• Do polygenic risk and stressful life events predict pharmacological treatment response in obsessive compulsive disorder? A gene-environment interaction approach

  Alemany-Navarro, María; Costas, Javier; Real, Eva; Segalàs, Cinto; Bertolín, Sara; Domènech Salgado, Laura, 1989-; Rabionet, Raquel; Carracedo, Ángel; Menchón, José M.; Alonso, Pino (Nature Research, 2019)

  The rate of response to pharmacological treatment in Obsessive-compulsive disorder (OCD) oscillates between 40 and 70%. Genetic and environmental factors have been associated with treatment response in OCD. This study ...
• Wnt/β-catenin signaling pathway safeguards epigenetic stability and homeostasis of mouse embryonic stem cells

  Theka, Ilda, 1984-; Sottile, Francesco, 1988-; Cammisa, Marco; Bonnin, Sarah; Sanchez-Delgado, Marta; Di Vicino, Umberto; Neguembor, Maria Victoria; Arumugam, Karthik; Aulicino, Francesco, 1987-; Monk, David; Riccio, Andrea; Cosma, Maria Pia, 1970- (Nature Research, 2019)

  Mouse embryonic stem cells (mESCs) are pluripotent and can differentiate into cells belonging to the three germ layers of the embryo. However, mESC pluripotency and genome stability can be compromised in prolonged in vitro ...
• The dawn of human matrilineal diversity

  Behar, Doron M.; Villems, Richard; Soodyall, Himla; Blue-Smith, Jason; Pereira, Luisa; Metspalu, Ene; Scozzari, Rosaria; Makkan, Heeran; Tzur, Shay; Comas, David, 1969-; Bertranpetit, Jaume, 1952-; Quintana Murci, Lluis; Tyler-Smith, Chris; Wells, R. Spencer; Rosset, Saharon; Genographic Consortium (University of Chicago Press, 2008)

  The quest to explain demographic history during the early part of human evolution has been limited because of the scarce paleoanthropological record from the Middle Stone Age. To shed light on the structure of the mitochondrial ...
• Anxiety and depression in women with breast cancer: Social and clinical determinants and influence of the social network and social support (DAMA cohort)

  Puigpinós i Riera, Rosa; Graells-Sans, A.; Serral Cano, Gemma, 1973-; Continente Garcia, Xavier, 1980-; Bargalló, Xavi; Doménech, Montserrat; Espinosa-Bravo, Martín; Grau, Jaume; Macià Guilà, Francesc Assís; Manzanera, Rafael; Pla, Margarida; Quintana, María Jesús; Sala Serra, Maria; Vidal, Eulalia (Elsevier, 2018)

  BACKGROUND: Anxiety and depression are the most prevalent mental health pathologies among women with breast cancer. Social, clinical and contextual variables may influence emotional stress among women with breast cancer. ...
• Is there adaptation in the human genome for taste perception and phase I biotransformation?

  Dobón Berenguer, Begoña, 1987-; Rossell, Carla; Walsh Capdevila, Sandra; Bertranpetit, Jaume, 1952- (BioMed Central, 2019)

  Background: During the modern human expansion, new environmental pressures may have driven adaptation, especially in genes related to the perception of ingested substances and their detoxification. Consequently, positive ...
• An integrative evolution theory of histo-blood group ABO and related genes

  Yamamoto, Fumiichiro; Cid, Emili; Yamamoto, Miyako; Saitou, Naruya; Bertranpetit, Jaume, 1952-; Blancher, Antoine (Nature Research, 2014)

  The ABO system is one of the most important blood group systems in transfusion/transplantation medicine. However, the evolutionary significance of the ABO gene and its polymorphism remained unknown. We took an integrative ...
• Childhood psychosocial stressors and adult onset arthritis: broad spectrum risk factors and allostatic load

  Korff, Michael von; Alonso Caballero, Jordi; Ormel, Johan; Angermeyer, Matthias C.; Bruffaerts, Ronny; Fleiz, Clara; Girolamo, Giovanni de; Kessler, Ronald C.; Kovess, Viviane; Posada Villa, José; Scott, Kate M.; Uda, Hidenori (Elsevier, 2009)

  Neural, endocrine, and immune stress mediators are hypothesized to increase risks of diverse chronic diseases, including arthritis. Retrospective data from the World Mental Health Surveys (N=18,309) were employed to assess ...
• Implications of modifying the duration requirement of generalized anxiety disorder in developed and developing countries

  Lee, Sing; Tsang, Adley; Ruscio, Ayelet Meron; Haro Abad, Josep Maria; Stein, Dan J.; Alonso Caballero, Jordi; Angermeyer, Matthias C.; Bromet, Evelyn J.; Demyttenaere, Koen; Girolamo, Giovanni de; de Graaf, Ron; Gureje, Oye; Iwata, Noboru; Karam, Elie G.; Lepine, Jean-Pierre; Levinson, Daphna; Medina Mora, Maria Elena; Browne, Mark Oakley; Posada Villa, José; Kessler, Ronald C. (Cambridge University Press, 2009)

  BACKGROUND: A number of western studies have suggested that the 6-month duration requirement of generalized anxiety disorder (GAD) does not represent a critical threshold in terms of onset, course, or risk factors of the ...
• Evaluating the drug use "gateway" theory using cross-national data: consistency and associations of the order of initiation of drug use among participants in the WHO World Mental Health Surveys

  Degenhardt, Louisa; Dierker, Lisa; Chiu, Wai Tat; Medina Mora, Maria Elena; Neumark, Yehuda; Sampson, Nancy A.; Alonso Caballero, Jordi; Angermeyer, Matthias C.; Anthony, James C.; Bruffaerts, Ronny; Girolamo, Giovanni de; de Graaf, Ron; Gureje, Oye; Karam, Aimee N.; Kostyuchenko, Stanislav; Lee, Sing; Lépine, Jean-Pierre; Levinson, Daphna; Nakamura, Yosikazu; Posada Villa, José; Stein, Dan J.; Wells, J. Elisabeth; Kessler, Ronald C. (Elsevier, 2010)

  BACKGROUND: It is unclear whether the normative sequence of drug use initiation, beginning with tobacco and alcohol, progressing to cannabis and then other illicit drugs, is due to causal effects of specific earlier drug ...
• The global burden of mental disorders: an update from the WHO World Mental Health (WMH) surveys

  Kessler, Ronald C.; Aguilar-Gaxiola, Sergio; Alonso Caballero, Jordi; Chatterji, Somnath; Lee, Sing; Ormel, Johan; Üstün, T. Bedirhan; Wang, Philip S. (Il Pensiero Scientifico, 2009)

  AIMS: The paper reviews recent findings from the WHO World Mental Health (WMH) surveys on the global burden of mental disorders. METHODS: The WMH surveys are representative community surveys in 28 countries throughout the ...
• Creating a transatlantic research enterprise for preventing Alzheimer's disease

  Khachaturian, Zaven; Camí, Jordi, 1952-; Andrieu, Sandrine; Avila, Jesús; Boada, Mercè; Breteler, Monique; Froelich, Lutz; Gauthier, Serge; Gómez-Isla, Teresa; Khachaturian, Ara S.; Kuller, Lewis H.; Larson, Eric B.; Lopez, Oscar L.; Martinez-Lage, José Manuel; Petersen, Ronald C.; Schellenberg, Gerard D.; Sunyer Deu, Jordi; Vellas, Bruno; Bain, Lisa J. (Elsevier, 2009)

  In recognition of the global problem posed by Alzheimer's disease and other dementias, an international think-tank meeting was convened by Biocat, the Pasqual Maragall Foundation, and the Lou Ruvo Brain Institute in February ...
• Clonal dynamics monitoring during clinical evolution in chronic lymphocytic leukaemia

  González-Rincón, Julia; Gómez, Sagrario; Martinez, Nerea; Troulé, Kevin; Perales-Patón, Javier; Derdak, Sophia; Beltran, Sergi; Fernández-Cuevas, Belén; Pérez-Sanz, Nuria; Nova-Gurumeta, Sara; Gut, Ivo Glynne; Al-Shahrour, Fátima; Piris, Miguel A.; García-Marco, J. A.; Sánchez-Beato, Margarita (Nature Research, 2019)

  Chronic lymphocytic leukaemia is the most prevalent leukaemia in Western countries. It is an incurable disease characterized by a highly variable clinical course. Chronic lymphocytic leukaemia is an ideal model for studying ...
• Analysis of Vibrio harveyi adaptation in sea water microcosms at elevated temperature provides insights into the putative mechanisms of its persistence and spread in the time of global warming

  Montánchez, Itxaso; Ogayar, Elixabet; Hernández Plágaro, Ander; Esteve-Codina, Anna; Gómez-Garrido, Jèssica; Orruño, Maite; Arana, Inés; Kaberdin, Vladimir R. (Nature Research, 2019)

  Discovering the means to control the increasing dissemination of pathogenic vibrios driven by recent climate change is challenged by the limited knowledge of the mechanisms in charge of Vibrio spp. persistence and spread ...
• Did psychotropic drug consumption increase during the 2008 financial crisis? A cross-sectional population-based study in Spain

  Arroyo, Elena; Cabrera-León, Andrés; Renart, Gemma; Saurina, Carme; Serra Saurina, Laura; Daponte, Antonio; Saez, Marc (BMJ Publishing Group, 2019)

  OBJECTIVES AND SETTING: Although psychotropic drugs are used to treat mental health disorders, little evidence analyses the effects the 2008 economic downturn had on psychotropic drug consumption in the case of Spain. We ...
• Human Early Life Exposome (HELIX) study: a European population-based exposome cohort

  Maitre, Léa; de Bont, Jeroen; Casas Sanahuja, Maribel; Robinson, Oliver; Basagaña Flores, Xavier; Borràs, Eva; Bustamante Pineda, Mariona; de Castro, Montserrat; Donaire González, David; Estivill, Xavier, 1955-; Fossati, Serena; González, Juan R.; Hernández-Ferrer, Carles; Júlvez Calvo, Jordi; Manzano Salgado, Cyntia Beatriz, 1987-; Sabido Aguade, Eduard; Sunyer Deu, Jordi; Tamayo-Uria, Ibon; Urquiza, José M.; van Gent, Diana; Vives Usano, Marta, 1990-; Warembourg, Charline; Nieuwenhuijsen, M.; Vrijheid, Martine (BMJ Publishing Group, 2018)

  PURPOSE: Essential to exposome research is the collection of data on many environmental exposures from different domains in the same subjects. The aim of the Human Early Life Exposome (HELIX) study was to measure and ...
• The chromatin remodeling complex Chd4/NuRD controls striated muscle identity and metabolic homeostasis

  Gómez-Del Arco, Pablo; Perdiguero, Eusebio, 1968-; Muñoz Cánoves, Pura, 1962-; Redondo, Juan Miguel (Elsevier, 2016)

  Heart muscle maintains blood circulation, while skeletal muscle powers skeletal movement. Despite having similar myofibrilar sarcomeric structures, these striated muscles differentially express specific sarcomere components ...
• Cilia control fat deposition during tissue repair

  Perdiguero, Eusebio, 1968-; Serrano Sánchez, Antonio L.; Muñoz Cánoves, Pura, 1962- (Elsevier, 2017)

  Fibro/adipogenic progenitors (FAPs) are emerging as crucial regulators of fibrous and fat deposits during skeletal muscle regeneration. In a recent issue of Cell, Kopinke et al. (2017) report that primary cilia induce the ...
• Proteostatic and metabolic control of stemness

  García Forero, Carlos; Sousa-Victor, Pedro; Muñoz Cánoves, Pura, 1962- (Elsevier, 2017)

  Adult stem cells, particularly those resident in tissues with little turnover, are largely quiescent and only activate in response to regenerative demands, while embryonic stem cells continuously replicate, suggesting ...
• Lack of glycogenin causes glycogen accumulation and muscle function impairment

  Testoni, Giorgia; Duran, Jordi; García-Rocha, Mar; Vilaplana, Francisco; Serrano, Antonio L.; Sebastián, David; López Soldado, Iliana; Sullivan, Mitchell A.; Slebe Concha, Juan Felipe, 1981-; Vilaseca, Marta; Muñoz Cánoves, Pura, 1962-; Guinovart, Joan J. (Joan Josep), 1947- (Elsevier, 2017)

  Glycogenin is considered essential for glycogen synthesis, as it acts as a primer for the initiation of the polysaccharide chain. Against expectations, glycogenin-deficient mice (Gyg KO) accumulate high amounts of glycogen ...
• Aged stem cells reprogram their daily rhythmic functions to adapt to stress

  Solanas, Guiomar; Oliveira Peixoto, Francisca; Perdiguero, Eusebio, 1968-; Jardí, Mercè; Ruiz Bonilla, Vanesa, 1979-; Datta, Debayan; Symeonidi, Aikaterini; Castellanos, Andrés; Welz, Patrick-Simon; Martín Caballero, Juan; Sassone-Corsi, Paolo; Muñoz Cánoves, Pura, 1962-; Aznar Benitah, Salvador (Elsevier, 2017)

  Normal homeostatic functions of adult stem cells have rhythmic daily oscillations that are believed to become arrhythmic during aging. Unexpectedly, we find that aged mice remain behaviorally circadian and that their ...

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