with numerous diseases. However, protein deposits can also function as membrane-less compartments for many cellular processes. What are the fitness ...
• RNA as a key factor in driving or preventing self-assembly of the TAR DNA-binding protein 43

  Zacco, Elsa; Graña-Montes, Ricardo; Martin, Stephen R.; Sanchez de Groot, Natalia; Alfano, Caterina; Tartaglia, Gian Gaetano; Pastore, Annalisa (Elsevier, 2019)

  Amyotrophic lateral sclerosis and frontotemporal lobar degeneration are incurable motor neuron diseases associated with muscle weakness, paralysis and respiratory failure. Accumulation of TAR DNA-binding protein 43 (TDP-43) ...
• Both moderate and severe exacerbations accelerate physical activity decline in COPD patients

  Demeyer, Heleen; Costilla-Frias, Marcos; Louvaris, Zafeiris; Gimeno Santos, Elena, 1980-; Tabberer, Maggie; Rabinovich, Roberto A.; de Jong, Corina; Polkey, Michael I.; Hopkinson, Nicholas S.; Karlsson, Niklas; Serra, Ignasi; Vogiatzis, Ioannis; Troosters, Thierry; García Aymerich, Judith; PROactive consortium (European Respiratory Society, 2018)
• Use of green spaces and blood glucose in children; a population-based CASPIAN-V study

  Dadvand, Payam; Poursafa, Parinaz; Heshmat, Ramin; Motlagh, Mohammad Esmaeil; Qorbani, Mostafa; Basagaña Flores, Xavier; Kelishadi, Roya (Elsevier, 2018)

  A limited but emerging body of evidence is suggestive for a beneficial association between contact with green spaces and glucose homeostasis in adults; however, such an evidence for children is scarce. We evaluated the ...
• The effects of transport mode use on self-perceived health, mental health, and social contact measures: A cross-sectional and longitudinal study

  Avila-Palencia, Ione, 1985-; Int Panis, Luc; Dons, Evi; Gaupp-Berghausen, Mailin; Raser, Elisabeth; Götschi, Thomas; Gerike, Regine; Brand, Christian; De Nazelle, Audrey; Orjuela, Juan Pablo; Anaya, Esther; Stigell, Erik; Kahlmeier, Sonja; Iacorossi, Francesco; Nieuwenhuijsen, Mark J. (Elsevier, 2018)

  Background: Transport mode choice has been associated with different health risks and benefits depending on which transport mode is used. We aimed to evaluate the association between different transport modes use and several ...
• BKV clearance time correlates with exhaustion state and T-cell receptor repertoire shape of BKV-specific T-cells in renal transplant patients

  Stervbo, Ulrik; Nienen, Mikalai; Weist, Benjamin J. D.; Kuchenbecker, Leon; Hecht, Jochen; Wehler, Patrizia; Westhoff, Timm H.; Reinke, Petra; Babel, Nina (Frontiers Media, 2019)

  Reactivation of the BK polyomavirus is known to lead to severe complications in kidney transplant patients. The current treatment strategy relies on decreasing the immunosuppression to allow the immune system to clear the ...
• Whole-genome sequencing of the opportunistic yeast pathogen candida inconspicua uncovers its hybrid origin

  Mixão, Verónica; Perez Hansen, Antonio; Saus Martínez, Ester; Boekhout, Teun; Lass-Florl, Cornelia; Gabaldón Estevan, Juan Antonio, 1973- (Frontiers Media, 2019)

  Fungal infections such as those caused by Candida species are increasingly common complications in immunocompromised patients. The list of causative agents of candidiasis is growing and comprises a set of emerging species ...
• Transcriptomics-based screening identifies pharmacological inhibition of hsp90 as a means to defer aging

  Janssens, Georges E.; Lin, Xin-Xuan; Millán Ariño, Lluís, 1984-; Kavšek, Alan; Sen, Ilke; Seinstra, Renée I.; Stroustrup, Nicholas; Nollen, Ellen A. A.; Riedel, Christian G. (Elsevier, 2019)

  Aging strongly influences human morbidity and mortality. Thus, aging-preventive compounds could greatly improve our health and lifespan. Here we screened for such compounds, known as geroprotectors, employing the power of ...

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