• DIA+: a data-independent acquisition method combining multiple precursor charges to improve peptide signal

  Borràs, Eva; Sabido Aguade, Eduard (American Chemical Society (ACS), 2018)

  Data-independent acquisition methods that acquire fragment ions from virtually any peptide in a sample have expanded the benefits of low-throughput targeted proteomics to proteome-wide analyses. While these methods have ...
• Sudemycin K: a synthetic antitumor splicing inhibitor variant with improved activity and versatile chemistry

  Makowski, Kamil; Vigevani, Luisa, 1985-; Albericio, Fernando; Valcárcel, J. (Juan); Álvarez, Mercedes (American Chemical Society (ACS), 2017)

  Important links exist between the process of pre-mRNA splicing and cancer, as illustrated by the frequent mutation of splicing factors in tumors and the emergence of various families of antitumor drugs that target components ...
• Adherencia al seguimiento de las personas con adenoma de alto riesgo diagnosticadas y excluidas del Programa de detección precoz de cáncer de colon y recto de Barcelona

  Otero Hernández, Isabel; Buron Pust, Andrea; Macià Guila, Francesc; Álvarez-Urturi, Cristina; Comas Serrano, Mercè; Román, Marta; Castells, Xavier (Elsevier, 2018)

  INTRODUCTION: Colorectal cancer screening programmes have been shown to reduce incidence and mortality. High-risk adenomas (HRA) are the most frequently diagnosed lesions in these programmes, and these patients are referred ...
• The Morphospace of language networks

  Seoane, Luís F., 1985-; Solé Vicente, Ricard, 1962- (Nature Publishing Group, 2018)

  What is the nature of language? How has it evolved in different species? Are there qualitative, well-defined classes of languages? Most studies of language evolution deal in a way or another with such theoretical contraption ...
• COSMIN methodology for evaluating the content validity of patient-reported outcome measures: a Delphi study

  Terwee, Caroline B.; Prinsen, Cecilia A.C.; Chiarotto, A.; Westerman, M. J.; Patrick, Donald L.; Alonso Caballero, Jordi; Bouter, Lex M.; De Vet, Henrica C. W.; Mokkink, Lidwine B. (Springer, 2018)

  Background: Content validity is the most important measurement property of a patient-reported outcome measure (PROM) and the most challenging to assess. Our aims were to: (1) develop standards for evaluating the quality ...
• COSMIN guideline for systematic reviews of patient-reported outcome measures

  Prinsen, Cecilia A.C.; Mokkink, Lidwine B.; Bouter, Lex M.; Alonso Caballero, Jordi; Patrick, Donald L.; De Vet, Henrica C. W.; Terwee, Caroline B. (Springer, 2018)

  Purpose: Systematic reviews of patient-reported outcome measures (PROMs) differ from reviews of interventions and diagnostic test accuracy studies and are complex. In fact, conducting a review of one or more PROMs comprises ...
• Balancing mesh-related complications and benefits in primary ventral and incisional hernia surgery. A meta-analysis and trial sequential analysis

  López-Cano, Manuel; Martin Dominguez, Lidia A.; Pereira Rodríguez, José Antonio; Armengol-Carrasco, Manuel; García-Alamino, Josep M. (Public Library of Science (PLoS), 2018)

  Background: Primary ventral hernia (PVH) and incisional hernia (IH) repair using a mesh appears to reduce hernia recurrence. However, are the benefits of mesh offset in part by mesh-related complications? The aim of this ...
• Genetic alterations in the molecular subtypes of bladder cancer: illustration in the cancer genome atlas dataset

  Choi, Woonyoung; Ochoa, Andrea; McConkey, David; Aine, Mattias; Höglund, Mattias; Kim, William Y.; Real, Francisco X.; Kiltie, Anne E.; Milsom, Ian; Dyrskjot, Lars; Lerner, Seth (Elsevier, 2017)

  CONTEXT: Recent whole genome mRNA expression profiling studies revealed that bladder cancers can be grouped into molecular subtypes, some of which share clinical properties and gene expression patterns with the intrinsic ...
• The association between psychotic experiences and disability: results from the WHO World Mental Health Surveys

  Navarro Mateu, Fernando; Alonso Caballero, Jordi; Saha, S.; Aguilar Gaxiola, Sergio; Al-Hamzawi, Ali; Andrade, Laura Helena; Bromet, Evelyn J.; Bruffaerts, Ronny; Chatterji, Somnath; Degenhardt, L.; Girolamo, Giovanni de; Jonge, Peter de; Fayyad, J.; Florescu, Silvia; Gureje, Oye; Haro Abad, Josep Maria; Hu, Chiyi; Karam, Elie G.; Kovess, Viviane; Lee, Sing; Medina Mora, Maria Elena; Ojagbemi, A.; Pennell, Beth-Ellen; Piazza, Marina; Posada Villa, José; Scott, Kate M.; Stagnaro, J. C.; Xavier, Miguel; Kendler, K. S.; Kessler, Ronald C.; McGrath, John J.; Lim, Carmen (Wiley, 2017)

  OBJECTIVE: While psychotic experiences (PEs) are known to be associated with a range of mental and general medical disorders, little is known about the association between PEs and measures of disability. We aimed to ...
• Time trends in health inequalities due to care in the context of the Spanish Dependency Law

  Salvador-Piedrafita, Maria; Malmusi, Davide, 1980-; Borrell i Thió, Carme (Elsevier, 2017)

  OBJECTIVE: In Spain, responsibility for care of old people and those in situations of dependency is assumed by families, and has an unequal social distribution according to gender and socioeconomic level. This responsibility ...
• Selective Mesh Augmentation to Prevent Incisional Hernias in Open Colorectal Surgery Is Safe and Cost-Effective

  Argudo Aguirre, Nuria; Pera, Miguel; López-Cano, Manuel; Hernández Martínez, Lourdes; Sancho, Juan José; Grande Posa, Luís; Pereira Rodríguez, José Antonio (Frontiers, 2018)
• Parastomal Hernia Prevention With Mesh in the Context of Laparoscopic Approach: An Opinion Based on Current Literature

  López-Cano, Manuel; Pereira Rodríguez, José Antonio (Frontiers, 2018)
• Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9

  Niu, Dong; Wei, Hong-Jiang; Lin, Lin; George, Haydy; Wang, Tao; Lee, I-Hsiu; Zhao, Hong-Ye; Wang, Yong; Kan, Yinan; Shrock, Ellen; Lesha, Emal; Wang, Gang; Luo, Yonglun; Qing, Yubo; Jiao, Deling; Zhao, Heng; Zhou, Xiaoyang; Wang, Shouqi; Wei, Hong; Güell Cargol, Marc; Wei, Hong; Church, George M.; Yang, Luhan (American Association for the Advancement of Science (AAAS), 2017)

  Xenotransplantation is a promising strategy to alleviate the shortage of organs for human transplantation. In addition to the concerns about pig-to-human immunological compatibility, the risk of cross-species transmission ...
• Coupling between distant biofilms and emergence of nutrient time-sharing

  Liu, Jintao; Martínez Corral, Rosa; Prindle, Arthur; Lee, Dong-yeon D.; Larkin, Joseph; Gabaldà Sagarra, Marçal,1988-; Garcia Ojalvo, Jordi; Süel, Gürol M. (American Association for the Advancement of Science (AAAS), 2017)

  Bacteria within communities can interact to organize their behavior. It has been unclear whether such interactions can extend beyond a single community to coordinate the behavior of distant populations. We discovered that ...
• Behavioral profiles of children with Williams syndrome from Spain and the United States: cross-cultural similarities and differences

  Pérez García, Débora, 1985-; Brun i Gasca, Carme; Pérez Jurado, Luis Alberto; Mervis, Carolyn B. (Editor de càrregaAmerican Association on Intellectual and Developmental Disabilities (AAIDD), 2017)

  To identify similarities and differences in the behavioral profile of children with Williams syndrome from Spain (n = 53) and the United States (n = 145), we asked parents of 6- to 14-year-olds with Williams syndrome to ...
• Impact of asthma on women and men: comparison with the general population using the EQ-5D-5L questionnaire

  Hernández, Gimena; Dima, Alexandra L.; Pont, Àngels; Garin Boronat, Olatz, 1979-; Martí-Pastor, Marc; Alonso Caballero, Jordi; Van Ganse, Eric; Laforest, Laurent; Bruin, Marijn de; Mayoral, Karina; Ferrer Forés, Maria Montserrat; ASTRO-LAB group (Public Library of Science (PLoS), 2018)

  Background: The aim was to evaluate the impact of asthma on patients’ Health-Related Quality of Life (HRQoL) by comparing asthmatic women and men with reference norms, to examine the factors which contributed to an impaired ...
• In Silico QT and APD prolongation assay for early screening of drug-induced proarrhythmic risk

  Romero, Lucia; Cano, Jordi; Gomis-Tena, Julio; Trenor, Beatriz; Sanz, Ferran; Pastor Maeso, Manuel; Saiz, Javier (American Chemical Society (ACS), 2018)

  Drug-induced proarrhythmicity is a major concern for regulators and pharmaceutical companies. For novel drug candidates, the standard assessment involves the evaluation of the potassium hERG channels block and the in vivo ...
• Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics

  Barbeira, Alvaro N.; Dickinson, Scott P.; Bonazzola, Rodrigo; Zheng, Jiamao; Wheeler, Heather E.; Torres, Jason M.; Torstenson, Eric S.; Shah Kaanan P.; Garcia, Tzintzuni; Edwards, Todd L.; Stahl, Eli A.; Huckins, Laura M.; GTEx Consortium; Nicolae, Dan L.; Cox, Nancy J.; Im, Hae Kyung (Nature Publishing Group, 2018)

  Scalable, integrative methods to understand mechanisms that link genetic variants with phenotypes are needed. Here we derive a mathematical expression to compute PrediXcan (a gene mapping approach) results using summary ...
• Health-related quality of life inequalities by sexual orientation: results from the Barcelona health interview survey

  Martí-Pastor, Marc; Pérez Albarracín, Glòria; German, Danielle; Pont Acuña, Àngels; Garin Boronat, Olatz, 1979-; Alonso Caballero, Jordi; Gotsens Miquel, Mercè, 1983-; Ferrer Forés, Maria Montserrat (Public Library of Science (PLoS), 2018)

  Background: Studies on health-related quality of life (HRQoL) inequalities according to sexual orientation are scarce. The aim of this study was to assess HRQoL inequalities between lesbian, gay, and bisexual (LGB) people ...
• Effects of virgin olive oils differing in their bioactive compound contents on metabolic syndrome and endothelial functional risk biomarkers in healthy adults: a randomized double-blind controlled trial

  Sánchez-Rodriguez, Estefanía; Lima-Cabello, Elena; Biel-Glesson, Sara; Fernández-Navarro, Jose-Ramón; Calleja, Miguel Angel; Roca Bigorra, Maria; Espejo-Calvo, Juan A.; Gil-Extremera, Blas; Soria-Florido, Maria; Torre Fornell, Rafael de la; Fitó Colomer, Montserrat; Covas Planells, Maria Isabel; Alche, Juan de Dios; Martínez de Victoria, Emilio; Gil, Angel; Mesa, Maria-Dolores (MDPI, 2018)

  The aim of this study was to evaluate the effect of virgin olive oils (VOOs) enriched with phenolic compounds and triterpenes on metabolic syndrome and endothelial function biomarkers in healthy adults. The trial was a ...

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