• Trends in smoking initiation in Europe over 40 years: A retrospective cohort study

  Marcon, Alessandro; Pesce, Giancarlo; Calciano, Lucia; Bellisario, Valeria; Dharmage, Shyamali C.; García Aymerich, Judith; Gislasson, Thorarinn; Heinrich, Joachim; Holm, Mathias; Janson, Christer; Jarvis, Deborah; Leynaert, Bénédicte; Matheson, Melanie C.; Pirina, Pietro; Svanes, Cecilie; Villani, Simona; Zuberbier, Torsten; Minelli, Cosetta; Accordini, Simone; Ageing Lungs In European Cohorts study (Public Library of Science (PLoS), 2018)

  BACKGROUND: Tobacco consumption is the largest avoidable health risk. Understanding changes of smoking over time and across populations is crucial to implementing health policies. We evaluated trends in smoking initiation ...
• Health effects of particulate matter air pollution in underground railway systems - a critical review of the evidence

  Loxham, Matthew; Nieuwenhuijsen, Mark J. (BioMed Central, 2019)

  Background: Exposure to ambient airborne particulate matter is a major risk factor for mortality and morbidity, associated with asthma, lung cancer, heart disease, myocardial infarction, and stroke, and more recently type ...
• Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration

  Liu, Xueping; Bustamante Pineda, Mariona; Vrijheid, Martine; Feenstra, Bjarke (Nature Research, 2019)

  The duration of pregnancy is influenced by fetal and maternal genetic and non-genetic factors. Here we report a fetal genome-wide association meta-analysis of gestational duration, and early preterm, preterm, and postterm ...
• GUILDify v2.0: a tool to identify molecular networks underlying human diseases, their comorbidities and their druggable targets

  Aguirre Plans, Joaquim; Piñero González, Janet, 1977-; Sanz, Ferran; Furlong, Laura I., 1971-; Fernández Fuentes, Narcís; Oliva Miguel, Baldomero; Guney, Emre (Elsevier, 2019)

  The genetic basis of complex diseases involves alterations on multiple genes. Unraveling the interplay between these genetic factors is key to the discovery of new biomarkers and treatments. In 2014, we introduced GUILDify, ...
• Exogenous female sex steroids may reduce lung ageing after menopause: A 20-year follow-up study of a general population sample (ECRHS)

  Triebner, Kai; García Aymerich, Judith; Gómez Real, Francisco (Elsevier, 2019)

  Objectives: Menopause involves hypoestrogenism, which is associated with numerous detrimental effects, including on respiratory health. Hormone replacement therapy (HRT) is often used to improve symptoms of menopause. The ...
• Impact of a riverside accessibility intervention on use, physical activity, and wellbeing: A mixed methods pre-post evaluation

  Vert, Cristina; Carrasco Turigas, Glòria; Zijlema, Wilma; Espinosa Díaz, Ana; Cano-Riu, Lia; Elliott, Lewis R.; Litt, Jill; Nieuwenhuijsen, Mark J.; Gascon Merlos, Mireia, 1984- (Elsevier, 2019)

  Introduction: Access to natural outdoor environments can promote physical activity, social cohesion, and improved psychological well-being. In 2016, an urban riverside regeneration project to facilitate access to the ...
• Effects of leisure-time and transport-related physical activities on the risk of incident and recurrent myocardial infarction and interaction with traffic-related air pollution: a cohort study

  Kubesch, Nadine Janet, 1975-; Therming Jørgensen, Jeanette; Hoffmann, Barbara; Loft, Steffen; Nieuwenhuijsen, Mark J.; Raaschou‑Nielsen, Ole; Pedersen, Marie; Hertel, Ole; Overvad, Kim; Tjønneland, Anne; Prescot, Eva; Andersen, Zorana J. (Wiley-Blackwell, 2018)

  Background: Physical activity enhances the uptake of air pollutants, possibly reducing its beneficial effects. We examined the effects of leisure‐time and transport‐related physical activities on the risk of myocardial ...
• Evaluation of different recruitment methods: longitudinal, web-based, pan-european physical activity through sustainable transport approaches (PASTA) Project

  Gaupp-Berghausen, Mailin; Raser, Elisabeth; Anaya Boig, Esther; Avila Palencia, Ione; De Nazelle, Audrey; Dons, Evi; Franzen, Helen; Gerike, Regine; Götschi, Thomas; Iacorossi, Francesco; Hössinger, Reinhard; Nieuwenhuijsen, Mark J.; Rojas Rueda, David, 1979-; Sánchez, Julian; Smeds, Emilia; Deforth, Manja; Standaert, Arnout; Stigell, Erik; Cole-Hunter, Tom; Int Panis, Luc (JMIR Publications, 2019)

  Background: Sufficient sample size and minimal sample bias are core requirements for empirical data analyses. Combining opportunistic recruitment with a Web-based survey and data-collection platform yields new benefits ...
• Colistin for the treatment of urinary tract infections caused by Extremely Drug-resistant pseudomonas aeruginosa: dose is critical

  Sorli Redó, M. Luisa; Luque Pardos, Sònia; Li, Jian; Campillo Ambrós, Núria; Danés, Marc; Montero, Maria Milagro; Montero, Maria Milagro; Segura, Concepción; Grau Cerrato, Santiago; Horcajada Gallego, Juan Pablo (Elsevier, 2019)

  Objectives: Optimal dosage regimens of colistin for the treatment of urinary tract infections (UTI) are unknown. Colistimethate sodium (CMS), the inactive prodrug of colistin, is mainly excreted in urine and converts to ...
• Colistin plus meropenem combination is synergistic in vitro Aagainst extensively drug-resistant pseudomonas aeruginosa, including high-risk clones

  Montero, Maria Milagro; Domene Ochoa, Sandra; López-Causapé, Carla; VanScoy, Brian; Luque Pardos, Sònia; Sorli Redó, M. Luisa; Campillo Ambrós, Núria; Padilla, Eduardo; Prim, Núria; Segura, Concepción; Pomar, Virginia; Rivera, Alba; Grau Cerrato, Santiago; Ambrose, Paul G.; Oliver, Antonio; Horcajada Gallego, Juan Pablo (Elsevier, 2019)

  Background: Extensively drug-resistant (XDR) Pseudomonas aeruginosa (P. aeruginosa) and particularly P. aeruginosa high-risk clones, are of growing concern because treatment options are limited. For years, colistin monotherapy ...
• Smartphone-based physical activity telecoaching in chronic obstructive pulmonary disease: mixed-methods study on patient experiences and lessons for implementation

  Loeckx, Matthias; Rabinovich, Roberto A.; Demeyer, Heleen; Louvaris, Zafeiris; Tanner, Rebecca; Rubio, Noah; Frei, Anja; de Jong, Corina; Gimeno Santos, Elena, 1980-; Rodrigues, Fernanda M.; Buttery, Sara C.; Hopkinson, Nicholas S.; Büsching, Gilbert; Strassmann, Alexandra; Serra Pons, Ignasi; Vogiatzis, Ioannis; García Aymerich, Judith; Polkey, Michael I.; Troosters, Thierry (JMIR Publications Inc., 2018)

  Background: Telecoaching approaches can enhance physical activity (PA) in patients with chronic obstructive pulmonary disease (COPD). However, their effectiveness is likely to be influenced by intervention-specific ...
• Association of gestational weight gain with adverse maternal and infant outcomes

  LifeCycle Project-Maternal Obesity and Childhood Outcomes Study Group (American Medical Association, 2019)

  Importance: Both low and high gestational weight gain have been associated with adverse maternal and infant outcomes, but optimal gestational weight gain remains uncertain and not well defined for all prepregnancy weight ...
• What can public health do for the welfare state? Occupational health could be an answer

  Benavides, Fernando G. (Fernando García); Serra, Consol; Delclos, George L. (BMJ Publishing Group, 2019)

  Background: The welfare state has a long history of uncertain future. Nonetheless, health indicators of people living in countries with a more universal and generous welfare state remain better than those living under less ...
• C/EBPα mediates the growth inhibitory effect of progestins on breast cancer cells

  Nacht, A. Silvina; Ferrari, Roberto; Zaurín Quer, Roser; Scabia, Valentina; Carbonell-Caballero, Jose; Le Dily, François; Quilez Oliete, Javier; Leopoldi, Alexandra; Brisken, Cathrin; Beato, Miguel; Vicent, Guillermo Pablo (EMBO Press, 2019)

  Steroid hormones are key gene regulators in breast cancer cells. While estrogens stimulate cell proliferation, progestins activate a single cell cycle followed by proliferation arrest. Here, we use biochemical and genome-wide ...
• Independent multiple factor association analysis for multiblock data in imaging genetics

  Vilor Tejedor, Natàlia, 1988-; Ikram, Mohammad Arfan; Roshchupkin, Gennady V.; Cáceres, Alejandro; Alemany, Silvia; Vernooij, Meike W.; Niessen, Wiro J.; Duijn, Cornelia M. van; Sunyer Deu, Jordi; Adams, Hieab H.; González Ruiz, Juan Ramón (Springer, 2019)

  Multivariate methods have the potential to better capture complex relationships that may exist between different biological levels. Multiple Factor Analysis (MFA) is one of the most popular methods to obtain factor scores ...
• Traffic-related air pollution and the local burden of childhood asthma in Bradford, UK

  Khreis, Haneen; Ramani, Tara; de Hoogh, Kees; Mueller, Natalie, 1988-; Rojas Rueda, David, 1979-; Zietsman, Joe; Nieuwenhuijsen, Mark J. (Elsevier, 2019)

  Background: Asthma is the most common chronic disease in children. Traffic-related air pollution (TRAP) may be an important exposure contributing to its development. In the UK, Bradford is a deprived city suffering from ...
• Implementation of home hospitalization and early discharge as an integrated care service: a ten years pragmatic assessment

  Hernández, Carme; Aibar, Jesus; Seijas, Nuria; Puig, Imma; Alonso, Albert; García Aymerich, Judith; Roca, Josep (Ubiquity Press, 2018)

  Home Hospitalization has proven efficacy, but its effectiveness and potential as an Integrated Care Service in a real world setting deserves to be explored. Objective: To evaluate implementation and 10 years follow-up of ...
• EGFR and KRAS mutations in the non-tumoral lung. Prognosis in patients with adenocarcinoma

  Chalela Rengifo, Roberto José; Bellosillo Paricio, Beatriz; Curull Serrano, Víctor; Longarón Rozalen, Raquel; Pascual Guàrdia, Sergi, 1979-; Badenes Bonet, Diana; Arriola Aperribay, Edurne; Sánchez-Font, Albert; Pijuan Andujar, Lara; Gea Guiral, Joaquim (MDPI, 2019)

  Tumor recurrence is frequent and survival rates remain extremely low in lung adenocarcinoma (ADC). We hypothesize that carcinogenic factors will promote loco-regional modifications not only in the future tumor, but throughout ...
• Low childhood nature exposure is associated with worse mental health in adulthood

  Preuß, Myriam; Nieuwenhuijsen, Mark J.; Márquez, Sandra; Cirach, Marta; Dadvand, Payam; Triguero Mas, Margarita, 1985-; Gidlow, Christopher J.; Grazuleviciene, Regina; Kruize, Hanneke; Zijlema, Wilma (MDPI, 2019)

  Exposure to natural outdoor environments (NOE) is associated with health benefits; however, evidence on the impact of NOE exposure during childhood on mental health (MH) and vitality in adulthood is scarce. This study was ...
• Health benefits of physical activity related to an urban riverside regeneration

  Vert, Cristina; Nieuwenhuijsen, Mark J.; Gascon Merlos, Mireia, 1984-; Grellier, James; Fleming, Lora E.; White, Mathew P.; Rojas Rueda, David, 1979- (MDPI, 2019)

  The promotion of physical activity through better urban design is one pathway by which health and well-being improvements can be achieved. This study aimed to quantify health and health-related economic impacts associated ...

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