• Yap/Taz-TEAD activity links mechanical cues to progenitor cell behavior during zebrafish hindbrain segmentation

  Voltes Cobo, Adrià, 1991-; Hevia, Covadonga F.; Engel-Pizcueta, Carolyn; Dingare, Chaitanya; Calzolari, Simone, 1983-; Terriente, Javier; Norden, Caren; Lecaudey, Virginie; Pujades Corbi, Cristina (Company of Biologists, 2019)

  Cells perceive their microenvironment through chemical and physical cues. However, how the mechanical signals are interpreted during embryonic tissue deformation to result in specific cell behaviors is largely unknown. The ...
• Human albumin impairs amyloid β-peptide fibrillation through its C-terminus: from docking modeling to protection against neurotoxicity in alzheimer's disease

  Picón-Pagès, Pol; Bonet Martínez, Jaume, 1982-; García-García, Javier, 1982-; Garcia-Buendia, Joan; Gutierrez, Daniela; Valle, Javier; Gómez-Casuso, Carmen E.S.; Sidelkivska, Valeriya; Alvarez, Alejandra; Perálvarez Marín, Alex; Suades, Albert; Fernàndez Busquets, Xavier; Andreu Martínez, David; Vicente García, Rubén, 1978-; Oliva Miguel, Baldomero; Muñoz López, Francisco José, 1964- (Elsevier, 2019)

  Alzheimer's disease (AD) is a neurodegenerative process characterized by the accumulation of extracellular deposits of amyloid β-peptide (Aβ), which induces neuronal death. Monomeric Aβ is not toxic but tends to aggregate ...
• Personal exposure to particulate matter in peri-urban India: predictors and association with ambient concentration at residence

  Sanchez, Margaux; Milà, Carles; Sreekanth, V.; Balakrishnan, Kalpana; Sambandam, Sankar; Nieuwenhuijsen, Mark J.; Kinra, Sanjay; Marshall, Julian D.; Tonne, Cathryn (Nature Research, 2019)

  Scalable exposure assessment approaches that capture personal exposure to particles for purposes of epidemiology are currently limited, but valuable, particularly in low-/middle-income countries where sources of personal ...
• Integrated assessment of exposure to PM2.5 in South India and its relation with cardiovascular risk: Design of the CHAI observational cohort study

  Tonne, Cathryn; Salmon, Maëlle; Sanchez, Margaux; Sreekanth, V.; Bhogadi, Santhi; Sambandam, Sankar; Balakrishnan, Kalpana; Kinra, Sanjay; Marshall, Julian D. (Elsevier, 2017)

  While there is convincing evidence that fine particulate matter causes cardiovascular mortality and morbidity, little of the evidence is based on populations outside of high income countries, leaving large uncertainties ...
• Applicability of the mutation-selection balance model to population genetics of heterozygous protein-truncating variants in humans

  Weghorn, Donate; Balick, Daniel J.; Cassa, Christopher; Kosmicki, Jack A.; Daly, Mark J.; Beier, David R.; Sunyaev, Shamil R. (Oxford University Press, 2019)

  The fate of alleles in the human population is believed to be highly affected by the stochastic force of genetic drift. Estimation of the strength of natural selection in humans generally necessitates a careful modeling ...
• Extensive post-transcriptional buffering of gene expression in the response to severe oxidative stress in baker's yeast

  Blevins, William R.; Tavella, Teresa; Moro, Simone G.; Blasco Moreno, Bernat, 1986-; Closa-Mosquera, Adrià; Díez Antón, Juana, 1962-; Carey, Lucas; Albà Soler, Mar (Nature Research, 2019)

  Cells responds to diverse stimuli by changing the levels of specific effector proteins. These changes are usually examined using high throughput RNA sequencing data (RNA-Seq); transcriptional regulation is generally assumed ...
• Sugar-containing beverages consumption and obesity in children aged 4-5 years in Spain: the INMA study

  Gonzalez-Palacios, Sandra; Navarrete-Muñoz, Eva-María; García-de-la-Hera, Manoli; Torres-Collado, Laura; Santa Marina, Loreto; Amiano, Pilar; Lopez-Espinosa, Maria-José; Tardón, Adonina; Riano-Galan, Isolina; Vrijheid, Martine; Sunyer Deu, Jordi; Vioque, Jesus (MDPI, 2019)

  The consumption of sugar-containing beverages (SCB) has been associated with obesity although the evidence in preschool children is scarce. Cross-sectional analyses were performed to assess the association between obesity ...
• Empirical mean-noise fitness landscapes reveal the fitness impact of gene expression noise

  Schmiedel, Jörn M.; Carey, Lucas; Lehner, Ben, 1978- (Nature Research, 2019)

  The effects of cell-to-cell variation (noise) in gene expression have proven difficult to quantify because of the mechanistic coupling of noise to mean expression. To independently quantify the effects of changes in mean ...
• Characterization of the non-stationary nature of steady-state visual evoked potentials using echo state networks

  Ibáñez Soria, David, 1983-; Soria Frisch, Aureli; García Ojalvo, Jordi; Ruffini, Giulio (Public Library of Science (PLoS), 2019)

  State Visual Evoked Potentials (SSVEPs) arise from a resonance phenomenon in the visual cortex that is produced by a repetitive visual stimulus. SSVEPs have long been considered a steady-state response resulting from purely ...
• Blockade of the sigma-1 receptor relieves cognitive and emotional impairments associated to chronic osteoarthritis pain

  Carcolé, Mireia; Zamanillo, Daniel; Merlos, Manuel; Fernández-Pastor, Begoña; Cabañero Ferri, David; Maldonado, Rafael, 1961- (Frontiers, 2019)

  Osteoarthritis is the most common musculoskeletal disease worldwide, often characterized by degradation of the articular cartilage, chronic joint pain and disability. Cognitive dysfunction, anxiety and depression are common ...
• Patterns of white matter hyperintensities associated with cognition in middle-aged cognitively healthy individuals

  Brugulat Serrat, Anna, 1986-; Salvadó, Gemma; Sudre, Carole H.; Grau-Rivera, Oriol; Suárez-Calvet, Marc; Falcon, Carles; Sánchez Benavides, Gonzalo; Gramunt Fombuena, Nina; Fauria, Karine; Cardoso, M. Jorge; Barkhof, Frederik; Molinuevo, José Luis; Gispert López, Juan Domingo; ALFA Study (Springer, 2019)

  White matter hyperintensities (WMH) are commonly detected in the brain of elderly individuals and have been associated with a negative impact on multiple cognitive domains. We aim to investigate the impact of global and ...
• Trajectories of sickness absence among salaried workers: evidence from the WORKss cohort in Catalonia (Spain), 2012-2014

  Ubalde López, Mònica, 1972-; Hernando-Rodriguez, Julio C.; Benavides, Fernando G. (Fernando García); Serra Saurina, Laura (BMJ Publishing Group, 2019)

  Objectives: Sickness absence (SA) is a widely studied integrated measure of health status. To better understand how SA behaves over time (SA trajectory) a longitudinal and individual-centred approach will allow identifying ...
• Relationship between the respiratory microbiome and the severity of airflow limitation, history of exacerbations and circulating eosinophils in COPD patients

  Millares, Laura; Pascual Guàrdia, Sergi, 1979-; Montón, Concepción; García-Nuñez, Marian; Lalmolda, Cristina; Faner, Rosa; Casadevall Fusté, Carme; Setó, Laia; Capilla, Silvia; Moreno, Amàlia; Castro-Acosta, Ady Angélica; Alvarez-Martinez, Carlos José; Sibila, Oriol; Peces-Barba, Germán; Cosio, Borja G.; Agustí, Alvar; Gea Guiral, Joaquim; Monsó, Eduard (BioMed Central, 2019)

  Background: The respiratory microbiome is altered in COPD patients but its relationship with core components of the disease, such as the severity of airflow limitation, the frequency of exacerbations or the circulating ...
• MASK (Mobile Airways Sentinel Network), una app móvil con la solución integral de ARIA en países de habla hispana

  Larenas-Linnemann, Desirée; Antó i Boqué, Josep Maria; Bousquet, Jean (UNLISTED PUBLISHER, 2019)

  Aunque existen guías clínicas de alta calidad sobre rinitis alérgica, numerosos pacientes reciben tratamiento deficiente, en parte debido al alto grado de automedicación. MASK (Mobile Airways Sentinel Network) forma parte ...
• Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen

  Menden, Michael P.; AstraZeneca-Sanger Drug Combination DREAM Consortium; Saez-Rodriguez, Julio (Nature Research, 2019)

  The effectiveness of most cancer targeted therapies is short-lived. Tumors often develop resistance that might be overcome with drug combinations. However, the number of possible combinations is vast, necessitating data-driven ...
• Electrical polarization enables integrative quality control during bacterial differentiation into spores

  Sirec, Teja; Benarroch, Jonatan M.; Buffard, Pauline; García Ojalvo, Jordi; Asally, Munehiro (Elsevier, 2019)

  Quality control of offspring is important for the survival of cells. However, the mechanisms by which quality of offspring cells may be checked while running genetic programs of cellular differentiation remain unclear. ...
• The role of socioeconomic status in the association of lung function and air pollution-A pooled analysis of three adult ESCAPE cohorts

  Keidel, Dirk; Antó i Boqué, Josep Maria; Basagaña Flores, Xavier; Burte, Marthe-Emilie, 1989-; Carsin, Anne-Elie; Sunyer Deu, Jordi; Jacquemin Leonard, Bénédicte; Probst-Hensch, Nicole (MDPI, 2019)

  Ambient air pollution is a leading environmental risk factor and its broad spectrum of adverse health effects includes a decrease in lung function. Socioeconomic status (SES) is known to be associated with both air pollution ...
• Spatially explicit analysis reveals complex human genetic gradients in the Iberian Peninsula

  Pimenta, João; Lopes, Alexandra M.; Carracedo, Ángel; Arenas, Miguel; Amorim, António; Comas, David, 1969- (Nature Research, 2019)

  The Iberian Peninsula is a well-delimited geographic region with a rich and complex human history. However, the causes of its genetic structure and past migratory dynamics are not yet fully understood. In order to shed ...
• Joint effect of paid working hours and multiple job holding on work absence due to health problems among basic education teachers in Brazil: the Educatel Study

  Rodríguez-Loureiro, Lucía; Artazcoz Lazcano, Lucía, 1963-; López Ruiz, María, 1982-; Assunção, Ada Ávila; Benavides, Fernando G. (Fernando García) (Escola Nacional De Saúde Pública, Fundação Oswaldo Cruz, 2019)

  The objectives were to assess the joint effect of working hours paid per week and multiple job holding on sickness absence, by sex, among basic education teachers in Brazil. This study is based on a survey carried out over ...
• Restrictive spirometry pattern is associated with low physical activity levels. A population based international study

  Carsin, Anne-Elie; Fuertes, Elaine; Antó i Boqué, Josep Maria; Guerra, Stefano; García Aymerich, Judith (Elsevier, 2019)

  Introduction: Restrictive spirometry pattern is an under-recognised disorder with a poor morbidity and mortality prognosis. We compared physical activity levels between adults with a restrictive spirometry pattern and with ...

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