• In vivo activation of the SK channel in the spinal cord reduces the NMDA receptor antagonist dose needed to produce antinociception in an inflammatory pain model

  Hipótilo, Lucia; Fakira, Amanda K.; Cabañero Ferri, David; Blandón, Rebecca; Carlton, Susan M.; Morón, Jose A.; Melyan, Zara (Lippincott Williams & Wilkins, 2015)

  N-methyl-D-aspartate receptor (NMDAR) antagonists have been shown to reduce mechanical hypersensitivity in animal models of inflammatory pain. However, their clinical use is associated with significant dose-limiting side ...
• Transcriptional diversity during lineage commitment of human blood progenitors

  Chen, Lu; Breschi, Alessandra, 1988-; Guigó Serra, Roderic; Palumbo, Emilio; Rendon, Augusto (American Association for the Advancement of Science (AAAS), 2014)

  Blood cells derive from hematopoietic stem cells through stepwise fating events. To characterize gene expression programs driving lineage choice, we sequenced RNA from eight primary human hematopoietic progenitor populations ...
• Absence of canonical marks of active chromatin in developmentally regulated genes

  Pérez-Lluch, Sílvia; Blanco, Enrique; Tilgner, Hagen, 1980-; Curado, Joao; Ruiz-Romero, Marina; Corominas Guiu, Montserrat; Guigó Serra, Roderic (Nature Research, 2015)

  The interplay of active and repressive histone modifications is assumed to have a key role in the regulation of gene expression. In contrast to this generally accepted view, we show that the transcription of genes temporally ...
• Advances in allergen-microarray technology for diagnosis and monitoring of allergy: The MeDALL allergen-chip

  Lupinek, Christian; Antó i Boqué, Josep Maria; Valenta, Rudolf (Elsevier, 2013)

  Allergy diagnosis based on purified allergen molecules provides detailed information regarding the individual sensitization profile of allergic patients, allows monitoring of the development of allergic disease and of the ...
• Functional network analysis reveals the relevance of SKIIP in the regulation of alternative splicing by p38 SAPK

  Posas Garriga, Francesc (Elsevier, 2019)
• Pathogenic copy number variants that affect gene expression contribute to genomic burden in cerebral palsy

  Corbett, Mark A.; van Eyk, Clare L.; Webber, Dani L.; Bent, Stephen J.; Newman, Morgan; Harper, Kelly; Berry, Jesia G.; Azmanov, Dimitar N.; Woodward, Karen J.; Gardner, Alison E.; Slee, Jennie; Pérez Jurado, Luis Alberto; MacLennan, Alastair H.; Gecz, Jozef (Nature Research, 2018)

  Cerebral palsy (CP) is the most frequent movement disorder of childhood affecting 1 in 500 live births in developed countries. We previously identified likely pathogenic de novo or inherited single nucleotide variants (SNV) ...
• Strategies for integrated analysis in imaging genetics studies

  Vilor Tejedor, Natàlia, 1988-; Alemany, Silvia; Cáceres, Alejandro; Bustamante Pineda, Mariona; Pujol Martí, Jesús, 1981-; Sunyer Deu, Jordi; González Ruiz, Juan Ramón (Elsevier, 2018)

  Imaging Genetics (IG) integrates neuroimaging and genomic data from the same individual, deepening our knowledge of the biological mechanisms behind neurodevelopmental domains and neurological disorders. Although the ...
• Extracranial estimation of neural mass model parameters using the unscented kalman filter

  Escuain-Poole, Lara; García Ojalvo, Jordi; Pons, Antonio J. (Frontiers, 2018)

  Data assimilation, defined as the fusion of data with preexisting knowledge, is particularly suited to elucidating underlying phenomena from noisy/insufficient observations. Although this approach has been widely used in ...
• Recurrence-based information processing in gene regulatory networks

  Gabaldà Sagarra, Marçal,1988-; Carey, Lucas; García Ojalvo, Jordi (American Institute of Physics (AIP), 2018)

  Cellular information processing is generally attributed to the complex networks of genes and proteins that regulate cell behavior. It is still unclear, however, what are the main features of those networks that allow a ...
• Systems analysis reveals complex biological processes during virus infection fate decisions

  Argilaguet Marqués, Jordi, 1977-; Pedragosa Marín, Mireia, 1988-; Esteve-Codina, Anna; Riera Domínguez, María Graciela, 1987-; Vidal, Enric; Peligero Cruz, Cristina, 1986-; Casella, Valentina; Andreu Martínez, David; Kaisho, Tsuneyasu; Bocharov, Gennady A.; Ludewig, Burkhard; Heath, Simon; Meyerhans, Andreas (Cold Spring Harbor Laboratory Press (CSHL Press), 2019)

  The processes and mechanisms of virus infection fate decisions that are the result of a dynamic virus-immune system interaction with either an efficient effector response and virus elimination or an alleviated immune ...
• Capturing variation impact on molecular interactions in the IMEx Consortium mutations data set

  Del Toro, N.; Piñero González, Janet, 1977-; Furlong, Laura I., 1971-; Porras, P.; IMEx Consortium Curators (Nature Research, 2019)

  The current wealth of genomic variation data identified at nucleotide level presents the challenge of understanding by which mechanisms amino acid variation affects cellular processes. These effects may manifest as distinct ...
• Low-frequency variation in TP53 has large effects on head circumference and intracranial volume

  Haworth, S.; Vrijheid, Martine; Guxens Junyent, Mònica; Sunyer Deu, Jordi; St. Pourcain, Beate (Nature Research, 2019)

  Cranial growth and development is a complex process which affects the closely related traits of head circumference (HC) and intracranial volume (ICV). The underlying genetic influences shaping these traits during the ...
• Germline variation at 8q24 and prostate cancer risk in men of European ancestry

  Matejcic, Marco; Kogevinas, Manolis; Haiman, Christopher A. (Nature Research, 2018)

  Chromosome 8q24 is a susceptibility locus for multiple cancers, including prostate cancer. Here we combine genetic data across the 8q24 susceptibility region from 71,535 prostate cancer cases and 52,935 controls of European ...
• Manic fringe deficiency imposes jagged1 addiction to intestinal tumor cells

  López Arribillaga, Erika; Rodilla, Verónica; Colomer Montañá, Carlota; Vert, Anna; Shelton, Amy; Cheng, Jason H.; Yan, Bing; González Pérez, Abel; Junttila, Melissa R.; Iglesias Coma, Mar; Torres, Ferran; Albanell Mestres, Joan; Villanueva, Alberto; Bigas Salvans, Anna; Siebel, Christian W.; Espinosa Blay, Lluís (Nature Research, 2018)

  Delta ligands regulate Notch signaling in normal intestinal stem cells, while Jagged1 activates Notch in intestinal adenomas carrying active β-catenin. We used the ApcMin/+ mouse model, tumor spheroid cultures, and ...
• Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants

  Dadaev, Tokhir; Kogevinas, Manolis; Castaño Vinyals, Gemma; Kote-Jarai, Zsofia (Nature Research, 2018)

  Prostate cancer is a polygenic disease with a large heritable component. A number of common, low-penetrance prostate cancer risk loci have been identified through GWAS. Here we apply the Bayesian multivariate variable ...
• Tumor-associated metabolic and inflammatory responses in early stage non-small cell lung cancer: Local patterns and prognostic significance

  Millares, Laura; Barreiro Portela, Esther; Cortes, Roldan; Martínez-Romero, Anabel; Balcells, Cristina; Cascante, Marta; Enguita, Ana Belen; Álvarez, Carlos; Rami-Porta, Ramón; Sánchez de Cos, Julio; Seijo, Luis; Monsó, Eduard; Grupo Colaborativo en Cáncer de Pulmón CIBERES-CIBERONC-SEPAR-Plataforma Biobanco Pulmonar (Elsevier, 2018)

  INTRODUCTION: Non-small cell lung cancer (NSCLC) patients diagnosed in early stage and surgically-treated have five-year mortality rate >20%. The identification of biomarkers able to predict progression and death may help ...
• Machine learning of coarse-grained molecular dynamics force fields

  Wang, Jiang; Olsson, Simon; Wehmeyer, Christoph; Pérez, Adrià; Charron, Nicholas E.; De Fabritiis, Gianni; Noé, Frank; Clementi, Cecilia (American Chemical Society (ACS), 2019)

  Atomistic or ab initio molecular dynamics simulations are widely used to predict thermodynamics and kinetics and relate them to molecular structure. A common approach to go beyond the time- and length-scales accessible ...
• Human cytomegalovirus antigen presentation by HLA-DR+ NKG2C+ adaptive NK cells specifically activates polyfunctional effector memory CD4+ T lymphocytes

  Costa García, Marcel, 1989-; Ataya, Michelle; Moraru, Manuela; Vilches, Carlos; López-Botet, Miguel; Muntasell i Castellví, Aura, 1972- (Frontiers, 2019)

  Natural killer (NK) cells play a dual role in the defense against viral pathogens by directly lysing infected cells as well as by regulating anti-viral T cell immunity. Infection by human cytomegalovirus (HCMV) promotes a ...
• An experimental assay of the interactions of amino acids from orthologous sequences shaping a complex fitness landscape

  Pokusaeva, Victoria O.; Usmanova, Dinara R.; Putintseva, Ekaterina V.; Espinar, Lorena; Sarkisyan, Karen S.; Mishin, Alexander S.; Bogatyreva, Natalya S.; Ivankov, Dmitry N.; Akopyan, Arseniy V.; Avvakumov, Sergey Ya; Povolotskaya, Inna, 1986-; Filion, Guillaume; Carey, Lucas; Kondrashov, Fyodor A., 1979- (Public Library of Science (PLoS), 2019)

  Characterizing the fitness landscape, a representation of fitness for a large set of genotypes, is key to understanding how genetic information is interpreted to create functional organisms. Here we determined the ...
• Genetic variation in pan species is shaped by demographic history and harbors lineage-specific functions

  Han, Sojung; Andrés Morán, Aida; Marquès i Bonet, Tomàs, 1975-; Kuhlwilm, Martin (Oxford University Press, 2019)

  Chimpanzees (Pan troglodytes) and bonobos (Pan paniscus) are the closest living relatives of humans, but the two species show distinct behavioral and physiological differences, particularly regarding female reproduction. ...

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