• Labyrinthopeptins exert broad-spectrum antiviral activity through lipid-binding-mediated virolysis

  Prochnow, Hans; Prado Martínez, Javier, 1987-; Meyerhans, Andreas; Brönstrup, Mark (American Society for Microbiology, 2019)

  To counteract the serious health threat posed by known and novel viral pathogens, drugs that target a variety of viruses through a common mechanism have attracted recent attention due to their potential in treating ...
• Functional analysis of human pathological semen samples in an oocyte cytoplasmic ex vivo system

  Amargant i Riera, Farners, 1990-; García, Désirée; Barragán, Montserrat; Vassena, Rita; Vernos, Isabelle, 1959- (Nature Research, 2018)

  Human fertilization and embryo development involve a wide range of critical processes that determine the successful development of a new organism. Although Assisted Reproduction Technologies (ART) may help solve infertility ...
• tarsal-less is expressed as a gap gene but has no gap gene phenotype in the moth midge Clogmia albipunctata

  Jiménez Guri, Eva; Wotton, Karl R.; Jaeger, Johannes, 1973- (Royal Society, 2018)

  Gap genes are involved in segment determination during early development of the vinegar fly Drosophila melanogaster and other dipteran insects (flies, midges and mosquitoes). They are expressed in overlapping domains along ...
• nextPARS: parallel probing of RNA structures in Illumina

  Saus Martínez, Ester; Willis, Jesse R.; Pryszcz, Leszek Piotr, 1985-; Hafez, Ahmed; Llorens, Carlos; Himmelbauer, Heinz; Gabaldón Estevan, Juan Antonio, 1973- (Cold Spring Harbor Laboratory Press (CSHL Press), 2018)

  RNA molecules play important roles in virtually every cellular process. These functions are often mediated through the adoption of specific structures that enable RNAs to interact with other molecules. Thus, determining ...
• Dicer-2 promotes mRNA activation through cytoplasmic polyadenylation

  Coll, Olga; Guitart, Tanit; Villalba, Ana; Papin, Catherine; Simonelig, Martine; Gebauer, Fátima (Cold Spring Harbor Laboratory Press (CSHL Press), 2018)

  Cytoplasmic polyadenylation is a widespread mechanism to regulate mRNA translation. In vertebrates, this process requires two sequence elements in target 3' UTRs: the U-rich cytoplasmic polyadenylation element and the ...
• Genetically encodable bioluminescent system from fungi

  Kotlobay, Alexey A.; Marcet Houben, Marina; Gabaldón Estevan, Juan Antonio, 1973-; Yampolsky, Ilia V. (National Academy of Sciences, 2018)

  Bioluminescence is found across the entire tree of life, conferring a spectacular set of visually oriented functions from attracting mates to scaring off predators. Half a dozen different luciferins, molecules that emit ...
• QCloud: A cloud-based quality control system for mass spectrometry-based proteomics laboratories

  Chiva, Cristina; Olivella, Roger; Borràs, Eva; Espadas, Guadalupe; Pastor, Olga; Solé, Amanda; Sabidó Aguadé, Eduard, 1981- (Public Library of Science (PLoS), 2018)

  The increasing number of biomedical and translational applications in mass spectrometry-based proteomics poses new analytical challenges and raises the need for automated quality control systems. Despite previous efforts ...
• RES complex is associated with intron definition and required for zebrafish early embryogenesis

  Fernández, Juan Pablo; Moreno Mateos, Miguel Ángel; Gohr, André; Miao, Liyun; Chan, Shun Hang; Irimia, Manuel; Giraldez, Antonio J. (Public Library of Science (PLoS), 2018)

  Pre-mRNA splicing is a critical step of gene expression in eukaryotes. Transcriptome-wide splicing patterns are complex and primarily regulated by a diverse set of recognition elements and associated RNA-binding proteins. ...
• The Integrator complex regulates differential snRNA processing and fate of adult stem cells in the highly regenerative planarian Schmidtea mediterranea

  Schmidt, David; Reuter, Hanna; Hüttner, Katja; Ruhe, Larissa; Rabert, Franziska; Seebeck, Florian; Irimia, Manuel; Solana, Jordi; Bartscherer, Kerstin (Public Library of Science (PLoS), 2018)

  In multicellular organisms, cell type diversity and fate depend on specific sets of transcript isoforms generated by post-transcriptional RNA processing. Here, we used Schmidtea mediterranea, a flatworm with extraordinary ...
• Walking along chromosomes with super-resolution imaging, contact maps, and integrative modeling

  Nir, Guy; Farabella, Irene; Soler-Vila, Paula; Martí Renom, Marc A.; Wu, C.-ting (Public Library of Science (PLoS), 2018)

  Chromosome organization is crucial for genome function. Here, we present a method for visualizing chromosomal DNA at super-resolution and then integrating Hi-C data to produce three-dimensional models of chromosome ...
• A new adaptation strategy to glucose starvation: modulation of the gluconate shunt and pentose phosphate pathway by the transcriptional repressor Rsv1

  Fraile Beneitez, Rodrigo; Sánchez Mir, Laura; Hidalgo Hernando, Elena (Wiley-VCH Verlag, 2019)

  Survival upon glucose starvation requires a delicate balance between different metabolic pathways. A recent work by the Roe laboratory provides a mechanistic link between glucose deprivation and the regulation of the pentose ...
• Hippo signaling controls cell cycle and restricts cell plasticity in planarians

  de Sousa, Nídia; Rodríguez Esteban, Gustavo; Rojo-Laguna, Jose Ignacio; Saló, Emili; Adell, Teresa (Public Library of Science (PLoS), 2018)

  The Hippo pathway plays a key role in regulating cell turnover in adult tissues, and abnormalities in this pathway are consistently associated with human cancers. Hippo was initially implicated in the control of cell ...
• Genome sequence of the brown rot fungal pathogen Monilinia laxa

  Naranjo Ortiz, Miguel Ángel, 1989-; Rodríguez-Píres, Silvia; Torres, Rosario; De Cal, Antonieta; Usall, Josep; Gabaldón Estevan, Juan Antonio, 1973- (American Society for Microbiology, 2018)

  Monilinia laxa (phylum Ascomycota) is a plant pathogen responsible for the brown rot blossom blight disease in stone fruit trees of the Rosaceae family, such as apricots. We report here the genome sequence of strain 8L of ...
• Characterization of iodine-related molecular processes in the marine microalga Tisochrysis lutea (Haptophyta)

  Hernández Javier, Laura; Benzekri, Hicham; Gut, Marta; Claros, M. Gonzalo; van Bergeijk, Stefanie; Cañavate, José Pedro; Manchado, Manuel (Frontiers, 2018)

  Iodine metabolism is essential for the antioxidant defense of marine algae and in the biogeochemical cycle of iodine. Moreover, some microalgae can synthetize thyroid hormone-like compounds that are essential to sustain ...
• Key features of turing systems are determined purely by network topology

  Diego, Xavier; Marcon, Luciano, 1983-; Müller, Patrick; Sharpe, James (American Physical Society, 2018)

  Turing’s theory of pattern formation is a universal model for self-organization, applicable to many systems in physics, chemistry, and biology. Essential properties of a Turing system, such as the conditions for the existence ...
• A damped oscillator imposes temporal order on posterior gap gene expression in Drosophila

  Verd Fernández, Berta, 1984-; Clark, Erik; Wotton, Karl R.; Janssens, Hilde; Jiménez Guri, Eva; Crombach, Anton; Jaeger, Johannes, 1973- (Public Library of Science (PLoS), 2018)

  Insects determine their body segments in two different ways. Short-germband insects, such as the flour beetle Tribolium castaneum, use a molecular clock to establish segments sequentially. In contrast, long-germband insects, ...
• HMC-reliefF: feature ranking for hierarchical multi-label classification

  Slavkov, Ivica; Karcheska, Jana; Kocev, Dragi; Džeroski, Sašo (ComSIS Consortium, 2018)

  In machine learning, the growing complexity of the available data poses an increased challenge for its analysis. The rising complexity is both in terms of the data becoming more high-dimensional as well as the data having ...
• Gender commonalities and differences in risk and protective factors of suicidal thoughts and behaviors: A cross-sectional study of Spanish university students

  Miranda-Mendizábal, Andrea; Torrent, Aina; Mortier, Philippe; Alonso Caballero, Jordi (Wiley, 2019)

  AIM: To assess gender differences in the association between risk/protective factors and suicidal thoughts and behaviors (STB); and whether there is any gender-interaction with those factors and STB; among Spanish university ...
• ResMarkerDB: a database of biomarkers of response to antibody therapy in breast and colorectal cancer

  Pérez-Granado, Judith; Piñero González, Janet, 1977-; Furlong, Laura I., 1971- (Oxford University Press, 2019)

  The clinical efficacy of therapeutic monoclonal antibodies for breast and colorectal cancer has greatly contributed to the improvement of patients' outcomes by individualizing their treatments according to their genomic ...
• Dose-response pharmacological study of mephedrone and its metabolites: pharmacokinetics, serotoninergic effects, and impact of CYP2D6 genetic variation

  Olesti Muñoz, Eulàlia; Farré Albaladejo, Magí; Carbó Banús, Marcel·lí; Papaseit Fontanet, Esther; Pérez Mañá, Clara; Torrens, Marta; Yubero Lahoz, Samanta, 1985-; Pujadas Bastardes, Mitona; Pozo Mendoza, Óscar J., 1975-; Torre Fornell, Rafael de la (Wiley, 2019)

  Mephedrone (MEPH), the most widely consumed synthetic cathinone, has been associated with acute toxicity episodes. The aim of this report was to study its metabolic disposition and the impact of genetic variation of CYP2D6 ...

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