• Mountain gorilla genomes reveal the impact of long-term population decline and inbreeding

  Xue, Yali; Prado Martínez, Javier, 1987-; de Manuel, Marc; Hernández Rodríguez, Jéssica, 1983-; Lobón, Irene; Marquès i Bonet, Tomàs, 1975-; Scally, Aylwyn (American Association for the Advancement of Science (AAAS), 2015)

  Mountain gorillas are an endangered great ape subspecies and a prominent focus for conservation, yet we know little about their genomic diversity and evolutionary past. We sequenced whole genomes from multiple wild individuals ...
• Membrane protein structure, function, and dynamics: a perspective from experiments and theory

  Cournia, Zoe; Selent, Jana; Bondar, Ana-Nicoleta (Springer, 2015)

  Membrane proteins mediate processes that are fundamental for the flourishing of biological cells. Membrane-embedded transporters move ions and larger solutes across membranes; receptors mediate communication between the ...
• The Genome 10K Project: a way forward

  Koepfli, Klaus-Peter; Paten, Benedict; Genome 10K Community of Scientists; O'Brien, Stephen J.; Marquès i Bonet, Tomàs, 1975- (Annual Reviews Inc, 2015)

  The Genome 10K Project was established in 2009 by a consortium of biologists and genome scientists determined to facilitate the sequencing and analysis of the complete genomes of 10,000 vertebrate species. Since then the ...
• Ion channels enable electrical communication in bacterial communities

  Prindle, Arthur; Liu, Jintao; Asally, Munehiro; Ly, San; Garcia Ojalvo, Jordi; Süel, Gürol M. (Nature Research, 2015)

  The study of bacterial ion channels has provided fundamental insights into the structural basis of neuronal signalling; however, the native role of ion channels in bacteria has remained elusive. Here we show that ion ...
• When are robots intelligent autonomous agents?

  Steels, Luc (Elsevier, 1995)

  The paper explores a biologically inspired definition of intelligent autonomous agents. Intelligence is related to whether behavior of a system contributes to its self-maintenance. Behavior becomes more intelligent (or ...
• The epidemiology of traumatic event exposure worldwide: results from the World Mental Health Survey Consortium

  Benjet, Corina; Alonso Caballero, Jordi; Koenen, Karestan C. (Cambridge University Press, 2016)

  BACKGROUND: Considerable research has documented that exposure to traumatic events has negative effects on physical and mental health. Much less research has examined the predictors of traumatic event exposure. Increased ...
• Ancient gene flow from early modern humans into Eastern Neanderthals

  Kuhlwilm, Martin; Prado Martínez, Javier, 1987-; Lalueza Fox, Carles, 1965-; Marquès i Bonet, Tomàs, 1975-; Castellano Hereza, Sergi (Nature Research, 2016)

  It has been shown that Neanderthals contributed genetically to modern humans outside Africa 47,000-65,000 years ago. Here we analyse the genomes of a Neanderthal and a Denisovan from the Altai Mountains in Siberia together ...
• Pathway and network analysis of cancer genomes

  Creixell, Pau; Gonzalez-Perez, Abel; López Bigas, Núria; Mutation Consequences and Pathway Analysis Working Group of the International Cancer Genome Consortium (Nature Research, 2015)

  Genomic information on tumors from 50 cancer types cataloged by the International Cancer Genome Consortium (ICGC) shows that only a few well-studied driver genes are frequently mutated, in contrast to many infrequently ...
• Circulating miRNAs, isomiRs and small RNA clusters in human plasma and breast milk

  Rubio Martínez, Mercedes, 1980-; Bustamante Pineda, Mariona; Hernandez-Ferrer, Carles, 1987-; Fernández-Orth, Dietmar; Pantano Rubiño, Lorena, 1982-; Sarria-Trujillo, Yaris; Piqué-Borras, Maria; Vellve del Amo, Kilian; Agramunt, Silvia; Carreras Collado, Ramón; Estivill, Xavier, 1955-; González Ruiz, Juan Ramón; Mayor, Alfredo (Public Library of Science (PLoS), 2018)

  Circulating small RNAs, including miRNAs but also isomiRs and other RNA species, have the potential to be used as non-invasive biomarkers for communicable and non-communicable diseases. This study aims to characterize and ...
• Socioeconomic inequalities in injury mortality in small areas of 15 European cities

  Gotsens, Mercè; Marí-Dell'Olmo, Marc; Pérez, Katherine; Palència, Laia; Martinez-Beneito, Miguel-Angel; Rodríguez-Sanz, Maica; Burström, Bo; Costa, Giuseppe; Deboosere, Patrick; Domínguez-Berjón, Felicitas; Dzúrová, Dagmar; Gandarillas, Ana; Hoffmann, Rasmus; Kovacs, Katalin; Marinacci, Chiara; Martikainen, Pekka; Pikhart, Hynek; Rosicova, Katarina; Saez, Marc; Santana, Paula; Riegelnig, Judith; Schwierz, Cornelia; Tarkiainen, Lasse; Borrell i Thió, Carme (Elsevier, 2013)

  This study analysed socioeconomic inequalities in mortality due to injuries in small areas of 15 European cities, by sex, at the beginning of this century. A cross-sectional ecological study with units of analysis being ...
• Head-to-head comparison between the EQ-5D-5L and the EQ-5D-3L in general population health surveys

  Martí-Pastor, Marc; Pont, Àngels; Ávila, Mónica; Garin Boronat, Olatz, 1979-; Vilagut Saiz, Gemma, 1975-; Forero, Carlos G.; Pardo Cladellas, Yolanda; Tresserras i Gaju, Ricard, 1957-; Medina-Bustos, Antonia; Garcia-Codina, Oriol; Cabasés, Juan; Rajmil Rajmil, Luis Alberto; Alonso Caballero, Jordi; Ferrer Forés, Maria Montserrat (BioMed Central, 2018)

  Background: The EQ-5D has been frequently used in national health surveys. This study is a head-to-head comparison to assess how expanding the number of levels from three (EQ-5D-3L) to five in the new EQ-5D-5L version has ...
• Concomitant THC and stress adolescent exposure induces impaired fear extinction and related neurobiological changes in adulthood

  Saravia, Rocío; Ten-Blanco, Marc; Julià Hernández, Marina; Gagliano, Humberto; Andero, Raül; Armario García, Antonio; Maldonado, Rafael, 1961-; Berrendero Díaz, Fernando, 1971- (Elsevier, 2019)

  Δ9-tetrahydrocannabinol (THC) consumption during adolescence is reported to be a risk factor for the appearance of psychiatric disorders later in life. The interaction between genetic or environmental events and cannabinoid ...
• Anti-inflammatory agents for smoking cessation? Focus on cognitive deficits associated with nicotine withdrawal in male mice

  Saravia, Rocío; Ten-Blanco, Marc; Grande, María T.; Maldonado, Rafael, 1961-; Berrendero Díaz, Fernando, 1971- (Elsevier, 2019)

  Nicotine withdrawal is associated with cognitive deficits including attention, working memory, and episodic memory impairments. These cognitive deficits are a hallmark of nicotine abstinence which could be targeted in order ...
• Soluble guanylate cyclase stimulation reduces oxidative stress in experimental Chronic Obstructive Pulmonary Disease

  Paul, Tanja; Salazar Degracia, Anna; Peinado, Victor I.; Tura-Ceide, Olga; Blanco, Isabel; Barreiro Portela, Esther; Barberà, Joan Albert (Public Library of Science (PLoS), 2018)

  OBJECTIVE: Soluble guanylate cyclase (sGC) is a key enzyme of the nitric oxide-cyclic guanosine 3',5'-monophosphate (NO-cGMP) signaling pathway, and its pharmacological stimulation has been shown to prevent the development ...
• Virulence genes and subclone status as markers of experimental virulence in a murine sepsis model among Escherichia coli sequence type 131 clinical isolates from Spain

  Merino, Irene; Porter, Stephen B.; Johnston, Brian D.; Clabots, Connie; Shaw, Evelyn; Horcajada Gallego, Juan Pablo; Cantón, Rafael; Ruiz-Garbajosa, Patricia; Johnson, James R.; ITUBRAS-GEIH group (Public Library of Science (PLoS), 2017)

  OBJECTIVE: To assess experimental virulence among sequence type 131 (ST131) Escherichia coli bloodstream isolates in relation to virulence genotype and subclone. METHODS: We analysed 48 Spanish ST131 bloodstream isolates ...
• Degenerate time-dependent network dynamics anticipate seizures in human epileptic brain

  Tauste Campo, Adrià; Principe, Alessandro; Ley Nacher, Miguel; Rocamora Zúñiga, Rodrigo Alberto; Deco, Gustavo (Public Library of Science (PLoS), 2018)

  Epileptic seizures are known to follow specific changes in brain dynamics. While some algorithms can nowadays robustly detect these changes, a clear understanding of the mechanism by which these alterations occur and ...
• Formoterol attenuates increased oxidative stress and myosin protein loss in respiratory and limb muscles of cancer cachectic rats

  Salazar Degracia, Anna; Busquets, Silvia; Argilés, Josep M.; López Soriano, Francisco J.; Barreiro Portela, Esther (PeerJ Inc., 2017)

  Muscle mass loss and wasting are characteristic features of patients with chronic conditions including cancer. Therapeutic options are still scarce. We hypothesized that cachexia-induced muscle oxidative stress may be ...
• Neolithic mitochondrial haplogroup H genomes and the genetic origins of Europeans

  Brotherton, Paul; Cooper, Alan; Genographic Consortium; Bertranpetit, Jaume, 1952-; Comas, David, 1969-; Martínez Cruz, Begoña; Mele, Marta (Nature Research, 2013)

  Haplogroup H dominates present-day Western European mitochondrial DNA variability (>40%), yet was less common (~19%) among Early Neolithic farmers (~5450 BC) and virtually absent in Mesolithic hunter-gatherers. Here we ...
• Ancient human genomes suggest three ancestral populations for present-day Europeans

  Lazaridis, Iosif; Krause, Johannes; Comas, David, 1969- (Nature Research, 2014)

  We sequenced the genomes of a ∼7,000-year-old farmer from Germany and eight ∼8,000-year-old hunter-gatherers from Luxembourg and Sweden. We analysed these and other ancient genomes with 2,345 contemporary humans to show ...
• Global diversity, population stratification, and selection of human copy-number variation

  Sudmant, Peter H.; Eichler, Evan E.; Comas, David, 1969- (American Association for the Advancement of Science (AAAS), 2015)

  In order to explore the diversity and selective signatures of duplication and deletion human copy-number variants (CNVs), we sequenced 236 individuals from 125 distinct human populations. We observed that duplications ...

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