• A combined transcriptomic and genomic analysis identifies a gene signature associated with the response to anti-TNF therapy in rheumatoid arthritis

  Aterido, Adrià; Cañete Crespillo, Juan de Dios; Tornero, Jesús; Blanco, Francisco; Fernández-Gutiérrez, Benjamín; Pérez-García, Carolina; Alperiz, Mercedes; Olivé, Alex; Corominas, Héctor; Martínez-Taboada, Víctor; González-Alvaro, Isidoro; Fernández-Nebro, Antonio; Erra, Alba; López Lasanta, María; López Corbeto, Mireia; Palau, Núria; Marsal, Sara; Julià, Antonio (Frontiers, 2019)

  Background: Rheumatoid arthritis (RA) is the most frequent autoimmune disease involving the joints. Although anti-TNF therapies have proven effective in the management of RA, approximately one third of patients do not show ...
• Personal exposure to radio-frequency electromagnetic fields in Europe: Is there a generation gap?

  Eeftens, Marloes; Struchen, Benjamin; Birks, Laura Ellen, 1983-; Cardis, Elisabeth; Estarlich, Marisa; Fernandez, Mariana F.; Gajšek, Peter; Gallastegi, Mara; Huss, Anke; Kheifets, Leeka; Meder, Inger Kristine; Olsen, Jørn; Torrent Quetglas, Maties; Trček, Tomaž; Valič, Blaž; Vermeulen, Roel; Vrijheid, Martine; van Wel, Luuk; Guxens Junyent, Mònica; Röösli, Martin (Elsevier, 2018)

  Background: Exposure to radiofrequency electromagnetic fields (RF-EMF) from mobile communication technologies is changing rapidly. To characterize sources and associated variability, we studied the differences and correlations ...
• In-utero and childhood chemical exposome in six European mother-child cohorts

  Haug, Line Småstuen; Casas Sanahuja, Maribel; Maitre, Léa; Basagaña Flores, Xavier; de Bont, Jeroen; González, Juan Ramón; Sunyer Deu, Jordi; Urquiza, José M.; Vrijheid, Martine; Thomsen, Cathrine (Elsevier, 2018)

  Background: Harmonized data describing simultaneous exposure to a large number of environmental contaminants in-utero and during childhood is currently very limited. Objectives: To characterize concentrations of a large ...
• Active commuting through natural environments is associated with better mental health: Results from the PHENOTYPE project

  Zijlema, Wilma; Avila Palencia, Ione; Triguero Mas, Margarita, 1985-; Gidlow, Christopher J.; Maas, Jolanda; Kruize, Hanneke; Andrušaitytė, Sandra; Grazuleviciene, Regina; Nieuwenhuijsen, Mark J. (Elsevier, 2018)

  Background: Commuting routes with natural features could promote walking or cycling for commuting. Commuting through natural environments (NE) could have mental health benefits as exposure to NE can reduce stress and improve ...
• Do physical activity, social cohesion, and loneliness mediate the association between time spent visiting green space and mental health?

  Berg, Magdalena van den; van Poppel, Mireille; van Kamp, Irene; Ruijsbroek, Annemarie; Triguero Mas, Margarita, 1985-; Gidlow, Christopher J.; Nieuwenhuijsen, Mark J.; Gražulevičiene, Regina; van Mechelen, Willem; Kruize, Hanneke; Maas, Jolanda (SAGE Publications, 2019)

  This cross-sectional study investigated whether physical activity, social cohesion, and loneliness mediate the association between time spent visiting green spaces and perceived mental health and vitality. Questionnaire ...
• COPD: preclinical models and emerging therapeutic targets

  Barreiro Portela, Esther; Wang, Xuejie; Tang, Jun (Informa Healthcare, 2019)

  Introduction: Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. Preclinical models of COPD have recently been developed. In those models, COPD/emphysema has been commonly ...
• Dog ownership, the natural outdoor environment and health: a cross-sectional study

  Zijlema, Wilma; Christian, Hayley; Triguero Mas, Margarita, 1985-; Cirach, Marta; Berg, Magdalena van den; Maas, Jolanda; Gidlow, Christopher J.; Kruize, Hanneke; Wendel-Vos, Wanda; Andrušaitytė, Sandra; Grazuleviciene, Regina; Litt, Jill; Nieuwenhuijsen, Mark J. (BMJ Publishing Group, 2019)

  Objectives: Dog owners walking their dog in natural outdoor environments (NOE) may benefit from the physical activity facilitated by dog walking and from time spent in nature. However, it is unclear whether dog owners ...
• Gestational weight gain charts for different body mass index groups for women in Europe, North America, and Oceania

  Santos, Susana; Vrijheid, Martine; Jaddoe, Vincent W. V. (BioMed Central, 2018)

  Background: Gestational weight gain differs according to pre-pregnancy body mass index and is related to the risks of adverse maternal and child health outcomes. Gestational weight gain charts for women in different ...
• Determinants of the urinary and serum metabolome in children from six European populations

  Lau, Chung-Ho E.; Maitre, Léa; Urquiza, José M.; Casas, Maribel; Vrijheid, Martine; Coen, Muireann (BioMed Central, 2018)

  Background: Environment and diet in early life can affect development and health throughout the life course. Metabolic phenotyping of urine and serum represents a complementary systems-wide approach to elucidate ...
• Childhood body composition trajectories and adolescent lung function. Findings from the ALSPAC study

  Peralta, Gabriela P.; Fuertes, Elaine; Granell, Raquel; Mahmoud, Osama; Roda, Célina; Serra Pons, Ignasi; Jarvis, Deborah; Henderson, John; García Aymerich, Judith (American Thoracic Society, 2019)

  Rationale: Body composition changes throughout life may explain the inconsistent associations reported between body mass index and lung function in children. Objectives: To assess the associations of body weight and ...
• Multifaceted intervention for the prevention and management of musculoskeletal pain in nursing staff: results of a cluster randomized controlled trial

  Soler-Font, Mercè; Ramada Rodilla, José María, 1961-; van Zon, Sander K.R.; Almansa, Josué; Bültmann, Ute; Serra, Consol (Public Library of Science (PLoS), 2019)

  Background: Nurses and nursing aides are at high risk of developing musculoskeletal pain (MSP). This study aimed to evaluate a multifaceted intervention to prevent and manage MSP in two hospitals. Material and methods: We ...
• The transcription factor NFAT5 limits infection-induced type I interferon responses

  Huerga Encabo, Hector, 1989-; Traveset, Laia; Argilaguet Marqués, Jordi, 1977-; Angulo, Ana; Nistal-Villán, Estanislao; Jaiswal, Rahul; Escalante, Carlos R.; Gekas, Christos; Meyerhans, Andreas; Aramburu, José (Aramburu Beltrán); López Rodríguez, M. Cristina (Rockefeller University Press, 2020)

  Type I interferon (IFN-I) provides effective antiviral immunity but can exacerbate harmful inflammatory reactions and cause hematopoietic stem cell (HSC) exhaustion; therefore, IFN-I expression must be tightly controlled. ...
• Adherence to reporting guidelines increases the number of citations: the argument for including a methodologist in the editorial process and peer-review

  Vilaró, Marta; Cortés, Jordi; Selva-O'Callaghan, Albert; Urrutia, Agustín; Ribera, Josep Maria; Cardellach, Francesc; Basagaña Flores, Xavier; Elmore, Matthew; Vilardell, Miquel; Altman, Douglas; González, José-Antonio; Cobo Valeri, Erik (BioMed Central, 2019)

  Background: From 2005 to 2010, we conducted 2 randomized studies on a journal (Medicina Clínica), where we took manuscripts received for publication and randomly assigned them to either the standard editorial process or ...
• Environmental health surveillance in a future European health information system

  Joas, Anke; Schöpel, Miriam; David, Madlen; Casas, Maribel; Koppen, Gudrun; Esteban, Marta; Knudsen, Lisbeth E.; Vrijheid, Martine; Schoeters, Greet; Castaño Calvo, Argelia; Schwedler, Gerda; Kolossa-Gehring, Marike; Joas, Reinhard (BioMed Central, 2019)

  Background: To date Health information (HI) in the European Union does not comprise indicators or other information related to impacts of hazardous chemicals in consumer products, food, drinking water or air on the health ...
• Associations of maternal cell-phone use during pregnancy with pregnancy duration and fetal growth in 4 birth cohorts

  Tsarna, Ermioni; Reedijk, Marije; Birks, Laura Ellen, 1983-; Guxens Junyent, Mònica; Ballester Díez, Ferran; Ha, Mina; Jiménez-Zabala, Ana; Kheifets, Leeka; Lertxundi, Aitana; Lim, Hyung-Ryul; Olsen, Jørn; González-Safont, Llúcia; Sudan, Madhuri; Cardis, Elisabeth; Vrijheid, Martine; Vrijkotte, Tanja; Huss, Anke; Vermeulen, Roel (Oxford University Press, 2019)

  Results from studies evaluating potential effects of prenatal exposure to radio-frequency electromagnetic fields from cell phones on birth outcomes have been inconsistent. Using data on 55,507 pregnant women and their ...
• ERS statement on respiratory muscle testing at rest and during exercise

  Laveneziana, Pierantonio; Barreiro Portela, Esther; Gea Guiral, Joaquim; Verges, Samuel (European Respiratory Society, 2019)

  Assessing respiratory mechanics and muscle function is critical for both clinical practice and research purposes. Several methodological developments over the past two decades have enhanced our understanding of respiratory ...
• The impact of genetic adaptation on chimpanzee subspecies differentiation

  Schmidt, Joshua M.; de Manuel, Marc; Marquès i Bonet, Tomàs, 1975-; Castellano Hereza, Sergi; Andrés Morán, Aida, 1976- (Public Library of Science (PLoS), 2019)

  Chimpanzees, humans' closest relatives, are in danger of extinction. Aside from direct human impacts such as hunting and habitat destruction, a key threat is transmissible disease. As humans continue to encroach upon their ...
• Re-annotation of 191 developmental and epileptic encephalopathy-associated genes unmasks de novo variants in SCN1A

  Steward, Charles A.; Uszczynska-Ratajczak, Barbara; Guigó Serra, Roderic; Frankish, Adam (Nature Research, 2019)

  The developmental and epileptic encephalopathies (DEE) are a group of rare, severe neurodevelopmental disorders, where even the most thorough sequencing studies leave 60-65% of patients without a molecular diagnosis. Here, ...
• Coupling the antimalarial cell penetrating peptide TP10 to classical antimalarial drugs primaquine and chloroquine produces strongly hemolytic conjugates

  Aguiar, Luísa; Biosca, Arnau; Lantero, Elena; Gut, Jiri; Vale, Nuno; Rosenthal, Philip J.; Nogueira, Fátima; Andreu Martínez, David; Fernàndez Busquets, Xavier; Gomes, Paula (MDPI, 2019)

  Recently, we disclosed primaquine cell penetrating peptide conjugates that were more potent than parent primaquine against liver stage Plasmodium parasites and non-toxic to hepatocytes. The same strategy was now applied ...
• Genetic instability as a driver for immune surveillance

  Aguadé-Gorgorió, Guim; Solé Vicente, Ricard, 1962- (BioMed Central, 2019)

  Background: Genetic instability is known to relate with carcinogenesis by providing tumors with a mechanism for fast adaptation. However, mounting evidence also indicates causal relation between genetic instability and ...

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