• Restrictive spirometry pattern is associated with low physical activity levels. A population based international study

  Carsin, Anne-Elie; Fuertes, Elaine; Antó i Boqué, Josep Maria; Guerra, Stefano; García Aymerich, Judith (Elsevier, 2019)

  Introduction: Restrictive spirometry pattern is an under-recognised disorder with a poor morbidity and mortality prognosis. We compared physical activity levels between adults with a restrictive spirometry pattern and with ...
• Effects of virgin olive oils differing in their bioactive compound contents on biomarkers of oxidative stress and inflammation in healthy adults: a randomized double-blind controlled trial

  Sánchez-Rodriguez, Estefanía; Biel-Glesson, Sara; Fernández-Navarro, Jose-Ramón; Calleja, Miguel Angel; Espejo-Calvo, Juan A.; Gil-Extremera, Blas; Torre Fornell, Rafael de la; Fitó Colomer, Montserrat; Covas Planells, Maria Isabel; Vilchez, Pedro; Alche, Juan de Dios; Martínez de Victoria, Emilio; Gil, Angel; Mesa, Maria-Dolores (MDPI, 2019)

  A regular consumption of virgin olive oil (VOO) is associated with a reduced risk of cardiovascular disease. We aimed to assess whether the raw intake of an optimized VOO (OVOO, 490 ppm of phenolic compounds and 86 ppm of ...
• Isotopologue multipoint calibration for proteomics biomarker quantification in clinical practice

  Chiva, Cristina; Pastor, Olga; Trilla Fuertes, Lucía; Gámez Pozo, Angelo; Fresno Vara, Juan Ángel; Sabidó Aguadé, Eduard, 1981- (American Chemical Society (ACS), 2019)

  Targeted proteomics has become the method of choice for biomarker validation in human biopsies due to its high sensitivity, reproducibility, accuracy, and precision. However, for targeted proteomics to be transferred to ...
• Cell sensing and decision-making in confinement: The role of TRPM7 in a tug of war between hydraulic pressure and cross-sectional area

  Zhao, Runchen; Afthinos, Alexandros; Zhu, Tian; Mistriotis, Panagiotis; Li, Yizeng; Serra Pascual, Selma A., 1981-; Zhang, Yuqi; Yankaskas, Christopher L.; He, Shuyu; Valverde, M. A. (Miguel Ángel), 1963-; Sun, Sean X.; Konstantopoulos, Konstantinos (American Association for the Advancement of Science (AAAS), 2019)

  How cells sense hydraulic pressure and make directional choices in confinement remains elusive. Using trifurcating Ψ-like microchannels of different hydraulic resistances and cross-sectional areas, we discovered that the ...
• Prenatal particulate air pollution and DNA methylation in newborns: an epigenome-wide meta-analysis

  Gruzieva, Olena; Kogevinas, Manolis; Ruiz, José L.; Bustamante Pineda, Mariona; Antó i Boqué, Josep Maria; Sunyer Deu, Jordi; Vrijheid, Martine; Hernandez-Ferrer, Carles, 1987-; Melén, Erik (National Institute of Environmental Health Sciences (NIEHS), 2019)

  BACKGROUND: Prenatal exposure to air pollution has been associated with childhood respiratory disease and other adverse outcomes. Epigenetics is a suggested link between exposures and health outcomes. OBJECTIVES: We aimed ...
• Linking cell dynamics with gene coexpression networks to characterize key events in chronic virus infections

  Pedragosa Marín, Mireia, 1988-; Riera Domínguez, María Graciela, 1987-; Casella, Valentina; Esteve-Codina, Anna; Steuerman, Yael; Seth, Celina; Bocharov, Gennady A.; Heath, Simon; Gat-Viks, Irit; Argilaguet Marqués, Jordi, 1977-; Meyerhans, Andreas (Frontiers Media, 2019)

  The host immune response against infection requires the coordinated action of many diverse cell subsets that dynamically adapt to a pathogen threat. Due to the complexity of such a response, most immunological studies have ...
• The moonlighting RNA-binding activity of cytosolic serine hydroxymethyltransferase contributes to control compartmentalization of serine metabolism

  Guiducci, Giulia; Paone, Alessio; Tramonti, Angela; Giardina, Giorgio; Rinaldo, Serena; Bouzidi, Amani; Magnifico, Maria C.; Marani, Marina; Menendez, Javier A.; Fatica, Alessandro; Macone, Alberto; Armaos, Alexandros; Tartaglia, Gian Gaetano; Contestabile, Roberto; Paiardini, Alessandro; Cutruzzolà, Francesca (Oxford University Press, 2019)

  Enzymes of intermediary metabolism are often reported to have moonlighting functions as RNA-binding proteins and have regulatory roles beyond their primary activities. Human serine hydroxymethyltransferase (SHMT) is essential ...
• miR-155 harnesses Phf19 to potentiate cancer immunotherapy through epigenetic reprogramming of CD8+ T cell fate

  Ji, Yun; Di Croce, Luciano; Gattinoni, Luca (Nature Research, 2019)

  T cell senescence and exhaustion are major barriers to successful cancer immunotherapy. Here we show that miR-155 increases CD8+ T cell antitumor function by restraining T cell senescence and functional exhaustion through ...
• Unraveling the cellular origin and clinical prognostic markers of infant B-cell acute lymphoblastic leukemia using genome-wide analysis

  Agraz-Doblas, Antonio; Bueno, Clara; Bashford-Rogers, Rachael; Roy, Anindita; Schneider, Pauline; Bardini, Michela; Ballerini, Paola; Cazzaniga, Gianni; Moreno, Thaidy; Revilla, Carlos; Gut, Marta; Valsecchi, Maria G.; Roberts, Irene; Pieters, Rob; De Lorenzo, Paola; Varela, Ignacio; Menéndez, Pablo; Stam, Ronald W. (Ferrata Storti Foundation, 2019)

  B-cell acute lymphoblastic leukemia is the commonest childhood cancer. In infants, B-cell acute lymphoblastic leukemia remains fatal, especially in patients with t(4;11), present in ~80% of cases. The pathogenesis of ...
• In vivo force application reveals a fast tissue softening and external friction increase during early embryogenesis

  D'Angelo, Arturo; Dierkes, Kai; Carolis, Carlo; Salbreux, Guillaume; Solon, Jérôme (Elsevier, 2019)

  During development, cell-generated forces induce tissue-scale deformations to shape the organism [1,2]. The pattern and extent of these deformations depend not solely on the temporal and spatial profile of the generated ...
• A novel protein domain in an ancestral splicing factor drove the evolution of neural microexons

  Torres Méndez, Antonio; Bonnal, Sophie; Marquez, Yamile; Roth, Jonathan; Iglesias, Marta; Permanyer, Jon; Almudí, Isabel; O'Hanlon, Dave; Guitart, Tanit; Soller, Matthias; Gingras, Anne-Claude; Gebauer, Fátima; Rentzsch, Fabian; Blencowe, Benjamin J.; Valcárcel, J. (Juan); Irimia, Manuel (Nature Research, 2019)

  The mechanisms by which entire programmes of gene regulation emerged during evolution are poorly understood. Neuronal microexons represent the most conserved class of alternative splicing in vertebrates, and are critical ...
• GRASP55 and UPR control interleukin-1β aggregation and secretion

  Chiritoiu, Marioara; Brouwers, Nathalie; Turacchio, Gabriele; Pirozzi, Marianella; Malhotra, Vivek (Elsevier, 2019)

  Signal-sequence-lacking interleukin (IL)-1β, is cleaved by caspase-1 to mature mIL-1β, which is secreted, without entering the endoplasmic reticulum. We report that macrophages of GRASP55-/- mice are defective in mIL-1β ...
• Insights of the tubulin code in gametes and embryos: from basic research to potential clinical applications in humans

  Amargant i Riera, Farners, 1990-; Barragan, Montserrat; Vassena, Rita; Vernos, Isabelle, 1959- (Oxford University Press, 2019)

  Microtubules are intracellular filaments that define in space and in time a large number of essential cellular functions such as cell division, morphology and motility, intracellular transport and flagella and cilia assembly. ...
• Variability of urinary concentrations of non-persistent chemicals in pregnant women and school-aged children

  Casas Sanahuja, Maribel; Basagaña Flores, Xavier; Manzano Salgado, Cyntia Beatriz, 1987-; de Bont, Jeroen; Donaire González, David; Gonzalez, Juan Ramon; Gracia Lavedan, Esther; Pañella, Pau; Robinson, Oliver; Urquiza, José M.; Vrijheid, Martine (Elsevier, 2018)

  Background: Exposome studies are challenged by exposure misclassification for non-persistent chemicals, whose temporal variability contributes to bias in dose-response functions. Objectives: We evaluated the variability ...
• Urine metabolic signatures of multiple environmental pollutants in pregnant women: an exposome approach

  Maitre, Léa; Robinson, Oliver; Martínez, David; Toledano, Mireille B.; Ibarluzea, Jesús; Marina, Loreto Santa; Sunyer Deu, Jordi; Villanueva, Cristina M.; Keun, Hector C.; Vrijheid, Martine; Coen, Muireann (American Chemical Society (ACS), 2018)

  Exposure to environmental pollutants, particularly during pregnancy, can have adverse consequences on child development but little is known about the effects of pollutant mixtures on endogenous metabolism in pregnant women. ...
• Long-term exposure to residential green and blue spaces and anxiety and depression in adults: A cross-sectional study

  Gascon Merlos, Mireia, 1984-; Sánchez Benavides, Gonzalo; Dadvand, Payam; Martínez, David; Gramunt Fombuena, Nina; Gotsens, Xavier; Cirach, Marta; Vert, Cristina; Molinuevo, José Luis; Crous-Bou, Marta; Nieuwenhuijsen, Mark J. (Elsevier, 2018)

  Background: Although exposure to natural outdoor environments has been consistently associated with improved perceived general health, available evidence on a protective association between this exposure and specific mental ...
• The effect of early growth patterns and lung function on the development of childhood asthma: a population based study

  Casas Sanahuja, Maribel; den Dekker, Herman T.; Kruithof, Claudia J.; Reiss, Irwin K.; Vrijheid, Martine; Sunyer Deu, Jordi; de Jongste, Johan; Jaddoe, Vincent W. V.; Duijts, Liesbeth (BMJ Publishing Group, 2018)

  Background: Infant weight gain is associated with lower lung function and a higher risk of childhood asthma. Detailed individual childhood growth patterns might be better predictors of childhood respiratory morbidity than ...
• Long-term exposure to trihalomethanes in drinking water and breast cancer in the Spanish multicase-control study on cancer (MCC-SPAIN)

  Font Ribera, Laia; Gràcia Lavedan, Esther; Castaño Vinyals, Gemma; Kogevinas, Manolis; Villanueva, Cristina M. (Elsevier, 2018)

  Background: Exposure to trihalomethanes (THMs) in drinking water has consistently been associated with an increased risk of bladder cancer, but evidence on other cancers including the breast is very limited. Objectives: ...
• When, where, and what? characterizing personal PM2.5 exposure in periurban India by integrating GPS, wearable camera, and ambient and personal monitoring data

  Milà, Carles; Salmon, Maëlle; Sanchez, Margaux; Ambros, Albert; Bhogadi, Santhi; Sreekanth, V.; Nieuwenhuijsen, Mark J.; Kinra, Sanjay; Marshall, Julian D.; Tonne, Cathryn (American Chemical Society (ACS), 2018)

  Evidence identifying factors that influence personal exposure to air pollutants in low- and middle-income countries is scarce. Our objective was to identify the relative contribution of the time of the day ( when?), location ...
• Drinking water disinfection by-products during pregnancy and child neuropsychological development in the INMA Spanish cohort study

  Villanueva, Cristina M.; Gracia Lavedan, Esther; Julvez, Jordi; Santa Marina, Loreto; Lertxundi, Nerea; Ibarluzea, Jesús; Llop, Sabrina; Ballester Díez, Ferran; Fernández Somoano, Ana; Tardón, Adonina; Vrijheid, Martine; Guxens Junyent, Mònica; Sunyer Deu, Jordi (Elsevier, 2018)

  Background: Disinfection by-products (DBPs) constitute a complex mixture of prevalent chemicals in drinking water and there is evidence of neurotoxicity for some of them. Objectives: We evaluated the association between ...

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