CSDE1: a versatile regulator of gene expression in cancer

Ciocia, Annagiulia; Mestre Farràs, Neus; Vicent Nacht, Ignacio; Guitart, Tanit; Gebauer, Fátima

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dc.contributor.author	Ciocia, Annagiulia
dc.contributor.author	Mestre Farràs, Neus
dc.contributor.author	Vicent Nacht, Ignacio
dc.contributor.author	Guitart, Tanit
dc.contributor.author	Gebauer, Fátima
dc.date.accessioned	2024-08-01T11:55:19Z
dc.date.available	2024-08-01T11:55:19Z
dc.date.issued	2024
dc.identifier.citation	Ciocia A, Mestre-Farràs N, Vicent-Nacht I, Guitart T, Gebauer F. CSDE1: a versatile regulator of gene expression in cancer. NAR Cancer. 2024 Apr 10;6(2):zcae014. DOI: 10.1093/narcan/zcae014
dc.identifier.issn	2632-8674
dc.identifier.uri	http://hdl.handle.net/10230/60878
dc.description.abstract	RNA-binding proteins (RBPs) have garnered significant attention in the field of cancer due to their ability to modulate diverse tumor traits. Once considered untargetable, RBPs have sparked renewed interest in drug development, particularly in the context of RNA-binding modulators of translation. This review focuses on one such modulator, the protein CSDE1, and its pivotal role in regulating cancer hallmarks. We discuss context-specific functions of CSDE1 in tumor development, its mechanisms of action, and highlight features that support its role as a molecular adaptor. Additionally, we discuss the regulation of CSDE1 itself and its potential value as biomarker and therapeutic target.
dc.description.sponsorship	Work in Gebauer lab is supported by the Spanish Ministry of Science and Innovation [PID2021-127948NB-100 funded by MCIN/AEI/10.13039/501100011033/FEDER, UE; Centro de Excelencia Severo Ochoa CEX2020-001049-S, MCIN/AEI /10.13039/501100011033]; Catalan Agency for Research and Universities [SGR-Cat-2021-01215]; Melanoma Research Alliance [Established Investigator Award 826530, https://doi.org/10.48050/pc.gr.143718].
dc.format.mimetype	application/pdf
dc.language.iso	eng
dc.publisher	Oxford University Press
dc.relation.ispartof	NAR Cancer. 2024 Apr 10;6(2):zcae014
dc.rights	© The Author(s) 2024. Published by Oxford University Press on behalf of NAR Cancer. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/
dc.subject.other	Expressió gènica
dc.title	CSDE1: a versatile regulator of gene expression in cancer
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	http://dx.doi.org/10.1093/narcan/zcae014
dc.relation.projectID	info:eu-repo/grantAgreement/ES/3PE/PID2021-127948NB-100
dc.relation.projectID	info:eu-repo/grantAgreement/ES/2PE/CEX2020-001049-S
dc.rights.accessRights	info:eu-repo/semantics/openAccess
dc.type.version	info:eu-repo/semantics/publishedVersion