• A single nucleotide polymorphism tags variation in the arylamine N-acetyltransferase 2 phenotype in populations of European background

  García Closas, Montserrat; Hein, David W.; Silverman, Debra T.; Malats i Riera, Núria; Yeager, Meredith; Jacobs, Kevin; Doll, Mark A.; Figueroa, Jonine D.; Baris, Dalsu; Schwenn, Molly; Kogevinas, Manolis; Johnson, Alison; Chatterjee, Nilanjan; Moore, Lee E.; Moeller, Timothy; Real, Francisco X.; Chanock, Stephen J.; Rothman, Nathaniel (Lippincott Williams & Wilkins, 2011)

  The arylamine N-acetyltransferase 2 (NAT2) slow acetylation phenotype is an established risk factor for urinary bladder cancer. We reported earlier on this risk association using NAT2 phenotypic categories inferred from ...
• A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci

  Rothman, Nathaniel; Real, Francisco X.; Serra, Consol; Lloreta Trull, Josep, 1958-; Chanock, Stephen J. (Nature Research, 2010)

  We conducted a multi-stage, genome-wide association study of bladder cancer with a primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of European descent from five studies followed by a ...
• International network of cancer genome projects

  The International Cancer Genome Consortium (Nature Research, 2010)

  The International Cancer Genome Consortium (ICGC) was launched to coordinate large-scale cancer genome studies in tumours from 50 different cancer types and/or subtypes that are of clinical and societal importance across ...
• Power and sample size calculations for longitudinal studies comparing rates of change with a time-varying exposure

  Basagaña Flores, Xavier; Liao, Xiaomei; Spiegelman, Donna (Wiley-VCH Verlag, 2010)

  Existing study design formulas for longitudinal studies assume that the exposure is time invariant or that it varies in a manner that is controlled by design. However, in observational studies, the investigator does not ...
• Socioeconomic inequalities in the use of dental care services in Europe: what is the role of public coverage?

  Palència Fernàndez, Laia; Espelt Hernández, Albert, 1981-; Cornejo Ovalle, Marco, 1969-; Borrell i Thió, Carme (Wiley-VCH Verlag, 2014)

  OBJECTIVES: The aim of this study was to analyse inequalities in the use of dental care services according to socioeconomic position (SEP) in individuals aged ≥50 years in European countries in 2006, to examine the association ...
• Power and sample size calculations for longitudinal studies estimating a main effect of a time-varying exposure

  Basagaña Flores, Xavier; Spiegelman, Donna (SAGE Publications, 2011)

  Existing study design formulas for longitudinal studies have assumed that the exposure is time-invariant. We derived sample size formulas for studies comparing rates of change by exposure when the exposure varies with time ...
• Cholinergic modulation of event-related oscillations (ERO)

  Sanchez-Alavez, Manuel; Robledo, Patricia, 1958-; Wills, Derek N.; Havstad, James; Ehlers, Cindy L. (Elsevier, 2014)

  The cholinergic system in the brain modulates patterns of activity involved in general arousal, attention processing, memory and consciousness. In the present study we determined the effects of selective cholinergic lesions ...
• Storage conditions and stability of global DNA methylation in placental tissue

  Vilahur Chiaraviglio, Nadia, 1982-; Baccarelli, Andrea A.; Bustamante Pineda, Mariona; Agramunt, Silvia; Byun, Hyang-Min; Fernandez, Mariana F.; Sunyer Deu, Jordi; Estivill, Xavier, 1955- (UNLISTED PUBLISHERFuture Medicine, 2013)

  AIM: The placenta is an informative and easily available tissue for many epidemiological studies. We analyzed the extent to which storage delay affects DNA methylation. MATERIAL & METHODS: Biopsies from two placentas were ...
• The effects of co-morbidity in defining major depression subtypes associated with long-term course and severity

  Wardenaar, Klaas J.; Alonso Caballero, Jordi; Kessler, Ronald C. (Cambridge University Press, 2014)

  BACKGROUND: Although variation in the long-term course of major depressive disorder (MDD) is not strongly predicted by existing symptom subtype distinctions, recent research suggests that prediction can be improved by using ...
• Birth cohorts in asthma and allergic diseases: report of a NIAID/NHLBI/MeDALL joint workshop

  Bousquet, Jean; Antó i Boqué, Josep Maria; Pinart, Mariona; Gergen, Peter J. (Elsevier, 2014)

  Population-based birth cohorts on asthma and allergies increasingly provide new insights into the development and natural history of the diseases. More than 130 birth cohorts focusing on asthma and allergy have been initiated ...
• Subthreshold posttraumatic stress disorder in the world health organization world mental health surveys

  McLaughlin, Katie A.; Alonso Caballero, Jordi; Kessler, Ronald C. (Elsevier, 2015)

  BACKGROUND: Although only a few people exposed to a traumatic event (TE) develop posttraumatic stress disorder (PTSD), symptoms that do not meet full PTSD criteria are common and often clinically significant. Individuals ...
• Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants

  van der Valk, Ralf J.P.; Cáceres, Alejandro; Sunyer Deu, Jordi; EArly Genetics & Lifecourse Epidemiology (EAGLE) Consortium (Elsevier, 2014)

  BACKGROUND: The fraction of exhaled nitric oxide (Feno) value is a biomarker of eosinophilic airway inflammation and is associated with childhood asthma. Identification of common genetic variants associated with childhood ...
• DSM-5 and ICD-11 definitions of posttraumatic stress disorder: investigating "narrow" and "broad" approaches

  Stein, Dan J.; Alonso Caballero, Jordi; Kessler, Ronald C. (Wiley-VCH Verlag, 2014)

  BACKGROUND: The development of the Diagnostic and Statistical Manual of Mental Disorders 5th edition (DSM-5) and ICD-11 has led to reconsideration of diagnostic criteria for posttraumatic stress disorder (PTSD). The World ...
• Sodium channel TRPM4 and sodium/calcium exchangers (NCX) cooperate in the control of Ca2+-induced mucin secretion from goblet cells

  Cantero Recasens, Gerard, 1984-; Butnaru, Cristian M.; Brouwers, Nathalie; Mitrovic, Sandra; Valverde, M. A. (Miguel Ángel), 1963-; Malhotra, Vivek (American Society for Biochemistry and Molecular Biology (ASBMB), 2019)

  Regulated mucin secretion is essential for the formation of the mucus layer that protects the underlying epithelial cells from foreign particles. Alterations in the quantity or quality of secreted mucins are therefore ...
• Dual Inhibitors of PARPs and ROCKs

  Antolín Hernández, Albert, 1984-; Mestres i López, Jordi (American Chemical Society (ACS), 2018)

  Recent network and system biology analyses suggest that most complex diseases are regulated by robust and highly interconnected pathways that could be better modulated by small molecules binding to multiple biological ...
• A new model for the estimation of cell proliferation dynamics using CFSE data

  Banks, H.T.; Sutton, Karyn L.; Thompson, W. Clayton; Bocharov, Gennady A.; Doumic, Marie; Schenkel, Tim; Argilaguet Marqués, Jordi, 1977-; Giest, Sandra; Peligero Cruz, Cristina, 1986-; Meyerhans, Andreas (Elsevier, 2011)

  CFSE analysis of a proliferating cell population is a popular tool for the study of cell division and divisionlinked changes in cell behavior. Recently Banks et al. (2011), Luzyanina et al. (2009), Luzyanina et al. (2007), ...
• Pancreatic cancer risk and levels of trace elements

  Amaral, André F.S.; Porta Serra, Miquel; Silverman, Debra T.; Milne, Roger L.; Kogevinas, Manolis; Rothman, Nathaniel; Cantor, Kenneth P; Jackson, Brian P.; Pumarega Rodríguez, José Antonio; López, Tomàs; Carrato, Alfredo; Guarner, Luisa; Real, Francisco X.; Malats i Riera, Núria (BMJ Publishing Group, 2012)

  Background and Aims: Knowledge on the aetiology of exocrine pancreatic cancer (EPC) is scant. The best established risk factor for EPC is tobacco smoking. Among other carcinogens, tobacco contains cadmium, a metal previously ...
• Effects of MDMA and related analogs on plasma 5-HT: relevance to 5-HT transporters in blood and brain

  Yubero Lahoz, Samanta, 1985-; Ayestas, Mario A.; Blough, Bruce E.; Partilla, John S.; Rothman, Richard B.; Torre Fornell, Rafael de la; Baumann, Michael H. (Elsevier, 2012)

  (±)-3,4-Methylenedioxymethamphetamine (MDMA) is an illicit drug that evokes transporter-mediated release of serotonin (5-HT) in the brain. 5-HT transporter (SERT) proteins are also expressed in non-neural tissues (e.g., ...
• KChIP3 coupled to Ca2+ oscillations exerts a tonic brake on baseline mucin release in the colon

  Cantero Recasens, Gerard, 1984-; Butnaru, Cristian M.; Valverde, M. A. (Miguel Ángel), 1963-; Naranjo, José R.; Brouwers, Nathalie; Malhotra, Vivek (eLife, 2018)

  Regulated mucin secretion from specialized goblet cells by exogenous agonist-dependent (stimulated) and -independent (baseline) manner is essential for the function of the epithelial lining. Over extended periods, baseline ...
• Transgenic over expression of nicotinic receptor alpha 5, alpha 3, and beta 4 subunit genes reduces ethanol intake in mice

  Gallego, Xavier; Ruiz-Medina, Jessica; Valverde Granados, Olga; Molas Casacuberta, Susanna, 1985-; Robles, Noemí; Sabrià, Josefa; Crabbe, John C.; Dierssen, Mara (Elsevier, 2012)

  Abuse of alcohol and smoking are extensively co-morbid. Some studies suggest partial commonality of action of alcohol and nicotine mediated through nicotinic acetylcholine receptors (nAChRs). We tested mice with transgenic ...

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