• SUMOylation of the brain-predominant Ataxin-3 isoform modulates its interaction with p97

  Almeida Cotrim, Bruno; Abreu, Isabel A.; Matos, Carlos A.; Fraga, Joana F.; Fernandes, Sara; Macedo, Maria G.; Gutiérrez Gallego, Ricardo, 1968-; Barbosa Pereira, Pedro José; Carvalho, Ana Luísa; Macedo Ribeiro, Sandra (Elsevier, 2015)

  BACKGROUND: Machado-Joseph Disease (MJD), a form of dominantly inherited ataxia belonging to the group of polyQ expansion neurodegenerative disorders, occurs when a threshold value for the number of glutamines in Ataxin-3 ...
• Analysis of the R1b-DF27 haplogroup shows that a large fraction of Iberian Y-chromosome lineages originated recently in situ

  Solé Morata, Neus; Villaescusa, Patricia; García-Fernández, Carla; Font-Porterias, Neus; Illescas, María José; Valverde, Laura; Tassi, Francesca; Ghirotto, Silvia; Férec, Claude; Rouault, Karen; Jiménez-Moreno, Susana; Martínez-Jarreta, Begoña; Pinheiro, María Fátima; Zarrabeitia, María T.; Carracedo, Ángel; Pancorbo, Marian M. de; Calafell i Majó, Francesc (Nature Publishing Group, 2017)

  Haplogroup R1b-M269 comprises most Western European Y chromosomes; of its main branches, R1b-DF27 is by far the least known, and it appears to be highly prevalent only in Iberia. We have genotyped 1072 R1b-DF27 chromosomes ...
• The functional impact of alternative splicing in cancer

  Climente González, Héctor; Porta-Pardo, Eduard; Godzik, Adam; Eyras Jiménez, Eduardo (Elsevier, 2017)

  Alternative splicing changes are frequently observed in cancer and are starting to be recognized as important signatures for tumor progression and therapy. However, their functional impact and relevance to tumorigenesis ...
• The myxobacterial metabolite soraphen A inhibits HIV-1 by reducing virus production and altering virion composition

  Fleta Soriano, Eric, 1983-; Smutna, Katarína; Martinez, Javier P; Lorca Oró, Cristina; Sadiq, S. Kashif; Mirambeau, Gilles; Lopez-Iglesias, Carmen; Bosch, Marta; Pol, Albert; Brönstrup, Mark; Díez Antón, Juana, 1962-; Meyerhans, Andreas (American Society for Microbiology, 2017)

  Soraphen A is a myxobacterial metabolite that blocks the acetyl-coenzyme A carboxylase of the host and was previously identified as a novel HIV inhibitor. Here, we report that soraphen A acts by reducing virus production ...
• Hippocampal protein kinase C signaling mediates the short-term memory impairment induced by delta9-tetrahydrocannabinol

  Busquets Garcia, Arnau, 1985-; Gomis González, Maria; Salgado Mendialdúa, Victòria; Galera López, Lorena; Puighermanal Puigvert, Emma, 1983-; Martín García, Elena, 1975-; Maldonado, Rafael, 1961-; Ozaita Mintegui, Andrés, 1969- (Nature Publishing Group, 2017)

  Cannabis affects cognitive performance through the activation of the endocannabinoid system, and the molecular mechanisms involved in this process are poorly understood. Using the novel object-recognition memory test in ...
• Provision of genetic services for autism and its impact on Spanish families

  Codina Solà, Marta; Pérez Jurado, Luis Alberto; Cuscó Martí, Ivon, 1973-; Serra Juhé, Clara, 1984- (Springer, 2017)

  Although a genetic evaluation can identify the etiology in 15-30% of individuals with autism spectrum disorder, several studies show an underuse of genetic services by affected families. We have explored the access to ...
• Impact of colistin plasma levels on the clinical outcome of patients with infections caused by extremely drug-resistant Pseudomonas aeruginosa

  Sorli Redó, M. Luisa; Luque Pardos, Sònia; Segura, Concepción; Campillo Ambrós, Núria; Montero , Maria Milagro; Esteve, Erika; Herrera, Sabina; Benito, Natividad; Álvarez Lerma, Francisco; Grau Cerrato, Santiago; Horcajada Gallego, Juan Pablo (BioMed Central, 2017)

  Background: Colistin has a narrow therapeutic window with nephrotoxicity being the major dose-limiting adverse effect. Currently, the optimal doses and therapeutic plasma levels are unknown. Methods: Prospective observational ...
• Reflection as a Deliberative and Distributed Practice: Assessing Neuro-Enhancement Technologies via Mutual Learning Exercises (MLEs)

  Zwart, Hub; Brenninkmeijer, Jonna; Eduard, Peter; Krabbenborg, Lotte; Laursen, Sheena; Revuelta, Gemma; Toonders, Winnie (SpringerOpen, 2017)

  In 1968, Jürgen Habermas claimed that, in an advanced technological society, the emancipatory force of knowledge can only be regained by actively recovering the ‘forgotten experience of reflection’. In this article, we ...
• Lack of a peroxiredoxin suppresses the lethality of cells devoid of electron donors by channelling electrons to oxidized ribonucleotide reductase

  Boronat i Llop, Susanna, 1965-; Domènech, Alba; Carmona, Mercè; García Santamarina, Sarela, 1978-; Bañó, M. Carmen; Ayté del Olmo, José; Hidalgo Hernando, Elena (Public Library of Science (PLoS), 2017)

  The thioredoxin and glutaredoxin pathways are responsible of recycling several enzymes which undergo intramolecular disulfide bond formation as part of their catalytic cycles such as the peroxide scavengers peroxiredoxins ...
• CYP3A genes and the association between prenatal methylmercury exposure and neurodevelopment

  Llop, Sabrina; Sunyer Deu, Jordi; Bustamante Pineda, Mariona; Broberg, Karin (Elsevier, 2017)

  Background: Results on the association between prenatal exposure to methylmercury (MeHg) and child neuropsychological development are heterogeneous. Underlying genetic differences across study populations could contribute ...
• Effect of exposure to polycyclic aromatic hydrocarbons on basal ganglia and attention-deficit hyperactivity disorder symptoms in primary school children

  Mortamais, Marion; Pujol Martí, Jesús, 1981-; van Drooge, Barend L.; Macià, Dídac; Martínez-Vilavella, Gerard; Reynes, Christelle; Sabatier, Robert; Rivas, Ioar; Grimalt Obrador, Joan; Forns i Guzman, Joan, 1981-; Álvarez Pedrerol, Mar, 1981-; Querol, Xavier; Sunyer Deu, Jordi (Elsevier, 2017)

  Background: Polycyclic aromatic hydrocarbons (PAHs) have been proposed as environmental risk factors for attention deficit hyperactivity disorder (ADHD). The effects of these pollutants on brain structures potentially ...
• Impact of monopolar radiofrequency coagulation on intraoperative blood loss during liver resection: a prospective randomised controlled trial

  Quesada Diez, Rita; Poves Prim, José Ignacio; Berjano, Enrique J.; Vilaplana, Carles; Andaluz, Anna; Moll, Xavier; Dorcaratto, Dimitri; Grande Posa, Luís; Burdío Pinilla, Fernando (Taylor & Francis (Routledge), 2017)

  PURPOSE: To evaluate the impact of using monopolar thermal coagulation based on radiofrequency (RF) currents on intraoperative blood loss during liver resection. MATERIALS AND METHODS: A prospective randomised controlled ...
• Indicadores contextuales para evaluar los determinantes sociales de la salud y la crisis económica española

  Cabrera-León, Andrés; Daponte, Antonio; Mateo, Inmaculada; Arroyo-Borrell, Elena; Bartoll, Xavier; Bravo, María José; Domínguez-Berjón, María Felicitas; Renart, Gemma; Álvarez-Dardet, Carlos; Marí Dell'Olmo, Marc, 1978-; Bolívar Muñoz, Julia; Saez, Marc; Escribà-Agüir, Vicenta; Palència Fernàndez, Laia; López, María José; Saurina, Carme; Puig i Barrachina, Vanessa, 1980-; Martín, Unai; Gotsens Miquel, Mercè, 1983-; Borrell i Thió, Carme; Serra Saurina, Laura; Sordo, Luis; Bacigalupe, Amaia; Rodríguez Sanz, Maica; Pérez Albarracín, Glòria; Espelt Hernández, Albert, 1981-; Ruiz-Canela, Miguel; Bernal, Mariola (Elsevier, 2017)

  Objetivo: Proporcionar indicadores para evaluar, en España y en sus comunidades autónomas, el impacto sobre la salud, sus determinantes sociales y las desigualdades en salud del contexto social y de la crisis económica más ...
• Deciphering the role of the signal- and Sty1 kinase-dependent phosphorylation of the stress-responsive transcription factor Atf1 on gene activation

  Salat Canela, Clàudia; Paulo Mirasol, Esther, 1984-; Sánchez Mir, Laura; Carmona, Mercè; Ayté del Olmo, José; Oliva Miguel, Baldomero; Hidalgo Hernando, Elena (American Society for Biochemistry and Molecular Biology (ASBMB), 2017)

  Adaptation to stress triggers the most dramatic shift in gene expression in fission yeast (Schizosaccharomyces pombe), and this response is driven by signaling via the MAPK Sty1. Upon activation, Sty1 accumulates in the ...
• New Potent Membrane-Targeting Antibacterial Peptides from Viral Capsid Proteins

  Dias, Susana A.; Freire, Joao Miguel; Pérez-Peinado, Clara; Domingues, Marco M.; Gaspar, Diana; Vale, Nuno; Gomes, Paula; Andreu Martínez, David; Henriques, Sónia T.; Castanho, Miguel A.R.B.; Veiga, Ana Salomé (Frontiers, 2017)

  The increasing prevalence of multidrug-resistant bacteria urges the development of new antibacterial agents. With a broad spectrum activity, antimicrobial peptides have been considered potential antibacterial drug leads. ...
• The role of alternative splicing in cancer

  Singh, Babita; Eyras Jiménez, Eduardo (Taylor & Francis (Routledge), 2017)

  The functional capacity of cells is defined by the transcriptome. Many recent studies have identified variations in the transcriptome of tumors due to alternative splicing changes, as well as mutations in splicing factors ...
• Using Electronic Health Records to Assess Depression and Cancer Comorbidities

  Mayer, Miguel Ángel, 1960-; Gutiérrez Sacristán, Alba; Leis Machin, Angela; De La Peña, Santiago; Sanz, Ferran; Furlong, Laura I., 1971- (IOS Press, 2017)

  Comorbid diseases are an important concern in oncology since they can affect the choice and effectiveness of treatment. What is particularly relevant is the fact that the diagnosis of depression in cancer patients has an ...
• Sculpting the labyrinth: Morphogenesis of the developing inner ear

  Alsina i Español, Berta; Whitfield, Tanya T. (Elsevier, 2017)

  The vertebrate inner ear is a precision sensory organ, acting as both a microphone to receive sound and an accelerometer to detect gravity and motion. It consists of a series of interlinked, fluid-filled chambers containing ...
• Sulfate metabolites as alternative markers for the detection of 4-chlorometandienone misuse in doping control

  Balcells Aribau, Georgina, 1987-; Gómez, Cristina; Garrostas, Lorena; Pozo Mendoza, Óscar J., 1975-; Ventura Alemany, Rosa (Wiley, 2016)

  Sulfate metabolites have been described as long-term metabolites for some anabolic androgenic steroids (AAS). 4-chlorometandienone (4Cl-MTD) is one of the most frequently detected AAS in sports drug testing and it is ...
• Hypofractionated boost after whole breast irradiation in breast carcinoma: chronic toxicity results and cosmesis

  Sanz Latiesas, Javier, 1967-; Rodríguez, Nuria; Foro Arnalot, Palmira; Dengra, Josefa; Reig, Anna; Pérez, Paula; Membrive, Ismael; Ortiz, Ana; Codinach, Maria; Algara López, Manuel-Ignacio (Springer, 2017)

  PURPOSE: To evaluate the impact of hypofractionated boost after hypofractionated whole breast irradiation in breast carcinoma. METHODS AND MATERIALS: Patients after breast conservative surgery were treated all time with ...

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