• Transcriptomics-based screening identifies pharmacological inhibition of hsp90 as a means to defer aging

  Janssens, Georges E.; Lin, Xin-Xuan; Millán Ariño, Lluís, 1984-; Kavšek, Alan; Sen, Ilke; Seinstra, Renée I.; Stroustrup, Nicholas; Nollen, Ellen A. A.; Riedel, Christian G. (Elsevier, 2019)

  Aging strongly influences human morbidity and mortality. Thus, aging-preventive compounds could greatly improve our health and lifespan. Here we screened for such compounds, known as geroprotectors, employing the power of ...
• JARID1B expression and its function in DNA damage repair are tightly regulated by miRNAs in breast cancer

  Mocavini, Ivano; Pippa, Simone; Licursi, Valerio; Paci, Paola; Trisciuoglio, Daniela; Mannironi, Cecilia; Presutti, Carlo; Negri, Rodolfo (Wiley Open Access, 2019)

  JARID1B/KDM5B histone demethylase's mRNA is markedly overexpressed in breast cancer tissues and cell lines and the protein has been shown to have a prominent role in cancer cell proliferation and DNA repair. However, the ...
• Bistable emergence of oscillations in growing Bacillus subtilis biofilms

  Martínez Corral, Rosa; Liu, Jintao; Süel, Gürol M.; García Ojalvo, Jordi (National Academy of Sciences, 2018)

  Biofilm communities of Bacillus subtilis bacteria have recently been shown to exhibit collective growth-rate oscillations mediated by electrochemical signaling to cope with nutrient starvation. These oscillations emerge ...
• Constant-Murley Score: systematic review and standardized evaluation in different shoulder pathologies

  Vrotsou, Kalliopi; Ávila Pacheco, Mónica Marcela, 1984-; Machón, Mónica; Mateo-Abad, Maider; Pardo Cladellas, Yolanda; Garin Boronat, Olatz, 1979-; Zaror, Carlos; González, Nerea; Escobar, Antonio; Cuéllar, Ricardo (SpringerOpen, 2018)

  PURPOSE: The objective of this study was to evaluate the psychometric properties of the Constant-Murley Score (CMS) in various shoulder pathologies, based on a systematic review and expert standardized evaluations. METHODS: ...
• Validity of the EQ-5D-5L and reference norms for the Spanish population

  Hernandez, Gimena; Garin Boronat, Olatz, 1979-; Pardo, Yolanda; Vilagut Saiz, Gemma, 1975-; Pont Acuña, Àngels; Suárez, Mónica; Neira, Montse; Rajmil Rajmil, Luis Alberto; Gorostiza, Inigo; Ramallo-Fariña, Yolanda; Cabases, Juan; Alonso Caballero, Jordi; Ferrer Forés, Maria Montserrat (Springer, 2018)

  BACKGROUND AND OBJECTIVE: The EuroQol 5 dimensions 5 levels (EQ-5D-5L) is the new version of EQ-5D, developed to improve its discriminatory capacity. This study aims to evaluate the construct validity of the Spanish version ...
• Change in functioning outcomes as a predictor of the course of depression: a 12-month longitudinal study

  Forero, Carlos G.; Olariu, Elena, 1984-; Álvarez López, Pilar; Castro-Rodriguez, José-Ignacio; Blasco Cubedo, Maria Jesus; Vilagut Saiz, Gemma, 1975-; Alonso Caballero, Jordi; INSAyD Investigators (Springer, 2018)

  PURPOSE: Functioning is a necessary diagnostic criterion for depression, and thus routinely assessed in depressive patients. While it is highly informative of disorder severity, its change has not been tested for prognostic ...
• A living liquid crystal dissected

  García Ojalvo, Jordi (Nature Research, 2019)

  A large-scale imaging study has tracked thousands of bacteria living in three-dimensional biofilms. This technical tour de force reveals the importance of mechanical interactions between cells for building local and global ...
• Magnesium flux modulates ribosomes to increase bacterial survival

  Lee, Dong-yeon D.; Galera Laporta, Letícia, 1985-; Bialecka-Fornal, Maja; Moon, Eun Chae; Shen, Zhouxin; Briggs, Steven P.; García Ojalvo, Jordi; Süel, Gürol M. (Elsevier, 2019)

  Bacteria exhibit cell-to-cell variability in their resilience to stress, for example, following antibiotic exposure. Higher resilience is typically ascribed to "dormant" non-growing cellular states. Here, by measuring ...
• Deficiency in p53 is required for doxorubicin induced transcriptional activation of NF-κB target genes in human breast cancer

  Dalmases Massegú, Alba, 1982-; González González, Irene; Menendez Romero, Silvia; Arpí Llucià, Oriol; Corominas Torres, Josep Maria; Servitja Tormo, Sonia; Tusquets, Ignasi; Chamizo, Cristina; Rincón, Raúl; Espinosa Blay, Lluís; Bigas Salvans, Anna; Eroles, Pilar; Furriol, Jessica; Lluch, Ana; Rovira Guerín, Ana; Albanell Mestres, Joan; Rojo, Federico (Impact Journals, 2014)

  NF-кB has been linked to doxorubicin resistance in breast cancer patients. NF-кB nuclear translocation and DNA binding in doxorubicin treated-breast cancer cells have been extensively examined; however its functional ...
• Chlorination disinfection by-products in drinking water and congenital anomalies: review and meta-analyses

  Nieuwenhuijsen, Mark J.; Martinez Murciano, David; Grellier, James; Bennett, James; Best, Nicky; Iszatt, Nina; Vrijheid, Martine; Toledano, Mireille B. (National Institute of Environmental Health Sciences (NIEHS), 2009)

  OBJECTIVES: The aim of this study was to review epidemiologic evidence, provide summary risk estimates of the association between exposure to chlorination disinfection by-products (DBPs) and congenital anomalies, and provide ...
• Ambient air pollution and risk of congenital anomalies: a systematic review and meta-analysis

  Vrijheid, Martine; Martinez Murciano, David; Manzanares, Sandra; Dadvand, Payam; Schembari, Anna, 1982-; Rankin, Judith; Nieuwenhuijsen, Mark J. (National Institute of Environmental Health Sciences (NIEHS), 2011)

  OBJECTIVE: We systematically reviewed epidemiologic studies on ambient air pollution and congenital anomalies and conducted meta-analyses for a number of air pollutant-anomaly combinations. DATA SOURCES AND EXTRACTION: ...
• European birth cohorts for environmental health research

  Vrijheid, Martine; Casas Sanahuja, Maribel; Kogevinas, Manolis; Nieuwenhuijsen, Mark J. (National Institute of Environmental Health Sciences (NIEHS), 2012)

  BACKGROUND: Many pregnancy and birth cohort studies investigate the health effects of early-life environmental contaminant exposure. An overview of existing studies and their data is needed to improve collaboration, ...
• Traffic-related air pollution, oxidative stress genes, and asthma (ECHRS)

  Castro Giner, Francesc; Künzli, Nino; Jacquemin Leonard, Bénédicte; Forsberg, Bertil; Cid Ibeas, Rafael de; Sunyer Deu, Jordi; Jarvis, Deborah; Briggs, David; Vienneau, Danielle; Norbäck, Dan; Gonzalez, Juan Ramon; Guerra, Stefano; Janson, Christer; Antó i Boqué, Josep Maria; Wjst, Matthias; Heinrich, Joachim; Estivill, Xavier, 1955-; Kogevinas, Manolis (National Institute of Environmental Health Sciences (NIEHS), 2009)

  BACKGROUND: Traffic-related air pollution is related with asthma, and this association may be modified by genetic factors. OBJECTIVES: We investigated the role of genetic polymorphisms potentially modifying the association ...
• Association between long-term exposure to traffic-related air pollution and subclinical atherosclerosis: the REGICOR study

  Rivera, Marcela, 1982-; Basagaña Flores, Xavier; Aguilera Jiménez, Inmaculada, 1977-; Foraster Pulido, Maria, 1984-; Agis, David; Groot, Eric de; Pérez Grau, Laura; Mendez, Michelle A.; Bouso, Laura; Targa, Jaume; Ramos, Rafel; Sala, Joan; Marrugat de la Iglesia, Jaume; Elosua Llanos, Roberto; Künzli, Nino (National Institute of Environmental Health Sciences (NIEHS), 2013)

  BACKGROUND: Epidemiological evidence of the effects of long-term exposure to air pollution on the chronic processes of atherogenesis is limited. OBJECTIVE: We investigated the association of long-term exposure to traffic-related ...
• Self-amplifying pulsatile protein dynamics without positive feedback

  Martínez Corral, Rosa; Raimundez, Elba; Lin, Yihan; Elowitz, Michael B.; García Ojalvo, Jordi (Elsevier, 2018)

  Many proteins exhibit dynamic activation patterns in the form of irregular pulses. Such behavior is typically attributed to a combination of positive and negative feedback loops in the underlying regulatory network. However, ...
• Metabolic basis of brain-like electrical signalling in bacterial communities

  Martínez Corral, Rosa, 1991-; Liu, Jintao; Prindle, Arthur; Süel, Gürol M.; García Ojalvo, Jordi (Royal Society, 2019)

  Information processing in the mammalian brain relies on a careful regulation of the membrane potential dynamics of its constituent neurons, which propagates across the neuronal tissue via electrical signalling. We recently ...
• Pigmentation phototype and prostate and breast cancer in a select Spanish population-A Mendelian randomization analysis in the MCC-Spain study

  Gómez-Acebo, Inés; Castaño Vinyals, Gemma; Kogevinas, Manolis; Llorca, Javier (Public Library of Science (PLoS), 2018)

  INTRODUCTION: Phototype has been associated with an increased risk of prostate cancer, and it is yet unknown if it is related to other hormone-dependent cancers, such as breast cancer or whether this association could be ...
• Detecting signs of depression in tweets in spanish: behavioral and linguistic analysis

  Leis Machin, Angela; Ronzano, Francesco; Mayer, Miguel Ángel, 1960-; Furlong, Laura I., 1971-; Sanz, Ferran (JMIR Publications, 2019)

  Background: Mental disorders have become a major concern in public health, and they are one of the main causes of the overall disease burden worldwide. Social media platforms allow us to observe the activities, thoughts, ...
• Patterns of genetic structure and adaptive positive selection in the Lithuanian population from high-density SNP data

  Urnikyte, Alina; Flores-Bello, André; Mondal, Mayukh, 1989-; Molyte, Alma; Comas, David, 1969-; Calafell i Majó, Francesc; Bosch Fusté, Elena; Kučinskas, Vaidutis (Nature Research, 2019)

  The analysis of geographically specific regions and the characterization of fine-scale patterns of genetic diversity may facilitate a much better understanding of the microevolutionary processes affecting local human ...
• HPV-relatedness definitions for classifying HPV-related oropharyngeal cancer patient do impact on TNM classification and patients' survival

  Taberna, Miren; Mena, Marisa; Tous, Sara; Pavón, Miquel A.; Oliva, Marc; León, Xavier; García, Jacinto; Guix Arnau, Marta, 1974-; Hijano Esque, Rafael; Bonfill, Teresa; Aguilà, Antón; Alemany, Laia; Mesía, Ricard (Public Library of Science (PLoS), 2018)

  BACKGROUND: Given the different nature and better outcomes of oropharyngeal carcinoma (OPC) associated with human papillomavirus (HPV) infection, a novel clinical stage classification for HPV-related OPC has been accepted ...

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