• La investigación responsable en los estudios de audiencia y recepción

  Figueras Maz, Mònica; Gómez Puertas, Lorena, 1978-; Revuelta, Gemma (Universidad Nacional de Educación a Distancia (UNED), 2019)

  La investigación responsable incluye, más allá de la ética en el contenido y el proceso, la implicación de múltiples actores y público, un acceso más fácil a los resultados científicos, la perspectiva de género, y la ...
• Impact of the Spanish smoking legislation among smokers: a longitudinal study with biomarkers in Barcelona (Spain)

  Lidón-Moyano, Cristina; Fu, Marcela; Pérez-Ortuño, Raúl; Ballbé, Montse; Feliu, Ariadna; Martín-Sánchez, Juan Carlos; Pascual Esteban, José A.; Fernández, Esteve; Martínez-Sánchez, Jose M. (Elsevier, 2018)

  BACKGROUND: The aim of this study is to assess the impact of the Spanish tobacco control legislation on smoking behavior and salivary cotinine concentration among smokers. METHODS: We used data from a longitudinal study, ...
• Stress response, behavior, and development are shaped by transposable element-induced mutations in Drosophila

  Rech, Gabriel E.; Bogaerts Márquez, María; Barrón, Maite G.; Merenciano, Miriam; Villanueva Cañas, José Luis, 1984-; Horváth, Vivien; Fiston Lavier, Anna Sophie; Luyten, Isabelle; Venkataram, Sandeep; Quesneville, Hadi; Petrov, Dmitri A.; González, Josefa (Public Library of Science (PLoS), 2019)

  Most of the current knowledge on the genetic basis of adaptive evolution is based on the analysis of single nucleotide polymorphisms (SNPs). Despite increasing evidence for their causal role, the contribution of structural ...
• Skeletal anomalies in the neandertal family of El Sidrón (Spain) support a role of inbreeding in neandertal extinction.

  Ríos, Luis; Kivell, Tracy L.; Lalueza Fox, Carles, 1965-; Estalrrich, Almudena; García-Tabernero, Antonio; Huguet, Rosa; Quintino, Yuliet; Rosas, Antonio (Nature Research, 2019)

  Neandertals disappeared from the fossil record around 40,000 bp, after a demographic history of small and isolated groups with high but variable levels of inbreeding, and episodes of interbreeding with other Paleolithic ...
• The longitudinal association between natural outdoor environments and mortality in 9218 older men from Perth, Western Australia

  Zijlema, Wilma; Stasinska, Ania; Blake, David; Dirgawati, Mila; Flicker, Leon; Yeap, Bu B.; Golledge, Jonathan; Hankey, Graeme J.; Nieuwenhuijsen, Mark J.; Heyworth, Jane (Elsevier, 2019)

  Background/Aim: Natural outdoor environments may mitigate harmful environmental factors associated with city living. We studied the longitudinal relationship between natural (‘green and blue’) outdoor environments and ...
• Maternal body mass index, gestational weight gain, and the risk of overweight and obesity across childhood: An individual participant data meta-analysis

  Voerman, Ellis; Vrijheid, Martine; Jaddoe, Vincent W. V. (Public Library of Science (PLoS), 2019)

  Background: Maternal obesity and excessive gestational weight gain may have persistent effects on offspring fat development. However, it remains unclear whether these effects differ by severity of obesity, and whether these ...
• Early-life exposome and lung function in children in Europe: an analysis of data from the longitudinal, population-based HELIX cohort

  Agier, Lydiane; Basagaña Flores, Xavier; Maitre, Léa; Casas Sanahuja, Maribel; de Castro, Montserrat; Donaire González, David; Nieuwenhuijsen, Mark J.; Robinson, Oliver; Sunyer Deu, Jordi; Tamayo-Uria, Ibon; Urquiza, José M.; Valentín, Antònia; Vrijheid, Martine; Siroux, Valérie (Elsevier, 2019)

  Background: Several single-exposure studies have documented possible effects of environmental factors on lung function, but none has relied on an exposome approach. We aimed to evaluate the association between a broad range ...
• People from Ibiza: an unexpected isolate in the Western Mediterranean

  Biagini, Simone Andrea; Solé Morata, Neus, 1988-; Matisso-Smith, Elizabeth; Zalloua, Pierre A.; Comas, David, 1969-; Calafell i Majó, Francesc (Springer, 2019)

  In this study, we seek to understand and to correlate the genetic patterns observed in the population of the island of Ibiza in the Western Mediterranean basin with past events. Genome-wide genotypes of 189 samples ...
• Oral fluid testing: promises and pitfalls

  Huestis, Marylin A.; Verstraete, Alain; Kwong, Tai C.; Morland, Jorg; Vincent, Michael J.; Torre Fornell, Rafael de la (American Association for Clinical Chemistry, 2011)

  Oral fluid is a promising new matrix for drug-testing programs for drug treatment, the workplace, pain management, and driving under the influence of drugs (DUID)7. As with any new technology, there are strengths and ...
• High and low suicidality in Europe: a fine-grained comparison of France and Spain within the ESEMeD surveys

  Kovess, Viviane; Boyd, Anders; Haro Abad, Josep Maria; Bruffaerts, Ronny; Vilagut Saiz, Gemma, 1975-; Lépine, Jean-Pierre; Gasquet, Isabelle; Alonso Caballero, Jordi (Elsevier, 2011)

  BACKGROUND: Suicidality risk-factors between countries with similar economic and religious background have been rarely compared, especially within genders. METHODS: Lifetime prevalence of suicide ideation, plans, and ...
• Comorbidity and disease burden in the National Comorbidity Survey Replication (NCS-R)

  Gadermann, Anne M.; Alonso Caballero, Jordi; Vilagut Saiz, Gemma, 1975-; Zaslavsky, Alan M.; Kessler, Ronald C. (Wiley-VCH Verlag, 2012)

  BACKGROUND: Disease burden estimates rarely consider comorbidity. Using a recently developed methodology for integrating information about comorbidity into disease burden estimates, we examined the comparative burdens of ...
• A SNAIL1-SMAD3/4 transcriptional repressor complex promotes TGF-beta mediated epithelial-mesenchymal transition

  Vincent, Theresa; Neve, Etienne P.A.; Johnson, Jill R.; Kukalev, Alexander; Rojo, Federico; Albanell Mestres, Joan; Pietras, Kristian; Virtanen, Ismo; Philipson, Lennart; Leopold, Philip L.; Crystal, Ronald G.; García de Herreros, Antonio; Moustakas, Aristidis; Petterson, Ralf F.; Fuxe, Jonas (Nature Research, 2009)

  Epithelial-mesenchymal transition (EMT) is essential for organogenesis and is triggered during carcinoma progression to an invasive state. Transforming growth factor-beta (TGF-beta) cooperates with signalling pathways, ...
• Neurobiological mechanisms involved in nicotine dependence and reward: participation of the endogenous opioid system

  Berrendero Díaz, Fernando, 1971-; Robledo, Patricia, 1958-; Trigo i Rodríguez, Josep M.; Martín García, Elena, 1975-; Maldonado, Rafael, 1961- (Elsevier, 2010)

  Nicotine is the primary component of tobacco that maintains the smoking habit and develops addiction. The adaptive changes of nicotinic acetylcholine receptors produced by repeated exposure to nicotine play a crucial role ...
• Network, transcriptomic and genomic features differentiate genes relevant for drug response

  Piñero González, Janet, 1977-; Gonzalez-Perez, Abel; Guney, Emre; Aguirre Plans, Joaquim; Sanz, Ferran; Oliva Miguel, Baldomero; Furlong, Laura I., 1971- (Frontiers, 2018)

  Understanding the mechanisms underlying drug therapeutic action and toxicity is crucial for the prevention and management of drug adverse reactions, and paves the way for a more efficient and rational drug design. The ...
• A single nucleotide polymorphism tags variation in the arylamine N-acetyltransferase 2 phenotype in populations of European background

  García Closas, Montserrat; Hein, David W.; Silverman, Debra T.; Malats i Riera, Núria; Yeager, Meredith; Jacobs, Kevin; Doll, Mark A.; Figueroa, Jonine D.; Baris, Dalsu; Schwenn, Molly; Kogevinas, Manolis; Johnson, Alison; Chatterjee, Nilanjan; Moore, Lee E.; Moeller, Timothy; Real, Francisco X.; Chanock, Stephen J.; Rothman, Nathaniel (Lippincott Williams & Wilkins, 2011)

  The arylamine N-acetyltransferase 2 (NAT2) slow acetylation phenotype is an established risk factor for urinary bladder cancer. We reported earlier on this risk association using NAT2 phenotypic categories inferred from ...
• A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci

  Rothman, Nathaniel; Real, Francisco X.; Serra, Consol; Lloreta Trull, Josep, 1958-; Chanock, Stephen J. (Nature Research, 2010)

  We conducted a multi-stage, genome-wide association study of bladder cancer with a primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of European descent from five studies followed by a ...
• International network of cancer genome projects

  The International Cancer Genome Consortium (Nature Research, 2010)

  The International Cancer Genome Consortium (ICGC) was launched to coordinate large-scale cancer genome studies in tumours from 50 different cancer types and/or subtypes that are of clinical and societal importance across ...
• Power and sample size calculations for longitudinal studies comparing rates of change with a time-varying exposure

  Basagaña Flores, Xavier; Liao, Xiaomei; Spiegelman, Donna (Wiley-VCH Verlag, 2010)

  Existing study design formulas for longitudinal studies assume that the exposure is time invariant or that it varies in a manner that is controlled by design. However, in observational studies, the investigator does not ...
• Socioeconomic inequalities in the use of dental care services in Europe: what is the role of public coverage?

  Palència Fernàndez, Laia; Espelt Hernández, Albert, 1981-; Cornejo Ovalle, Marco, 1969-; Borrell i Thió, Carme (Wiley-VCH Verlag, 2014)

  OBJECTIVES: The aim of this study was to analyse inequalities in the use of dental care services according to socioeconomic position (SEP) in individuals aged ≥50 years in European countries in 2006, to examine the association ...
• Power and sample size calculations for longitudinal studies estimating a main effect of a time-varying exposure

  Basagaña Flores, Xavier; Spiegelman, Donna (SAGE Publications, 2011)

  Existing study design formulas for longitudinal studies have assumed that the exposure is time-invariant. We derived sample size formulas for studies comparing rates of change by exposure when the exposure varies with time ...

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