• Impact of cytomegalovirus infection on B cell differentiation and cytokine production in multiple sclerosis

  Zabalza, Ana; Vera, Andrea; Alari-Pahissa, Elisenda; Munteis Olivas, Elvira; Moreira Villanueva, Antía; Yélamos López, José; Llop, Mireia; López-Botet, M. (Miguel); Martínez Rodríguez, Jose E. (BioMed Central, 2020)

  Background: Human cytomegalovirus (HCMV) infection has been recently associated with a low risk of multiple sclerosis (MS), yet the basis behind this observation remains uncertain. In this study, we aimed to determine in ...
• A novel hydroxylation step in the taxane biosynthetic pathway: A new approach to paclitaxel production by synthetic biology

  Sánchez Muñoz, Raúl, 1990-; Pérez Mata, Edgar; Almagro, Lorena; Cusidó Vidal, Rosa M.; Bonfill Baldrich, Ma. Mercedes; Palazón, Javier; Moyano Claramunt, Elisabet (Frontiers, 2020)

  Engineered plant cell lines have the potential to achieve enhanced metabolite production rates, providing a high-yielding source of compounds of interest. Improving the production of taxanes, pharmacologically valuable ...
• Personal exposure to particulate air pollution and vascular damage in peri-urban South India

  Ranzani, Otavio; Milà, Carles; Sanchez, Margaux; Bhogadi, Santhi; Kulkarni, Bharati; Balakrishnan, Kalpana; Sambandam, Sankar; Sunyer Deu, Jordi; Marshall, Julian D.; Kinra, Sanjay; Tonne, Cathryn (Elsevier, 2020)

  Objective: Air pollution is a leading preventable risk factor for cardiovascular diseases. Previous studies mostly relied on concentrations at residence, which might not represent personal exposure. Personal air pollution ...
• Cord blood DNA methylation reflects cord blood C-reactive protein levels but not maternal levels: a longitudinal study and meta-analysis

  Yeung, Edwina H.; Guan, Weihua; Zeng, Xuehuo; Salas Díaz, Lucas Andrés, 1980-; Mumford, Sunni L.; Prado Bert, Paula de; van Meel, Evelien R.; Malmberg, Anni; Sunyer Deu, Jordi; Duijts, Liesbeth; Felix, Janine Frédérique; Czamara, Darina; Hämäläinen, Esa; Binder, Elisabeth B.; Räikkönen, Katri; Lahti, Jari; London, Stephanie J.; Silver, Robert M.; Schisterman, Enrique F. (BioMed Central, 2020)

  Background: Prenatal inflammation has been proposed as an important mediating factor in several adverse pregnancy outcomes. C-reactive protein (CRP) is an inflammatory cytokine easily measured in blood. It has clinical ...
• Attenuated epigenetic suppression of muscle stem cell necroptosis is required for efficient regeneration of dystrophic muscles

  Sreenivasan, Krishnamoorthy; Ianni, Alessandro; Künne, Carsten; Strilic, Boris; Günther, Stefan; Perdiguero, Eusebio, 1968-; Krüger, Marcus; Spuler, Simone; Offermanns, Stefan; Gómez del Arco, Pablo; Redondo, Juan Miguel; Muñoz Cánoves, Pura, 1962-; Kim, Johnny; Braun, Thomas (Elsevier, 2020)

  Somatic stem cells expand massively during tissue regeneration, which might require control of cell fitness, allowing elimination of non-competitive, potentially harmful cells. How or if such cells are removed to restore ...
• CoDysAn: A telemedicine tool to improve awareness and diagnosis for patients with congenital dyserythropoietic anemia

  Tornador Antolin, Cristian, 1979-; Sánchez Prados, Edgar; Cadenas, Beatriz; Russo, Roberta; Venturi, Veronica; Andolfo, Immacolata; Hernández Rodriguez, Ines; Iolascon, Achille; Sánchez, Mayka (Frontiers, 2019)

  Congenital Dyserythropoietic Anemia (CDA) is a heterogeneous group of hematological disorders characterized by chronic hyporegenerative anemia and distinct morphological abnormalities of erythroid precursors in the bone ...
• Closing the gap between therapeutic use and mode of action in remedial herbs

  Olivés Farrés, Joaquim, 1987-; Mestres i López, Jordi (Frontiers, 2019)

  The ancient tradition of taking parts of a plant or preparing plant extracts for treating certain discomforts and maladies has long been lacking a scientific rationale to support its preparation and still widespread use ...
• License to kill? Domestic cats affect a wide range of native fauna in a highly biodiverse mediterranean country

  Mori, Emiliano; Menchetti, Mattia; Camporesi, Alberto; Cavigioli, Luca; Tabarelli de Fatis, Karol; Girardello, Marco (Frontiers, 2019)

  Amongst domestic animals, the domestic cat, Felis catus, is widely considered to be one of the most serious threats to wildlife conservation. This is particularly evident for island ecosystems, as data for mainland countries ...
• Organophosphate pesticide metabolite concentrations in urine during pregnancy and offspring nonverbal IQ at age 6 years

  Jusko, Todd A.; van den Dries, Michiel; Pronk, Anjoeka; Shaw, Pamela A.; Guxens Junyent, Mònica; Spaan, Suzanne; Jaddoe, Vincent W. V.; Tiemeier, Henning; Longnecker, Matthew P. (National Institute of Environmental Health Sciences (NIEHS), 2019)

  Background: Susceptibility to organophosphate (OP) pesticide neurotoxicity may be greatest during the prenatal period; however, previous studies have produced mixed findings concerning in utero OP pesticide exposure and ...
• Does the oxidative stress play a role in the associations between outdoor air pollution and persistent asthma in adults? Findings from the EGEA study

  Havet, Anaïs; Li, Zhen; Zerimech, Farid; Sanchez, Margaux; Siroux, Valérie; Le Moual, Nicole; Brunekreef, Bert; Künzli, Nino; Jacquemin Leonard, Bénédicte; Varraso, Raphaëlle; Matran, Regis; Nadif, Rachel (BioMed Central, 2019)

  Background: Evidences that oxidative stress plays a role in the associations between outdoor air pollution and asthma are growing. We aimed to study the role of plasma fluorescent oxidation products levels (FlOPs; an ...
• Associations of black carbon with lung function and airway inflammation in schoolchildren

  Paunescu, Alexandra-Cristina; Casas Sanahuja, Maribel; Ferrero, Amparo; Pañella, Pau; Bougas, Nicolas; Beydon, Nicole; Just, Jocelyne; Lezmi, Guillaume; Sunyer Deu, Jordi; Ballester Díez, Ferran; Momas, Isabelle (Elsevier, 2019)

  Background: Few studies have investigated the 24-hour respiratory health effects of personal black carbon (BC) and ultrafine particles (UFP) exposure in schoolchildren. The objective of this study was to investigate these ...
• Organophosphate pesticide metabolite concentrations in urine during pregnancy and offspring attention-deficit hyperactivity disorder and autistic traits

  van den Dries, Michiel; Guxens Junyent, Mònica; Pronk, Anjoeka; Spaan, Suzanne; El Marroun, Hanan; Jusko, Todd A.; Longnecker, Matthew P.; Ferguson, Kelly K.; Tiemeier, Henning (Elsevier, 2019)

  Background: Prenatal exposure to organophosphate (OP) pesticides has been associated with altered neuronal cell development and behavioral changes in animal offspring. However, the few studies investigating the association ...
• A decade of structural variants: description, history and methods to detect structural variation

  Escaramís, Geòrgia; Docampo, Elisa; Rabionet, Raquel (Oxford University Press, 2015)

  In the past decade, the view on genomic structural variation (SV) has been changed completely. SVs, previously considered rare events, are now recognized as the largest source of interindividual genetic variation affecting ...
• Validation of self-reported perception of proximity to industrial facilities: MCC-Spain study

  Castelló, Adela; Castaño Vinyals, Gemma; O'Callaghan Gordo, Cristina; Kogevinas, Manolis; García-Pérez, Javier (Elsevier, 2020)

  Background: Self-reported data about environmental exposures can lead to measurement error. Objectives: To validate the self-reported perception of proximity to industrial facilities. Methods: MCC-Spain is a population-based ...
• Lack of association between particulate air pollution and blood glucose levels and diabetic status in peri-urban India

  Curto Tirado, Ariadna, 1987-; Ranzani, Otavio; Milà, Carles; Sanchez, Margaux; Marshall, Julian D.; Kulkarni, Bharati; Bhogadi, Santhi; Kinra, Sanjay; Wellenius, Gregory A.; Tonne, Cathryn (Elsevier, 2019)

  Background: Limited evidence exists on the effect of particulate air pollution on blood glucose levels. We evaluated the associations of residential and personal levels of fine particulate matter (PM2.5) and black carbon ...
• Long-term exposure to atmospheric metals assessed by mosses and mortality in France

  Lequy, Emeline; Siemiatycki, Jack; Leblond, Sébastien; Meyer, Caroline; Zhivin, Sergey; Vienneau, Danielle; de Hoogh, Kees; Goldberg, Marcel; Zins, Marie; Jacquemin Leonard, Bénédicte (Elsevier, 2019)

  Background: Long-term exposure to air pollution affects health, but little is known about exposure to atmospheric metals. Estimating exposure to atmospheric metals across large spatial areas remains challenging. Metal ...
• Hemimetabolous insects elucidate the origin of sexual development via alternative splicing

  Wexler, Judith; Delaney, Emily Kay; Belles, Xavier; Schal, Coby; Wada-Katsumata, Ayako; Amicucci, Matthew J.; Kopp, Artyom (eLife, 2019)

  Insects are the only known animals in which sexual differentiation is controlled by sex-specific splicing. The doublesex transcription factor produces distinct male and female isoforms, which are both essential for ...
• Aquatic Coleoptera of North Oman, with description of new species of Hydraenidae and Hydrophilidae

  Ribera, Ignacio; Hernando, Carles; Cieslak, Alexandra (Sciendo, 2019)

  We report the aquatic Coleoptera (families Dryopidae, Dytiscidae, Georissidae, Gyrinidae, Heteroceridae, Hydraenidae, Hydrophilidae and Limnichidae) from North Oman, mostly based on the captures of fourteen localities ...
• Intrapulmonary concentrations of meropenem administered by continuous infusion in critically ill patients with nosocomial pneumonia: a randomized pharmacokinetic trial

  Benítez-Cano, Adela; Luque Pardos, Sònia; Sorli Redó, M. Luisa; Carazo Cordobés, Jesús; Ramos Delgado, M.; Campillo Ambrós, Núria; Curull Serrano, Víctor; Sánchez-Font, Albert; Vilaplana, Carles; Horcajada Gallego, Juan Pablo; Adalia Bartolomé, Ramón; Bermejo Martínez, Silvia; Samsó Sabé, Enric; Hope, William; Grau Cerrato, Santiago (BioMed Central, 2020)

  Background: Optimal antimicrobial drug exposure in the lung is required for successful treatment outcomes for nosocomial pneumonia. Little is known about the intrapulmonary pharmacokinetics (PK) of meropenem when administered ...
• Clinical interest of LMO2 testing for the diagnosis of aggressive large B-Cell lymphomas

  Vazquez de las Heras, Ivonne; Papaleo, Natalia; García, Eugenia; Salido Galeote, Marta; Salar Silvestre, Antonio; Hernández Llodrà, Sílvia; Calvo Gonzalo, Xavier; Colomo Saperas, Luis Alberto (MDPI, 2020)

  MYC rearrangements usually confer aggressive biological behavior to large B-cell lymphomas. In this study, we aimed to evaluate the relevance of LMO2 detection to the clinical approach to these tumors. First, the ability ...

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