• Socioeconomic inequalities in injury mortality in small areas of 15 European cities

  Gotsens, Mercè; Marí-Dell'Olmo, Marc; Pérez, Katherine; Palència, Laia; Martinez-Beneito, Miguel-Angel; Rodríguez-Sanz, Maica; Burström, Bo; Costa, Giuseppe; Deboosere, Patrick; Domínguez-Berjón, Felicitas; Dzúrová, Dagmar; Gandarillas, Ana; Hoffmann, Rasmus; Kovacs, Katalin; Marinacci, Chiara; Martikainen, Pekka; Pikhart, Hynek; Rosicova, Katarina; Saez, Marc; Santana, Paula; Riegelnig, Judith; Schwierz, Cornelia; Tarkiainen, Lasse; Borrell i Thió, Carme (Elsevier, 2013)

  This study analysed socioeconomic inequalities in mortality due to injuries in small areas of 15 European cities, by sex, at the beginning of this century. A cross-sectional ecological study with units of analysis being ...
• Head-to-head comparison between the EQ-5D-5L and the EQ-5D-3L in general population health surveys

  Martí-Pastor, Marc; Pont, Àngels; Ávila, Mónica; Garin Boronat, Olatz, 1979-; Vilagut Saiz, Gemma, 1975-; Forero, Carlos G.; Pardo Cladellas, Yolanda; Tresserras i Gaju, Ricard, 1957-; Medina-Bustos, Antonia; Garcia-Codina, Oriol; Cabasés, Juan; Rajmil Rajmil, Luis Alberto; Alonso Caballero, Jordi; Ferrer Forés, Maria Montserrat (BioMed Central, 2018)

  Background: The EQ-5D has been frequently used in national health surveys. This study is a head-to-head comparison to assess how expanding the number of levels from three (EQ-5D-3L) to five in the new EQ-5D-5L version has ...
• Concomitant THC and stress adolescent exposure induces impaired fear extinction and related neurobiological changes in adulthood

  Saravia, Rocío; Ten-Blanco, Marc; Julià Hernández, Marina; Gagliano, Humberto; Andero, Raül; Armario García, Antonio; Maldonado, Rafael, 1961-; Berrendero Díaz, Fernando, 1971- (Elsevier, 2019)

  Δ9-tetrahydrocannabinol (THC) consumption during adolescence is reported to be a risk factor for the appearance of psychiatric disorders later in life. The interaction between genetic or environmental events and cannabinoid ...
• Anti-inflammatory agents for smoking cessation? Focus on cognitive deficits associated with nicotine withdrawal in male mice

  Saravia, Rocío; Ten-Blanco, Marc; Grande, María T.; Maldonado, Rafael, 1961-; Berrendero Díaz, Fernando, 1971- (Elsevier, 2019)

  Nicotine withdrawal is associated with cognitive deficits including attention, working memory, and episodic memory impairments. These cognitive deficits are a hallmark of nicotine abstinence which could be targeted in order ...
• Soluble guanylate cyclase stimulation reduces oxidative stress in experimental Chronic Obstructive Pulmonary Disease

  Paul, Tanja; Salazar Degracia, Anna; Peinado, Victor I.; Tura-Ceide, Olga; Blanco, Isabel; Barreiro Portela, Esther; Barberà, Joan Albert (Public Library of Science (PLoS), 2018)

  OBJECTIVE: Soluble guanylate cyclase (sGC) is a key enzyme of the nitric oxide-cyclic guanosine 3',5'-monophosphate (NO-cGMP) signaling pathway, and its pharmacological stimulation has been shown to prevent the development ...
• Virulence genes and subclone status as markers of experimental virulence in a murine sepsis model among Escherichia coli sequence type 131 clinical isolates from Spain

  Merino, Irene; Porter, Stephen B.; Johnston, Brian D.; Clabots, Connie; Shaw, Evelyn; Horcajada Gallego, Juan Pablo; Cantón, Rafael; Ruiz-Garbajosa, Patricia; Johnson, James R.; ITUBRAS-GEIH group (Public Library of Science (PLoS), 2017)

  OBJECTIVE: To assess experimental virulence among sequence type 131 (ST131) Escherichia coli bloodstream isolates in relation to virulence genotype and subclone. METHODS: We analysed 48 Spanish ST131 bloodstream isolates ...
• Degenerate time-dependent network dynamics anticipate seizures in human epileptic brain

  Tauste Campo, Adrià; Principe, Alessandro; Ley Nacher, Miguel; Rocamora Zúñiga, Rodrigo Alberto; Deco, Gustavo (Public Library of Science (PLoS), 2018)

  Epileptic seizures are known to follow specific changes in brain dynamics. While some algorithms can nowadays robustly detect these changes, a clear understanding of the mechanism by which these alterations occur and ...
• Formoterol attenuates increased oxidative stress and myosin protein loss in respiratory and limb muscles of cancer cachectic rats

  Salazar Degracia, Anna; Busquets, Silvia; Argilés, Josep M.; López Soriano, Francisco J.; Barreiro Portela, Esther (PeerJ Inc., 2017)

  Muscle mass loss and wasting are characteristic features of patients with chronic conditions including cancer. Therapeutic options are still scarce. We hypothesized that cachexia-induced muscle oxidative stress may be ...
• Neolithic mitochondrial haplogroup H genomes and the genetic origins of Europeans

  Brotherton, Paul; Cooper, Alan; Genographic Consortium; Bertranpetit, Jaume, 1952-; Comas, David, 1969-; Martínez Cruz, Begoña; Mele, Marta (Nature Research, 2013)

  Haplogroup H dominates present-day Western European mitochondrial DNA variability (>40%), yet was less common (~19%) among Early Neolithic farmers (~5450 BC) and virtually absent in Mesolithic hunter-gatherers. Here we ...
• Ancient human genomes suggest three ancestral populations for present-day Europeans

  Lazaridis, Iosif; Krause, Johannes; Comas, David, 1969- (Nature Research, 2014)

  We sequenced the genomes of a ∼7,000-year-old farmer from Germany and eight ∼8,000-year-old hunter-gatherers from Luxembourg and Sweden. We analysed these and other ancient genomes with 2,345 contemporary humans to show ...
• Global diversity, population stratification, and selection of human copy-number variation

  Sudmant, Peter H.; Eichler, Evan E.; Comas, David, 1969- (American Association for the Advancement of Science (AAAS), 2015)

  In order to explore the diversity and selective signatures of duplication and deletion human copy-number variants (CNVs), we sequenced 236 individuals from 125 distinct human populations. We observed that duplications ...
• The GenoChip: a new tool for genetic anthropology

  Elhaik, Eran; Greenspan, Elliott; Staats, Sean; Krahn, Thomas; Tyler-Smith, Chris; Xue, Yali; Tofanelli, Sergio; Francalacci, Paolo; Cucca, Francesco; Pagani, Luca; Jin, Li; Li, Hui; Schurr, Theodore G.; Greenspan, Bennett; Wells, R. Spencer; Genographic Consortium; Bertranpetit, Jaume, 1952-; Comas, David, 1969-; Martínez Cruz, Begoña (Oxford University Press, 2013)

  The Genographic Project is an international effort aimed at charting human migratory history. The project is nonprofit and nonmedical, and, through its Legacy Fund, supports locally led efforts to preserve indigenous and ...
• Timing of gene expression in a cell-fate decision system

  Aymoz, Delphine; Solé, Carme; Pierre, Jean-Jerrold; Schmitt, Marta; Nadal Clanchet, Eulàlia de; Posas Garriga, Francesc; Pelet, Serge (Wiley-Blackwell, 2018)

  During development, morphogens provide extracellular cues allowing cells to select a specific fate by inducing complex transcriptional programs. The mating pathway in budding yeast offers simplified settings to understand ...
• A novel mechanism for the prevention of transcription replication conflicts

  Canal de Torres, Berta, 1988-; Duch, Alba; Posas Garriga, Francesc; Nadal Clanchet, Eulàlia de (Taylor & Francis, 2018)

  Transcription and replication complexes can coincide in space and time. Such coincidences may result in collisions that trigger genomic instability. The phosphorylation of Mrc1 by different signaling kinases is part of a ...
• European evidence-based guidelines on pancreatic cystic neoplasms

  European Study Group on Cystic Tumours of the Pancreas (BMJ Publishing Group, 2018)

  Evidence-based guidelines on the management of pancreatic cystic neoplasms (PCN) are lacking. This guideline is a joint initiative of the European Study Group on Cystic Tumours of the Pancreas, United European Gastroenterology, ...
• Long-term cardiovascular prognosis after transient ischemic attack: Associated predictors

  Ois Santiago, Angel Javier; Zabalza, Ana; Moreira Villanueva, Antía; Cuadrado Godia, Elisa; Jiménez Conde, Jordi; Giralt-Steinhauer, Eva; Rodríguez Campello, Ana María; Soriano Tarraga, Carolina; Roquer, Jaume (Lippincott Williams & Wilkins, 2018)

  OBJECTIVE: To determine long-term cardiovascular risk after TIA and to identify the factors associated with increased risk. METHODS: This was a prospective observational registry of TIA patients admitted to the emergency ...
• Relation between circulating CC16 concentrations, lung function, and development of chronic obstructive pulmonary disease across the lifespan: a prospective study

  Guerra, Stefano; Halonen, Marilyn; Vasquez, Monica M.; Spangenberg, Amber; Stern, Debra A.; Morgan, Wayne J.; Wright, Anne L.; Carsin, Anne-Elie; Dobaño, Carlota; Barreiro Portela, Esther; Zock, Jan-Paul; Martínez-Moratalla, Jesús; Sunyer Deu, Jordi; Antó i Boqué, Josep Maria; Martinez, Fernando D. (Elsevier, 2015)

  BACKGROUND: Low concentrations of the anti-inflammatory protein CC16 (approved symbol SCGB1A1) in serum have been associated with accelerated decline in forced expiratory volume in 1 s (FEV1) in patients with chronic ...
• Pediatric-onset and adult-onset separation anxiety disorder across countries in the world mental health survey

  Silove, Derrick; Alonso Caballero, Jordi; Bromet, Evelyn J.; Gruber, Mike; Sampson, Nancy A.; Andrade, Laura Helena; Benjet, Corina; Caldas de Almeida, José Miguel; Girolamo, Giovanni de; Jonge, Peter de; Demyttenaere, Koen; Fiestas, Fabian; Florescu, Silvia; Gureje, Oye; He, Yanling; Karam, Elie G.; Lepine, Jean-Pierre; Murphy, Sam; Villa-Posada, Jose; Zarkov, Zahari; Kessler, Ronald C. (American Psychiatric Publishing, 2015)

  OBJECTIVE: The age-at-onset criterion for separation anxiety disorder was removed in DSM-5, making it timely to examine the epidemiology of separation anxiety disorder as a disorder with onsets spanning the life course, ...
• Associations between DSM-IV mental disorders and subsequent COPD diagnosis

  Rapsey, Charlene M.; Lim, Carmen; Al-Hamzawi, Ali; Alonso Caballero, Jordi; Bruffaerts, Ronny; Caldas de Almeida, José Miguel; Florescu, Silvia; Girolamo, Giovanni de; Hu, Chiyi; Kessler, Ronald C.; Kovess, Viviane; Levinson, Daphna; Medina Mora, Maria Elena; Murphy, Sam; Ono, Yutaka; Piazza, Marina; Posada Villa, José; Have, Margeet ten; Wojtyniak, Bogdan J.; Scott, Kate M. (Elsevier, 2015)

  OBJECTIVES: COPD and mental disorder comorbidity is commonly reported, although findings are limited by substantive weaknesses. Moreover, few studies investigate mental disorder as a risk for COPD onset. This research aims ...
• Association between mental disorders and subsequent adult onset asthma

  Alonso Caballero, Jordi; Jonge, Peter de; Lim, Carmen; Aguilar Gaxiola, Sergio; Bruffaerts, Ronny; Caldas de Almeida, José Miguel; Liu, Zhaorui; O'Neill, Siobhan; Stein, Dan J.; Viana, Maria Carmen; Al-Hamzawi, Ali; Angermeyer, Matthias C.; Borges, Guilherme; Ciutan, Marius; Girolamo, Giovanni de; Fiestas, Fabian; Haro Abad, Josep Maria; Hu, Chiyi; Kessler, Ronald C.; Lépine, Jean-Pierre; Levinson, Daphna; Nakamura, Yosikazu; Posada Villa, José; Wojtyniak, Bogdan J.; Scott, Kate M. (Elsevier, 2014)

  BACKGROUND AND OBJECTIVES: Associations between asthma and anxiety and mood disorders are well established, but little is known about their temporal sequence. We examined associations between a wide range of DSM-IV mental ...

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