• The mutational landscape of a prion-like domain

  Bolognesi, Benedetta; Faure, Andre J.; Seuma, Mireia; Schmiedel, Jörn M.; Tartaglia, Gian Gaetano; Lehner, Ben, 1978- (Nature Research, 2019)

  Insoluble protein aggregates are the hallmarks of many neurodegenerative diseases. For example, aggregates of TDP-43 occur in nearly all cases of amyotrophic lateral sclerosis (ALS). However, whether aggregates cause ...
• Engaging chromatin: PRC2 structure meets function

  Chammas, Paul, 1992-; Mocavini, Ivano; Di Croce, Luciano (Nature Research, 2020)

  Polycomb repressive complex 2 (PRC2) is a key epigenetic multiprotein complex involved in the regulation of gene expression in metazoans. PRC2 is formed by a tetrameric core that endows the complex with histone methyltransferase ...
• The bivalent genome: characterization, structure, and regulation

  Blanco, Enrique; González Ramírez, Mar; Alcaine Colet, Anna, 1992-; Aranda Aragón, Sergio; Di Croce, Luciano (Elsevier, 2020)

  An intricate molecular machinery is at the core of gene expression regulation in every cell. During the initial stages of organismal development, the coordinated activation of diverse transcriptional programs is crucial ...
• Spatially clustered loci with multiple enhancers are frequent targets of HIV-1 integration

  Lucic, Bojana; Chen, Heng-Chang; Kuzman, Maja; Zorita, Eduard; Wegner, Julia; Minneker, Vera; Wang, Wei; Fronza, Raffaele; Laufs, Stefanie; Schmidt, Manfred; Stadhouders, Ralph; Roukos, Vassilis; Vlahovicek, Kristian; Filion, Guillaume; Lusic, Marina (Nature Research, 2019)

  HIV-1 recurrently targets active genes and integrates in the proximity of the nuclear pore compartment in CD4+ T cells. However, the genomic features of these genes and the relevance of their transcriptional activity for ...
• Using single-cell transcriptomics to understand functional states and interactions in microbial eukaryotes

  Ku, Chuan; Sebé-Pedrós, Arnau (Royal Society, 2019)

  Understanding the diversity and evolution of eukaryotic microorganisms remains one of the major challenges of modern biology. In recent years, we have advanced in the discovery and phylogenetic placement of new eukaryotic ...
• Origin and evolution of eukaryotic transcription factors

  de Mendoza, Alex; Sebé-Pedrós, Arnau (Elsevier, 2019)

  Transcription factors (TFs) have a central role in genome regulation directing gene transcription through binding specific DNA sequences. Eukaryotic genomes encode a large diversity of TF classes, each defined by unique ...
• Resumen ejecutivo de ARIA 2019: Vías integradas de atención para la rinitis alérgica en Argentina, España y México

  Ivancevich, Juan Carlos; Antó i Boqué, Josep Maria; Bousquet, Jean (Colegio Mexicano de Inmunología Clínica y Alergia, A.C., 2019)

  El impacto sanitario y económico de las enfermedades alérgicas está aumentando rápidamente y se necesitan cambios en las estrategias para su manejo. Su influencia reduce al menos en un tercio la capacidad de desempeño ...
• Accurate detection of m6A RNA modifications in native RNA sequences

  Liu, Huanle; Begik, Oguzhan; Lucas, Morghan C.; Ramirez, Jose Miguel; Mason, Christopher E.; Wiener, David; Schwartz, Schraga; Mattick, John S.; Smith, Martin A.; Novoa, Eva Maria (Nature Research, 2019)

  The epitranscriptomics field has undergone an enormous expansion in the last few years; however, a major limitation is the lack of generic methods to map RNA modifications transcriptome-wide. Here, we show that using direct ...
• A tunable dual-input system for on-demand dynamic gene expression regulation

  Pedone, Elisa, 1985-; Postiglione, Lorena; Aulicino, Francesco, 1987-; Rocca, Dan L.; Montes Olivas, Sandra; Khazim, Mahmoud; di Bernardo, Diego; Cosma, Maria Pia, 1970-; Marucci, Lucia (Nature Research, 2019)

  Cellular systems have evolved numerous mechanisms to adapt to environmental stimuli, underpinned by dynamic patterns of gene expression. In addition to gene transcription regulation, modulation of protein levels, dynamics ...
• From single drug targets to synergistic network pharmacology in ischemic stroke

  Casas, Ana I.; Hassan, Ahmed; Larsen, Simon J.; Gomez-Rangel, Vanessa; Elbatreek, Mahmoud; Kleikers, Pamela W. M.; Guney, Emre; Egea, Javier; López, Manuela G.; Baumbach, Jan; Schmidt, Harald H.H.W. (National Academy of Sciences, 2019)

  Drug discovery faces an efficacy crisis to which ineffective mainly single-target and symptom-based rather than mechanistic approaches have contributed. We here explore a mechanism-based disease definition for network ...
• Advances and applications in the quest for orthologs

  Glover, Natasha; Dessimoz, Christophe; Ebersberger, Ingo; Forslund, Sofia K.; Gabaldón Estevan, Juan Antonio, 1973-; Huerta Cepas, Jaime; Martin, Maria-Jesus; Muffato, Matthieu; Patricio, Mateus; Pereira, Cecile; Sousa da Silva, Alan; Wang, Yan-Dong; Sonnhammer, Erik; Thomas, Paul D. (Oxford University Press, 2019)

  Gene families evolve by the processes of speciation (creating orthologs), gene duplication (paralogs), and horizontal gene transfer (xenologs), in addition to sequence divergence and gene loss. Orthologs in particular play ...
• Microbiome and colorectal cancer: Roles in carcinogenesis and clinical potential

  Saus Martínez, Ester; Iraola Guzman, Susana; Willis, Jesse R.; Brunet-Vega, Anna; Gabaldón Estevan, Juan Antonio, 1973- (Elsevier, 2019)

  The gastrointestinal tract harbors most of the microbiota associated with humans. In recent years, there has been a surge of interest in assessing the relationships between the gut microbiota and several gut alterations, ...
• Early smoking-onset age and risk of cardiovascular disease and mortality

  Fa-Binefa, Manel; Clarà Velasco, Alberto; Pérez-Fernández, Silvia; Grau Magaña, Maria; Dégano, Irene R.; Martí-Lluch, Ruth; Ramos, Rafel; Marrugat de la Iglesia, Jaume; Elosua Llanos, Roberto (Elsevier, 2019)

  Early smoking onset age (SOA) is a public health concern with scant empirical evidence of its role in health outcomes. The study had two aims: i) to assess whether an early SOA was associated with the risk of fatal and ...
• Microtubule nucleation during central spindle assembly requires NEDD1 phosphorylation on serine 405 by Aurora A

  Courthéoux, Thibault; Reboutier, David; Vazeille, Thibaut; Cremet, Jean-Yves; Benaud, Christelle; Vernos, Isabelle, 1959-; Prigent, Claude (Company of Biologists, 2019)

  During mitosis, the cell sequentially constructs two microtubule-based spindles to ensure faithful segregation of chromosomes. A bipolar spindle first pulls apart the sister chromatids, then a central spindle further ...
• Kinesin-8 and Dis1/TOG collaborate to limit spindle elongation from prophase to anaphase A for proper chromosome segregation in fission yeast

  Pinder, Corinne; Matsuo, Yuzy; Maurer, Sebastian; Toda, Takashi (Company of Biologists, 2019)

  High-fidelity chromosome segregation relies on proper microtubule regulation. Kinesin-8 has been shown to destabilise microtubules to reduce metaphase spindle length and chromosome movements in multiple species. XMAP215/chTOG ...
• Molecular rescue of Dyrk1A overexpression alterations in mice with Fontup® dietary supplement: role of green tea catechins

  Gu, Yuchen; Moroy, Gautier; Paul, Jean-Louis; Rebillat, Anne-Sophie; Dierssen, Mara; Torre Fornell, Rafael de la; Cieuta-Walti, Cécile; Dairou, Julien; Janel, Nathalie (MDPI, 2020)

  Epigallocatechin gallate (EGCG) is an inhibitor of DYRK1A, a serine/threonine kinase considered to be a major contributor of cognitive dysfunctions in Down syndrome (DS). Two clinical trials in adult patients with DS have ...
• Metagenomic analysis of a blood stain from the French revolutionary Jean-Paul Marat (1743-1793)

  de Dios, Toni; van Dorp, Lucy; Charlier, Philippe; Morfopoulou, Sofia; Lizano, Esther; Bon, Celine; Le Bitouzé, Corinne; Alvarez-Estape, Marina; Marquès i Bonet, Tomàs, 1975-; Balloux, François; Lalueza Fox, Carles, 1965- (Elsevier, 2020)

  The French revolutionary Jean-Paul Marat (1743-1793) was assassinated in 1793 in his bathtub, where he was trying to find relief from the debilitating skin disease he was suffering from. At the time of his death, Marat was ...
• Effect modification of FADS2 polymorphisms on the association between breastfeeding and intelligence: results from a collaborative meta-analysis

  Pires Hartwig, Fernando; Dalmau Bueno, Albert; Guxens Junyent, Mònica; Bustamante Pineda, Mariona; Gomes Victora, Cesar (Oxford University Press, 2019)

  Background: Accumulating evidence suggests that breastfeeding benefits children’s intelligence, possibly due to long-chain polyunsaturated fatty acids (LC-PUFAs) present in breast milk. Under a nutritional adequacy hypothesis, ...
• Gene fusions derived by transcriptional readthrough are driven by segmental duplication in human

  McCartney, Ann M.; Hyland, Edel M.; Cormican, Paul; Moran, Raymond J.; Webb, Andrew E.; Lee, Kate D.; Hernández Rodríguez, Jéssica, 1983-; Prado Martínez, Javier, 1987-; Creevey, Christopher J.; Aspden, Julie L.; McInerney, James O.; Marquès i Bonet, Tomàs, 1975-; O'Connell, Mary J. (Oxford University Press, 2019)

  Gene fusion occurs when two or more individual genes with independent open reading frames becoming juxtaposed under the same open reading frame creating a new fused gene. A small number of gene fusions described in detail ...
• ScoreInvHap: inversion genotyping for genome-wide association studies

  Ruiz-Arenas, Carlos; Cáceres, Alejandro; López Sánchez, Marcos, 1986-; Tolosana, Ignacio; Pérez Jurado, Luis Alberto; González Ruiz, Juan Ramón (Public Library of Science (PLoS), 2019)

  Polymorphic inversions contribute to adaptation and phenotypic variation. However, large multi-centric association studies of inversions remain challenging. We present scoreInvHap, a method to genotype inversions from SNP ...

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